Dr. Hans-Wolfgang Klafki

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unigoe
 

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  • 2022 | Journal Article | Research Paper | 
    ​ ​Diagnostic performance of automated plasma amyloid-β assays combined with pre-analytical immunoprecipitation​
    Klafki, H.-W. ; Vogelgsang, J.; Manuilova, E.; Bauer, C.; Jethwa, A.; Esselmann, H.   & Jahn-Brodmann, A. et al.​ (2022) 
    Alzheimer's Research & Therapy, 14(1) art. 127​.​ DOI: https://doi.org/10.1186/s13195-022-01071-y 
    ​Details  DOI 
  • 2021 | Journal Article | 
    ​ ​The Role of Cathepsin B in the Degradation of Aβ and in the Production of Aβ Peptides Starting With Ala2 in Cultured Astrocytes​
    Oberstein, T. J.; Utz, J.; Spitzer, P.; Klafki, H. W. ; Wiltfang, J. ; Lewczuk, P.   & Kornhuber, J.  et al.​ (2021) 
    Frontiers in Molecular Neuroscience, 13.​ DOI: https://doi.org/10.3389/fnmol.2020.615740 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​N‐terminal heterogeneity of parenchymal and vascular amyloid‐β deposits in Alzheimer’s disease​
    Zampar, S.; Klafki, H. W. ; Sritharen, K.; Bayer, T. A. ; Wiltfang, J. ; Rostagno, A. & Ghiso, J. et al.​ (2020) 
    Neuropathology and Applied Neurobiology, 46(7) pp. 673​-685​.​ DOI: https://doi.org/10.1111/nan.12637 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Development and Technical Validation of an Immunoassay for the Detection of APP669–711 (Aβ−3–40) in Biological Samples​
    Klafki, H. W. ; Rieper, P.; Matzen, A.; Zampar, S.; Wirths, O. ; Vogelgsang, J. & Osterloh, D. et al.​ (2020) 
    International Journal of Molecular Sciences, 21(18) pp. 6564​.​ DOI: https://doi.org/10.3390/ijms21186564 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​N-Terminal Truncated Aβ4-42 Is a Substrate for Neprilysin Degradation in vitro and in vivo​
    Hornung, K.; Zampar, S.; Engel, N.; Klafki, H. ; Liepold, T. ; Bayer, T. A.   & Wiltfang, J.  et al.​ (2019) 
    Journal of Alzheimer's Disease, 67(3) pp. 849​-858​.​ DOI: https://doi.org/10.3233/JAD-181134 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​The Effect of <b><i>SH2B1</i></b> Variants on Expression of Leptin- and Insulin-Induced Pathways in Murine Hypothalamus​
    Giuranna, J.; Volckmar, A.-L.; Heinen, A.; Peters, T.; Schmidt, B.; Spieker, A. & Straub, H. et al.​ (2018) 
    Obesity Facts, 11(2) pp. 93​-108​.​ DOI: https://doi.org/10.1159/000486962 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Reproducibility of Alzheimer’s Disease Cerebrospinal Fluid-Biomarker Measurements under Clinical Routine Conditions​
    Vogelgsang, J.; Wedekind, D. ; Bouter, C. ; Klafki, H.-W.   & Wiltfang, J. ​ (2018) 
    Journal of Alzheimer's Disease, 62(1) pp. 203​-212​.​ DOI: https://doi.org/10.3233/JAD-170793 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Micro-droplet arrays for micro-compartmentalization using an air/water interface​
    Kunding, A. H.; Busk, L. L.; Webb, H.; Klafki, H. W. ; Otto, M. ; Kutter, J. P. & Dufva, M.​ (2018) 
    Lab on a Chip, 18(18) pp. 2797​-2805​.​ DOI: https://doi.org/10.1039/C8LC00608C 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​N-truncated Aβ4–x peptides in sporadic Alzheimer’s disease cases and transgenic Alzheimer mouse models​
    Wirths, O. ; Walter, S.; Kraus, I. ; Klafki, H. W. ; Stazi, M.; Oberstein, T. J. & Ghiso, J. et al.​ (2017) 
    Alzheimer's Research & Therapy, 9(1) art. 80​.​ DOI: https://doi.org/10.1186/s13195-017-0309-z 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Amyloid-β-Secondary Structure Distribution in Cerebrospinal Fluid and Blood Measured by an Immuno-Infrared-Sensor: A Biomarker Candidate for Alzheimer’s Disease​
    Nabers, A.; Ollesch, J.; Schartner, J.; Kötting, C.; Genius, J.; Hafermann, H. & Klafki, H.  et al.​ (2016) 
    Analytical Chemistry, 88(5) pp. 2755​-2762​.​ DOI: https://doi.org/10.1021/acs.analchem.5b04286 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Association of Plasma β-Amyloid with Cognitive Performance and Decline in Chronic Kidney Disease​
    Gronewold, J.; Todica, O.; Klafki, H.-W. ; Seidel, U. K.; Kaltwasser, B.; Wiltfang, J.   & Kribben, A. et al.​ (2016) 
    Molecular Neurobiology,.​ DOI: https://doi.org/10.1007/s12035-016-0243-2 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Validation of a Commercial Chemiluminescence Immunoassay for the Simultaneous Measurement of Three Different Amyloid-β Peptides in Human Cerebrospinal Fluid and Application to a Clinical Cohort​
    Klafki, H.-W. ; Hafermann, H.; Bauer, C.; Haußmann, U.; Kraus, I. ; Schuchhardt, J. & Muck, S. et al.​ (2016) 
    Journal of Alzheimer's Disease, 54(2) pp. 691​-705​.​ DOI: https://doi.org/10.3233/jad-160398 
    ​Details  DOI 
  • 2016 | Journal Article | 
    ​ ​Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse model​
    Hüttenrauch, M. ; Brauß, A.; Kurdakova, A.; Borgers, H.; Klinker, F. ; Liebetanz, D.   & Salinas-Riester, G.  et al.​ (2016) 
    Translational Psychiatry, 6(5) art. e800​.​ DOI: https://doi.org/10.1038/tp.2016.65 
    ​Details  DOI 
  • 2016 | Journal Article | 
    ​ ​Modified serpinA1 as risk marker for Parkinson’s disease dementia: Analysis of baseline data​
    Halbgebauer, S.; Nagl, M.; Klafki, H. ; Haußmann, U.; Steinacker, P. ; Oeckl, P. & Kassubek, J. et al.​ (2016) 
    Scientific Reports, 6(1).​ DOI: https://doi.org/10.1038/srep26145 
    ​Details  DOI 
  • 2016 | Journal Article | 
    ​ ​Solid-Phase Synthesis and Characterization of N-Terminally Elongated Aβ−3-x-Peptides​
    Beyer, I.; Rezaei-Ghaleh, N. ; Klafki, H.-W. ; Jahn, O. ; Haußmann, U.; Wiltfang, J.   & Zweckstetter, M.  et al.​ (2016) 
    Chemistry - A European Journal, 22(25) pp. 8685​-8693​.​ DOI: https://doi.org/10.1002/chem.201600892 
    ​Details  DOI 
  • 2016 | Journal Article | 
    ​ ​Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer’s disease and transgenic mouse models​
    Reinert, J. ; Richard, B. C. ; Klafki, H. W. ; Friedrich, B.; Bayer, T. A. ; Wiltfang, J.   & Kovacs, G. G. et al.​ (2016) 
    Acta Neuropathologica Communications, 4(1) art. 24​.​ DOI: https://doi.org/10.1186/s40478-016-0294-7 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article
    ​ ​Factors Responsible for Plasma β-Amyloid Accumulation in Chronic Kidney Disease​
    Gronewold, J.; Klafki, H.-W. ; Baldelli, E.; Kaltwasser, B.; Seidel, U. K.; Todica, O. & Volsek, M. et al.​ (2016) 
    Molecular Neurobiology, 53(5) pp. 3136​-3145​.​ DOI: https://doi.org/10.1007/s12035-015-9218-y 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article
    ​ ​Validation of soluble amyloid-β precursor protein assays as diagnostic CSF biomarkers for neurodegenerative diseases​
    van Waalwijk van Doorn, L. J. C.; Koel-Simmelink, M. J.; Haußmann, U.; Klafki, H. ; Struyfs, H.; Linning, P. & Knölker, H.-J. et al.​ (2016) 
    Journal of Neurochemistry, 137(1) pp. 112​-121​.​ DOI: https://doi.org/10.1111/jnc.13527 
    ​Details  DOI  PMID  PMC 
  • 2015 | Journal Article
    ​ ​N-Truncated Aβ2-X Starting with Position Two in Sporadic Alzheimer’s Disease Cases and Two Alzheimer Mouse Models​
    Savastano, A. ; Klafki, H. ; Haußmann, U.; Oberstein, T. J.; Muller, P.; Wirths, O.   & Wiltfang, J.  et al.​ (2015) 
    Journal of Alzheimer's Disease, 49(1) pp. 101​-110​.​ DOI: https://doi.org/10.3233/jad-150394 
    ​Details  DOI 
  • 2015 | Journal Article
    ​ ​An infrared sensor analysing label-free the secondary structure of the Abeta peptide in presence of complex fluids​
    Nabers, A.; Ollesch, J.; Schartner, J.; Kötting, C.; Genius, J.; Haußmann, U. & Klafki, H.  et al.​ (2015) 
    Journal of Biophotonics, 9(3) pp. 224​-234​.​ DOI: https://doi.org/10.1002/jbio.201400145 
    ​Details  DOI 
  • 2015 | Journal Article | 
    ​ ​Detection and Differentiation of Threonine- and Tyrosine-Monophosphorylated Forms of ERK1/2 by Capillary Isoelectric Focusing-Immunoassay​
    Kraus, I. ; Besong Agbo, D.; Otto, M. ; Wiltfang, J.   & Klafki, H. ​ (2015) 
    Scientific Reports, 5(1) art. 12767​.​ DOI: https://doi.org/10.1038/srep12767 
    ​Details  DOI 
  • 2014 | Journal Article
    ​ ​High-Fat Diet Induced Isoform Changes of the Parkinson’s Disease Protein DJ-1​
    Poschmann, G.; Seyfarth, K.; Besong Agbo, D.; Klafki, H.-W. ; Rozman, J.; Wurst, W. & Wiltfang, J.  et al.​ (2014) 
    Journal of Proteome Research, 13(5) pp. 2339​-2351​.​ DOI: https://doi.org/10.1021/pr401157k 
    ​Details  DOI 
  • 2014 | Journal Article
    ​ ​Capillary isoelectric focusing immunoassay as a new nanoscale approach for the detection of oligoclonal bands​
    Halbgebauer, S.; Haußmann, U.; Klafki, H. ; Tumani, H. ; Wiltfang, J.   & Otto, M. ​ (2014) 
    ELECTROPHORESIS, 36(2) pp. 355​-362​.​ DOI: https://doi.org/10.1002/elps.201400339 
    ​Details  DOI 
  • 2014 | Journal Article | 
    ​ ​Astrocytes and microglia but not neurons preferentially generate N-terminally truncated Aβ peptides​
    Oberstein, T. J.; Spitzer, P.; Klafki, H.-W. ; Linning, P.; Neff, F.; Knölker, H.-J. & Lewczuk, P.  et al.​ (2014) 
    Neurobiology of Disease, 73 pp. 24​-35​.​ DOI: https://doi.org/10.1016/j.nbd.2014.08.031 
    ​Details  DOI 
  • 2003 | Journal Article
    ​ ​Highly conserved and disease-specific patterns of carboxyterminally truncated Aβ peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation​
    Wiltfang, J. ; Esselmann, H. ; Bibl, M. ; Smirnov, A. ; Otto, M. ; Paul, S.   & Schmidt, B.  et al.​ (2003) 
    Journal of Neurochemistry, 81(3) pp. 481​-496​.​ DOI: https://doi.org/10.1046/j.1471-4159.2002.00818.x 
    ​Details  DOI 

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