Prof. Dr. Mathias Bähr

 
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  • 2022 Journal Article | Research Paper | 
    ​ ​α-Synuclein Impacts on Intrinsic Neuronal Network Activity Through Reduced Levels of Cyclic AMP and Diminished Numbers of Active Presynaptic Terminals​
    Leite, K.; Garg, P.; Spitzner, F. P.; Guerin Darvas, S.; Bähr, M. ; Priesemann, V.   & Kügler, S. ​ (2022) 
    Frontiers in Molecular Neuroscience15.​ DOI: https://doi.org/10.3389/fnmol.2022.868790 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article
    ​ ​Patterning inconsistencies restrict the true potential of dopaminergic neurons derived from human induced pluripotent stem cells​
    Mahajani, S.; Bähr, M.   & Kügler, S. ​ (2021) 
    Neural Regeneration Research16(4) pp. 692​.​ DOI: https://doi.org/10.4103/1673-5374.295316 
    Details  DOI 
  • 2020 Journal Article | Research Paper | 
    ​ ​Dopamine promotes the neurodegenerative potential of β‐synuclein​
    Raina, A.; Leite, K.; Guerin, S.; Mahajani, S. U.; Chakrabarti, K. S.; Voll, D. & Becker, S.  et al.​ (2020) 
    Journal of Neurochemistry156(5) pp. 674​-691​.​ DOI: https://doi.org/10.1111/jnc.15134 
    Details  DOI  PMID  PMC 
  • 2019 Journal Article
    ​ ​Neuronal Trans-differentiation by Transcription Factors Ascl1 and Nurr1: Induction of a Dopaminergic Neurotransmitter Phenotype in Cortical GABAergic Neurons​
    Raina, A.; Mahajani, S.; Bähr, M.   & Kügler, S. ​ (2019) 
    Molecular Neurobiology57(1) pp. 249​-260​.​ DOI: https://doi.org/10.1007/s12035-019-01701-x 
    Details  DOI 
  • 2019 Journal Article | 
    ​ ​Homogenous generation of dopaminergic neurons from multiple hiPSC lines by transient expression of transcription factors​
    Mahajani, S.; Raina, A.; Fokken, C.; Kügler, S.   & Bähr, M. ​ (2019) 
    Cell Death & Disease10(12).​ DOI: https://doi.org/10.1038/s41419-019-2133-9 
    Details  DOI 
  • 2018 Journal Article
    ​ ​Therapeutic efficacy of regulable GDNF expression for Huntington's and Parkinson's disease by a high-induction, background-free “GeneSwitch” vector​
    Cheng, S.; Tereshchenko, J. ; Zimmer, V.; Vachey, G.; Pythoud, C.; Rey, M. & Liefhebber, J. et al.​ (2018) 
    Experimental Neurology309 pp. 79​-90​.​ DOI: https://doi.org/10.1016/j.expneurol.2018.07.017 
    Details  DOI 
  • 2017 Journal Article | 
    ​ ​Long-Term Assessment of AAV-Mediated Zinc Finger Nuclease Expression in the Mouse Brain​
    Zahur, M. ; Tolö, J. ; Bähr, M.   & Kügler, S. ​ (2017) 
    Frontiers in Molecular Neuroscience10 art. 142​.​ DOI: https://doi.org/10.3389/fnmol.2017.00142 
    Details  DOI 
  • 2015 Journal Article | Research Paper
    ​ ​AAV-mediated expression of BAG1 and ROCK2-shRNA promote neuronal survival and axonal sprouting in a rat model of rubrospinal tract injury​
    Challagundla, M.; Koch, J. C. ; Ribas, V. T. ; Michel, U. ; Kügler, S. ; Ostendorf, T. & Bradke, F. et al.​ (2015) 
    Journal of Neurochemistry134(2) pp. 261​-275​.​ DOI: https://doi.org/10.1111/jnc.13102 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article
    ​ ​Dimerization propensities of Synucleins are not predictive for Synuclein aggregation​
    Eckermann, K.; Kügler, S.   & Bähr, M. ​ (2015) 
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease1852(8) pp. 1658​-1664​.​ DOI: https://doi.org/10.1016/j.bbadis.2015.05.002 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper | 
    ​ ​Alpha-synuclein mutations impair axonal regeneration in models of Parkinson's disease​
    Tönges, L. ; Szegö, E. M. ; Hause, P.; Saal, K.-A. ; Tatenhorst, L. ; Koch, J. C.   & D'Hedouville, Z. et al.​ (2014) 
    Frontiers in Aging Neuroscience6 art. UNSP 239​.​ DOI: https://doi.org/10.3389/fnagi.2014.00239 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper
    ​ ​Pharmacologically controlled, discontinuous GDNF gene therapy restores motor function in a rat model of Parkinson's disease​
    Tereshchenko, J. ; Maddalena, A.; Bähr, M.   & Kügler, S. ​ (2014) 
    Neurobiology of Disease65 pp. 35​-42​.​ DOI: https://doi.org/10.1016/j.nbd.2014.01.009 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​β-Synuclein Aggregates and Induces Neurodegeneration in Dopaminergic Neurons​
    Taschenberger, G. ; Toloe, J. ; Tereshchenko, J. ; Akerboom, J.; Wales, P. ; Benz, R. & Becker, S.  et al.​ (2013) 
    Annals of Neurology74(1) pp. 109​-118​.​ DOI: https://doi.org/10.1002/ana.23905 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | 
    ​ ​Adeno-associated Virus-mediated, Mifepristone-regulated Transgene Expression in the Brain​
    Maddalena, A.; Tereshchenko, J. ; Bähr, M.   & Kügler, S. ​ (2013) 
    Molecular therapy. Nucleic acids2.​ DOI: https://doi.org/10.1038/mtna.2013.35 
    Details  DOI  PMID  PMC 
  • 2012 Journal Article | Research Paper | 
    ​ ​HDAC1 Regulates Fear Extinction in Mice​
    Bahari-Javan, S. ; Maddalena, A.; Kerimoglu, C. ; Wittnam, J.; Held, T.; Bähr, M.   & Burkhardt, S.  et al.​ (2012) 
    The Journal of Neuroscience32(15) pp. 5062​-5073​.​ DOI: https://doi.org/10.1523/JNEUROSCI.0079-12.2012 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Journal Article | Research Paper | 
    ​ ​Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons​
    Taschenberger, G. ; Garrido, M.; Tereshchenko, Y. ; Baehr, M. ; Zweckstetter, M.   & Kügler, S. ​ (2012) 
    Acta Neuropathologica123(5) pp. 671​-683​.​ DOI: https://doi.org/10.1007/s00401-011-0926-8 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Journal Article | Research Paper | 
    ​ ​Efficient Gene Therapy for Parkinson's Disease Using Astrocytes as Hosts for Localized Neurotrophic Factor Delivery​
    Drinkut, A.; Tereshchenko, Y. ; Schulz, J. B. ; Bähr, M.   & Kügler, S. ​ (2012) 
    Molecular Therapy20(3) pp. 534​-543​.​ DOI: https://doi.org/10.1038/mt.2011.249 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article | Research Paper | 
    ​ ​Glutathione depletion and overproduction both initiate degeneration of nigral dopaminergic neurons​
    Garrido, M.; Tereshchenko, Y. ; Zhevtsova, Z.; Taschenberger, G. ; Bähr, M.   & Kügler, S. ​ (2011) 
    Acta Neuropathologica121(4) pp. 475​-485​.​ DOI: https://doi.org/10.1007/s00401-010-0791-x 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article | Research Paper | 
    ​ ​Sumoylation inhibits alpha-synuclein aggregation and toxicity​
    Krumova, P.; Meulmeester, E.; Garrido, M.; Tirard, M.; Hsiao, H.-H.; Bossis, G. & Urlaub, H.  et al.​ (2011) 
    The Journal of Cell Biology194(1) pp. 49​-60​.​ DOI: https://doi.org/10.1083/jcb.201010117 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article | Research Paper
    ​ ​CNS-Expressed Cathepsin D Prevents Lymphopenia in a Murine Model of Congenital Neuronal Ceroid Lipofuscinosis​
    Shevtsova, Z.; Garrido, M.; Weishaupt, J. ; Saftig, P. ; Bähr, M. ; Lühder, F.   & Kügler, S. ​ (2010) 
    The American Journal of Pathology177(1) pp. 271​-279​.​ DOI: https://doi.org/10.2353/ajpath.2010.091267 
    Details  DOI  PMID  PMC  WoS 
  • 2008 Journal Article | Research Paper
    ​ ​BAG1 promotes axonal outgrowth and regeneration in vivo via Raf-1 and reduction of ROCK activity​
    Planchamp, V. ; Bermel, C. ; Tönges, L. ; Ostendorf, T.; Kügler, S. ; Reed, J. C. & Kermer, P.  et al.​ (2008) 
    Brain131 pp. 2606​-2619​.​ DOI: https://doi.org/10.1093/brain/awn196 
    Details  DOI  PMID  PMC  WoS 
  • 2006 Journal Article | Research Paper
    ​ ​Potentiation of in vivo neuroprotection by BclX(L) and GDNF co-expression depends on post-lesion time in deafferentiated CNS neurons​
    Shevtsova, Z.; Malik, I. ; Garrido, M.; Schoell, U.; Bähr, M.   & Kügler, S. ​ (2006) 
    Gene Therapy13(22) pp. 1569​-1578​.​ DOI: https://doi.org/10.1038/sj.gt.3302822 
    Details  DOI  PMID  PMC  WoS 
  • 2006 Journal Article | Research Paper
    ​ ​Comparison of test systems for RNAinterference​
    Malik, I. ; Garrido, M.; Bähr, M. ; Kügler, S.   & Michel, U. ​ (2006) 
    Biochemical and Biophysical Research Communications341(1) pp. 245​-253​.​ DOI: https://doi.org/10.1016/j.bbrc.2005.12.173 
    Details  DOI  PMID  PMC  WoS 
  • 2001 Journal Article | Research Paper
    ​ ​Neuron-specific expression of therapeutic proteins: Evaluation of different cellular promoters in recombinant adenoviral vectors​
    Kügler, S. ; Meyn, L.; Holzmüller, H.; Gerhardt, E. ; Isenmann, S.; Schulz, J. B.   & Bähr, M. ​ (2001) 
    Molecular and Cellular Neuroscience17(1) pp. 78​-96​.​ DOI: https://doi.org/10.1006/mcne.2000.0929 
    Details  DOI  PMID  PMC  WoS 
  • 2001 Journal Article | Research Paper
    ​ ​Rescue from death but not from functional impairment: caspase inhibition protects dopaminergic cells against 6-hydroxydopamine-induced apoptosis but not against the loss of their terminals​
    Coelln, R. von; Kugler, S. ; Weller, M.; Dichgans, J.; Bähr, M.   & Schulz, J. B. ​ (2001) 
    Journal of Neurochemistry77(1) pp. 263​-273​.​ DOI: https://doi.org/10.1046/j.1471-4159.2001.t01-1-00236.x 
    Details  DOI  PMID  PMC  WoS 
  • 2000 Journal Article | Research Paper
    ​ ​Protection by synergistic effects of adenovirus-mediated X-chromosome-linked inhibitor of apoptosis and glial cell line-derived neurotrophic factor gene transfer in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease​
    Eberhardt, O.; Coelln, R. V.; Kugler, S. ; Lindenau, J.; Rathke-Hartlieb, S.; Gerhardt, E.   & Haid, S. et al.​ (2000) 
    The Journal of Neuroscience20(24) pp. 9126​-9134​.​ DOI: https://doi.org/10.1523/JNEUROSCI.20-24-09126.2000 
    Details  DOI  PMID  PMC  WoS 

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