RG Outeiro (Experimental Neurodegeneration)

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  • 2023 | Journal Article | 
    ​ ​The alpha-synuclein oligomers activate nuclear factor of activated T-cell (NFAT) modulating synaptic homeostasis and apoptosis​
    Sant’Anna, R.; Robbs, B. K.; de Freitas, J. A.; dos Santos, P. P.; König, A.; Outeiro, T. F. & Foguel, D.​ (2023) 
    Molecular Medicine, 29(1) art. 111​.​ DOI: https://doi.org/10.1186/s10020-023-00704-8 
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  • 2023 | Journal Article | 
    ​ ​Chemical Synthesis of Alpha‐Synuclein Proteins via Solid‐Phase Peptide Synthesis and Native Chemical Ligation​
    Gatzemeier, L. M.; Meyer, F.; Diederichsen, U. & Outeiro, T. F.​ (2023) 
    Chemistry: a European Journal, 29(33) art. e202300649​.​ DOI: https://doi.org/10.1002/chem.202300649 
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  • 2023 | Journal Article | 
    ​ ​Intermittent Lead Exposure Induces Behavioral and Cardiovascular Alterations Associated with Neuroinflammation​
    Shvachiy, L.; Amaro-Leal, Â.; Outeiro, T. F. ; Rocha, I. & Geraldes, V.​ (2023) 
    Cells, 12(5) pp. 818​.​ DOI: https://doi.org/10.3390/cells12050818 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains​
    Peña-Díaz, S.; Pujols, J.; Vasili, E.; Pinheiro, F.; Santos, J.; Manglano-Artuñedo, Z. & Outeiro, T. F.  et al.​ (2022) 
    The Journal of Biological Chemistry, art. 101902​.​ DOI: https://doi.org/10.1016/j.jbc.2022.101902 
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  • 2022 | Journal Article | Overview | 
    ​ ​Production of Recombinant Alpha-Synuclein: Still No Standardized Protocol in Sight​
    Al-Azzani, M.; König, A. & Outeiro, T. F. ​ (2022) 
    Biomolecules, 12(2).​ DOI: https://doi.org/10.3390/biom12020324 
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  • 2022 | Journal Article | Research Paper | 
    ​ ​Prion-like α-synuclein pathology in the brain of infants with Krabbe disease​
    Hatton, C.; Ghanem, S. S.; Koss, D. J.; Abdi, I. Y.; Gibbons, E.; Guerreiro, R. & Bras, J. et al.​ (2022) 
    Brain: A Journal of Neurology,.​ DOI: https://doi.org/10.1093/brain/awac002 
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  • 2022 | Journal Article | Research Paper | 
    ​ ​Glycation modulates alpha-synuclein fibrillization kinetics: a sweet spot for inhibition​
    Farzadfard, A.; König, A.; Petersen, S. V.; Nielsen, J.; Vasili, E.; Dominguez-Meijide, A. & Buell, A. K. et al.​ (2022) 
    Journal of Biological Chemistry, art. S0021925822002885​.​ DOI: https://doi.org/10.1016/j.jbc.2022.101848 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Rapidly Signal‐enhanced Metabolites for Atomic Scale Monitoring of Living Cells with Magnetic Resonance​
    Ding, Y.; Korchak, S.; Mamone, S.; Jagtap, A. P.; Stevanato, G.; Sternkopf, S. & Moll, D. et al.​ (2022) 
    Chemistry Methods, 2(7).​ DOI: https://doi.org/10.1002/cmtd.202200023 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Aromaticity at position 39 in α‐synuclein: A modulator of amyloid fibril assembly and membrane‐bound conformations​
    Buratti, F. A.; Boeffinger, N.; Garro, H. A.; Flores, J. S.; Hita, F. J.; Gonçalves, P. do C. & Copello, F. dos R. et al.​ (2022) 
    Protein Science, 31(7).​ DOI: https://doi.org/10.1002/pro.4360 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | 
    ​ ​From Molecular to Functional Effects of Different Environmental Lead Exposure Paradigms​
    Shvachiy, L.; Amaro-Leal, Â.; Outeiro, T. F. ; Rocha, I. & Geraldes, V.​ (2022) 
    Biology, 11(8) pp. 1164​.​ DOI: https://doi.org/10.3390/biology11081164 
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  • 2022 | Journal Article | Research Paper | 
    ​ ​Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells​
    Vasili, E.; Dominguez-Meijide, A.; Flores-León, M.; Al-Azzani, M.; Kanellidi, A.; Melki, R. & Stefanis, L. et al.​ (2022) 
    Molecular Neurobiology,.​ DOI: https://doi.org/10.1007/s12035-021-02713-2 
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  • 2022 | Journal Article | Research Paper | 
    ​ ​Glycation modulates glutamatergic signaling and exacerbates Parkinson’s disease-like phenotypes​
    Chegão, A.; Guarda, M.; Alexandre, B. M.; Shvachiy, L.; Temido-Ferreira, M.; Marques-Morgado, I. & Fernandes Gomes, B. et al.​ (2022) 
    npj Parkinson's Disease, 8(1) art. 51​.​ DOI: https://doi.org/10.1038/s41531-022-00314-x 
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  • 2022 | Journal Article | Research Paper | 
    ​ ​Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation​
    Torres-Garcia, L.; P. Domingues, J. M.; Brandi, E.; Haikal, C.; Mudannayake, J. M.; Brás, I. C. & Gerhardt, E.  et al.​ (2022) 
    Scientific Reports, 12(1) art. 2987​.​ DOI: https://doi.org/10.1038/s41598-022-06846-9 
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  • 2022 | Journal Article | 
    ​ ​Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies​
    Koss, D. J.; Erskine, D.; Porter, A.; Palmoski, P.; Menon, H.; Todd, O. G. J. & Leite, M. et al.​ (2022) 
    Acta Neuropathologica Communications, 10(1).​ DOI: https://doi.org/10.1186/s40478-022-01403-x 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | 
    ​ ​Kynurenine 3-Monooxygenase Interacts with Huntingtin at the Outer Mitochondrial Membrane​
    Swaih, A. M.; Breda, C.; Sathyasaikumar, K. V.; Allcock, N.; Collier, M. E. W.; Mason, R. P. & Feasby, A. et al.​ (2022) 
    Biomedicines, 10(9) pp. 2294​.​ DOI: https://doi.org/10.3390/biomedicines10092294 
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  • 2022 | Journal Article | Overview | 
    ​ ​Extracellular alpha-synuclein: Sensors, receptors, and responses​
    Domingues, R.; Sant’Anna, R.; da Fonseca, A. C. C.; Robbs, B. K.; Foguel, D. & Outeiro, T. F. ​ (2022) 
    Neurobiology of Disease, 168 art. S0969996122000882​.​ DOI: https://doi.org/10.1016/j.nbd.2022.105696 
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo​
    Dominguez-Meijide, A.; Parrales, V.; Vasili, E.; González-Lizárraga, F.; König, A.; Lázaro, D. F.   & Lannuzel, A. et al.​ (2021) 
    Neurobiology of Disease, 151 pp. 105256​.​ DOI: https://doi.org/10.1016/j.nbd.2021.105256 
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Identification of Two Novel Peptides That Inhibit α-Synuclein Toxicity and Aggregation​
    Popova, B.; Wang, D.; Rajavel, A.; Dhamotharan, K.; Lázaro, D. F.; Gerke, J. & Uhrig, J. F. et al.​ (2021) 
    Frontiers in Molecular Neuroscience, 14.​ DOI: https://doi.org/10.3389/fnmol.2021.659926 
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  • 2021 | Journal Article | Editorial Contribution (Editorial, Introduction, Epilogue) | 
    ​ ​Emerging concepts in synucleinopathies​
    Outeiro, T. F. ​ (2021) 
    Acta Neuropathologica, 141(4) pp. 469​-470​.​ DOI: https://doi.org/10.1007/s00401-021-02290-7 
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  • 2021 | Journal Article | Overview | 
    ​ ​Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease​
    Oliveira, L. M. A.; Gasser, T.; Edwards, R.; Zweckstetter, M. ; Melki, R.; Stefanis, L. & Lashuel, H. A. et al.​ (2021) 
    npj Parkinson's Disease, 7(1) art. 65​.​ DOI: https://doi.org/10.1038/s41531-021-00203-9 
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity​
    Medina, L.; González-Lizárraga, F.; Dominguez-Meijide, A.; Ploper, D.; Parrales, V.; Sequeira, S. & Cima-Omori, M.-S. et al.​ (2021) 
    Frontiers in Aging Neuroscience, 13.​ DOI: https://doi.org/10.3389/fnagi.2021.635760 
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Cerebral dopamine neurotrophic factor reduces α-synuclein aggregation and propagation and alleviates behavioral alterations in vivo​
    Albert, K.; Raymundo, D. P.; Panhelainen, A.; Eesmaa, A.; Shvachiy, L.; Araújo, G. R. & Chmielarz, P. et al.​ (2021) 
    Molecular Therapy, 29(9) pp. 2821​-2840​.​ DOI: https://doi.org/10.1016/j.ymthe.2021.04.035 
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  • 2021 | Journal Article | Research Paper | 
    ​ ​MPV17 Mutations Are Associated With a Quiescent Energetic Metabolic Profile​
    Jacinto, S.; Guerreiro, P. ; de Oliveira, R. M.; Cunha-Oliveira, T.; Santos, M. J.; Grazina, M. & Rego, A. C. et al.​ (2021) 
    Frontiers in Cellular Neuroscience, 15.​ DOI: https://doi.org/10.3389/fncel.2021.641264 
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  • 2021 | Journal Article | Overview | 
    ​ ​Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies​
    Brás, I. C. & Outeiro, T. F. ​ (2021) 
    Cells, 10(2) pp. 375​.​ DOI: https://doi.org/10.3390/cells10020375 
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Small Molecule Fisetin Modulates Alpha–Synuclein Aggregation​
    Rosado-Ramos, R.; Godinho-Pereira, J.; Marques, D.; Figueira, I.; Outeiro, T. F. ; Menezes, R. & Nunes dos Santos, C.​ (2021) 
    Molecules, 26(11) pp. 3353​.​ DOI: https://doi.org/10.3390/molecules26113353 
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Alpha‐synuclein oligomerization and aggregation: A model will always be a model​
    Outeiro, T. F. ​ (2021) 
    Journal of Neurochemistry, 157(4) pp. 889​-890​.​ DOI: https://doi.org/10.1111/jnc.15264 
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Alpha-Synuclein Antibody Characterization: Why Semantics Matters​
    Outeiro, T. F. ​ (2021) 
    Molecular Neurobiology, 58(5) pp. 2202​-2203​.​ DOI: https://doi.org/10.1007/s12035-020-02269-7 
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Cellular Prion Protein Mediates α‐Synuclein Uptake, Localization, and Toxicity In Vitro and In Vivo​
    Thom, T.; Schmitz, M.; Fischer, A.; Correia, A.; Correia, S.; Llorens, F. & Pique, A. et al.​ (2021) 
    Movement Disorders, 37(1) art. mds.28774​.​ DOI: https://doi.org/10.1002/mds.28774 
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  • 2021 | Journal Article | Overview | 
    ​ ​Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders​
    Erskine, D.; Koss, D.; Korolchuk, V. I.; Outeiro, T. F. ; Attems, J. & McKeith, I.​ (2021) 
    Acta Neuropathologica, 141(4) pp. 511​-526​.​ DOI: https://doi.org/10.1007/s00401-021-02266-7 
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  • 2021 | Journal Article | Overview | 
    ​ ​Dysfunction of RAB39B‐ Mediated Vesicular Trafficking in Lewy Body Diseases​
    Koss, D. J.; Campesan, S.; Giorgini, F. & Outeiro, T. F. ​ (2021) 
    Movement Disorders,.​ DOI: https://doi.org/10.1002/mds.28605 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases​
    Menezes, R.; Foito, A.; Jardim, C.; Costa, I.; Garcia, G.; Rosado-Ramos, R. & Freitag, S. et al.​ (2020) 
    Antioxidants, 9(9) pp. 789​.​ DOI: https://doi.org/10.3390/antiox9090789 
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  • 2020 | Journal Article | Overview | 
    ​ ​Synucleinopathies: Where we are and where we need to go​
    Brás, I. C.; Dominguez‐Meijide, A.; Gerhardt, E. ; Koss, D.; Lázaro, D. F. ; Santos, P. I. & Vasili, E. et al.​ (2020) 
    Journal of Neurochemistry, 153(4) pp. 433​-454​.​ DOI: https://doi.org/10.1111/jnc.14965 
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  • 2020 | Journal Article | Overview | 
    ​ ​Pharmacological Modulators of Tau Aggregation and Spreading​
    Dominguez-Meijide, A.; Vasili, E. & Outeiro, T. F. ​ (2020) 
    Brain Sciences, 10(11) pp. 858​.​ DOI: https://doi.org/10.3390/brainsci10110858 
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  • 2020 | Journal Article | Overview | 
    ​ ​The Role of Alpha-Synuclein and Other Parkinson’s Genes in Neurodevelopmental and Neurodegenerative Disorders​
    Morato Torres, C. A.; Wassouf, Z.; Zafar, F.; Sastre, D.; Outeiro, T. F.   & Schüle, B.​ (2020) 
    International Journal of Molecular Sciences, 21(16) pp. 5724​.​ DOI: https://doi.org/10.3390/ijms21165724 
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  • 2020 | Journal Article | Overview | 
    ​ ​From iPS Cells to Rodents and Nonhuman Primates: Filling Gaps in Modeling Parkinson's Disease​
    Outeiro, T. F. ; Heutink, P.; Bezard, E. & Cenci, A. M.​ (2020) 
    Movement Disorders,.​ DOI: https://doi.org/10.1002/mds.28387 
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  • 2020 | Journal Article | Editorial Contribution (Editorial, Introduction, Epilogue) | 
    ​ ​Editorial: Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases​
    Lázaro, D. F. ; Bellucci, A.; Brundin, P. & Outeiro, T. F. ​ (2020) 
    Frontiers in Molecular Neuroscience, 12.​ DOI: https://doi.org/10.3389/fnmol.2019.00312 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​RAB39B is redistributed in dementia with Lewy bodies and is sequestered within aβ plaques and Lewy bodies​
    Koss, D. J.; Bondarevaite, O.; Adams, S.; Leite, M.; Giorgini, F.; Attems, J. & Outeiro, T. F. ​ (2020) 
    Brain Pathology, 31(1) pp. 120​-132​.​ DOI: https://doi.org/10.1111/bpa.12890 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization​
    Dominguez-Meijide, A.; Vasili, E.; König, A.; Cima-Omori, M.-S.; Ibáñez de Opakua, A.; Leonov, A.   & Ryazanov, S.  et al.​ (2020) 
    Scientific Reports, 10(1).​ DOI: https://doi.org/10.1038/s41598-020-69744-y 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Protein trapping leads to altered synaptic proteostasis in synucleinopathies​
    Santos, P. I. & Outeiro, T. F. ​ (2020) 
    The FEBS Journal,.​ DOI: https://doi.org/10.1111/febs.15364 
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity​
    Carija, A.; Pinheiro, F.; Pujols, J.; Brás, I. C.; Lázaro, D. F.; Santambrogio, C. & Grandori, R. et al.​ (2019) 
    Redox Biology, 22 pp. 101135​.​ DOI: https://doi.org/10.1016/j.redox.2019.101135 
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  • 2019 | Journal Article | Overview | 
    ​ ​Epigenetics of the Synapse in Neurodegeneration​
    Xylaki, M.; Atzler, B. & Outeiro, T. F. ​ (2019) 
    Current Neurology and Neuroscience Reports, 19(10).​ DOI: https://doi.org/10.1007/s11910-019-0995-y 
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies​
    Szegő, É. M.; Dominguez-Meijide, A.; Gerhardt, E.; König, A.; Koss, D. J.; Li, W. & Pinho, R. et al.​ (2019) 
    Cell Reports, 28(1) pp. 65.e6​-77.e6​.​ DOI: https://doi.org/10.1016/j.celrep.2019.06.009 
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  • 2018 | Journal Article | Research Paper | 
    ​ ​Membrane binding, internalization, and sorting of alpha-synuclein in the cell​
    Masaracchia, C.; Hnida, M.; Gerhardt, E.; Lopes da Fonseca, T.; Villar-Pique, A.; Branco, T. & Stahlberg, M. A. et al.​ (2018) 
    Acta Neuropathologica Communications, 6(1) art. 79​.​ DOI: https://doi.org/10.1186/s40478-018-0578-1 
    ​Details  DOI  PMID  PMC 

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