Prof. Dr. med. Lars Siegfried Maier

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  • 2022 | Journal Article
    ​ ​Lebek, Simon, et al. "Na v 1.8 Dysregulates Na and Ca Leading to Arrhythmias in Patients with Sleep-disordered Breathing​." ​American Journal of Respiratory and Critical Care Medicine, ​2022, , ​doi: 10.1164/rccm.202205-0981LE. 
    ​Details  DOI 
  • 2022 | Journal Article
    ​ ​Körtl, Thomas, et al. "Atrial Fibrillation Burden Specifically Determines Human Ventricular Cellular Remodeling​." ​JACC: Clinical Electrophysiology, vol. 8, no. 11, ​2022, pp. 1357​-1366​, ​doi: 10.1016/j.jacep.2022.07.016. 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​Baier, Maria J., et al. "Phosphorylation of RyR2 Ser‐2814 by CaMKII mediates β1‐adrenergic stress induced Ca 2+ ‐leak from the sarcoplasmic reticulum​." ​FEBS Open Bio, ​2021, , ​doi: 10.1002/2211-5463.13274. 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​Kreitmeier, K. G., et al. "CaMKII δ Met281/282 oxidation is not required for recovery of calcium transients during acidosis​." ​American Journal of Physiology-Heart and Circulatory Physiology, vol. 320, no. 3, ​2021, pp. H1199​-H1212​, ​doi: 10.1152/ajpheart.00040.2020. 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Kolijn, Detmar, et al. "Empagliflozin improves endothelial and cardiomyocyte function in human heart failure with preserved ejection fraction via reduced pro-inflammatory-oxidative pathways and protein kinase Gα oxidation​." ​Cardiovascular Research, vol. 117, no. 2, ​2020, pp. 495​-507​, ​doi: 10.1093/cvr/cvaa123. 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Trum, M., et al. "Inhibition of cardiac potassium currents by oxidation-activated protein kinase A contributes to early afterdepolarizations in the heart​." ​American Journal of Physiology-Heart and Circulatory Physiology, vol. 319, no. 6, ​2020, pp. H1347​-H1357​, ​doi: 10.1152/ajpheart.00182.2020. 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Li, Wener, et al. "Disease Phenotypes and Mechanisms of iPSC-Derived Cardiomyocytes From Brugada Syndrome Patients With a Loss-of-Function SCN5A Mutation​." ​Frontiers in Cell and Developmental Biology, vol. 8, ​2020, , ​doi: 10.3389/fcell.2020.592893. 
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  • 2020 | Journal Article
    ​ ​Pabel, Steffen, et al. "Dantrolene reduces CaMKIIδC-mediated atrial arrhythmias​." ​Europace, vol. 22, no. 7, ​2020, pp. 1111​-1118​, ​doi: 10.1093/europace/euaa079. 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Bengel, Philipp, et al. "Contribution of the neuronal sodium channel NaV1.8 to sodium- and calcium-dependent cellular proarrhythmia​." ​Journal of Molecular and Cellular Cardiology, vol. 144, ​2020, pp. 35​-46​, ​doi: 10.1016/j.yjmcc.2020.05.002. 
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  • 2020 | Journal Article
    ​ ​Scholz, Karl Heinrich, et al. "Long-term effects of a standardized feedback-driven quality improvement program for timely reperfusion therapy in regional STEMI care networks​." ​European Heart Journal. Acute Cardiovascular Care, ​2020, , ​doi: 10.1177/2048872620907323. 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper
    ​ ​Hofhuis, Julia, et al. "Dysferlin links excitation-contraction coupling to structure and maintenance of the cardiac transverse-axial tubule system​." ​Europace, vol. 22, no. 7, ​2020, pp. 1119​-1131​, ​doi: 10.1093/europace/euaa093. 
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  • 2020 | Journal Article | Research Paper
    ​ ​Reil, Jan‐Christian, et al. "CaMKII activity contributes to homeometric autoregulation of the heart: A novel mechanism for the Anrep effect​." ​The Journal of Physiology, vol. 598, no. 15, ​2020, pp. 3129​-3153​, ​doi: 10.1113/JP279607. 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Pabel, Steffen, et al. "Inhibition of NaV1.8 prevents atrial arrhythmogenesis in human and mice​." ​Basic Research in Cardiology, vol. 115, no. 2, ​2020, , ​doi: 10.1007/s00395-020-0780-8. 
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Ahmad, Shakil, et al. "The functional consequences of sodium channel NaV1.8 in human left ventricular hypertrophy​." ​ESC Heart Failure, vol. 6, no. 1, ​2019, pp. 154​-163​, ​doi: 10.1002/ehf2.12378. 
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  • 2018 | Journal Article
    ​ ​Mustroph, Julian, et al. "Empagliflozin reduces Ca/calmodulin-dependent kinase II activity in isolated ventricular cardiomyocytes​." ​ESC Heart Failure, vol. 5, no. 4, ​2018, pp. 642​-648​, ​doi: 10.1002/ehf2.12336. 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Olivotto, Iacopo, et al. "Efficacy of Ranolazine in Patients With Symptomatic Hypertrophic Cardiomyopathy​." ​Circulation: Heart Failure, vol. 11, no. 1, ​2018, , ​doi: 10.1161/CIRCHEARTFAILURE.117.004124. 
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  • 2018 | Journal Article
    ​ ​Neef, Stefan, et al. "Improvement of cardiomyocyte function by a novel pyrimidine-based CaMKII-inhibitor​." ​Journal of Molecular and Cellular Cardiology, vol. 115, ​2018, pp. 73​-81​, ​doi: 10.1016/j.yjmcc.2017.12.015. 
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  • 2018 | Journal Article | Research Paper
    ​ ​Pabel, Steffen, et al. "Empagliflozin directly improves diastolic function in human heart failure​." ​European Journal of Heart Failure, vol. 20, no. 12, ​2018, pp. 1690​-1700​, ​doi: 10.1002/ejhf.1328. 
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  • 2018 | Journal Article | Research Paper
    ​ ​Dybkova, Nataliya, et al. "Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart​." ​Cardiovascular Research, vol. 114, no. 13, ​2018, pp. 1728​-1737​, ​doi: 10.1093/cvr/cvy152. 
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  • 2018 | Journal Article | Research Paper
    ​ ​Fischer, Thomas H., et al. "Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure​." ​European Journal of Heart Failure, vol. 20, no. 12, ​2018, pp. 1673​-1685​, ​doi: 10.1002/ejhf.1297. 
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  • 2017 | Journal Article
    ​ ​Towhidul Islam, M M, et al. "Modulation of Cardiac Function by Oxidized Type I Protein Kinase A​." ​Free Radical Biology and Medicine, vol. 112, ​2017, pp. 123​-124​, ​doi: 10.1016/j.freeradbiomed.2017.10.187. 
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  • 2017 | Journal Article | Research Paper
    ​ ​Eiringhaus, J., et al. "PP1 activation as novel antiarrhythmic approach in human heart failure​." ​European Heart Journal, vol. 38, no. suppl_1, ​2017, p. 1236​, ​doi: 10.1093/eurheartj/ehx493.P5841. 
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  • 2017 | Journal Article
    ​ ​Molina, Cristina E, et al. "Identification of optimal reference genes for transcriptomic analyses in normal and diseased human heart​." ​Cardiovascular Research, vol. 114, no. 2, ​2017, pp. 247​-258​, ​doi: 10.1093/cvr/cvx182. 
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  • 2017 | Journal Article
    ​ ​Mesubi, Olurotimi, et al. "CaMKII oxidation causes increased atrial fibrillation in diabetic mice​." ​Journal of Molecular and Cellular Cardiology, vol. 112, ​2017, pp. 161​-162​, ​doi: 10.1016/j.yjmcc.2017.07.092. 
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  • 2017 | Journal Article
    ​ ​Thiele, Holger, et al. "PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock​." ​New England Journal of Medicine, vol. 377, no. 25, ​2017, pp. 2419​-2432​, ​doi: 10.1056/nejmoa1710261. 
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  • 2017 | Journal Article | Research Paper | 
    ​ ​Perera, Ruwan K., et al. "Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4​." ​Scientific Reports, vol. 7, no. 1, ​2017, , ​doi: 10.1038/s41598-017-15632-x. 
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  • 2017 | Journal Article | Research Paper
    ​ ​Hofhuis, Julia, et al. "Dysferlin mediates membrane tubulation and links T-tubule biogenesis to muscular dystrophy​." ​Journal of Cell Science, vol. 130, no. 5, ​2017, pp. 841​-852​, ​doi: 10.1242/jcs.198861. 
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  • 2017 | Journal Article | Research Paper
    ​ ​Dewenter, Matthias, et al. "Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure​." ​Circulation: Heart Failure, vol. 10, no. 5, ​2017, pp. 1​-9​, ​doi: 10.1161/CIRCHEARTFAILURE.117.003840. 
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  • 2017 | Journal Article | Research Paper
    ​ ​Neef, Stefan, et al. "Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity​." ​Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 390, no. 8, ​2017, pp. 857​-862​, ​doi: 10.1007/s00210-017-1376-1. 
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  • 2016 | Journal Article | Research Paper
    ​ ​Fischer, Thomas H., et al. "Sex-dependent alterations of Ca2+ cycling in human cardiac hypertrophy and heart failure​." ​EP Europace, vol. 18, no. 9, ​2016, pp. 1440​-1448​, ​doi: 10.1093/europace/euv313. 
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  • 2016 | Journal Article | Research Paper
    ​ ​Hartmann, Nico H., et al. "The combined effects of ranolazine and dronedarone on human atrial and ventricular electrophysiology​." ​Journal of Molecular and Cellular Cardiology, vol. 94, ​2016, pp. 95​-106​, ​doi: 10.1016/j.yjmcc.2016.03.012. 
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  • 2016 | Journal Article | Research Paper
    ​ ​Hartmann, Nico H., et al. "Antiarrhythmic effects of dantrolene in human diseased cardiomyocytes​." ​Heart Rhythm, vol. 14, no. 3, ​2016, pp. 412​-419​, ​doi: 10.1016/j.hrthm.2016.09.014. 
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  • 2015 | Conference Abstract
    ​ ​Xu, X. X., et al. "Epigenetic balance of aberrant rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis​." ​European Journal of Heart Failure, vol. 17, ​2015, . ​
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  • 2015 | Journal Article | Research Paper
    ​ ​Chang Liao, Mei-Ling, et al. "Sensing Cardiac Electrical Activity With a Cardiac Myocyte-Targeted Optogenetic Voltage Indicator​." ​Circulation Research, vol. 117, no. 5, ​2015, pp. 401​-412​, ​doi: 10.1161/CIRCRESAHA.117.306143. 
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  • 2015 | Journal Article | Research Paper
    ​ ​Fischer, Thomas H., et al. "Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII​." ​Cardiovascular Research, vol. 107, no. 1, ​2015, pp. 184​-196​, ​doi: 10.1093/cvr/cvv153. 
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  • 2015 | Journal Article | Research Paper
    ​ ​Hellenkamp, Kristian, et al. "The German CPU Registry: Dyspnea independently predicts negative short-term outcome in patients admitted to German Chest Pain Units​." ​International Journal of Cardiology, vol. 181, ​2015, pp. 88​-95​, ​doi: 10.1016/j.ijcard.2014.11.199. 
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  • 2015 | Journal Article | Research Paper
    ​ ​Xu, Xingbo, et al. "Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis​." ​Cardiovascular Research, vol. 105, no. 3, ​2015, pp. 279​-291​, ​doi: 10.1093/cvr/cvv015. 
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  • 2015 | Journal Article | Research Paper | 
    ​ ​Sprenger, Julia U., et al. "In vivo model with targeted cAMP biosensor reveals changes in receptor-microdomain communication in cardiac disease​." ​Nature Communications, vol. 6, ​2015, , ​doi: 10.1038/ncomms7965. 
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  • 2014 | Conference Abstract
    ​ ​Tiburcy, Malte, et al. "Ryanodine receptor calcium leak contributes to statin-induced myopathy​." ​Naunyn-Schmiedeberg s Archives of Pharmacology, vol. 387, ​2014, . ​
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  • 2014 | Journal Article | Overview
    ​ ​Förster, A., and L. S. Maier. "Herzinsuffizienz: „From Bench to Bedside“ – Neues im Bereich der Ionenhomöostase​." ​Journal für Kardiologie - Austrian Journal of Cardiology, vol. 21, no. 7-8, ​2014, pp. 208​-213​. ​
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  • 2014 | Journal Article | Research Paper
    ​ ​Walther, Stefanie, et al. "Urocortin 2 stimulates nitric oxide production in ventricular myocytes via Akt- and PKA-mediated phosphorylation of eNOS at serine 1177​." ​AJP Heart and Circulatory Physiology, vol. 307, no. 5, ​2014, pp. H689​-H700​, ​doi: 10.1152/ajpheart.00694.2013. 
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  • 2014 | Journal Article | Research Paper
    ​ ​Kreussner, Michael M., et al. "Cardiac CaM Kinase II Genes δ and γ Contribute to Adverse Remodeling but Redundantly Inhibit Calcineurin-Induced Myocardial Hypertrophy​." ​Circulation, vol. 130, no. 15, ​2014, pp. 1262​-1273​, ​doi: 10.1161/CIRCULATIONAHA.114.006185. 
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  • 2014 | Journal Article | Overview | 
    ​ ​Mustroph, Julian, Lars S. Maier, and Stefan Wagner. "CaMKII regulation of cardiac K channels​." ​Frontiers in Pharmacology, vol. 5, ​2014, , ​doi: 10.3389/fphar.2014.00020. 
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  • 2014 | Journal Article | Overview
    ​ ​Maier, Lars S.. "Experimental Antiarrhythmic Targets: CaMKII Inhibition - Ready for Clinical Evaluation?​." ​Current Medicinal Chemistry, vol. 21, no. 11, ​2014, pp. 1299​-1307​, ​doi: 10.2174/09298673113209990171. 
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  • 2014 | Journal Article | Overview
    ​ ​Köhler, Anne C., Can M. Sag, and Lars S. Maier. "Reactive oxygen species and excitation-contraction coupling in the context of cardiac pathology​." ​Journal of Molecular and Cellular Cardiology, vol. 73, ​2014, pp. 92​-102​, ​doi: 10.1016/j.yjmcc.2014.03.001. 
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  • 2014 | Journal Article | Research Paper
    ​ ​Wagner, Stefan, et al. "NADPH oxidase 2 mediates angiotensin II-dependent cellular arrhythmias via PKA and CaMKII​." ​Journal of Molecular and Cellular Cardiology, vol. 75, ​2014, pp. 206​-215​, ​doi: 10.1016/j.yjmcc.2014.07.011. 
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  • 2014 | Journal Article | Research Paper
    ​ ​Sag, Can M., et al. "Enhanced late INa induces proarrhythmogenic SR Ca leak in a CaMKII-dependent manner​." ​Journal of Molecular and Cellular Cardiology, vol. 76, ​2014, pp. 94​-105​, ​doi: 10.1016/j.yjmcc.2014.08.016. 
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  • 2014 | Journal Article | Research Paper
    ​ ​Unsoeld, Bernhard W., et al. "Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction​." ​Cardiovascular Research, vol. 101, no. 1, ​2014, pp. 97​-107​, ​doi: 10.1093/cvr/cvt235. 
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  • 2014 | Journal Article | Research Paper | 
    ​ ​Sossalla, Samuel Tobias, et al. "Effects of Ranolazine on Torsades de Pointes Tachycardias in a Healthy Isolated Rabbit Heart Model​." ​Cardiovascular Therapeutics, vol. 32, no. 4, ​2014, pp. 170​-177​, ​doi: 10.1111/1755-5922.12078. 
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  • 2014 | Journal Article | Research Paper
    ​ ​Dybkova, Nataliya, et al. "Tubulin polymerization disrupts cardiac beta-adrenergic regulation of late I-Na​." ​Cardiovascular Research, vol. 103, no. 1, ​2014, pp. 168​-177​, ​doi: 10.1093/cvr/cvu120. 
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  • 2014 | Journal Article | Research Paper | 
    ​ ​Fischer, Thomas H., et al. "Ca2+/calmodulin-dependent protein kinase II equally induces sarcoplasmic reticulum Ca2+ leak in human ischaemic and dilated cardiomyopathy​." ​European Journal of Heart Failure, vol. 16, no. 12, ​2014, pp. 1292​-1300​, ​doi: 10.1002/ejhf.163. 
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  • 2013 | Conference Abstract
    ​ ​Vettel, Christiane, et al. "Phosphodiesterase-2 is upregulated in failing hearts and blunts beta-AR mediated chronotropic and inotropic effects​." ​Naunyn-Schmiedeberg s Archives of Pharmacology, vol. 386, ​2013, . ​
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  • 2013 | Journal Article | Research Paper | 
    ​ ​Schwoerer, A. P., et al. "Enhanced Ca2+ influx through cardiac L-type Ca2+ channels maintains the systolic Ca2+ transient in early cardiac atrophy induced by mechanical unloading​." ​Pflügers Archiv - European Journal of Physiology, vol. 465, no. 12, ​2013, pp. 1763​-1773​, ​doi: 10.1007/s00424-013-1316-y. 
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  • 2013 | Journal Article | Research Paper | 
    ​ ​Sag, Can Martin, et al. "Ionizing radiation regulates cardiac Ca handling via increased ROS and activated CaMKII​." ​Basic Research in Cardiology, vol. 108, no. 6, ​2013, , ​doi: 10.1007/s00395-013-0385-6. 
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  • 2013 | Journal Article | Overview
    ​ ​Wagner, Stefan, et al. "Redox Regulation of Sodium and Calcium Handling​." ​Antioxidants & Redox Signaling, vol. 18, no. 9, ​2013, pp. 1063​-1077​, ​doi: 10.1089/ars.2012.4818. 
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  • 2013 | Journal Article | Research Paper
    ​ ​Neef, Stefan, et al. "While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in CaMKII delta-KO mice​." ​Journal of Molecular and Cellular Cardiology, vol. 59, ​2013, pp. 107​-116​, ​doi: 10.1016/j.yjmcc.2013.02.014. 
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  • 2013 | Journal Article | Overview
    ​ ​Sag, Can M., Stefan Wagner, and Lars S. Maier. "Role of oxidants on calcium and sodium movement in healthy and diseased cardiac myocytes​." ​Free Radical Biology and Medicine, vol. 63, ​2013, pp. 338​-349​, ​doi: 10.1016/j.freeradbiomed.2013.05.035. 
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  • 2013 | Journal Article | Research Paper
    ​ ​Luo, Min, et al. "Diabetes increases mortality after myocardial infarction by oxidizing CaMKII​." ​Journal of Clinical Investigation, vol. 123, no. 3, ​2013, pp. 1262​-1274​, ​doi: 10.1172/JCI65268. 
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  • 2013 | Journal Article | Overview | 
    ​ ​Fischer, Thomas H., Stefan Neef, and Lars S. Maier. "The Ca-calmodulin dependent kinase II: A promising target for future antiarrhythmic therapies?​." ​Journal of Molecular and Cellular Cardiology, vol. 58, ​2013, pp. 182​-187​, ​doi: 10.1016/j.yjmcc.2012.11.003. 
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  • 2013 | Journal Article | Research Paper
    ​ ​Purohit, Anil, et al. "Oxidized Ca2+/Calmodulin-Dependent Protein Kinase II Triggers Atrial Fibrillation​." ​Circulation, vol. 128, no. 16, ​2013, pp. 1748​-1757​, ​doi: 10.1161/CIRCULATIONAHA.113.003313. 
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  • 2013 | Journal Article | Research Paper
    ​ ​Mehel, Hind, et al. "Phosphodiesterase-2 Is Up-Regulated in Human Failing Hearts and Blunts β-Adrenergic Responses in Cardiomyocytes​." ​Journal of the American College of Cardiology, vol. 62, no. 17, ​2013, pp. 1596​-1606​, ​doi: 10.1016/j.jacc.2013.05.057. 
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  • 2013 | Journal Article | Overview
    ​ ​Neef, Stefan, and Lars S. Maier. "Novel aspects of excitation-contraction coupling in heart failure​." ​Basic Research in Cardiology, vol. 108, no. 4, ​2013, pp. 1​-11​, ​doi: 10.1007/s00395-013-0360-2. 
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  • 2013 | Journal Article | Research Paper
    ​ ​Streckfuss-Boemeke, Katrin, et al. "Comparative study of human-induced pluripotent stem cells derived from bone marrow cells, hair keratinocytes, and skin fibroblasts​." ​European heart journal, vol. 34, no. 33, ​2013, pp. 2618​-2629​, ​doi: 10.1093/eurheartj/ehs203. 
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  • 2013 | Journal Article | Research Paper
    ​ ​Toischer, Karl, et al. "Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease​." ​Journal of Molecular and Cellular Cardiology, vol. 61, ​2013, pp. 111​-122​, ​doi: 10.1016/j.yjmcc.2013.03.021. 
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  • 2013 | Journal Article | Editorial Contribution (Editorial, Introduction, Epilogue)
    ​ ​Wagner, Stefan, and Lars S. Maier. "Small conductance Ca-activated K channel: Small but powerful proarrhythmogenic?​." ​Heart Rhythm, vol. 10, no. 6, ​2013, pp. 899​-900​, ​doi: 10.1016/j.hrthm.2013.02.002. 
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  • 2013 | Journal Article | Research Paper
    ​ ​Fischer, Thomas H., et al. "Ca2+/Calmodulin-Dependent Protein Kinase II and Protein Kinase A Differentially Regulate Sarcoplasmic Reticulum Ca2+ Leak in Human Cardiac Pathology​." ​Circulation, vol. 128, no. 9, ​2013, pp. 970​-981​, ​doi: 10.1161/CIRCULATIONAHA.113.001746. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Overview | 
    ​ ​Fischer, Thomas H., Lars S. Maier, and Samuel Tobias Sossalla. "The ryanodine receptor leak: how a tattered receptor plunges the failing heart into crisis​." ​Heart Failure Reviews, vol. 18, no. 4, ​2013, pp. 475​-483​, ​doi: 10.1007/s10741-012-9339-6. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Letter Note | 
    ​ ​Maier, Lars S., et al. "The German CPU Registry: Comparison of troponin positive to troponin negative patients​." ​International Journal of Cardiology, vol. 168, no. 2, ​2013, pp. 1651​-1653​, ​doi: 10.1016/j.ijcard.2013.03.009. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Maier, Lars S., et al. "RAnoLazIne for the Treatment of Diastolic Heart Failure in Patients With Preserved Ejection Fraction: ​The RALI-DHF Proof-of-Concept Study​." ​JACC: Heart Failure, vol. 1, no. 2, ​2013, pp. 115​-122​, ​doi: 10.1016/j.jchf.2012.12.002. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Overview | 
    ​ ​Maier, Lars S., and Samuel Tobias Sossalla. "The late Na current as a therapeutic target: Where are we?​." ​Journal of Molecular and Cellular Cardiology, vol. 61, ​2013, pp. 44​-50​, ​doi: 10.1016/j.yjmcc.2013.03.001. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article
    ​ ​Hasenfuss, Gerd, et al. "Influence of the Novel Inotropic Agent Levosimendan on Isometric Tension and Calcium Cycling in Failing Human Myocardium​." ​Circulation, vol. 98, no. 20, ​2012, pp. 2141​-2147​, ​doi: 10.1161/01.cir.98.20.2141. 
    ​Details  DOI 
  • 2012 | Journal Article
    ​ ​Pieske, Burkert, et al. "Functional Effects of Endothelin and Regulation of Endothelin Receptors in Isolated Human Nonfailing and Failing Myocardium​." ​Circulation, vol. 99, no. 14, ​2012, pp. 1802​-1809​, ​doi: 10.1161/01.cir.99.14.1802. 
    ​Details  DOI 
  • 2012 | Journal Article
    ​ ​Pieske, Burkert, et al. "Ca2+ Handling and Sarcoplasmic Reticulum Ca2+ Content in Isolated Failing and Nonfailing Human Myocardium​." ​Circulation Research, vol. 85, no. 1, ​2012, pp. 38​-46​, ​doi: 10.1161/01.res.85.1.38. 
    ​Details  DOI 
  • 2012 | Conference Abstract
    ​ ​Toischer, Karl, et al. "Afterload but not preload induces proliferation of cardiomyocytes and improves survival in cyclinD2-overexpressing mice​." ​European Heart Journal, vol. 33, ​2012, . ​
    ​Details  WoS 
  • 2012 | Conference Abstract
    ​ ​Guan, Kaomei, et al. "Comparative studies of human induced pluripotent stem cells derived from bone marrow cells, hair keratinocytes and skin fibroblasts​." ​European Heart Journal, vol. 33, ​2012, pp. 21​-22​. ​
    ​Details  WoS 
  • 2012 | Journal Article | Overview | 
    ​ ​Maier, Lars S.. "New Treatment Options for Late Na Current, Arrhythmias, and Diastolic Dysfunction​." ​Current Heart Failure Reports, vol. 9, no. 3, ​2012, pp. 183​-191​, ​doi: 10.1007/s11897-012-0099-3. 
    ​Details  DOI 
  • 2012 | Journal Article | 
    ​ ​Schotola, Hanna, et al. "Mild metabolic acidosis impairs the beta-adrenergic response in isolated human failing myocardium​." ​CRITICAL CARE, vol. 16, no. 4, ​2012, , ​doi: 10.1186/cc11468. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article | Research Paper
    ​ ​Schroeter, Marco R., et al. "Leptin promotes the mobilization of vascular progenitor cells and neovascularization by NOX2-mediated activation of MMP9​." ​Cardiovascular Research, vol. 93, no. 1, ​2012, pp. 170​-180​, ​doi: 10.1093/cvr/cvr275. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article | Research Paper
    ​ ​Mohamed, Belal A., et al. "Targeted disruption of Hspa4 gene leads to cardiac hypertrophy and fibrosis​." ​Journal of Molecular and Cellular Cardiology, vol. 53, no. 4, ​2012, pp. 459​-468​, ​doi: 10.1016/j.yjmcc.2012.07.014. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article | Letter Note
    ​ ​Toischer, Karl, et al. "Response to Letter Regarding Article, "Differential Cardiac Remodeling in Preload Versus Afterload"​." ​Circulation, vol. 123, no. 16, ​2011, , ​doi: 10.1161/CIRCULATIONAHA.110.017566. 
    ​Details  DOI  WoS 
  • 2011 | Journal Article | Research Paper
    ​ ​Sossalla, Samuel, et al. "Effects of different proton pump inhibitors on cardiac contractility in isolated human failing myocardium​." ​Journal of Cardiovascular Surgery, vol. 52, no. 3, ​2011, pp. 437​-444​. ​
    ​Details  PMID  PMC  WoS 
  • 2011 | Conference Abstract
    ​ ​Neef, Stefan, et al. "Ablation of Phosphatase-1-Inhibitor-1 is Detrimental in CaMKII Overexpression Despite Reduction of SR Ca2+Leak​." ​Circulation, vol. 124, no. 21, ​2011, . ​
    ​Details  WoS 
  • 2011 | Conference Abstract
    ​ ​Sossalla, Samuel Tobias, et al. "Pressure overload-induced hypertrophy and heart failure are associated with arrhythmic triggers caused by late INa​." ​European Heart Journal, vol. 32, ​2011, pp. 997​-998​. ​
    ​Details  WoS 
  • 2011 | Journal Article | Research Paper | 
    ​ ​Seidler, Tim, et al. "Limitations of FKBP12.6-directed treatment strategies for maladaptive cardiac remodeling and heart failure​." ​Journal of Molecular and Cellular Cardiology, vol. 50, no. 1, ​2011, pp. 33​-42​, ​doi: 10.1016/j.yjmcc.2010.08.016. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article | Research Paper | 
    ​ ​Sossalla, Samuel, et al. "Diastolic dysfunction and arrhythmias caused by overexpression of CaMKII delta(C) can be reversed by inhibition of late Na+ current​." ​Basic Research in Cardiology, vol. 106, no. 2, ​2011, pp. 263​-272​, ​doi: 10.1007/s00395-010-0136-x. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article | Research Paper
    ​ ​Knöll, Ralph, et al. "Telethonin Deficiency Is Associated With Maladaptation to Biomechanical Stress in the Mammalian Heart​." ​Circulation Research, vol. 109, no. 7, ​2011, pp. 758​-U153​, ​doi: 10.1161/CIRCRESAHA.111.245787. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article | Research Paper
    ​ ​Jacobshagen, Claudius, et al. "Ranolazine for the Treatment of Heart Failure With Preserved Ejection Fraction: Background, Aims, and Design of the RALI-DHF Study​." ​Clinical Cardiology, vol. 34, no. 7, ​2011, pp. 426​-432​, ​doi: 10.1002/clc.20897. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Conference Abstract
    ​ ​Toischer, Karl, et al. "Differential cardiac remodeling in preload versus afterload​." ​European Heart Journal, vol. 31, ​2010, . ​
    ​Details  WoS 
  • 2010 | Journal Article
    ​ ​Schott, Peter, et al. "Proteome changes in CaMKIIδC-overexpressing cardiac myocytes​." ​Cardiovascular Pathology, vol. 19, no. 6, ​2010, pp. e241​-e250​, ​doi: 10.1016/j.carpath.2009.11.005. 
    ​Details  DOI 
  • 2010 | Journal Article | 
    ​ ​Silter, Monique, et al. "Impaired Ca2+-handling in HIF-1 alpha(+/-) mice as a consequence of pressure overload​." ​Pflügers Archiv - European Journal of Physiology, vol. 459, no. 4, ​2010, pp. 569​-577​, ​doi: 10.1007/s00424-009-0748-x. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | Research Paper | 
    ​ ​Jacobshagen, Claudius, et al. "Effects of mild hypothermia on hemodynamics in cardiac arrest survivors and isolated failing human myocardium​." ​Clinical Research in Cardiology, vol. 99, no. 5, ​2010, pp. 267​-276​, ​doi: 10.1007/s00392-010-0113-2. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | Research Paper | 
    ​ ​Sossalla, Samuel, et al. "Altered Na+ Currents in Atrial Fibrillation Effects of Ranolazine on Arrhythmias and Contractility in Human Atrial Myocardium​." ​Journal of the American College of Cardiology, vol. 55, no. 21, ​2010, pp. 2330​-2342​, ​doi: 10.1016/j.jacc.2009.12.055. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | Research Paper | 
    ​ ​Toischer, Karl, et al. "Differential Cardiac Remodeling in Preload Versus Afterload​." ​Circulation, vol. 122, no. 10, ​2010, pp. 993​-1003​, ​doi: 10.1161/CIRCULATIONAHA.110.943431. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | Research Paper
    ​ ​Neef, Stefan, et al. "CaMKII-Dependent Diastolic SR Ca2+ Leak and Elevated Diastolic Ca2+ Levels in Right Atrial Myocardium of Patients With Atrial Fibrillation​." ​Circulation Research, vol. 106, no. 6, ​2010, pp. 1134​-1144​, ​doi: 10.1161/CIRCRESAHA.109.203836. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | Research Paper | 
    ​ ​Sossalla, Samuel, et al. "Inhibition of Elevated Ca2+/Calmodulin-Dependent Protein Kinase II Improves Contractility in Human Failing Myocardium​." ​Circulation Research, vol. 107, no. 9, ​2010, pp. 1150​-U215​, ​doi: 10.1161/CIRCRESAHA.110.220418. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | Research Paper
    ​ ​Knöll, Ralph, et al. "A Common MLP (Muscle LIM Protein) Variant Is Associated With Cardiomyopathy​." ​Circulation Research, vol. 106, no. 4, ​2010, pp. 695​-704​, ​doi: 10.1161/CIRCRESAHA.109.206243. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | Research Paper | 
    ​ ​Wittoepper, Katrin, et al. "Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging​." ​Journal of Clinical Investigation, vol. 120, no. 2, ​2010, pp. 617​-626​, ​doi: 10.1172/JCI40545. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2009 | Journal Article | Research Paper
    ​ ​Jacobshagen, Claudius, et al. "Effects of large volume, ice-cold intravenous fluid infusion on respiratory function in cardiac arrest survivors​." ​Resuscitation, vol. 80, no. 11, ​2009, pp. 1223​-1228​, ​doi: 10.1016/j.resuscitation.2009.06.032. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2009 | Journal Article | Research Paper | 
    ​ ​Lehnart, Stephan E., Lars S. Maier, and Gerd Hasenfuß. "Abnormalities of calcium metabolism and myocardial contractility depression in the failing heart​." ​Heart Failure Reviews, vol. 14, no. 4, ​2009, pp. 213​-224​, ​doi: 10.1007/s10741-009-9146-x. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2008 | Journal Article | Research Paper
    ​ ​Jacobshagen, Claudius, et al. "Inhibition of PI3K improves contractility in alpha(1)-adrenergically stimulated myocardium​." ​Frontiers in Bioscience, vol. 13, ​2008, pp. 6841​-6849​, ​doi: 10.2741/3192. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2008 | Journal Article | Research Paper
    ​ ​Jacobshagen, Claudius, et al. "Celecoxib modulates hypertrophic signalling and prevents load-induced cardiac dysfunction​." ​European Journal of Heart Failure, vol. 10, no. 4, ​2008, pp. 334​-342​, ​doi: 10.1016/j.ejheart.2008.02.013. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2008 | Journal Article | Research Paper
    ​ ​Lewinski, Dirk von, et al. "Frequency-dependence of the slow force response​." ​Frontiers in Bioscience, vol. 13, ​2008, pp. 7202​-7209​, ​doi: 10.2741/3222. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2008 | Journal Article | Research Paper
    ​ ​Sossalla, Samuel, et al. "Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts - Role of late sodium current and intracellular ion accumulation​." ​Journal of Molecular and Cellular Cardiology, vol. 45, no. 1, ​2008, pp. 32​-43​, ​doi: 10.1016/j.yjmcc.2008.03.006. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2008 | Journal Article | Research Paper
    ​ ​Mauritz, Christina, et al. "Generation of functional murine cardiac myocytes from induced pluripotent stem cells​." ​Circulation, vol. 118, no. 5, ​2008, pp. 507​-517​, ​doi: 10.1161/CIRCULATIONAHA.108.778795. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2008 | Journal Article | Research Paper | 
    ​ ​Hasenfuß, Gerd, and Lars S. Maier. "Mechanism of action of the new anti-ischemia drug ranolazine​." ​Clinical Research in Cardiology, vol. 97, no. 4, ​2008, pp. 222​-226​, ​doi: 10.1007/s00392-007-0612-y. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2007 | Journal Article | Research Paper
    ​ ​Guan, Kaomei, et al. "Generation of functional cardiomyocytes from adult mouse spermatogonial stem cells​." ​Circulation Research, vol. 100, no. 11, ​2007, pp. 1615​-1625​, ​doi: 10.1161/01.RES.0000269182.22798.d9. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2007 | Journal Article | Research Paper
    ​ ​Schillinger, Wolfgang, et al. "Negative inotropy of the gastric proton pump inhibitor pantoprazole in myocardium from humans and rabbits - Evaluation of mechanisms​." ​Circulation, vol. 116, no. 1, ​2007, pp. 57​-66​, ​doi: 10.1161/CIRCULATIONAHA.106.666008. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2007 | Review
    ​ ​Seidler, Tim, Gerd Hasenfuß, and Lars S. Maier. "Targeting altered calcium physiology in the heart: Translational approaches to excitation, contraction, and transcription​." ​Physiology, vol. 22, no. 5, ​2007, pp. 328​-334​, ​doi: 10.1152/physiol.00015.2007. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2006 | Journal Article | Research Paper
    ​ ​Koegler, Harald, et al. "Relevance of brain natriuretic peptide in preload-dependent regulation of cardiac sarcoplasmic reticulum Ca2+ ATPase expression​." ​Circulation, vol. 113, no. 23, ​2006, pp. 2724​-2732​, ​doi: 10.1161/CIRCULATIONAHA.105.608828. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2006 | Journal Article | Research Paper
    ​ ​Guan, Kaomei, et al. "Pluripotency of spermatogonial stem cells from adult mouse testis​." ​Nature, vol. 440, no. 7088, ​2006, pp. 1199​-1203​, ​doi: 10.1038/nature04697. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2006 | Journal Article | Research Paper
    ​ ​Wagner, Stefan, et al. "Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels​." ​Journal of Clinical Investigation, vol. 116, no. 12, ​2006, pp. 3127​-3138​, ​doi: 10.1172/JCI26620. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2006 | Journal Article | Research Paper
    ​ ​Schillinger, Wolfgang, et al. "High intracellular Na+ preserves myocardial function at low heart rates in isolated myocardium from failing hearts​." ​European Journal of Heart Failure, vol. 8, no. 7, ​2006, pp. 673​-680​, ​doi: 10.1016/j.ejheart.2006.01.013. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2005 | Conference Abstract
    ​ ​Guan, Kaomei, et al. "Adult mouse spermatogonial stem cells differentiate into cardiovascular lineages and generate functional cardiomyocytes​." ​Circulation Research, vol. 97, no. 11, ​2005, . ​
    ​Details  WoS 
  • 2003 | Journal Article | Research Paper
    ​ ​Wagner, Stefan, et al. "Na+-Ca2+ exchanger overexpression predisposes to reactive oxygen species-induced injury​." ​Cardiovascular Research, vol. 60, no. 2, ​2003, pp. 404​-412​, ​doi: 10.1016/j.cardiores.2003.08.006. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2002 | Journal Article | Research Paper
    ​ ​Hasenfuß, Gerd, et al. "Influence of pyruvate on contractile performance and Ca2+ cycling in isolated failing human myocardium​." ​Circulation, vol. 105, no. 2, ​2002, pp. 194​-199​, ​doi: 10.1161/hc0202.102238. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2001 | Journal Article | Research Paper
    ​ ​Weisser, J, et al. "Influence of mild hypothermia on myocardial contractility and circulatory function​." ​Basic Research in Cardiology, vol. 96, no. 2, ​2001, pp. 198​-205​, ​doi: 10.1007/s003950170071. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2000 | Journal Article | Research Paper
    ​ ​Janssen, P. M. L., et al. "Influence of cyclosporine A on contractile function, calcium handling, and energetics in isolated human and rabbit myocardium​." ​Cardiovascular Research, vol. 47, no. 1, ​2000, pp. 99​-107​, ​doi: 10.1016/S0008-6363(00)00052-3. 
    ​Details  DOI  PMID  PMC  WoS 
  • 1999 | Journal Article
    ​ ​Hasenfuß, Gerd, et al. "Relationship Between Na + -Ca 2+ –Exchanger Protein Levels and Diastolic Function of Failing Human Myocardium​." ​Circulation, vol. 99, no. 5, ​1999, pp. 641​-648​, ​doi: 10.1161/01.CIR.99.5.641. 
    ​Details  DOI 
  • 1998 | Journal Article
    ​ ​Schillinger, W., et al. "Influence of SR Ca2+-ATPase and Na+-Ca2+-exchanger on the force-frequency relation​." ​Basic Research in Cardiology, vol. 93, no. Supplement 1, ​1998, pp. 38​-45​, ​doi: 10.1007/s003950050208. 
    ​Details  DOI 
  • 1998 | Journal Article | Research Paper
    ​ ​Schlotthauer, K., et al. "Frequency-dependent changes in contribution of SR Ca2+ to Ca2+ transients in failing human myocardium assessed with ryanodine​." ​Journal of Molecular and Cellular Cardiology, vol. 30, no. 7, ​1998, pp. 1285​-1294​, ​doi: 10.1006/jmcc.1998.0690. 
    ​Details  DOI  PMID  PMC  WoS 

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