RG Cyganek (Stem Cell Unit)

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  • 2024 | Journal Article
    ​ ​Rapöhn, Marcel, Lukas Cyganek, Niels Voigt, Gerd Hasenfuß, Stephan E Lehnart, and Jörg W Wegener. "Non-invasive analysis of contractility during identical maturations revealed two phenotypes in ventricular but not in atrial iPSC-CM​." ​American Journal of Physiology. Heart and Circulatory Physiology (2024): . ​https://doi.org/10.1152/ajpheart.00527.2023.
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  • 2024 | Journal Article
    ​ ​Dobner, Jochen, Thach Nguyen, Mario Gustavo Pavez-Giani, Lukas Cyganek, Felix Distelmaier, Jean Krutmann, Alessandro Prigione, and Andrea Rossi. "mtDNA analysis using Mitopore​." ​Molecular Therapy. Methods & Clinical Development ​32, no. 2 (2024): ​101231​. ​https://doi.org/10.1016/j.omtm.2024.101231.
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  • 2024 | Journal Article
    ​ ​Knauer, Carolin, Henrike Haltern, Eric Schoger, Sebastian Kügler, Lennart Roos, Laura C. Zelarayán, Gerd Hasenfuss, Wolfram-Hubertus Zimmermann, Bernd Wollnik, and Lukas Cyganek. "Preclinical evaluation of CRISPR-based therapies for Noonan syndrome caused by deep-intronic LZTR1 variants​." ​Molecular Therapy - Nucleic Acids ​35, no. 1 (2024): ​102123​. ​https://doi.org/10.1016/j.omtn.2024.102123.
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  • 2023 | Journal Article | 
    ​ ​Priesmeier, Laura, Eric Schoger, Lukas Cyganek, and Laura Cecilia Zelarayán. "Combining a tetracycline (Tet)-inducible gRNA system and CRISPRa for titratable and timely controlled enhancement of endogenous SHISA3 activation in human induced pluripotent stem cells (hiPSC)​." ​Stem Cell Research ​71 (2023): ​103163​. ​https://doi.org/10.1016/j.scr.2023.103163.
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  • 2023 | Journal Article | 
    ​ ​Seibertz, Fitzwilliam, Henry Sutanto, Rebekka Dülk, Julius Ryan D. Pronto, Robin Springer, Markus Rapedius, Aiste Liutkute et al. "Electrophysiological and calcium-handling development during long-term culture of human-induced pluripotent stem cell-derived cardiomyocytes​." ​Basic Research in Cardiology ​118, no. 1 (2023): ​14​. ​https://doi.org/10.1007/s00395-022-00973-0.
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  • 2023 | Preprint
    ​ ​Busley, Alexandra Viktoria, Óscar Gutiérrez-Gutiérrez, Elke Hammer, Martin Steinegger, Linda Böhmer, Henning Schroeder, Mandy Kleinsorge et al​. "LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome​." ​Preprint, submitted ​​2023. ​https://mbexc.uni-goettingen.de/literature/publications/646 https://sfb1002.med.uni-goettingen.de/production/literature/publications/465. https://doi.org/10.1101/2023.01.10.523203.
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  • 2023 | Journal Article
    ​ ​Busley, Alexandra Viktoria, and Lukas Cyganek. "Generation of a genetically-modified induced pluripotent stem cell line harboring a Noonan syndrome-associated gene variant MRAS p.G23V​." ​Stem Cell Research ​69 (2023): ​103108​. ​https://doi.org/10.1016/j.scr.2023.103108.
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  • 2023 | Journal Article
    ​ ​Busley, Alexandra Viktoria, Mandy Kleinsorge, and Lukas Cyganek. "Generation of a genetically-modified induced pluripotent stem cell line harboring an oncogenic gene variant KRAS p.G12V​." ​Stem Cell Research ​69 (2023): ​103105​. ​https://doi.org/10.1016/j.scr.2023.103105.
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  • 2023 | Preprint
    ​ ​Weber, Frederike, Sara Klas, Vanessa Hindmarsh, Gabriela Salinas, Karl Toischer, Gerd Hasenfuss, and Lukas Cyganek​. "Secreted-Frizzled-Related Protein 5 Modulates Calcium Handling in Human Ipsc-Cardiomyocytes​." ​Preprint, submitted ​​2023. ​https://mbexc.uni-goettingen.de/literature/publications/903. https://doi.org/10.2139/ssrn.4544232.
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  • 2023 | Journal Article | 
    ​ ​Nakhaei-Rad, Saeideh, Fereshteh Haghighi, Farhad Bazgir, Julia Dahlmann, Alexandra Viktoria Busley, Marcel Buchholzer, Karolin Kleemann et al. "Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues​." ​Communications Biology ​6, no. 1 (2023): . ​https://doi.org/10.1038/s42003-023-05013-8.
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  • 2023 | Journal Article
    ​ ​Seibertz, Fitzwilliam, Tony Rubio, Robin Springer, Fiona Popp, Melanie Ritter, Aiste Liutkute, Lena Bartelt et al. "Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy development​." ​Cardiovascular Research (2023): ​cvad143​. ​https://doi.org/10.1093/cvr/cvad143.
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  • 2023 | Journal Article | 
    ​ ​Chowdhury, Arpita, Angela Boshnakovska, Abhishek Aich, Aditi Methi, Ana Maria Vergel Leon, Ivan Silbern, Christian Lüchtenborg et al. "Metabolic switch from fatty acid oxidation to glycolysis in knock‐in mouse model of Barth syndrome​." ​EMBO Molecular Medicine (2023): ​e17399​. ​https://doi.org/10.15252/emmm.202317399.
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  • 2022 | Journal Article | Research Paper | 
    ​ ​Li, Wener, Xiaojing Luo, Mareike S. Poetsch, Reinhard Oertel, Kapil Nichani, Martin Schneider, Anna Strano et al. "Synergistic Adverse Effects of Azithromycin and Hydroxychloroquine on Human Cardiomyocytes at a Clinically Relevant Treatment Duration​." ​Pharmaceuticals ​15, no. 2 (2022): . ​https://doi.org/10.3390/ph15020220.
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  • 2022 | Journal Article | Overview | 
    ​ ​Pavez-Giani, Mario G., and Lukas Cyganek. "Recent Advances in Modeling Mitochondrial Cardiomyopathy Using Human Induced Pluripotent Stem Cells​." ​Frontiers in Cell and Developmental Biology ​9 (2022): ​800529​. ​https://doi.org/10.3389/fcell.2021.800529.
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  • 2022 | Journal Article
    ​ ​Zhong, Rujia, Feng Zhang, Zhen Yang, Yingrui Li, Qiang Xu, Huan Lan, Lukas Cyganek et al. "Epigenetic mechanism of L-type calcium channel β-subunit downregulation in short QT human induced pluripotent stem cell-derived cardiomyocytes with CACNB2 mutation​." ​EP Europace (2022): ​euac091​. ​https://doi.org/10.1093/europace/euac091.
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  • 2022 | Journal Article | Research Paper | 
    ​ ​Lyra-Leite, Davi M., Óscar Gutiérrez-Gutiérrez, Meimei Wang, Yang Zhou, Lukas Cyganek, and Paul W. Burridge. "A review of protocols for human iPSC culture, cardiac differentiation, subtype-specification, maturation, and direct reprogramming​." ​STAR Protocols ​3, no. 3 (2022): ​101560​. ​https://doi.org/10.1016/j.xpro.2022.101560.
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  • 2022 | Preprint
    ​ ​Nakhaei-Rad, Saeideh, Farhad Bazgir, Julia Dahlmann, Alexandra Viktoria Busley, Marcel Buchholzer, Fereshteh Haghighi, Anne Schänzer et al​. "Alteration of myocardial structure and function in RAF1-associated Noonan syndrome: Insights from cardiac disease modeling based on patient-derived iPSCs​." ​Preprint, submitted ​​2022. ​https://mbexc.uni-goettingen.de/literature/publications/575 https://sfb1002.med.uni-goettingen.de/production/literature/publications/477. https://doi.org/10.1101/2022.01.22.477319.
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  • 2022 | Journal Article | 
    ​ ​Seibertz, Fitzwilliam, Markus Rapedius, Funsho E. Fakuade, Philipp Tomsits, Aiste Liutkute, Lukas Cyganek, Nadine Becker et al. "A modern automated patch-clamp approach for high throughput electrophysiology recordings in native cardiomyocytes​." ​Communications Biology ​5, no. 1 (2022): . ​https://doi.org/10.1038/s42003-022-03871-2.
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Barbarics, Boris, Katja Eildermann, Lars Kaderali, Lukas Cyganek, Uwe Plessmann, Julius Bodemeyer, Thomas Paul et al. "Proteomic mapping of atrial and ventricular heart tissue in patients with aortic valve stenosis​." ​Scientific Reports ​11, no. 1 (2021): ​24389​. ​https://doi.org/10.1038/s41598-021-03907-3.
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  • 2021 | Book Chapter
    ​ ​Kusch, Harald, Robert Kossen, Markus Suhr, Luca Freckmann, Linus Weber, Christian Henke, Christoph Lehmann et al. "Management of Metadata Types in Basic Cardiological Research​." ​In German Medical Data Sciences 2021: Digital Medicine: Recognize – Understand – Heal, edited by Rainer Röhrig, Tim Beißbarth, Jochem König, Claudia Ose, Geraldine Rauch, Ulrich Sax, Björn Schreiweis et al.​, 59​-68​. ​​2021. https://doi.org/10.3233/SHTI210542.
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  • 2021 | Journal Article | Research Paper
    ​ ​Fomin, Andrey, Anna Gärtner, Lukas Cyganek, Malte Tiburcy, Izabela Tuleta, Luisa Wellers, Lina Folsche et al. "Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations​." ​Science Translational Medicine ​13, no. 618 (2021): . ​https://doi.org/10.1126/scitranslmed.abd3079.
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Sattler, Katherine, Ibrahim El-Battrawy, Lukas Cyganek, Siegfried Lang, Huan Lan, Xin Li, Zhihan Zhao et al. "TRPV1 activation and internalization is part of the LPS-induced inflammation in human iPSC-derived cardiomyocytes​." ​Scientific Reports ​11, no. 1 (2021): ​14689​. ​https://doi.org/10.1038/s41598-021-93958-3.
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  • 2021 | Journal Article | Research Paper
    ​ ​Peper, Jonas, Daniel Kownatzki-Danger, Gunnar Weninger, Fitzwilliam Seibertz, Julius Ryan D. Pronto, Henry Sutanto, David Pacheu-Grau, Robin Hindmarsh, Sören Brandenburg, and Stephan E. Lehnart. "Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes​." ​Circulation Research ​128, no. 6 (2021): . ​https://doi.org/10.1161/CIRCRESAHA.119.316547.
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Rössler, Uta, Anna Floriane Hennig, Nina Stelzer, Shroddha Bose, Johannes Kopp, Kent Søe, Lukas Cyganek et al. "Efficient generation of osteoclasts from human induced pluripotent stem cells and functional investigations of lethal CLCN7 ‐related osteopetrosis​." ​Journal of Bone and Mineral Research ​36, no. 8 (2021): ​1621​-1635​. ​https://doi.org/10.1002/jbmr.4322.
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Schoger, Eric, Wolfram-Hubertus Zimmermann, Lukas Cyganek, and Laura Cecilia Zelarayán. "Establishment of two homozygous CRISPR interference (CRISPRi) knock-in human induced pluripotent stem cell (hiPSC) lines for titratable endogenous gene repression​." ​Stem Cell Research ​55 (2021): ​S1873506121003202​. ​https://doi.org/10.1016/j.scr.2021.102473.
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Schoger, Eric, Wolfram-Hubertus Zimmermann, Lukas Cyganek, and Laura Cecilia Zelarayán. "Establishment of a second generation homozygous CRISPRa human induced pluripotent stem cell (hiPSC) line for enhanced levels of endogenous gene activation​." ​Stem Cell Research ​56 (2021): ​S1873506121003652​. ​https://doi.org/10.1016/j.scr.2021.102518.
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Yousefi, Roya, Eugenio F Fornasiero, Lukas Cyganek, Julio Montoya, Stefan Jakobs, Silvio O Rizzoli, Peter Rehling, and David Pacheu‐Grau. "Monitoring mitochondrial translation in living cells​." ​EMBO reports ​22, no. 4 (2021): . ​https://doi.org/10.15252/embr.202051635.
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  • 2020 | Preprint
    ​ ​Yousefi, Roya, Eugenio F. Fornasiero, Lukas Cyganek, Stefan Jakobs, Silvio O. Rizzoli, Peter Rehling, and David Pacheu-Grau​. "Local translation in synaptic mitochondria influences synaptic transmission​." ​Preprint, submitted ​​2020. ​https://mbexc.uni-goettingen.de/literature/publications/168 https://sfb1002.med.uni-goettingen.de/production/literature/publications/382 https://sfb1286.uni-goettingen.de/literature/publications/93. https://doi.org/10.1101/2020.07.22.215194.
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Beuthner, Bo E. C., Rodi Topci, Mareike Derks, Thomas Franke, Sandra Seelke, Miriam Puls, Andreas Schuster et al. "Interdisciplinary Research on Aortic Valve Stenosis: A Longitudinal Collection of Biospecimens and Clinical Data of Patients Undergoing Transcatheter Aortic Valve Replacement​." ​Open Journal of Bioresources ​7 (2020): . ​https://doi.org/10.5334/ojb.65.
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Schoger, Eric, Loukas Argyriou, Wolfram-Hubertus Zimmermann, Lukas Cyganek, and Laura Cecilia Zelarayán. "Generation of homozygous CRISPRa human induced pluripotent stem cell (hiPSC) lines for sustained endogenous gene activation​." ​Stem Cell Research ​48 (2020): ​101944​. ​https://doi.org/10.1016/j.scr.2020.101944.
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Khadjeh, Sara, Vanessa Hindmarsh, Frederike Weber, Lukas Cyganek, Ramon O. Vidal, Setare Torkieh, Katrin Streckfuss-Bömeke et al. "CRISPLD1: a novel conserved target in the transition to human heart failure​." ​Basic Research in Cardiology ​115, no. 3 (2020): . ​https://doi.org/10.1007/s00395-020-0784-4.
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Luo, Xiaojing, Wener Li, Karolina Künzel, Sarah Henze, Lukas Cyganek, Anna Strano, Mareike S. Poetsch, Mario Schubert, and Kaomei Guan. "IP3R-Mediated Compensatory Mechanism for Calcium Handling in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes With Cardiac Ryanodine Receptor Deficiency​." ​Frontiers in Cell and Developmental Biology ​8 (2020): . ​https://doi.org/10.3389/fcell.2020.00772.
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  • 2020 | Journal Article | Research Paper
    ​ ​Hanses, Ulrich, Mandy Kleinsorge, Lennart Roos, Gökhan Yigit, Yun Li, Boris Barbarics, Ibrahim El-Battrawy et al. "Intronic CRISPR Repair in a Preclinical Model of Noonan Syndrome–Associated Cardiomyopathy​." ​Circulation ​142, no. 11 (2020): ​1059​-1076​. ​https://doi.org/10.1161/CIRCULATIONAHA.119.044794.
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Ganapathi, Mythily, Loukas Argyriou, Francisco Martínez-Azorín, Susanne Morlot, Gökhan Yigit, Teresa M. Lee, Bernd Auber et al. "Bi-allelic missense disease-causing variants in RPL3L associate neonatal dilated cardiomyopathy with muscle-specific ribosome biogenesis​." ​Human Genetics ​139, no. 11 (2020): ​1443​-1454​. ​https://doi.org/10.1007/s00439-020-02188-6.
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Kleinsorge, Mandy, and Lukas Cyganek. "Subtype-Directed Differentiation of Human iPSCs into Atrial and Ventricular Cardiomyocytes​." ​STAR Protocols ​1, no. 1 (2020): ​100026​. ​https://doi.org/10.1016/j.xpro.2020.100026.
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  • 2019 | Conference Paper
    ​ ​Springer, R., F. Seibertz, R. A. Solano, T. Rubio, Lukas Cyganek, Wolfram-Hubertus Zimmermann, and Niels Voigt. "P1235Acetylcholine-activated inward-rectifier potassium currents in atrial cardiomyocytes derived from induced pluripotent stem cells and atrial engineered heart muscle preparations​." ​European Heart Journal ​40​, ​no. Suppl. 1 (2019): https://doi.org/10.1093/eurheartj/ehz748.0193.
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  • 2019 | Conference Abstract
    ​ ​Lehmann, Christoph, Markus Suhr, Nadine Umbach, Lukas Cyganek, Mandy Kleinsorge, Sara Yasemin Nussbeck, and Harald Kusch. "Leaving spreadsheets behind – FAIR documentation and representation of human stem cell lines in the Collaborative Research Centre 1002 Meeting Abstract​." ​GMS German Medical Science  ​(2019): https://doi.org/10.3205/19gmds037.
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  • 2018 | Journal Article | Research Paper | 
    ​ ​Cyganek, Lukas, Malte Tiburcy, Karolina Sekeres, Kathleen Gerstenberg, Hanibal Bohnenberger, Christof Lenz, Sarah Henze et al. "Deep phenotyping of human induced pluripotent stem cell–derived atrial and ventricular cardiomyocytes​." ​JCI Insight ​3, no. 12 (2018): ​e99941​. ​https://doi.org/10.1172/jci.insight.99941.
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  • 2017 | Journal Article | Research Paper | 
    ​ ​Borchert, Thomas, Daniela Hübscher, Celina I. Guessoum, Tuan-Dinh D. Lam, Jelena R. Ghadri, Isabel N. Schellinger, Malte Tiburcy et al. "Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy​." ​Journal of the American College of Cardiology ​70, no. 8 (2017): ​975​-991​. ​https://doi.org/10.1016/j.jacc.2017.06.061.
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  • 2015 | Journal Article | Research Paper | 
    ​ ​Kruse, Vanessa, Carina Hamann, Sebastian Monecke, Lukas Cyganek, Leslie Elsner, Daniela Huebscher, Lutz Walter, Katrin Streckfuss-Boemeke, Kaomei Guan, and Ralf Dressel. "Human Induced Pluripotent Stem Cells Are Targets for Allogeneic and Autologous Natural Killer (NK) Cells and Killing Is Partly Mediated by the Activating NK Receptor DNAM-1​." ​PLoS One ​10, no. 5 (2015): ​e0125544​. ​https://doi.org/10.1371/journal.pone.0125544.
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  • 2013 | Journal Article | Overview | 
    ​ ​Cyganek, Lukas, Simin Chen, Thomas Borchert, and Kaomei Guan. "Cardiac Progenitor Cells and their Therapeutic Application for Cardiac Repair​." ​Journal of Clinical & Experimental Cardiology ​S11 (2013): ​008​. ​https://doi.org/10.4172/2155-9880.S11-008.
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