SFB 1002 | S01: In vivo und in vitro Krankheitsmodelle RSS Feed


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  • 2024 | Journal Article
    ​ ​Preclinical evaluation of CRISPR-based therapies for Noonan syndrome caused by deep-intronic LZTR1 variants​
    Knauer, C.; Haltern, H.; Schoger, E.; Kügler, S.; Roos, L.; Zelarayán, L. C. & Hasenfuss, G. et al.​ (2024) 
    Molecular Therapy - Nucleic Acids, 35(1) art. 102123​.​ DOI: https://doi.org/10.1016/j.omtn.2024.102123 
    ​Details  DOI  PMID  PMC 
  • 2023 | Journal Article
    ​ ​Generation of a genetically-modified induced pluripotent stem cell line harboring a Noonan syndrome-associated gene variant MRAS p.G23V​
    Busley, A. V. & Cyganek, L.​ (2023) 
    Stem Cell Research, 69 art. 103108​.​ DOI: https://doi.org/10.1016/j.scr.2023.103108 
    ​Details  DOI  null 
  • 2023 | Journal Article
    ​ ​Generation of a genetically-modified induced pluripotent stem cell line harboring an oncogenic gene variant KRAS p.G12V​
    Busley, A. V.; Kleinsorge, M. & Cyganek, L.​ (2023) 
    Stem Cell Research, 69 art. 103105​.​ DOI: https://doi.org/10.1016/j.scr.2023.103105 
    ​Details  DOI 
  • 2023 | Preprint
    ​ ​Bioengineering of a human innervated cardiac muscle model​
    Schneider, L. V.; Guobin, B.; Methi, A.; Jensen, O.; Schmoll, K. A.; Setya, M. G.& Sakib, S. et al.​ (2023). DOI: https://doi.org/10.1101/2023.08.18.552653 
    ​Details  DOI 
  • 2023 | Journal Article
    ​ ​Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy development​
    Seibertz, F.; Rubio, T.; Springer, R.; Popp, F.; Ritter, M.; Liutkute, A. & Bartelt, L. et al.​ (2023) 
    Cardiovascular Research, art. cvad143​.​ DOI: https://doi.org/10.1093/cvr/cvad143 
    ​Details  DOI  PMID  PMC 
  • 2023 | Journal Article
    ​ ​4D‐Printable Photocrosslinkable Polyurethane‐Based Inks for Tissue Scaffold and Actuator Applications​
    Goodarzi Hosseinabadi, H.; Biswas, A.; Bhusal, A.; Yousefinejad, A.; Lall, A.; Zimmermann, W. & Miri, A. K. et al.​ (2023) 
    Small, art. 2306387​.​ DOI: https://doi.org/10.1002/smll.202306387 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Overview
    ​ ​Remote control of the heart and beyond​
    Zimmermann, W.-H. ​ (2022) 
    Science, 376(6596) pp. 917​-918​.​ DOI: https://doi.org/10.1126/science.abq0605 
    ​Details  DOI  PMID  PMC 
  • 2022 | Preprint
    ​ ​Alteration of myocardial structure and function in RAF1-associated Noonan syndrome: Insights from cardiac disease modeling based on patient-derived iPSCs​
    Nakhaei-Rad, S.; Bazgir, F.; Dahlmann, J.; Busley, A. V.; Buchholzer, M.; Haghighi, F.& Schänzer, A. et al.​ (2022). DOI: https://doi.org/10.1101/2022.01.22.477319 
    ​Details  DOI 
  • 2022 | Book Chapter
    ​ ​Defined Engineered Human Myocardium for Disease Modeling, Drug Screening, and Heart Repair​
    Tiburcy, M. ; Meyer, T. ; Satin, P.-L.& Zimmermann, W.-H. ​ (2022)
    In:​Coulombe, Kareen L.K.; Black III, Lauren D.​ (Eds.), Cardiac Tissue Engineering : Methods and Protocols pp. 213​-225. ​New York, NY: ​Springer US. DOI: https://doi.org/10.1007/978-1-0716-2261-2_14 
    ​Details  DOI  PMID  PMC 
  • 2021 | Book Chapter
    ​ ​Management of Metadata Types in Basic Cardiological Research​
    Kusch, H. ; Kossen, R. ; Suhr, M.; Freckmann, L.; Weber, L.; Henke, C.& Lehmann, C. et al.​ (2021)
    In:​Röhrig, Rainer; Beißbarth, Tim; König, Jochem; Ose, Claudia; Rauch, Geraldine; Sax, Ulrich; Schreiweis, Björn, et al.​ (Eds.), German Medical Data Sciences 2021: Digital Medicine: Recognize – Understand – Heal pp. 59​-68.  DOI: https://doi.org/10.3233/SHTI210542 
    ​Details  DOI  PMID  PMC 
  • 2021 | Preprint
    ​ ​Human engineered skeletal muscle of hypaxial origin from pluripotent stem cells with advanced function and regenerative capacity​
    Shahriyari, M.; Islam, M. R.; Sakib, M. S.; Rika, A.; Krüger, D.; Kaurani, L.& Anandakumar, H. et al.​ (2021). DOI: https://doi.org/10.1101/2021.07.12.452030 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper
    ​ ​Fibroblast Derived Human Engineered Connective Tissue for Screening Applications​
    Santos, G. L.; Meyer, T. ; Tiburcy, M. ; DeGrave, A.; Zimmermann, W.-H.   & Lutz, S. ​ (2021) 
    Journal of Visualized Experiments,(174).​ DOI: https://doi.org/10.3791/62700 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper
    ​ ​Organs-on-chip models for cardiovascular drug development​
    Zimmermann, W.-H. ​ (2021) 
    Cardiovascular Research, 117(12) pp. e164​-e165​.​ DOI: https://doi.org/10.1093/cvr/cvab229 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper
    ​ ​Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes​
    Peper, J.; Kownatzki-Danger, D.; Weninger, G.; Seibertz, F.; Pronto, J. R. D.; Sutanto, H. & Pacheu-Grau, D. et al.​ (2021) 
    Circulation Research, 128(6).​ DOI: https://doi.org/10.1161/CIRCRESAHA.119.316547 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper
    ​ ​Network-driven discovery yields new insight into Shox2-dependent cardiac rhythm control​
    Hoffmann, S.; Schmitteckert, S.; Raedecke, K.; Rheinert, D.; Diebold, S.; Roeth, R. & Weiss, B. et al.​ (2021) 
    Biochimica et Biophysica Acta. Gene Regulatory Mechanisms, 1864(4-5) pp. 194702​.​ DOI: https://doi.org/10.1016/j.bbagrm.2021.194702 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Overview
    ​ ​Tissue engineered heart repair from preclinical models to first-in-patient studies​
    Zimmermann, W.-H. ​ (2020) 
    Current Opinion in Physiology, 14 pp. 70​-77​.​ DOI: https://doi.org/10.1016/j.cophys.2020.02.001 
    ​Details  DOI 
  • 2020 | Preprint
    ​ ​Local translation in synaptic mitochondria influences synaptic transmission​
    Yousefi, R.; Fornasiero, E. F.; Cyganek, L.; Jakobs, S. ; Rizzoli, S. O. ; Rehling, P.  & Pacheu-Grau, D.​ (2020). DOI: https://doi.org/10.1101/2020.07.22.215194 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper
    ​ ​Dysferlin links excitation-contraction coupling to structure and maintenance of the cardiac transverse-axial tubule system​
    Hofhuis, J. ; Bersch, K.; Wagner, S. ; Molina, C. E. ; Fakuade, F. E.; Iyer, L. M.   & Streckfuß-Bömeke, K.  et al.​ (2020) 
    Europace, 22(7) pp. 1119​-1131​.​ DOI: https://doi.org/10.1093/europace/euaa093 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper
    ​ ​Inhibition of Prolyl-Hydroxylase Domain Enzymes Protects From Reoxygenation Injury in Engineered Human Myocardium​
    Levent, E. ; Noack, C. ; Zelarayán, L. C. ; Katschinski, D. M. ; Zimmermann, W.-H.   & Tiburcy, M. ​ (2020) 
    Circulation, 142(17) pp. 1694​-1696​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.119.044471 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper
    ​ ​Intronic CRISPR Repair in a Preclinical Model of Noonan Syndrome–Associated Cardiomyopathy​
    Hanses, U.; Kleinsorge, M.; Roos, L.; Yigit, G. ; Li, Y. ; Barbarics, B. & El-Battrawy, I. et al.​ (2020) 
    Circulation, 142(11) pp. 1059​-1076​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.119.044794 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper
    ​ ​Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide​
    Montiel, V.; Bella, R.; Michel, L. Y. M.; Esfahani, H.; De Mulder, D.; Robinson, E. L. & Deglasse, J.-P. et al.​ (2020) 
    Science Translational Medicine, 12(564) art. eaay2176​.​ DOI: https://doi.org/10.1126/scitranslmed.aay2176 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper
    ​ ​CRISPR-Mediated Activation of Endogenous Gene Expression in the Postnatal Heart​
    Schoger, E.; Carroll, K. J.; Iyer, L. M. ; McAnally, J. R.; Tan, W.; Liu, N. & Noack, C.  et al.​ (2020) 
    Circulation Research, 126(1) pp. 6​-24​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.118.314522 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Overview
    ​ ​ESC Working Group on Cellular Biology of the Heart: position paper for Cardiovascular Research: tissue engineering strategies combined with cell therapies for cardiac repair in ischaemic heart disease and heart failure​
    Madonna, R.; Van Laake, L. W; Botker, H. E.; Davidson, S. M; De Caterina, R.; Engel, F. B & Eschenhagen, T.  et al.​ (2019) 
    Cardiovascular Research, 115(3) pp. 488​-500​.​ DOI: https://doi.org/10.1093/cvr/cvz010 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper
    ​ ​Cardiac macrotissues-on-a-plate models for phenotypic drug screens​
    Meyer, T. ; Tiburcy, M.   & Zimmermann, W.-H. ​ (2019) 
    Advanced Drug Delivery Reviews, 140 pp. 93​-100​.​ DOI: https://doi.org/10.1016/j.addr.2019.03.002 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper
    ​ ​Engineered heart tissue models from hiPSC-derived cardiomyocytes and cardiac ECM for disease modeling and drug testing applications​
    Goldfracht, I.; Efraim, Y.; Shinnawi, R.; Kovalev, E.; Huber, I.; Gepstein, A. & Arbel, G. et al.​ (2019) 
    Acta Biomaterialia, 92 pp. 145​-159​.​ DOI: https://doi.org/10.1016/j.actbio.2019.05.016 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing​
    Long, C.; Li, H.; Tiburcy, M. ; Rodriguez-Caycedo, C.; Kyrychenko, V.; Zhou, H. & Zhang, Y. et al.​ (2018) 
    Science Advances, 4(1) art. eaap9004​.​ DOI: https://doi.org/10.1126/sciadv.aap9004 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Overview
    ​ ​Translating Myocardial Remuscularization​
    Zimmermann, W.-H. ​ (2017) 
    Circulation Research, 120(2) pp. 278​-281​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.116.310194 
    ​Details  DOI 
  • 2017 | Journal Article | Research Paper
    ​ ​Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair​
    Tiburcy, M. ; Hudson, J. E.; Balfanz, P.; Schlick, S.; Meyer, T. ; Chang Liao, M.-L. & Levent, E. et al.​ (2017) 
    Circulation, 135(19) pp. 1832​-1847​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.116.024145 
    ​Details  DOI 
  • 2017 | Journal Article | Overview
    ​ ​Myocardial Tissue Engineering for Regenerative Applications​
    Fujita, B.   & Zimmermann, W.-H. ​ (2017) 
    Current Cardiology Reports, 19(9) art. 78​.​ DOI: https://doi.org/10.1007/s11886-017-0892-4 
    ​Details  DOI 
  • 2017 | Journal Article | Overview
    ​ ​Engineered Heart Repair​
    Fujita, B.   & Zimmermann, W.-H. ​ (2017) 
    Clinical Pharmacology & Therapeutics, 102(2) pp. 197​-199​.​ DOI: https://doi.org/10.1002/cpt.724 
    ​Details  DOI 
  • 2017 | Journal Article | Overview
    ​ ​Remuscularization of the failing heart​
    Zimmermann, W.-H. ​ (2017) 
    The Journal of Physiology, 595(12) pp. 3685​-3690​.​ DOI: https://doi.org/10.1113/jp273098 
    ​Details  DOI 
  • 2017 | Journal Article | Research Paper
    ​ ​Stretch-activated two-pore-domain (K2P) potassium channels in the heart: Focus on atrial fibrillation and heart failure​
    Schmidt, C.; Wiedmann, F.; Kallenberger, S. M.; Ratte, A.; Schulte, J. S.; Scholz, B. & Müller, F. U. et al.​ (2017) 
    Progress in Biophysics and Molecular Biology, 130 pp. 233​-243​.​ DOI: https://doi.org/10.1016/j.pbiomolbio.2017.05.004 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article | Research Paper
    ​ ​Axial tubule junctions control rapid calcium signaling in atria​
    Brandenburg, S. ; Kohl, T. ; Williams, G. S. B.; Gusev, K.; Wagner, E. ; Rog-Zielinska, E. A. & Hebisch, E. et al.​ (2016) 
    Journal of Clinical Investigation, 126(10) pp. 3999​-4015​.​ DOI: https://doi.org/10.1172/JCI88241 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Editorial Contribution (Editorial, Introduction, Epilogue)
    ​ ​Strip and Dress the Human Heart​
    Zimmermann, W.-H. ​ (2016) 
    Circulation Research, 118(1) pp. 12​-13​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.115.307938 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Sensing Cardiac Electrical Activity With a Cardiac Myocyte-Targeted Optogenetic Voltage Indicator​
    Chang Liao, M.-L.; Boer, T. P. de; Mutoh, H.; Raad, N.; Richter, C. ; Wagner, E.   & Downie, B. R. et al.​ (2015) 
    Circulation Research, 117(5) pp. 401​-412​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.117.306143 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation​
    Godier-Furnemont, A. F. G.; Tiburcy, M. ; Wagner, E. ; Dewenter, M. ; Laemmle, S.; El-Armouche, A.   & Lehnart, S. E.  et al.​ (2015) 
    Biomaterials, 60 pp. 82​-91​.​ DOI: https://doi.org/10.1016/j.biomaterials.2015.03.055 
    ​Details  DOI  PMID  PMC  WoS 

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