SFB 1002 | S01: In vivo und in vitro Krankheitsmodelle RSS Feed


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  • 2024 | Journal Article
    ​ ​Knauer, Carolin, Henrike Haltern, Eric Schoger, Sebastian Kügler, Lennart Roos, Laura C. Zelarayán, Gerd Hasenfuss, Wolfram-Hubertus Zimmermann, Bernd Wollnik, and Lukas Cyganek. "Preclinical evaluation of CRISPR-based therapies for Noonan syndrome caused by deep-intronic LZTR1 variants​." ​Molecular Therapy - Nucleic Acids ​35, no. 1 (2024): ​102123​. ​https://doi.org/10.1016/j.omtn.2024.102123.
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  • 2023 | Journal Article | 
    ​ ​Priesmeier, Laura, Eric Schoger, Lukas Cyganek, and Laura Cecilia Zelarayán. "Combining a tetracycline (Tet)-inducible gRNA system and CRISPRa for titratable and timely controlled enhancement of endogenous SHISA3 activation in human induced pluripotent stem cells (hiPSC)​." ​Stem Cell Research ​71 (2023): ​103163​. ​https://doi.org/10.1016/j.scr.2023.103163.
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  • 2023 | Journal Article
    ​ ​Busley, Alexandra Viktoria, and Lukas Cyganek. "Generation of a genetically-modified induced pluripotent stem cell line harboring a Noonan syndrome-associated gene variant MRAS p.G23V​." ​Stem Cell Research ​69 (2023): ​103108​. ​https://doi.org/10.1016/j.scr.2023.103108.
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  • 2023 | Journal Article
    ​ ​Busley, Alexandra Viktoria, Mandy Kleinsorge, and Lukas Cyganek. "Generation of a genetically-modified induced pluripotent stem cell line harboring an oncogenic gene variant KRAS p.G12V​." ​Stem Cell Research ​69 (2023): ​103105​. ​https://doi.org/10.1016/j.scr.2023.103105.
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  • 2023 | Preprint
    ​ ​Schneider, Lennart Valentin, Bao Guobin, Aditi Methi, Ole Jensen, Kea Aline Schmoll, Michael Gani Setya, Sadman Sakib et al​. "Bioengineering of a human innervated cardiac muscle model​." ​Preprint, submitted ​​2023. ​https://mbexc.uni-goettingen.de/literature/publications/746 https://sfb1002.med.uni-goettingen.de/production/literature/publications/483. https://doi.org/10.1101/2023.08.18.552653.
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  • 2023 | Journal Article | 
    ​ ​Nakhaei-Rad, Saeideh, Fereshteh Haghighi, Farhad Bazgir, Julia Dahlmann, Alexandra Viktoria Busley, Marcel Buchholzer, Karolin Kleemann et al. "Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues​." ​Communications Biology ​6, no. 1 (2023): . ​https://doi.org/10.1038/s42003-023-05013-8.
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  • 2023 | Journal Article
    ​ ​Seibertz, Fitzwilliam, Tony Rubio, Robin Springer, Fiona Popp, Melanie Ritter, Aiste Liutkute, Lena Bartelt et al. "Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy development​." ​Cardiovascular Research (2023): ​cvad143​. ​https://doi.org/10.1093/cvr/cvad143.
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  • 2023 | Journal Article
    ​ ​Goodarzi Hosseinabadi, Hossein, Arpan Biswas, Anant Bhusal, Ali Yousefinejad, Aastha Lall, Wolfram‐Hubertus Zimmermann, Amir K. Miri, and Leonid Ionov. "4D‐Printable Photocrosslinkable Polyurethane‐Based Inks for Tissue Scaffold and Actuator Applications​." ​Small (2023): ​2306387​. ​https://doi.org/10.1002/smll.202306387.
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  • 2023 | Journal Article | 
    ​ ​Chowdhury, Arpita, Angela Boshnakovska, Abhishek Aich, Aditi Methi, Ana Maria Vergel Leon, Ivan Silbern, Christian Lüchtenborg et al. "Metabolic switch from fatty acid oxidation to glycolysis in knock‐in mouse model of Barth syndrome​." ​EMBO Molecular Medicine (2023): ​e17399​. ​https://doi.org/10.15252/emmm.202317399.
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  • 2022 | Journal Article | Research Paper | 
    ​ ​Li, Wener, Xiaojing Luo, Mareike S. Poetsch, Reinhard Oertel, Kapil Nichani, Martin Schneider, Anna Strano et al. "Synergistic Adverse Effects of Azithromycin and Hydroxychloroquine on Human Cardiomyocytes at a Clinically Relevant Treatment Duration​." ​Pharmaceuticals ​15, no. 2 (2022): . ​https://doi.org/10.3390/ph15020220.
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  • 2022 | Journal Article | Overview
    ​ ​Zimmermann, Wolfram-Hubertus. "Remote control of the heart and beyond​." ​Science ​376, no. 6596 (2022): ​917​-918​. ​https://doi.org/10.1126/science.abq0605.
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  • 2022 | Journal Article | Research Paper | 
    ​ ​Lyra-Leite, Davi M., Óscar Gutiérrez-Gutiérrez, Meimei Wang, Yang Zhou, Lukas Cyganek, and Paul W. Burridge. "A review of protocols for human iPSC culture, cardiac differentiation, subtype-specification, maturation, and direct reprogramming​." ​STAR Protocols ​3, no. 3 (2022): ​101560​. ​https://doi.org/10.1016/j.xpro.2022.101560.
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  • 2022 | Preprint
    ​ ​Nakhaei-Rad, Saeideh, Farhad Bazgir, Julia Dahlmann, Alexandra Viktoria Busley, Marcel Buchholzer, Fereshteh Haghighi, Anne Schänzer et al​. "Alteration of myocardial structure and function in RAF1-associated Noonan syndrome: Insights from cardiac disease modeling based on patient-derived iPSCs​." ​Preprint, submitted ​​2022. ​https://mbexc.uni-goettingen.de/literature/publications/575 https://sfb1002.med.uni-goettingen.de/production/literature/publications/477. https://doi.org/10.1101/2022.01.22.477319.
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  • 2022 | Book Chapter
    ​ ​Tiburcy, Malte, Tim Meyer, Pierre-Luc Satin, and Wolfram-Hubertus Zimmermann. "Defined Engineered Human Myocardium for Disease Modeling, Drug Screening, and Heart Repair​." ​In Cardiac Tissue Engineering : Methods and Protocols, edited by Kareen L.K. Coulombe, Lauren D. Black III​, 213​-225​. ​​New York, NY: ​Springer US, ​2022. https://doi.org/10.1007/978-1-0716-2261-2_14.
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  • 2021 | Book Chapter
    ​ ​Kusch, Harald, Robert Kossen, Markus Suhr, Luca Freckmann, Linus Weber, Christian Henke, Christoph Lehmann et al. "Management of Metadata Types in Basic Cardiological Research​." ​In German Medical Data Sciences 2021: Digital Medicine: Recognize – Understand – Heal, edited by Rainer Röhrig, Tim Beißbarth, Jochem König, Claudia Ose, Geraldine Rauch, Ulrich Sax, Björn Schreiweis et al.​, 59​-68​. ​​2021. https://doi.org/10.3233/SHTI210542.
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  • 2021 | Preprint
    ​ ​Shahriyari, Mina, Md Rezaul Islam, M. Sadman Sakib, Anastasia Rika, Dennis Krüger, Lalit Kaurani, Harithaa Anandakumar et al​. "Human engineered skeletal muscle of hypaxial origin from pluripotent stem cells with advanced function and regenerative capacity​." ​Preprint, submitted ​​2021. ​https://mbexc.uni-goettingen.de/literature/publications/412 https://sfb1002.med.uni-goettingen.de/production/literature/publications/417. https://doi.org/10.1101/2021.07.12.452030.
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Kittana, Naim, Mohyeddin Assali, Wolfram-Hubertus Zimmermann, Norman Liaw, Gabriela Leao Santos, Abdul Rehman, and Susanne Lutz. "Modulating the Biomechanical Properties of Engineered Connective Tissues by Chitosan-Coated Multiwall Carbon Nanotubes​." ​International Journal of Nanomedicine ​Volume 16 (2021): ​989​-1000​. ​https://doi.org/10.2147/IJN.S289107.
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Sattler, Katherine, Ibrahim El-Battrawy, Lukas Cyganek, Siegfried Lang, Huan Lan, Xin Li, Zhihan Zhao et al. "TRPV1 activation and internalization is part of the LPS-induced inflammation in human iPSC-derived cardiomyocytes​." ​Scientific Reports ​11, no. 1 (2021): ​14689​. ​https://doi.org/10.1038/s41598-021-93958-3.
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  • 2021 | Journal Article | Research Paper
    ​ ​Santos, Gabriela L., Tim Meyer, Malte Tiburcy, Alisa DeGrave, Wolfram-Hubertus Zimmermann, and Susanne Lutz. "Fibroblast Derived Human Engineered Connective Tissue for Screening Applications​." ​Journal of Visualized Experiments no. 174 (2021): . ​https://doi.org/10.3791/62700.
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  • 2021 | Journal Article | Research Paper
    ​ ​Zimmermann, Wolfram-Hubertus. "Organs-on-chip models for cardiovascular drug development​." ​Cardiovascular Research ​117, no. 12 (2021): ​e164​-e165​. ​https://doi.org/10.1093/cvr/cvab229.
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  • 2021 | Journal Article | Research Paper
    ​ ​Peper, Jonas, Daniel Kownatzki-Danger, Gunnar Weninger, Fitzwilliam Seibertz, Julius Ryan D. Pronto, Henry Sutanto, David Pacheu-Grau, Robin Hindmarsh, Sören Brandenburg, and Stephan E. Lehnart. "Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes​." ​Circulation Research ​128, no. 6 (2021): . ​https://doi.org/10.1161/CIRCRESAHA.119.316547.
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Rössler, Uta, Anna Floriane Hennig, Nina Stelzer, Shroddha Bose, Johannes Kopp, Kent Søe, Lukas Cyganek et al. "Efficient generation of osteoclasts from human induced pluripotent stem cells and functional investigations of lethal CLCN7 ‐related osteopetrosis​." ​Journal of Bone and Mineral Research ​36, no. 8 (2021): ​1621​-1635​. ​https://doi.org/10.1002/jbmr.4322.
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  • 2021 | Journal Article | Research Paper
    ​ ​Hoffmann, S., S. Schmitteckert, K. Raedecke, D. Rheinert, S. Diebold, R. Roeth, B. Weiss, M. Granzow, B. Niesler, and G. A. Rappold. "Network-driven discovery yields new insight into Shox2-dependent cardiac rhythm control​." ​Biochimica et Biophysica Acta. Gene Regulatory Mechanisms ​1864, no. 4-5 (2021): ​194702​. ​https://doi.org/10.1016/j.bbagrm.2021.194702.
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Schoger, Eric, Wolfram-Hubertus Zimmermann, Lukas Cyganek, and Laura Cecilia Zelarayán. "Establishment of two homozygous CRISPR interference (CRISPRi) knock-in human induced pluripotent stem cell (hiPSC) lines for titratable endogenous gene repression​." ​Stem Cell Research ​55 (2021): ​S1873506121003202​. ​https://doi.org/10.1016/j.scr.2021.102473.
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Schoger, Eric, Wolfram-Hubertus Zimmermann, Lukas Cyganek, and Laura Cecilia Zelarayán. "Establishment of a second generation homozygous CRISPRa human induced pluripotent stem cell (hiPSC) line for enhanced levels of endogenous gene activation​." ​Stem Cell Research ​56 (2021): ​S1873506121003652​. ​https://doi.org/10.1016/j.scr.2021.102518.
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Yousefi, Roya, Eugenio F Fornasiero, Lukas Cyganek, Julio Montoya, Stefan Jakobs, Silvio O Rizzoli, Peter Rehling, and David Pacheu‐Grau. "Monitoring mitochondrial translation in living cells​." ​EMBO reports ​22, no. 4 (2021): . ​https://doi.org/10.15252/embr.202051635.
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  • 2020 | Journal Article | Overview
    ​ ​Zimmermann, Wolfram-Hubertus. "Tissue engineered heart repair from preclinical models to first-in-patient studies​." ​Current Opinion in Physiology ​14 (2020): ​70​-77​. ​https://doi.org/10.1016/j.cophys.2020.02.001.
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  • 2020 | Preprint
    ​ ​Yousefi, Roya, Eugenio F. Fornasiero, Lukas Cyganek, Stefan Jakobs, Silvio O. Rizzoli, Peter Rehling, and David Pacheu-Grau​. "Local translation in synaptic mitochondria influences synaptic transmission​." ​Preprint, submitted ​​2020. ​https://mbexc.uni-goettingen.de/literature/publications/168 https://sfb1002.med.uni-goettingen.de/production/literature/publications/382 https://sfb1286.uni-goettingen.de/literature/publications/93. https://doi.org/10.1101/2020.07.22.215194.
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  • 2020 | Journal Article | Research Paper
    ​ ​Hofhuis, Julia, Kristina Bersch, Stefan Wagner, Cristina Espinosa Molina, Funsho E. Fakuade, Lavanya M. Iyer, Katrin Streckfuß-Bömeke et al. "Dysferlin links excitation-contraction coupling to structure and maintenance of the cardiac transverse-axial tubule system​." ​Europace ​22, no. 7 (2020): ​1119​-1131​. ​https://doi.org/10.1093/europace/euaa093.
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Rathjens, Franziska S., Alica Blenkle, Lavanya M. Iyer, Anke Renger, Fahima Syeda, Claudia Noack, Andreas Jungmann, Matthias Dewenter, Karl Toischer, and Maria Patapia Zafeiriou. "Preclinical evidence for the therapeutic value of TBX5 normalization in arrhythmia control​." ​Cardiovascular Research (2020): . ​https://doi.org/10.1093/cvr/cvaa239.
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Zheng, X., L. Zhang, Y. Kuang, V. Venkataramani, F. Jin, K. Hein, M. P. Zafeiriou et al. "Extracellular Vesicles Derived from Neural Progenitor Cells––a Preclinical Evaluation for Stroke Treatment in Mice​." ​Translational Stroke Research ​12, no. 1 (2020): ​185​-203​. ​https://doi.org/10.1007/s12975-020-00814-z.
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Tiburcy, Malte, Tim Meyer, Norman Y. Liaw, and Wolfram-Hubertus Zimmermann. "Generation of Engineered Human Myocardium in a Multi-well Format​." ​STAR Protocols ​1, no. 1 (2020): ​100032​. ​https://doi.org/10.1016/j.xpro.2020.100032.
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Zschüntzsch, Jana, Pia Vanessa Jouvenal, Yaxin Zhang, Florian Klinker, Malte Tiburcy, David Liebetanz, Dörthe Malzahn, Heinrich Brinkmeier, and Jens Schmidt. "Long‐term human IgG treatment improves heart and muscle function in a mouse model of Duchenne muscular dystrophy​." ​Journal of Cachexia, Sarcopenia and Muscle ​11, no. 4 (2020): ​1018​-1031​. ​https://doi.org/10.1002/jcsm.12569.
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  • 2020 | Journal Article | Research Paper
    ​ ​Levent, Elif, Claudia Noack, Laura C. Zelarayán, Dörthe M. Katschinski, Wolfram-Hubertus Zimmermann, and Malte Tiburcy. "Inhibition of Prolyl-Hydroxylase Domain Enzymes Protects From Reoxygenation Injury in Engineered Human Myocardium​." ​Circulation ​142, no. 17 (2020): ​1694​-1696​. ​https://doi.org/10.1161/CIRCULATIONAHA.119.044471.
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  • 2020 | Journal Article | Research Paper
    ​ ​Hanses, Ulrich, Mandy Kleinsorge, Lennart Roos, Gökhan Yigit, Yun Li, Boris Barbarics, Ibrahim El-Battrawy et al. "Intronic CRISPR Repair in a Preclinical Model of Noonan Syndrome–Associated Cardiomyopathy​." ​Circulation ​142, no. 11 (2020): ​1059​-1076​. ​https://doi.org/10.1161/CIRCULATIONAHA.119.044794.
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  • 2020 | Journal Article | Research Paper
    ​ ​Montiel, Virginie, Ramona Bella, Lauriane Y. M. Michel, Hrag Esfahani, Delphine De Mulder, Emma L. Robinson, Jean-Philippe Deglasse et al. "Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide​." ​Science Translational Medicine ​12, no. 564 (2020): ​eaay2176​. ​https://doi.org/10.1126/scitranslmed.aay2176.
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  • 2020 | Journal Article | Research Paper
    ​ ​Schoger, Eric, Kelli J. Carroll, Lavanya M. Iyer, John R. McAnally, Wei Tan, Ning Liu, Claudia Noack et al. "CRISPR-Mediated Activation of Endogenous Gene Expression in the Postnatal Heart​." ​Circulation Research ​126, no. 1 (2020): ​6​-24​. ​https://doi.org/10.1161/CIRCRESAHA.118.314522.
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Kleinsorge, Mandy, and Lukas Cyganek. "Subtype-Directed Differentiation of Human iPSCs into Atrial and Ventricular Cardiomyocytes​." ​STAR Protocols ​1, no. 1 (2020): ​100026​. ​https://doi.org/10.1016/j.xpro.2020.100026.
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Zafeiriou, Maria-Patapia, Guobin Bao, James Hudson, Rashi Halder, Alica Blenkle, Marie-Kristin Schreiber, Andre Fischer, Detlev Schild, and Wolfram-Hubertus Zimmermann. "Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids​." ​Nature Communications ​11, no. 1 (2020): . ​https://doi.org/10.1038/s41467-020-17521-w.
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Mohamed, Belal A., Manar Elkenani, Joanna Jakubiczka-Smorag, Eric Buchholz, Sabrina Koszewa, Dawid Lbik, Moritz Schnelle, Gerd Hasenfuss, and Karl Toischer. "Genetic deletion of calcium/calmodulin-dependent protein kinase type II delta does not mitigate adverse myocardial remodeling in volume-overloaded hearts​." ​Scientific Reports ​9, no. 1 (2019): ​9889​. ​https://doi.org/10.1038/s41598-019-46332-3.
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  • 2019 | Journal Article | Overview
    ​ ​Madonna, Rosalinda, Linda W Van Laake, Hans Erik Botker, Sean M Davidson, Raffaele De Caterina, Felix B Engel, Thomas Eschenhagen et al. "ESC Working Group on Cellular Biology of the Heart: position paper for Cardiovascular Research: tissue engineering strategies combined with cell therapies for cardiac repair in ischaemic heart disease and heart failure​." ​Cardiovascular Research ​115, no. 3 (2019): ​488​-500​. ​https://doi.org/10.1093/cvr/cvz010.
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Schlick, Susanne F., Florian Spreckelsen, Malte Tiburcy, Lavanya M. Iyer, Tim Meyer, Laura C. Zelarayan, Stefan Luther, Ulrich Parlitz, Wolfram-Hubertus Zimmermann, and Florian Rehfeldt. "Agonistic and antagonistic roles of fibroblasts and cardiomyocytes on viscoelastic stiffening of engineered human myocardium​." ​Progress in Biophysics and Molecular Biology ​144 (2019): ​51​-60​. ​https://doi.org/10.1016/j.pbiomolbio.2018.11.011.
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Brandenburg, Sören, Jan Pawlowitz, Benjamin Eikenbusch, Jonas Peper, Tobias Kohl, Gyuzel Y. Mitronova, Samuel Sossalla et al. "Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis​." ​JCI insight ​4, no. 12 (2019): . ​https://doi.org/10.1172/jci.insight.127116.
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Noack, Claudia, Lavanya M. Iyer, Norman Y. Liaw, Eric Schoger, Sara Khadjeh, Eva Wagner, Monique Woelfer et al. "KLF15-Wnt–Dependent Cardiac Reprogramming Up-Regulates SHISA3 in the Mammalian Heart​." ​Journal of the American College of Cardiology ​74, no. 14 (2019): ​1804​-1819​. ​https://doi.org/10.1016/j.jacc.2019.07.076.
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Santos, Gabriela Leão, Svenja Hartmann, Wolfram-Hubertus Zimmermann, Anne Ridley, and Susanne Lutz. "Inhibition of Rho-associated kinases suppresses cardiac myofibroblast function in engineered connective and heart muscle tissues​." ​Journal of Molecular and Cellular Cardiology ​134 (2019): ​13​-28​. ​https://doi.org/10.1016/j.yjmcc.2019.06.015.
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Burczyk, Martina S., Martin D. Burkhalter, Teresa Casar Tena, Laurel A. Grisanti, Michael Kauk, Sabrina Matysik, Cornelia Donow et al. "Muscarinic receptors promote pacemaker fate at the expense of secondary conduction system tissue in zebrafish​." ​JCI Insight ​4, no. 20 (2019): . ​https://doi.org/10.1172/jci.insight.121971.
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  • 2019 | Journal Article | Research Paper
    ​ ​Meyer, Tim, Malte Tiburcy, and Wolfram-Hubertus Zimmermann. "Cardiac macrotissues-on-a-plate models for phenotypic drug screens​." ​Advanced Drug Delivery Reviews ​140 (2019): ​93​-100​. ​https://doi.org/10.1016/j.addr.2019.03.002.
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  • 2019 | Journal Article | Research Paper
    ​ ​Goldfracht, Idit, Yael Efraim, Rami Shinnawi, Ekaterina Kovalev, Irit Huber, Amira Gepstein, Gil Arbel, Naim Shaheen, Malte Tiburcy, and Lior Gepstein. "Engineered heart tissue models from hiPSC-derived cardiomyocytes and cardiac ECM for disease modeling and drug testing applications​." ​Acta Biomaterialia ​92 (2019): ​145​-159​. ​https://doi.org/10.1016/j.actbio.2019.05.016.
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Trautsch, Irina, Eriona Heta, Poh Loong Soong, Elif Levent, Viacheslav O. Nikolaev, Ivan Bogeski, Dörthe M. Katschinski, Manuel Mayr, and Wolfram-Hubertus Zimmermann. "Optogenetic Monitoring of the Glutathione Redox State in Engineered Human Myocardium​." ​Frontiers in Physiology ​10 (2019): . ​https://doi.org/10.3389/fphys.2019.00272.
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  • 2018 | Journal Article | Research Paper | 
    ​ ​Iyer, Lavanya M, Sankari Nagarajan, Monique Woelfer, Eric Schoger, Sara Khadjeh, Maria Patapia Zafiriou, Vijayalakshmi Kari et al. "A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart​." ​Nucleic Acids Research ​46, no. 6 (2018): ​2850​-2867​. ​https://doi.org/10.1093/nar/gky049.
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  • 2018 | Journal Article | Research Paper | 
    ​ ​Cyganek, Lukas, Malte Tiburcy, Karolina Sekeres, Kathleen Gerstenberg, Hanibal Bohnenberger, Christof Lenz, Sarah Henze et al. "Deep phenotyping of human induced pluripotent stem cell–derived atrial and ventricular cardiomyocytes​." ​JCI Insight ​3, no. 12 (2018): ​e99941​. ​https://doi.org/10.1172/jci.insight.99941.
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  • 2018 | Journal Article | Research Paper
    ​ ​Long, Chengzu, Hui Li, Malte Tiburcy, Cristina Rodriguez-Caycedo, Viktoriia Kyrychenko, Huanyu Zhou, Yu Zhang et al. "Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing​." ​Science Advances ​4, no. 1 (2018): ​eaap9004​. ​https://doi.org/10.1126/sciadv.aap9004.
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  • 2018 | Journal Article | Research Paper | 
    ​ ​Chowdhury, Arpita, Abhishek Aich, Gaurav Jain, Katharina Wozny, Christian Lüchtenborg, Magnus Hartmann, Olaf Bernhard et al. "Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia​." ​Cell Reports ​25, no. 3 (2018): ​561​-570.e6​. ​https://doi.org/10.1016/j.celrep.2018.09.057.
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  • 2018 | Journal Article | Research Paper | 
    ​ ​Gröschel, Carina, André Sasse, Sebastian Monecke, Charlotte Röhrborn, Leslie Elsner, Michael Didié, Verena Reupke et al. "CD8+-T Cells With Specificity for a Model Antigen in Cardiomyocytes Can Become Activated After Transverse Aortic Constriction but Do Not Accelerate Progression to Heart Failure​." ​Frontiers in Immunology ​9 (2018): ​2665​. ​https://doi.org/10.3389/fimmu.2018.02665.
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  • 2017 | Journal Article | Overview
    ​ ​Zimmermann, Wolfram-Hubertus. "Translating Myocardial Remuscularization​." ​Circulation Research ​120, no. 2 (2017): ​278​-281​. ​https://doi.org/10.1161/CIRCRESAHA.116.310194.
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  • 2017 | Journal Article | Research Paper
    ​ ​Tiburcy, Malte, James E. Hudson, Paul Balfanz, Susanne Schlick, Tim Meyer, Mei-Ling Chang Liao, Elif Levent et al. "Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair​." ​Circulation ​135, no. 19 (2017): ​1832​-1847​. ​https://doi.org/10.1161/CIRCULATIONAHA.116.024145.
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  • 2017 | Journal Article | Overview
    ​ ​Fujita, Buntaro, and Wolfram-Hubertus Zimmermann. "Myocardial Tissue Engineering for Regenerative Applications​." ​Current Cardiology Reports ​19, no. 9 (2017): ​78​. ​https://doi.org/10.1007/s11886-017-0892-4.
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  • 2017 | Journal Article | Overview
    ​ ​Fujita, B., and W.-H. Zimmermann. "Engineered Heart Repair​." ​Clinical Pharmacology & Therapeutics ​102, no. 2 (2017): ​197​-199​. ​https://doi.org/10.1002/cpt.724.
    ​Details  DOI 
  • 2017 | Journal Article | Overview
    ​ ​Zimmermann, Wolfram-Hubertus. "Remuscularization of the failing heart​." ​The Journal of Physiology ​595, no. 12 (2017): ​3685​-3690​. ​https://doi.org/10.1113/jp273098.
    ​Details  DOI 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Didié, Michael, Satish Galla, Vijayakumar Muppala, Ralf Dressel, and Wolfram-Hubertus Zimmermann. "Immunological Properties of Murine Parthenogenetic Stem Cell-Derived Cardiomyocytes and Engineered Heart Muscle​." ​Frontiers in Immunology ​8 (2017): ​955​. ​https://doi.org/10.3389/fimmu.2017.00955.
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  • 2017 | Journal Article | Overview | 
    ​ ​Koopman, Charlotte D., Wolfram H. Zimmermann, Thomas Knöpfel, and Teun P. de Boer. "Cardiac optogenetics: using light to monitor cardiac physiology​." ​Basic Research in Cardiology ​112, no. 5 (2017): ​56​. ​https://doi.org/10.1007/s00395-017-0645-y.
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  • 2017 | Journal Article | Research Paper | 
    ​ ​Gröschel, Carina, André Sasse, Charlotte Röhrborn, Sebastian Monecke, Michael Didié, Leslie Elsner, Vanessa Kruse et al. "T helper cells with specificity for an antigen in cardiomyocytes promote pressure overload-induced progression from hypertrophy to heart failure​." ​Scientific Reports ​7, no. 1 (2017): ​15998​. ​https://doi.org/10.1038/s41598-017-16147-1.
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  • 2017 | Journal Article | Research Paper | 
    ​ ​Johannsen, Hannah, Vijayakumar Muppala, Carina Gröschel, Sebastian Monecke, Leslie Elsner, Michael Didié, Wolfram-Hubertus Zimmermann, and Ralf Dressel. "Immunological Properties of Murine Parthenogenetic Stem Cells and Their Differentiation Products​." ​Frontiers in Immunology ​8 (2017): ​924​. ​https://doi.org/10.3389/fimmu.2017.00924.
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  • 2017 | Journal Article | Research Paper | 
    ​ ​Noack, Claudia, Luis Peter Haupt, Wolfram-Hubertus Zimmermann, Katrin Streckfuss-Bömeke, and Laura Cecilia Zelarayán. "Generation of a KLF15 homozygous knockout human embryonic stem cell line using paired CRISPR/Cas9n, and human cardiomyocytes derivation​." ​Stem Cell Research ​23 (2017): ​127​-131​. ​https://doi.org/10.1016/j.scr.2017.07.007.
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  • 2017 | Journal Article | Research Paper | 
    ​ ​Toischer, Karl, Wuqiang Zhu, Mark Hünlich, Belal A. Mohamed, Sara Khadjeh, Sean P. Reuter, Katrin Schäfer, Deepak Ramanujam, Stefan Engelhardt, and Gerd Hasenfuß. "Cardiomyocyte proliferation prevents failure in pressure overload but not volume overload​." ​Journal of Clinical Investigation ​127, no. 12 (2017): ​4285​-4296​. ​https://doi.org/10.1172/JCI81870.
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  • 2017 | Journal Article | Research Paper
    ​ ​Schmidt, Constanze, Felix Wiedmann, Stefan M. Kallenberger, Antonius Ratte, Jan S. Schulte, Beatrix Scholz, Frank Ulrich Müller et al. "Stretch-activated two-pore-domain (K2P) potassium channels in the heart: Focus on atrial fibrillation and heart failure​." ​Progress in Biophysics and Molecular Biology ​130 (2017): ​233​-243​. ​https://doi.org/10.1016/j.pbiomolbio.2017.05.004.
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  • 2017 | Journal Article | Research Paper | 
    ​ ​Kyrychenko, Viktoriia, Sergii Kyrychenko, Malte Tiburcy, John M. Shelton, Chengzu Long, Jay W. Schneider, Wolfram-Hubertus Zimmermann, Rhonda Bassel-Duby, and Eric N. Olson. "Functional correction of dystrophin actin binding domain mutations by genome editing​." ​JCI Insight ​2, no. 18 (2017): ​e95918​. ​https://doi.org/10.1172/jci.insight.95918.
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  • 2016 | Journal Article | Research Paper
    ​ ​Brandenburg, Sören, Tobias Kohl, George S. B. Williams, Konstantin Gusev, Eva Wagner, Eva A. Rog-Zielinska, Elke Hebisch et al. "Axial tubule junctions control rapid calcium signaling in atria​." ​Journal of Clinical Investigation ​126, no. 10 (2016): ​3999​-4015​. ​https://doi.org/10.1172/JCI88241.
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Editorial Contribution (Editorial, Introduction, Epilogue)
    ​ ​Zimmermann, Wolfram-Hubertus. "Strip and Dress the Human Heart​." ​Circulation Research ​118, no. 1 (2016): ​12​-13​. ​https://doi.org/10.1161/CIRCRESAHA.115.307938.
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Chang Liao, Mei-Ling, Teun P. de Boer, Hiroki Mutoh, Nour Raad, Claudia Richter, Eva Wagner, Bryan R. Downie et al. "Sensing Cardiac Electrical Activity With a Cardiac Myocyte-Targeted Optogenetic Voltage Indicator​." ​Circulation Research ​117, no. 5 (2015): ​401​-412​. ​https://doi.org/10.1161/CIRCRESAHA.117.306143.
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Godier-Furnemont, Amandine F. G., Malte Tiburcy, Eva Wagner, Matthias Dewenter, Simon Laemmle, Ali El-Armouche, Stephan E. Lehnart, Gordana Vunjak-Novakovic, and Wolfram-Hubertus Zimmermann. "Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation​." ​Biomaterials ​60 (2015): ​82​-91​. ​https://doi.org/10.1016/j.biomaterials.2015.03.055.
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper | 
    ​ ​Hesse, Amke R., Elif Levent, Anke Zieseniss, Malte Tiburcy, Wolfram-Hubertus Zimmermann, and Dörthe M. Katschinski. "Lights on for HIF-1 alpha: Genetically Enhanced Mouse Cardiomyocytes for Heart Tissue Imaging​." ​Cellular Physiology and Biochemistry ​34, no. 2 (2014): ​455​-462​. ​https://doi.org/10.1159/000363014.
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  • 2014 | Journal Article | Research Paper | 
    ​ ​Izarra, Alberto, Isabel Moscoso, Elif Levent, Susana Canon, Inmaculada Cerrada, Antonio Diez-Juan, Vanessa Blanca et al. "miR-133a Enhances the Protective Capacity of Cardiac Progenitors Cells after Myocardial Infarction​." ​Stem Cell Reports ​3, no. 6 (2014): ​1029​-1042​. ​https://doi.org/10.1016/j.stemcr.2014.10.010.
    ​Details  DOI  PMID  PMC  WoS 

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