RG Lehnart (Cellular Biophysics and Translational Cardiology Section)

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  • 2024 | Journal Article
    ​ ​Non-invasive analysis of contractility during identical maturations revealed two phenotypes in ventricular but not in atrial iPSC-CM​
    Rapöhn, M.; Cyganek, L.; Voigt, N.; Hasenfuß, G.; Lehnart, S. E & Wegener, J. W​ (2024) 
    American Journal of Physiology. Heart and Circulatory Physiology,.​ DOI: https://doi.org/10.1152/ajpheart.00527.2023 
    ​Details  DOI  PMID  PMC 
  • 2024 | Journal Article
    ​ ​3D Super-Resolution Nuclear Q-FISH Imaging Reveals Cell-Cycle-Related Telomere Changes​
    Pochechueva, T. V.; Schwenzer, N.; Kohl, T.; Brandenburg, S.; Kaltenecker, G.; Wollnik, B. & Lehnart, S. E.​ (2024) 
    International Journal of Molecular Sciences, 25(6) pp. 3183​.​ DOI: https://doi.org/10.3390/ijms25063183 
    ​Details  DOI 
  • 2024 | Journal Article | Editorial Contribution (Editorial, Introduction, Epilogue)
    ​ ​SERCA2a microdomain cAMP changes in heart failure with preserved ejection fraction​
    Gotthardt, M. & Lehnart, S. E.​ (2024) 
    Cardiovascular Research, art. cvae030​.​ DOI: https://doi.org/10.1093/cvr/cvae030 
    ​Details  DOI  PMID  PMC 
  • 2024 | Preprint
    ​ ​Nanoscale architecture and dynamics of CaV1.3 channel clusters in cardiac myocytes revealed by single channel nanoscopy​
    Schwenzer, N.; Tsukanov, R.; Kohl, T.; Basak, S.; Seibertz, F.; Voigt, N.& Enderlein, J. et al.​ (2024). DOI: https://doi.org/10.1101/2024.02.26.582084 
    ​Details  DOI 
  • 2023 | Journal Article
    ​ ​A dual-targeted drug inhibits cardiac ryanodine receptor Ca 2+ leak but activates SERCA2a Ca 2+ uptake​
    Wegener, J. W.; Mitronova, G. Y.; ElShareif, L.; Quentin, C.; Belov, V.; Pochechueva, T. & Hasenfuss, G. et al.​ (2023) 
    Life Science Alliance, 7(2) art. e202302278​.​ DOI: https://doi.org/10.26508/lsa.202302278 
    ​Details  DOI  PMID  PMC 
  • 2023 | Journal Article
    ​ ​An Alternative Mechanism of Subcellular Iron Uptake Deficiency in Cardiomyocytes​
    Dai, Y.; Ignatyeva, N.; Xu, H.; Wali, R.; Toischer, K.; Brandenburg, S. & Lenz, C. et al.​ (2023) 
    Circulation Research, art. CIRCRESAHA.122.321157​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.122.321157 
    ​Details  DOI  PMID  PMC 
  • 2023 | Journal Article | Overview
    ​ ​Cardiac multiscale bioimaging: from nano- through micro- to mesoscales​
    Tolstik, E.; Lehnart, S. E.; Soeller, C.; Lorenz, K. & Sacconi, L.​ (2023) 
    Trends in Biotechnology,.​ DOI: https://doi.org/10.1016/j.tibtech.2023.08.007 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Research Paper
    ​ ​Modulatorische Einheiten bei Herzinsuffizienz​
    Hasenfuß, G. P. ; Kaul, A.; Lehnart, S. E. ; Linke, W. A. ; Zelarayan, L. C.   & Zimmermann, W.-H. ​ (2022) 
    Der Kardiologe, 16(2) pp. 109​-114​.​ DOI: https://doi.org/10.1007/s12181-022-00540-w 
    ​Details  DOI 
  • 2022 | Journal Article
    ​ ​Dysferlin facilitates the de novo biogenesis of tubular membranes in hypertrophic remodelling​
    Paulke, N.; Amlaz, S.; Fleischhacker, C.; Kohl, T.; Kownatzki-Danger, D.; Hasenfuss, G.   & Lehnart, S.  et al.​ (2022) 
    European Heart Journal, 43(Suppl. 2).​ DOI: https://doi.org/10.1093/eurheartj/ehac544.2944 
    ​Details  DOI 
  • 2022 | Journal Article | Discussion
    ​ ​New Insights into the Proteolytic Regulation of the Structural Protein Junctophilin-2 by Calpain​
    Weninger, G. & Lehnart, S. E. ​ (2022) 
    Journal of Cellular Signaling, 3(4).​ DOI: https://doi.org/10.33696/Signaling.3.081 
    ​Details  DOI 
  • 2022 | Journal Article | Overview
    ​ ​The Role of Junctophilin Proteins in Cellular Function​
    Lehnart, S. E.   & Wehrens, X. H. T.​ (2022) 
    Physiological Reviews,.​ DOI: https://doi.org/10.1152/physrev.00024.2021 
    ​Details  DOI  PMID  PMC 
  • 2021 | Book Chapter
    ​ ​Management of Metadata Types in Basic Cardiological Research​
    Kusch, H. ; Kossen, R. ; Suhr, M.; Freckmann, L.; Weber, L.; Henke, C.& Lehmann, C. et al.​ (2021)
    In:​Röhrig, Rainer; Beißbarth, Tim; König, Jochem; Ose, Claudia; Rauch, Geraldine; Sax, Ulrich; Schreiweis, Björn, et al.​ (Eds.), German Medical Data Sciences 2021: Digital Medicine: Recognize – Understand – Heal pp. 59​-68.  DOI: https://doi.org/10.3233/SHTI210542 
    ​Details  DOI  PMID  PMC 
  • 2021 | Preprint
    ​ ​Analyzing cross-talk between superimposed signals: Vector norm dependent hidden Markov models and applications​
    Vanegas, L. J.; Eltzner, B.; Rudolf, D. ; Dura, M.; Lehnart, S. E.  & Munk, A. ​ (2021). DOI: https://doi.org/10.48550/arXiv.2103.06071 
    ​Details  DOI  arXiv 
  • 2021 | Research Data
    ​ ​Online Supplemental Files for "Caveolin3 Stabilizes McT1-mediated Lactate/Proton Transport in Cardiomyocytes"​
    Lehnart, S. E. ​ (2021)
     DOI: https://doi.org/10.25625/ffe7lj 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper
    ​ ​CaMKII inhibition has dual effects on spontaneous Ca 2+ release and Ca 2+ alternans in ventricular cardiomyocytes from mice with a gain-of-function RyR2 mutation​
    Sadredini, M.; Haugsten Hansen, M.; Frisk, M.; Louch, W. E.; Lehnart, S. E. ; Sjaastad, I. & Korseberg Stokke, M.​ (2021) 
    American Journal of Physiology-Heart and Circulatory Physiology, 321(2) pp. H446​-H460​.​ DOI: https://doi.org/10.1152/ajpheart.00011.2021 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper
    ​ ​Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes​
    Peper, J.; Kownatzki-Danger, D.; Weninger, G.; Seibertz, F.; Pronto, J. R. D.; Sutanto, H. & Pacheu-Grau, D. et al.​ (2021) 
    Circulation Research, 128(6).​ DOI: https://doi.org/10.1161/CIRCRESAHA.119.316547 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper
    ​ ​cAMP Imaging at Ryanodine Receptors Reveals β2-Adrenoceptor Driven Arrhythmias​
    Berisha, F.; Götz, K.; Wegener, J. W.; Brandenburg, S. ; Subramanian, H.; Molina, C. E. & Rueffer, A. et al.​ (2021) 
    Circulation Research,.​ DOI: https://doi.org/10.1161/CIRCRESAHA.120.318234 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper
    ​ ​Loss of SPEG Inhibitory Phosphorylation of Ryanodine Receptor Type-2 Promotes Atrial Fibrillation​
    Campbell, H. M.; Quick, A. P.; Abu-Taha, I.; Chiang, D. Y.; Kramm, C. F.; Word, T. A. & Brandenburg, S. et al.​ (2020) 
    Circulation, 142(12) pp. 1159​-1172​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.120.045791 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper
    ​ ​14-3-3 binding creates a memory of kinase action by stabilizing the modified state of phospholamban​
    Menzel, J. ; Kownatzki-Danger, D.; Tokar, S.; Ballone, A.; Unthan-Fechner, K.; Kilisch, M.   & Lenz, C.  et al.​ (2020) 
    Science Signaling, 13(647) pp. eaaz1436​.​ DOI: https://doi.org/10.1126/scisignal.aaz1436 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper
    ​ ​Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation​
    Alsina, K. M.; Hulsurkar, M.; Brandenburg, S. ; Kownatzki-Danger, D.; Lenz, C. ; Urlaub, H.   & Abu-Taha, I. et al.​ (2019) 
    Circulation, 140(8) pp. 681​-693​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.119.039642 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Overview
    ​ ​Ryanodine receptor dysfunction and the resolution revolution: how Nobel Prize-winning techniques transform cardiovascular research​
    Voigt, N.   & Lehnart, S. E. ​ (2018) 
    Cardiovascular Research, 114(14) pp. e106​-e109​.​ DOI: https://doi.org/10.1093/cvr/cvy235 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression​
    Mohamed, B. A. ; Hartmann, N. ; Tirilomis, P.; Sekeres, K.; Li, W.; Neef, S. & Richter, C.  et al.​ (2018) 
    Science Translational Medicine, 10(458) art. eaan0724​.​ DOI: https://doi.org/10.1126/scitranslmed.aan0724 
    ​Details  DOI  PMID  PMC 
  • 2017 | Conference Abstract
    ​ ​P1334 - The relevant role of SR Ca leak in the development of heart failure​
    Mohamed, B. A.; Kattner, L.; Guan, K. ; Lehnart, S. E. ; Luther, S. ; Sossalla, S.   & Hasenfuß, G.  et al.​ (2017)
    European Journal of Heart Failure, 19(Suppl. 1) ​Heart Failure 2017 and the 4th World Congress on Acute Heart Failure​, Paris.
    ​Details 
  • 2017 | Conference Paper
    ​ ​Towards sustainable research data management in advanced light microscopy​
    Henke, C.; Kusch, H. ; Marzec, B.; Nußbeck, S. Y. & Umbach, N.​ (2017)
    ​62. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e. V. (GMDS)​, Oldenburg. DOI: https://doi.org/10.3205/17gmds094 
    ​Details  DOI 
  • 2016 | Book Chapter
    ​ ​Optogenetic Light Crafting Tools for the Control of Cardiac Arrhythmias​
    Richter, C. ; Christoph, J. ; Lehnart, S. E.  & Luther, S. ​ (2016)
    In:​Kianianmomeni, Arash​ (Ed.), Optogenetics: Methods and Protocols pp. 293​-302. ​New York: ​Humana Press. DOI: https://doi.org/10.1007/978-1-4939-3512-3_20 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article | Research Paper
    ​ ​Axial tubule junctions control rapid calcium signaling in atria​
    Brandenburg, S. ; Kohl, T. ; Williams, G. S. B.; Gusev, K.; Wagner, E. ; Rog-Zielinska, E. A. & Hebisch, E. et al.​ (2016) 
    Journal of Clinical Investigation, 126(10) pp. 3999​-4015​.​ DOI: https://doi.org/10.1172/JCI88241 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper
    ​ ​Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release​
    Manotheepan, R.; Danielsen, T. K.; Sadredini, M.; Anderson, M. E.; Carlson, C. R.; Lehnart, S. E.   & Sjaastad, I. et al.​ (2016) 
    Cardiovascular Research, 111(3) pp. 295​-306​.​ DOI: https://doi.org/10.1093/cvr/cvw095 
    ​Details  DOI  PMID  PMC 
  • 2016 | Conference Paper
    ​ ​The molecular and functional identities of atrial cardiomyocytes in health and disease​
    Brandenburg, S. ; Arakel, E. C. ; Schwappach, B.   & Lehnart, S. E. ​ (2016)
    ​Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (7, Part B) pp. 1882​-1893. (Vol. 1863). ​8th Ascona International Workshop on Cardiomyocyte Biology - Integration of Developmental and Environmental Cues​, Ascona, SWITZERLAND.
    Amsterdam​: Elsevier Science Bv. DOI: https://doi.org/10.1016/j.bbamcr.2015.11.025 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper
    ​ ​"Reduced" Coumarin Dyes with an O-Phosphorylated 2,2-Dimethyl-4-( hydroxymethyl)-1,2,3,4-tetrahydroquinoline Fragment: Synthesis, Spectra, and STED Microscopy​
    Nizamov, S.; Sednev, M. V. ; Bossi, M. L. ; Hebisch, E.; Frauendorf, H. ; Lehnart, S. E.   & Belov, V. N.  et al.​ (2016) 
    Chemistry - A European Journal, 22(33) pp. 11631​-11642​.​ DOI: https://doi.org/10.1002/chem.201601252 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Sensing Cardiac Electrical Activity With a Cardiac Myocyte-Targeted Optogenetic Voltage Indicator​
    Chang Liao, M.-L.; Boer, T. P. de; Mutoh, H.; Raad, N.; Richter, C. ; Wagner, E.   & Downie, B. R. et al.​ (2015) 
    Circulation Research, 117(5) pp. 401​-412​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.117.306143 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation​
    Godier-Furnemont, A. F. G.; Tiburcy, M. ; Wagner, E. ; Dewenter, M. ; Laemmle, S.; El-Armouche, A.   & Lehnart, S. E.  et al.​ (2015) 
    Biomaterials, 60 pp. 82​-91​.​ DOI: https://doi.org/10.1016/j.biomaterials.2015.03.055 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Optogenetic determination of the myocardial requirements for extrasystoles by cell type-specific targeting of ChannelRhodopsin-2​
    Zaglia, T.; Pianca, N.; Borile, G.; Da Broi, F.; Richter, C. ; Campione, M. & Lehnart, S. E.  et al.​ (2015) 
    Proceedings of the National Academy of Sciences of the United States of America, 112(32) pp. E4495​-E4504​.​ DOI: https://doi.org/10.1073/pnas.1509380112 
    ​Details  DOI  PMID  PMC 
  • 2015 | Journal Article
    ​ ​Intensity matters: Ryanodine receptor regulation during exercise​
    Kohl, T. ; Weninger, G.; Zalk, R.; Eaton, P. & Lehnart, S. E. ​ (2015) 
    Proceedings of the National Academy of Sciences of the United States of America, 112(50) pp. 15271​-15272​.​ DOI: https://doi.org/10.1073/pnas.1521051112 
    ​Details  DOI  PMID  PMC 
  • 2015 | Journal Article | Research Paper
    ​ ​Microdomain switch of cGMP-regulated phosphodiesterases leads to ANP-induced augmentation of β-adrenoceptor-stimulated contractility in early cardiac hypertrophy​
    Perera, R. K. ; Sprenger, J. U.; Steinbrecher, J. H.; Hübscher, D. ; Lehnart, S. E. ; Abesser, M. & Schuh, K. et al.​ (2015) 
    Circulation Research, 116(8) pp. 1304​-1311​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.116.306082 
    ​Details  DOI  PMID  PMC 
  • 2014 | Journal Article | Research Paper
    ​ ​Analysis of tubular membrane networks in cardiac myocytes from atria and ventricles​
    Wagner, E. ; Brandenburg, S. ; Kohl, T.   & Lehnart, S. E. ​ (2014) 
    Journal of Visualized Experiments,(92) art. e51823​.​ DOI: https://doi.org/10.3791/51823 
    ​Details  DOI  PMID  PMC 
  • 2014 | Journal Article | Research Paper
    ​ ​Transgenic mice for real-time visualization of cGMP in intact adult cardiomyocytes​
    Götz, K. R.; Sprenger, J. U.; Perera, R. K. ; Steinbrecher, J. H.; Lehnart, S. E. ; Kuhn, M. & Gorelik, J. et al.​ (2014) 
    Circulation Research, 114(8) pp. 1235​-1245​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.114.302437 
    ​Details  DOI  PMID  PMC 
  • 2013 | Journal Article | Overview
    ​ ​Understanding the physiology of heart failure through cellular and in vivo models-towards targeting of complex mechanisms​
    Lehnart, S. E. ​ (2013) 
    Experimental Physiology, 98(3) pp. 622​-628​.​ DOI: https://doi.org/10.1113/expphysiol.2012.068262 
    ​Details  DOI  PMID  PMC 
  • 2013 | Journal Article | Overview
    ​ ​Imaging T-tubules: dynamic membrane structures for deep functions​
    Kohl, T.   & Lehnart, S. E. ​ (2013) 
    Cardiovascular Research, 98(2) pp. 162​-164​.​ DOI: https://doi.org/10.1093/cvr/cvt058 
    ​Details  DOI  PMID  PMC 
  • 2012 | Journal Article | Research Paper
    ​ ​Stimulated Emission Depletion Live-Cell Super-Resolution Imaging Shows Proliferative Remodeling of T-Tubule Membrane Structures After Myocardial Infarction​
    Wagner, E. ; Lauterbach, M. A.; Kohl, T. ; Westphal, V. ; Williams, G. S. B.; Steinbrecher, J. H. & Streich, J.-H. et al.​ (2012) 
    Circulation Research, 111(4) pp. 402​-414​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.112.274530 
    ​Details  DOI  PMID  PMC  WoS 

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