Prof. Dr. med. Matthias Dobbelstein

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  • 2023 | Journal Article | 
    ​ ​N4-hydroxycytidine, the active compound of Molnupiravir, promotes SARS-CoV-2 mutagenesis and escape from a neutralizing nanobody​
    Zibat, A.; Zhang, X.; Dickmanns, A.; Stegmann, K. M.; Dobbelstein, A. W.; Alachram, H. & Soliwoda, R. et al.​ (2023) 
    iScience, 26(10) art. 107786​.​ DOI: https://doi.org/10.1016/j.isci.2023.107786 
    ​Details  DOI 
  • 2022 | Journal Article | 
    ​ ​Therapeutische Nanobodies gegen SARS-CoV-2​
    Güttler, T.; Dobbelstein, M.   & Görlich, D.​ (2022) 
    BIOspektrum, 28(1) pp. 39​-42​.​ DOI: https://doi.org/10.1007/s12268-022-1684-y 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression​
    Giansanti, C.; Manzini, V.; Dickmanns, A.; Dickmanns, A. ; Palumbieri, M. D.; Sanchi, A. & Kienle, S. M. et al.​ (2022) 
    Cell Reports, 39(9) art. 110879​.​ DOI: https://doi.org/10.1016/j.celrep.2022.110879 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication​
    Stegmann, K. M.; Dickmanns, A.; Heinen, N.; Blaurock, C.; Karrasch, T.; Breithaupt, A. & Klopfleisch, R. et al.​ (2022) 
    iScience, 25(5) art. S2589004222005636​.​ DOI: https://doi.org/10.1016/j.isci.2022.104293 
    ​Details  DOI 
  • 2021 | Journal Article | 
    ​ ​MDM2-Driven Ubiquitination Rapidly Removes p53 from Its Cognate Promoters​
    Henningsen, K. M.; Manzini, V.; Magerhans, A.; Gerber, S. & Dobbelstein, M. ​ (2021) 
    Biomolecules, 12(1) pp. 22​.​ DOI: https://doi.org/10.3390/biom12010022 
    ​Details  DOI 
  • 2021 | Journal Article | 
    ​ ​HSP90 Inhibition Synergizes with Cisplatin to Eliminate Basal-like Pancreatic Ductal Adenocarcinoma Cells​
    Ewers, K. M.; Patil, S.; Kopp, W.; Thomale, J.; Quilitz, T.; Magerhans, A. & Wang, X. et al.​ (2021) 
    Cancers, 13(24) pp. 6163​.​ DOI: https://doi.org/10.3390/cancers13246163 
    ​Details  DOI 
  • 2021 | Journal Article | 
    ​ ​Neutralization of SARS‐CoV‐2 by highly potent, hyperthermostable, and mutation‐tolerant nanobodies​
    Güttler, T.; Aksu, M.; Dickmanns, A.; Stegmann, K. M.; Gregor, K.; Rees, R. & Taxer, W. et al.​ (2021) 
    The EMBO Journal, 40(19).​ DOI: https://doi.org/10.15252/embj.2021107985 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis​
    Müller, A.; Dickmanns, A.; Resch, C.; Schäkel, K.; Hailfinger, S.; Dobbelstein, M.   & Schulze-Osthoff, K. et al.​ (2020) 
    Journal of Clinical Investigation, 130(11) pp. 5765​-5781​.​ DOI: https://doi.org/10.1172/JCI134217 
    ​Details  DOI 
  • 2020 | Journal Article | Erratum | 
    ​ ​Correction: The integrated stress response induces R-loops and hinders replication fork progression​
    Choo, J. A. M. Y.; Schlösser, D.; Manzini, V.; Magerhans, A. & Dobbelstein, M. ​ (2020) 
    Cell Death & Disease, 11(7).​ DOI: https://doi.org/10.1038/s41419-020-02817-y 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​The integrated stress response induces R-loops and hinders replication fork progression​
    Choo, J. A. M. Y.; Schlösser, D.; Manzini, V.; Magerhans, A. & Dobbelstein, M. ​ (2020) 
    Cell Death & Disease, 11(7).​ DOI: https://doi.org/10.1038/s41419-020-2727-2 
    ​Details  DOI 
  • 2018 | Journal Article | Erratum | 
    ​ ​Correction: Strong antitumor synergy between DNA crosslinking and HSP90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells​
    Kramer, D. ; Stark, N. ; Schulz-Heddergott, R. ; Erytch, N.; Edmunds, S. ; Roßmann, L.   & Bastians, H.  et al.​ (2018) 
    Cell Death and Differentiation, 26(4) pp. 780​-780​.​ DOI: https://doi.org/10.1038/s41418-018-0190-8 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​CDK4 inhibition diminishes p53 activation by MDM2 antagonists​
    Sriraman, A.; Dickmanns, A.; Najafova, Z.; Johnsen, S. A. & Dobbelstein, M. ​ (2018) 
    Cell Death & Disease, 9(9) art. 918​.​ DOI: https://doi.org/10.1038/s41419-018-0968-0 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | 
    ​ ​Strong antitumor synergy between DNA crosslinking and HSP90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells​
    Kramer, D.; Stark, N. ; Schulz-Heddergott, R.; Erytch, N.; Edmunds, S.; Rossmann, L.   & Bastians, H. et al.​ (2017) 
    Cell Death and Differentiation, 24(2) pp. 300​-316​.​ DOI: https://doi.org/10.1038/cdd.2016.124 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | 
    ​ ​Comprehensive identification of genes driven by ERV9-LTRs reveals TNFRSF10B as a re-activatable mediator of testicular cancer cell death​
    Beyer, U.; Kroenung, S. K.; Leha, A.; Walter, L. & Dobbelstein, M. ​ (2016) 
    Cell Death and Differentiation, 23(1) pp. 64​-75​.​ DOI: https://doi.org/10.1038/cdd.2015.68 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | 
    ​ ​LTR12 promoter activation in a broad range of human tumor cells by HDAC inhibition​
    Kronung, S. K.; Beyer, U.; Chiaramonte, M. L.; Dolfini, D.; Mantovani, R. & Dobbelstein, M. ​ (2016) 
    Oncotarget, 7(23) pp. 33484​-33497​.​ DOI: https://doi.org/10.18632/oncotarget.9255 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | 
    ​ ​p53 Activity Results in DNA Replication Fork Processivity​
    Klusmann, I.; Rodewald, S.; Mueller, L.; Friedrich, M.; Wienken, M.; Li, Y. & Schulz-Heddergott, R.  et al.​ (2016) 
    Cell Reports, 17(7) pp. 1845​-1857​.​ DOI: https://doi.org/10.1016/j.celrep.2016.10.036 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | 
    ​ ​Cooperation of Nutlin-3a and a Wip1 inhibitor to induce p53 activity​
    Sriraman, A.; Radovanovic, M.; Wienken, M.; Najafova, Z.; Li, Y. & Dobbelstein, M. ​ (2016) 
    Oncotarget, 7(22) pp. 31623​-31638​.​ DOI: https://doi.org/10.18632/oncotarget.9302 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | 
    ​ ​Usp22 deficiency impairs intestinal epithelial lineage specification in vivo.​
    Kosinsky, R. L.; Wegwitz, F.; Hellbach, N.; Dobbelstein, M. ; Mansouri, A.; Vogel, T. & Begus-Nahrmann, Y. et al.​ (2015) 
    Oncotarget, 6(35) pp. 37906​-37918​.​ DOI: https://doi.org/10.18632/oncotarget.5412 
    ​Details  DOI  PMID  PMC 
  • 2015 | Journal Article | 
    ​ ​5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair.​
    Srinivas, U. S.; Dyczkowski, J.; Beißbarth, T. ; Gaedcke, J. ; Mansour, W. Y.; Borgmann, K. & Dobbelstein, M. ​ (2015) 
    Oncotarget, 6(14) pp. 12574​-12586​.​ DOI: https://doi.org/10.18632/oncotarget.3728 
    ​Details  DOI  PMID  PMC 
  • 2015 | Journal Article | Erratum | 
    ​ ​Erratum: Corrigendum: Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment​
    Alexandrova, E. M.; Yallowitz, A. R.; Li, D.; Xu, S.; Schulz, R.; Proia, D. A. & Lozano, G. et al.​ (2015) 
    Nature, 527(7578) pp. 398​-398​.​ DOI: https://doi.org/10.1038/nature15720 
    ​Details  DOI 
  • 2015 | Journal Article | 
    ​ ​Screening analysis of ubiquitin ligases reveals G2E3 as a potential target for chemosensitizing cancer cells​
    Schmidt, F.; Kunze, M.; Loock, A.-C. & Dobbelstein, M. ​ (2015) 
    Oncotarget, 6(2) pp. 617​-632​.​
    ​Details  PMID  PMC  WoS 
  • 2015 | Journal Article | 
    ​ ​Mdm2 inhibition confers protection of p53-proficient cells from the cytotoxic effects of Wee1 inhibitors​
    Li, Y.; Saini, P.; Sriraman, A. & Dobbelstein, M. ​ (2015) 
    Oncotarget, 6(32) pp. 32339​-32352​.​ DOI: https://doi.org/10.18632/oncotarget.5891 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | 
    ​ ​Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment​
    Alexandrova, E. M.; Yallowitz, A. R.; Li, D.; Xu, S.; Schulz, R.; Proia, D. A. & Lozano, G. et al.​ (2015) 
    Nature, 523(7560) pp. 352​-+​.​ DOI: https://doi.org/10.1038/nature14430 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | 
    ​ ​Wee1 is required to sustain ATR/Chk1 signaling upon replicative stress.​
    Saini, P.; Li, Y. & Dobbelstein, M. ​ (2015) 
    Oncotarget, 6(15) pp. 13072​-13087​.​ DOI: https://doi.org/10.18632/oncotarget.3865 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper | 
    ​ ​Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice​
    Gogiraju, R.; Xu, X.; Bochenek, M. L.; Steinbrecher, J. H.; Lehnart, S. E. ; Wenzel, P. & Kessel, M.  et al.​ (2015) 
    Journal of the American Heart Association, 4(2) art. e001770​.​ DOI: https://doi.org/10.1161/JAHA.115.001770 
    ​Details  DOI  PMID  PMC 
  • 2015 | Journal Article | 
    ​ ​A pro-apoptotic function of iASPP by stabilizing p300 and CBP through inhibition of BRMS1 E3 ubiquitin ligase activity​
    Kramer, D.; Schoen, M.; Bayerlova, M.; Bleckmann, A.; Schoen, M. P.; Zoernig, M. & Dobbelstein, M. ​ (2015) 
    Cell Death and Disease, 6 art. e1634​.​ DOI: https://doi.org/10.1038/cddis.2015.17 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | 
    ​ ​Overcoming EMT-driven therapeutic resistance by BH3 mimetics.​
    Keitel, U.; Scheel, C. & Dobbelstein, M. ​ (2014) 
    Oncoscience, 1(11) pp. 706​-708​.​
    ​Details  PMID  PMC 
  • 2014 | Journal Article | 
    ​ ​HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer​
    Schulz, R.; Streller, F.; Scheel, A. H.; Rueschoff, J.; Reinert, M. C.; Dobbelstein, M.   & Marchenko, N. D. et al.​ (2014) 
    Cell Death and Disease, 5 art. e980​.​ DOI: https://doi.org/10.1038/cddis.2013.508 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | 
    ​ ​Bcl-xL mediates therapeutic resistance of a mesenchymal breast cancer cell subpopulation​
    Keitel, U.; Scheel, A.; Thomale, J.; Halpape, R.; Kaulfuß, S.; Scheel, C. & Dobbelstein, M. ​ (2014) 
    Oncotarget, 5(23) pp. 11778​-11791​.​ DOI: https://doi.org/10.18632/oncotarget.2634 
    ​Details  DOI  PMID  PMC 
  • 2014 | Journal Article | 
    ​ ​UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib​
    Landmann, H.; Proia, D. A.; He, S.; Ogden, F. L.; Kramer, F.-J. ; Beißbarth, T.   & Grade, M.  et al.​ (2014) 
    Cell Death and Disease, 5 art. e1411​.​ DOI: https://doi.org/10.1038/cddis.2014.378 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article | 
    ​ ​Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression​
    Schulz, R.; Marchenko, N. D.; Holembowski, L.; Fingerle-Rowson, G.; Pesic, M.; Zender, L. & Dobbelstein, M.  et al.​ (2012) 
    Journal of Experimental Medicine, 209(2) pp. 275​-289​.​ DOI: https://doi.org/10.1084/jem.20111117 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | 
    ​ ​E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis​
    Lize, M.; Pilarski, S. & Dobbelstein, M. ​ (2010) 
    Cell Death and Differentiation, 17(3) pp. 452​-458​.​ DOI: https://doi.org/10.1038/cdd.2009.188 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | Letter Note | 
    ​ ​Brdm2-an aberrant hypomorphic p63 allele​
    Talos, F.; Wolff, S.; Beyer, U.; Dobbelstein, M.   & Moll, U. M.​ (2010) 
    Cell Death and Differentiation, 17(1) pp. 184​-186​.​ DOI: https://doi.org/10.1038/cdd.2009.158 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | 
    ​ ​p73 is an essential regulator of neural stem cell maintenance in embryonal and adult CNS neurogenesis​
    Talos, F.; Abraham, A.; Vaseva, A. V.; Holembowski, L. ; Tsirka, S. E.; Scheel, A. & Bode, D. et al.​ (2010) 
    Cell Death and Differentiation, 17(12) pp. 1816​-1829​.​ DOI: https://doi.org/10.1038/cdd.2010.131 
    ​Details  DOI  PMID  PMC  WoS 
  • 2009 | Journal Article | 
    ​ ​The alpha/beta carboxy-terminal domains of p63 are required for skin and limb development. New insights from the Brdm2 mouse which is not a complete p63 knockout but expresses p63 gamma-like proteins​
    Wolff, S.; Talos, F.; Palacios, G.; Beyer, U.; Dobbelstein, M.   & Moll, U. M.​ (2009) 
    Cell Death and Differentiation, 16(8) pp. 1108​-1117​.​ DOI: https://doi.org/10.1038/cdd.2009.25 
    ​Details  DOI  PMID  PMC  WoS 
  • 2008 | Journal Article | 
    ​ ​NF-Y Dependent Epigenetic Modifications Discriminate between Proliferating and Postmitotic Tissue​
    Gurtner, A.; Fuschi, P.; Magi, F.; Colussi, C.; Gaetano, C.; Dobbelstein, M.   & Sacchi, A. et al.​ (2008) 
    PLoS ONE, 3(4) art. e2047​.​ DOI: https://doi.org/10.1371/journal.pone.0002047 
    ​Details  DOI  PMID  PMC 
  • 2008 | Journal Article | 
    ​ ​BRCA1 and Tip60 determine the cellular response to ultraviolet irradiation through distinct pathways​
    Kranz, D.; Dohmesen, C. & Dobbelstein, M. ​ (2008) 
    The Journal of Cell Biology, 182(1) pp. 197​-213​.​ DOI: https://doi.org/10.1083/jcb.200712014 
    ​Details  DOI  PMID  PMC  WoS 
  • 2008 | Journal Article | 
    ​ ​p53-Responsive MicroRNAs 192 and 215 Are Capable of Inducing Cell Cycle Arrest​
    Braun, C. J.; Zhang, X.; Savelyeva, I.; Wolff, S.; Moll, U. M.; Schepeler, T. & Orntoft, T. F. et al.​ (2008) 
    Cancer Research, 68(24) pp. 10094​-10104​.​ DOI: https://doi.org/10.1158/0008-5472.CAN-08-1569 
    ​Details  DOI  PMID  PMC  WoS 

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