Prof. Dr. med. Lars Siegfried Maier

 
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  • 2022 Journal Article
    ​ ​Lebek S, Hegner P, Hultsch R, Rohde J, Rupprecht L, Schmid C, et al. ​Na v 1.8 Dysregulates Na and Ca Leading to Arrhythmias in Patients with Sleep-disordered Breathing​. ​​American Journal of Respiratory and Critical Care Medicine. ​2022;. ​doi:10.1164/rccm.202205-0981LE. 
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  • 2022 Journal Article
    ​ ​Körtl T, Stehle T, Riedl D, Trausel J, Rebs S, Pabel S, et al. ​Atrial Fibrillation Burden Specifically Determines Human Ventricular Cellular Remodeling​. ​​JACC: Clinical Electrophysiology. ​2022;​8​(11):​​1357​-1366​. ​doi:10.1016/j.jacep.2022.07.016. 
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  • 2021 Journal Article
    ​ ​Baier MJ, Noack J, Seitz MT, Maier LS, Neef S. ​Phosphorylation of RyR2 Ser‐2814 by CaMKII mediates β1‐adrenergic stress induced Ca 2+ ‐leak from the sarcoplasmic reticulum​. ​​FEBS Open Bio. ​2021;. ​doi:10.1002/2211-5463.13274. 
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  • 2021 Journal Article
    ​ ​Kreitmeier KG, Tarnowski D, Nanadikar MS, Baier MJ, Wagner S, Katschinski DM, et al. ​CaMKII δ Met281/282 oxidation is not required for recovery of calcium transients during acidosis​. ​​American Journal of Physiology-Heart and Circulatory Physiology. ​2021;​320​(3):​​H1199​-H1212​. ​doi:10.1152/ajpheart.00040.2020. 
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  • 2020 Journal Article
    ​ ​Kolijn D, Pabel S, Tian Y, Lódi M, Herwig M, Carrizzo A, et al. ​Empagliflozin improves endothelial and cardiomyocyte function in human heart failure with preserved ejection fraction via reduced pro-inflammatory-oxidative pathways and protein kinase Gα oxidation​. ​​Cardiovascular Research. ​2020;​117​(2):​​495​-507​. ​doi:10.1093/cvr/cvaa123. 
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  • 2020 Journal Article
    ​ ​Trum M, Islam MMT, Lebek S, Baier M, Hegner P, Eaton P, et al. ​Inhibition of cardiac potassium currents by oxidation-activated protein kinase A contributes to early afterdepolarizations in the heart​. ​​American Journal of Physiology-Heart and Circulatory Physiology. ​2020;​319​(6):​​H1347​-H1357​. ​doi:10.1152/ajpheart.00182.2020. 
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  • 2020 Journal Article
    ​ ​Li W, Stauske M, Luo X, Wagner S, Vollrath M, Mehnert CS, et al. ​Disease Phenotypes and Mechanisms of iPSC-Derived Cardiomyocytes From Brugada Syndrome Patients With a Loss-of-Function SCN5A Mutation​. ​​Frontiers in Cell and Developmental Biology. ​2020;​8​. ​doi:10.3389/fcell.2020.592893. 
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  • 2020 Journal Article
    ​ ​Pabel S, Mustroph J, Stehle T, Lebek S, Dybkova N, Keyser A, et al. ​Dantrolene reduces CaMKIIδC-mediated atrial arrhythmias​. ​​Europace. ​2020;​22​(7):​​1111​-1118​. ​doi:10.1093/europace/euaa079. 
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  • 2020 Journal Article
    ​ ​Bengel P, Ahmad S, Tirilomis P, Trum M, Dybkova N, Wagner S, et al. ​Contribution of the neuronal sodium channel NaV1.8 to sodium- and calcium-dependent cellular proarrhythmia​. ​​Journal of Molecular and Cellular Cardiology. ​2020;​144​:​​35​-46​. ​doi:10.1016/j.yjmcc.2020.05.002. 
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  • 2020 Journal Article
    ​ ​Scholz KH, Lengenfelder B, Jacobshagen C, Fleischmann C, Moehlis H, Olbrich H, et al. ​Long-term effects of a standardized feedback-driven quality improvement program for timely reperfusion therapy in regional STEMI care networks​. ​​European Heart Journal. Acute Cardiovascular Care. ​2020;. ​doi:10.1177/2048872620907323. 
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  • 2020 Journal Article | Research Paper
    ​ ​Hofhuis J, Bersch K, Wagner S, Molina CE, Fakuade FE, Iyer LM, et al. ​Dysferlin links excitation-contraction coupling to structure and maintenance of the cardiac transverse-axial tubule system​. ​​Europace. ​2020;​22​(7):​​1119​-1131​. ​doi:10.1093/europace/euaa093. 
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  • 2020 Journal Article | Research Paper
    ​ ​Reil J, Reil G, Kovács Á, Sequeira V, Waddingham MT, Lodi M, et al. ​CaMKII activity contributes to homeometric autoregulation of the heart: A novel mechanism for the Anrep effect​. ​​The Journal of Physiology. ​2020;​598​(15):​​3129​-3153​. ​doi:10.1113/JP279607. 
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  • 2020 Journal Article | Research Paper | 
    ​ ​Pabel S, Ahmad S, Tirilomis P, Stehle T, Mustroph J, Knierim M, et al. ​Inhibition of NaV1.8 prevents atrial arrhythmogenesis in human and mice​. ​​Basic Research in Cardiology. ​2020;​115​(2). ​doi:10.1007/s00395-020-0780-8. 
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  • 2019 Journal Article | Research Paper | 
    ​ ​Ahmad S, Tirilomis P, Pabel S, Dybkova N, Hartmann N, Molina CE, et al. ​The functional consequences of sodium channel NaV1.8 in human left ventricular hypertrophy​. ​​ESC Heart Failure. ​2019;​6​(1):​​154​-163​. ​doi:10.1002/ehf2.12378. 
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  • 2018 Journal Article
    ​ ​Mustroph J, Wagemann O, Lücht CM, Trum M, Hammer KP, Sag CM, et al. ​Empagliflozin reduces Ca/calmodulin-dependent kinase II activity in isolated ventricular cardiomyocytes​. ​​ESC Heart Failure. ​2018;​5​(4):​​642​-648​. ​doi:10.1002/ehf2.12336. 
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  • 2018 Journal Article
    ​ ​Olivotto I, Camici PG, Merlini PA, Rapezzi C, Patten M, Climent V, et al. ​Efficacy of Ranolazine in Patients With Symptomatic Hypertrophic Cardiomyopathy​. ​​Circulation: Heart Failure. ​2018;​11​(1). ​doi:10.1161/CIRCHEARTFAILURE.117.004124. 
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  • 2018 Journal Article
    ​ ​Neef S, Steffens A, Pellicena P, Mustroph J, Lebek S, Ort KR, et al. ​Improvement of cardiomyocyte function by a novel pyrimidine-based CaMKII-inhibitor​. ​​Journal of Molecular and Cellular Cardiology. ​2018;​115​:​​73​-81​. ​doi:10.1016/j.yjmcc.2017.12.015. 
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  • 2018 Journal Article | Research Paper
    ​ ​Pabel S, Wagner S, Bollenberg H, Bengel P, Kovács Á, Schach C, et al. ​Empagliflozin directly improves diastolic function in human heart failure​. ​​European Journal of Heart Failure. ​2018;​20​(12):​​1690​-1700​. ​doi:10.1002/ejhf.1328. 
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  • 2018 Journal Article | Research Paper
    ​ ​Dybkova N, Ahmad S, Pabel S, Tirilomis P, Hartmann N, Fischer T, et al. ​Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart​. ​​Cardiovascular Research. ​2018;​114​(13):​​1728​-1737​. ​doi:10.1093/cvr/cvy152. 
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  • 2018 Journal Article | Research Paper
    ​ ​Fischer TH, Eiringhaus J, Dybkova N, Saadatmand A, Pabel S, Weber S, et al. ​Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure​. ​​European Journal of Heart Failure. ​2018;​20​(12):​​1673​-1685​. ​doi:10.1002/ejhf.1297. 
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  • 2017 Journal Article
    ​ ​Towhidul Islam , Eaton P, Maier L, Wagner S. ​Modulation of Cardiac Function by Oxidized Type I Protein Kinase A​. ​​Free Radical Biology and Medicine. ​2017;​112​:​​123​-124​. ​doi:10.1016/j.freeradbiomed.2017.10.187. 
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  • 2017 Journal Article | Research Paper
    ​ ​Eiringhaus J, Fischer TH, Kohn M, Wang Y, Maier LS, Hasenfuss G, et al. ​PP1 activation as novel antiarrhythmic approach in human heart failure​. ​​European Heart Journal. ​2017;​38​(suppl_1):​​1236​. ​doi:10.1093/eurheartj/ehx493.P5841. 
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  • 2017 Journal Article
    ​ ​Molina C, Jacquet E, Ponien P, Muñoz-Guijosa C, Baczkó I, Maier L, et al. ​Identification of optimal reference genes for transcriptomic analyses in normal and diseased human heart​. ​​Cardiovascular Research. ​2017;​114​(2):​​247​-258​. ​doi:10.1093/cvr/cvx182. 
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  • 2017 Journal Article
    ​ ​Mesubi O, Rokita A, Abrol N, Wu Y, Chen B, Wang Q, et al. ​CaMKII oxidation causes increased atrial fibrillation in diabetic mice​. ​​Journal of Molecular and Cellular Cardiology. ​2017;​112​:​​161​-162​. ​doi:10.1016/j.yjmcc.2017.07.092. 
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  • 2017 Journal Article
    ​ ​Thiele H, Akin I, Sandri M, Fuernau G, de Waha S, Meyer-Saraei R, et al. ​PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock​. ​​New England Journal of Medicine. ​2017;​377​(25):​​2419​-2432​. ​doi:10.1056/nejmoa1710261. 
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  • 2017 Journal Article | Research Paper | 
    ​ ​Perera RK, Fischer TH, Wagner M, Dewenter M, Vettel C, Bork NI, et al. ​Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4​. ​​Scientific Reports. ​2017;​7​(1). ​doi:10.1038/s41598-017-15632-x. 
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  • 2017 Journal Article | Research Paper
    ​ ​Hofhuis J, Bersch K, Büssenschütt R, Drzymalski M, Liebetanz D, Nikolaev VO, et al. ​Dysferlin mediates membrane tubulation and links T-tubule biogenesis to muscular dystrophy​. ​​Journal of Cell Science. ​2017;​130​(5):​​841​-852​. ​doi:10.1242/jcs.198861. 
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  • 2017 Journal Article | Research Paper
    ​ ​Dewenter M, Neef S, Vettel C, Lämmle S, Beushausen C, Zelarayan LC, et al. ​Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure​. ​​Circulation: Heart Failure. ​2017;​10​(5):​​1​-9​. ​doi:10.1161/CIRCHEARTFAILURE.117.003840. 
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  • 2017 Journal Article | Research Paper
    ​ ​Neef S, Heijman J, Otte K, Dewenter M, Saadatmand AR, Meyer-Roxlau S, et al. ​Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity​. ​​Naunyn-Schmiedeberg's Archives of Pharmacology. ​2017;​390​(8):​​857​-862​. ​doi:10.1007/s00210-017-1376-1. 
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  • 2016 Journal Article | Research Paper
    ​ ​Fischer TH, Herting J, Eiringhaus J, Pabel S, Hartmann NH, Ellenberger D, et al. ​Sex-dependent alterations of Ca2+ cycling in human cardiac hypertrophy and heart failure​. ​​EP Europace. ​2016;​18​(9):​​1440​-1448​. ​doi:10.1093/europace/euv313. 
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  • 2016 Journal Article | Research Paper
    ​ ​Hartmann NH, Mason FE, Braun I, Pabel S, Voigt N, Schotola H, et al. ​The combined effects of ranolazine and dronedarone on human atrial and ventricular electrophysiology​. ​​Journal of Molecular and Cellular Cardiology. ​2016;​94​:​​95​-106​. ​doi:10.1016/j.yjmcc.2016.03.012. 
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  • 2016 Journal Article | Research Paper
    ​ ​Hartmann NH, Pabel S, Herting J, Schatter F, Renner A, Gummert J, et al. ​Antiarrhythmic effects of dantrolene in human diseased cardiomyocytes​. ​​Heart Rhythm. ​2016;​14​(3):​​412​-419​. ​doi:10.1016/j.hrthm.2016.09.014. 
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  • 2015 Conference Abstract
    ​ ​Xu XX, Tan X, Tampe B, Liu X, Maier LS, Sossalla ST, et al. ​Epigenetic balance of aberrant rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis​. ​​European Journal of Heart Failure. ​2015;​17​
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  • 2015 Journal Article | Research Paper
    ​ ​Chang Liao, Mei-Ling, Boer TP, Mutoh H, Raad N, Richter C, Wagner E, et al. ​Sensing Cardiac Electrical Activity With a Cardiac Myocyte-Targeted Optogenetic Voltage Indicator​. ​​Circulation Research. ​2015;​117​(5):​​401​-412​. ​doi:10.1161/CIRCRESAHA.117.306143. 
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  • 2015 Journal Article | Research Paper
    ​ ​Fischer TH, Herting J, Mason FE, Hartmann N, Watanabe S, Nikolaev VO, et al. ​Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII​. ​​Cardiovascular Research. ​2015;​107​(1):​​184​-196​. ​doi:10.1093/cvr/cvv153. 
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  • 2015 Journal Article | Research Paper
    ​ ​Hellenkamp K, Darius H, Giannitsis E, Erbel R, Haude M, Hamm C, et al. ​The German CPU Registry: Dyspnea independently predicts negative short-term outcome in patients admitted to German Chest Pain Units​. ​​International Journal of Cardiology. ​2015;​181​:​​88​-95​. ​doi:10.1016/j.ijcard.2014.11.199. 
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  • 2015 Journal Article | Research Paper
    ​ ​Xu X, Tan X, Tampe B, Nyamsuren G, Liu X, Maier LS, et al. ​Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis​. ​​Cardiovascular Research. ​2015;​105​(3):​​279​-291​. ​doi:10.1093/cvr/cvv015. 
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  • 2015 Journal Article | Research Paper | 
    ​ ​Sprenger JU, Perera RK, Steinbrecher JH, Lehnart SE, Maier LS, Hasenfuß G, et al. ​In vivo model with targeted cAMP biosensor reveals changes in receptor-microdomain communication in cardiac disease​. ​​Nature Communications. ​2015;​6​. ​doi:10.1038/ncomms7965. 
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  • 2014 Conference Abstract
    ​ ​Tiburcy M, Engel G, Sanders, Sonka-Johanna, Sowa T, Maier LS, Zimmermann, Wolfram-Hubertus. ​Ryanodine receptor calcium leak contributes to statin-induced myopathy​. ​​Hannover, GERMANY. ​Naunyn-Schmiedeberg s Archives of Pharmacology. ​2014;​387​
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  • 2014 Journal Article | Overview
    ​ ​Förster A, Maier LS. ​Herzinsuffizienz: „From Bench to Bedside“ – Neues im Bereich der Ionenhomöostase​. ​​Journal für Kardiologie - Austrian Journal of Cardiology. ​2014;​21​(7-8):​​208​-213​. ​
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  • 2014 Journal Article | Research Paper
    ​ ​Walther S, Pluteanu F, Renz S, Nikonova Y, Maxwell JT, Yang, Li-Zhen, et al. ​Urocortin 2 stimulates nitric oxide production in ventricular myocytes via Akt- and PKA-mediated phosphorylation of eNOS at serine 1177​. ​​AJP Heart and Circulatory Physiology. ​2014;​307​(5):​​H689​-H700​. ​doi:10.1152/ajpheart.00694.2013. 
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  • 2014 Journal Article | Research Paper
    ​ ​Kreussner MM, Lehmann LH, Keranov S, Hoting, Marc-Oscar, Oehl U, Kohlhaas M, et al. ​Cardiac CaM Kinase II Genes δ and γ Contribute to Adverse Remodeling but Redundantly Inhibit Calcineurin-Induced Myocardial Hypertrophy​. ​​Circulation. ​2014;​130​(15):​​1262​-1273​. ​doi:10.1161/CIRCULATIONAHA.114.006185. 
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  • 2014 Journal Article | Overview | 
    ​ ​Mustroph J, Maier LS, Wagner S. ​CaMKII regulation of cardiac K channels​. ​​Frontiers in Pharmacology. ​2014;​5​. ​doi:10.3389/fphar.2014.00020. 
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  • 2014 Journal Article | Overview
    ​ ​Maier LS. ​Experimental Antiarrhythmic Targets: CaMKII Inhibition - Ready for Clinical Evaluation?​. ​​Current Medicinal Chemistry. ​2014;​21​(11):​​1299​-1307​. ​doi:10.2174/09298673113209990171. 
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  • 2014 Journal Article | Overview
    ​ ​Köhler AC, Sag CM, Maier LS. ​Reactive oxygen species and excitation-contraction coupling in the context of cardiac pathology​. ​​Journal of Molecular and Cellular Cardiology. ​2014;​73​:​​92​-102​. ​doi:10.1016/j.yjmcc.2014.03.001. 
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  • 2014 Journal Article | Research Paper
    ​ ​Wagner S, Dantz C, Flebbe H, Azizian A, Sag CM, Engels S, et al. ​NADPH oxidase 2 mediates angiotensin II-dependent cellular arrhythmias via PKA and CaMKII​. ​​Journal of Molecular and Cellular Cardiology. ​2014;​75​:​​206​-215​. ​doi:10.1016/j.yjmcc.2014.07.011. 
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  • 2014 Journal Article | Research Paper
    ​ ​Sag CM, Mallwitz A, Wagner S, Hartmann N, Schotola H, Fischer TH, et al. ​Enhanced late INa induces proarrhythmogenic SR Ca leak in a CaMKII-dependent manner​. ​​Journal of Molecular and Cellular Cardiology. ​2014;​76​:​​94​-105​. ​doi:10.1016/j.yjmcc.2014.08.016. 
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  • 2014 Journal Article | Research Paper
    ​ ​Unsoeld BW, Kaul A, Sbroggi M, Schubert C, Regitz-Zagrosek V, Brancaccio M, et al. ​Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction​. ​​Cardiovascular Research. ​2014;​101​(1):​​97​-107​. ​doi:10.1093/cvr/cvt235. 
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  • 2014 Journal Article | Research Paper | 
    ​ ​Sossalla ST, Wallisch N, Toischer K, Sohns C, Vollmann D, Seegers J, et al. ​Effects of Ranolazine on Torsades de Pointes Tachycardias in a Healthy Isolated Rabbit Heart Model​. ​​Cardiovascular Therapeutics. ​2014;​32​(4):​​170​-177​. ​doi:10.1111/1755-5922.12078. 
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  • 2014 Journal Article | Research Paper
    ​ ​Dybkova N, Wagner S, Backs J, Hund TJ, Mohler PJ, Sowa T, et al. ​Tubulin polymerization disrupts cardiac beta-adrenergic regulation of late I-Na​. ​​Cardiovascular Research. ​2014;​103​(1):​​168​-177​. ​doi:10.1093/cvr/cvu120. 
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  • 2014 Journal Article | Research Paper | 
    ​ ​Fischer TH, Eiringhaus J, Dybkova N, Foerster A, Herting J, Kleinwaechter A, et al. ​Ca2+/calmodulin-dependent protein kinase II equally induces sarcoplasmic reticulum Ca2+ leak in human ischaemic and dilated cardiomyopathy​. ​​European Journal of Heart Failure. ​2014;​16​(12):​​1292​-1300​. ​doi:10.1002/ejhf.163. 
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  • 2013 Conference Abstract
    ​ ​Vettel C, Mehel H, Emons J, Wittkoepper K, Dewenter M, Laemmle S, et al. ​Phosphodiesterase-2 is upregulated in failing hearts and blunts beta-AR mediated chronotropic and inotropic effects​. ​​Naunyn-Schmiedeberg s Archives of Pharmacology. ​2013;​386​
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  • 2013 Journal Article | Research Paper | 
    ​ ​Schwoerer AP, Neef S, Broichhausen I, Jacubeit J, Tiburcy M, Wagner M, et al. ​Enhanced Ca2+ influx through cardiac L-type Ca2+ channels maintains the systolic Ca2+ transient in early cardiac atrophy induced by mechanical unloading​. ​​Pflügers Archiv - European Journal of Physiology. ​2013;​465​(12):​​1763​-1773​. ​doi:10.1007/s00424-013-1316-y. 
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  • 2013 Journal Article | Research Paper | 
    ​ ​Sag CM, Wolff HA, Neumann K, Opiela, Marie-Kristin, Zhang J, Steuer F, et al. ​Ionizing radiation regulates cardiac Ca handling via increased ROS and activated CaMKII​. ​​Basic Research in Cardiology. ​2013;​108​(6). ​doi:10.1007/s00395-013-0385-6. 
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  • 2013 Journal Article | Overview
    ​ ​Wagner S, Rokita AG, Anderson ME, Maier LS. ​Redox Regulation of Sodium and Calcium Handling​. ​​Antioxidants & Redox Signaling. ​2013;​18​(9):​​1063​-1077​. ​doi:10.1089/ars.2012.4818. 
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  • 2013 Journal Article | Research Paper
    ​ ​Neef S, Sag CM, Daut M, Baeumer H, Grefe C, El-Armouche A, et al. ​While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in CaMKII delta-KO mice​. ​​Journal of Molecular and Cellular Cardiology. ​2013;​59​:​​107​-116​. ​doi:10.1016/j.yjmcc.2013.02.014. 
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  • 2013 Journal Article | Overview
    ​ ​Sag CM, Wagner S, Maier LS. ​Role of oxidants on calcium and sodium movement in healthy and diseased cardiac myocytes​. ​​Free Radical Biology and Medicine. ​2013;​63​:​​338​-349​. ​doi:10.1016/j.freeradbiomed.2013.05.035. 
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  • 2013 Journal Article | Research Paper
    ​ ​Luo M, Guan X, Luczak ED, Lang D, Kutschke W, Gao Z, et al. ​Diabetes increases mortality after myocardial infarction by oxidizing CaMKII​. ​​Journal of Clinical Investigation. ​2013;​123​(3):​​1262​-1274​. ​doi:10.1172/JCI65268. 
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  • 2013 Journal Article | Overview | 
    ​ ​Fischer TH, Neef S, Maier LS. ​The Ca-calmodulin dependent kinase II: A promising target for future antiarrhythmic therapies?​. ​​Journal of Molecular and Cellular Cardiology. ​2013;​58​:​​182​-187​. ​doi:10.1016/j.yjmcc.2012.11.003. 
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  • 2013 Journal Article | Research Paper
    ​ ​Purohit A, Rokita AG, Guan X, Chen B, Koval OM, Voigt N, et al. ​Oxidized Ca2+/Calmodulin-Dependent Protein Kinase II Triggers Atrial Fibrillation​. ​​Circulation. ​2013;​128​(16):​​1748​-1757​. ​doi:10.1161/CIRCULATIONAHA.113.003313. 
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  • 2013 Journal Article | Research Paper
    ​ ​Mehel H, Emons J, Vettel C, Wittköpper K, Seppelt D, Dewenter M, et al. ​Phosphodiesterase-2 Is Up-Regulated in Human Failing Hearts and Blunts β-Adrenergic Responses in Cardiomyocytes​. ​​Journal of the American College of Cardiology. ​2013;​62​(17):​​1596​-1606​. ​doi:10.1016/j.jacc.2013.05.057. 
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  • 2013 Journal Article | Overview
    ​ ​Neef S, Maier LS. ​Novel aspects of excitation-contraction coupling in heart failure​. ​​Basic Research in Cardiology. ​2013;​108​(4):​​1​-11​. ​doi:10.1007/s00395-013-0360-2. 
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  • 2013 Journal Article | Research Paper
    ​ ​Streckfuss-Boemeke K, Wolf F, Azizian A, Stauske M, Tiburcy M, Wagner S, et al. ​Comparative study of human-induced pluripotent stem cells derived from bone marrow cells, hair keratinocytes, and skin fibroblasts​. ​​European heart journal. ​2013;​34​(33):​​2618​-2629​. ​doi:10.1093/eurheartj/ehs203. 
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  • 2013 Journal Article | Research Paper
    ​ ​Toischer K, Hartmann N, Wagner S, Fischer TH, Herting J, Danner BC, et al. ​Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease​. ​​Journal of Molecular and Cellular Cardiology. ​2013;​61​:​​111​-122​. ​doi:10.1016/j.yjmcc.2013.03.021. 
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  • 2013 Journal Article | Editorial Contribution (Editorial, Introduction, Epilogue)
    ​ ​Wagner S, Maier LS. ​Small conductance Ca-activated K channel: Small but powerful proarrhythmogenic?​. ​​Heart Rhythm. ​2013;​10​(6):​​899​-900​. ​doi:10.1016/j.hrthm.2013.02.002. 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​Fischer TH, Herting J, Tirilomis T, Renner A, Neef S, Toischer K, et al. ​Ca2+/Calmodulin-Dependent Protein Kinase II and Protein Kinase A Differentially Regulate Sarcoplasmic Reticulum Ca2+ Leak in Human Cardiac Pathology​. ​​Circulation. ​2013;​128​(9):​​970​-981​. ​doi:10.1161/CIRCULATIONAHA.113.001746. 
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  • 2013 Journal Article | Overview | 
    ​ ​Fischer TH, Maier LS, Sossalla ST. ​The ryanodine receptor leak: how a tattered receptor plunges the failing heart into crisis​. ​​Heart Failure Reviews. ​2013;​18​(4):​​475​-483​. ​doi:10.1007/s10741-012-9339-6. 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Letter Note | 
    ​ ​Maier LS, Darius H, Giannitsis E, Erbel R, Haude M, Hamm C, et al. ​The German CPU Registry: Comparison of troponin positive to troponin negative patients​. ​​International Journal of Cardiology. ​2013;​168​(2):​​1651​-1653​. ​doi:10.1016/j.ijcard.2013.03.009. 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​Maier LS, Layug B, Karwatowska-Prokopczuk E, Belardinelli L, Lee S, Sander J, et al. ​RAnoLazIne for the Treatment of Diastolic Heart Failure in Patients With Preserved Ejection Fraction: ​The RALI-DHF Proof-of-Concept Study​. ​​JACC: Heart Failure. ​2013;​1​(2):​​115​-122​. ​doi:10.1016/j.jchf.2012.12.002. 
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  • 2013 Journal Article | Overview | 
    ​ ​Maier LS, Sossalla ST. ​The late Na current as a therapeutic target: Where are we?​. ​​Journal of Molecular and Cellular Cardiology. ​2013;​61​:​​44​-50​. ​doi:10.1016/j.yjmcc.2013.03.001. 
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  • 2012 Journal Article
    ​ ​Hasenfuss G, Pieske B, Castell M, Kretschmann B, Maier LS, Just H. ​Influence of the Novel Inotropic Agent Levosimendan on Isometric Tension and Calcium Cycling in Failing Human Myocardium​. ​​Circulation. ​2012;​98​(20):​​2141​-2147​. ​doi:10.1161/01.cir.98.20.2141. 
    Details  DOI 
  • 2012 Journal Article
    ​ ​Pieske B, Beyermann B, Breu V, Löffler BM, Schlotthauer K, Maier LS, et al. ​Functional Effects of Endothelin and Regulation of Endothelin Receptors in Isolated Human Nonfailing and Failing Myocardium​. ​​Circulation. ​2012;​99​(14):​​1802​-1809​. ​doi:10.1161/01.cir.99.14.1802. 
    Details  DOI 
  • 2012 Journal Article
    ​ ​Pieske B, Maier LS, Bers DM, Hasenfuß G. ​Ca2+ Handling and Sarcoplasmic Reticulum Ca2+ Content in Isolated Failing and Nonfailing Human Myocardium​. ​​Circulation Research. ​2012;​85​(1):​​38​-46​. ​doi:10.1161/01.res.85.1.38. 
    Details  DOI 
  • 2012 Conference Abstract
    ​ ​Toischer K, Huenlich M, Zhang W, Reuter S, Maier LS, Sossalla ST, et al. ​Afterload but not preload induces proliferation of cardiomyocytes and improves survival in cyclinD2-overexpressing mice​. ​​Munchen, GERMANY. ​European Heart Journal. ​2012;​33​
    Details  WoS 
  • 2012 Conference Abstract
    ​ ​Guan K, Streckfuss-Bömeke K, Wolf F, Azizian A, Stauske M, Tiburcy M, et al. ​Comparative studies of human induced pluripotent stem cells derived from bone marrow cells, hair keratinocytes and skin fibroblasts​. ​​Munchen, GERMANY. ​European Heart Journal. ​2012;​33​:21​-22​. ​
    Details  WoS 
  • 2012 Journal Article | Overview | 
    ​ ​Maier LS. ​New Treatment Options for Late Na Current, Arrhythmias, and Diastolic Dysfunction​. ​​Current Heart Failure Reports. ​2012;​9​(3):​​183​-191​. ​doi:10.1007/s11897-012-0099-3. 
    Details  DOI 
  • 2012 Journal Article | 
    ​ ​Schotola H, Toischer K, Popov, Aron-Frederik, Renner A, Schmitto JD, Gummert JF, et al. ​Mild metabolic acidosis impairs the beta-adrenergic response in isolated human failing myocardium​. ​​CRITICAL CARE. ​2012;​16​(4). ​doi:10.1186/cc11468. 
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  • 2012 Journal Article | Research Paper
    ​ ​Schroeter MR, Stein S, Heida, Nana-Maria, Leifheit-Nestler M, Cheng, I-Fen, Gogiraju R, et al. ​Leptin promotes the mobilization of vascular progenitor cells and neovascularization by NOX2-mediated activation of MMP9​. ​​Cardiovascular Research. ​2012;​93​(1):​​170​-180​. ​doi:10.1093/cvr/cvr275. 
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  • 2012 Journal Article | Research Paper
    ​ ​Mohamed BA, Barakat AZ, Zimmermann, Wolfram-Hubertus, Bittner RE, Muehlfeld C, Huenlich M, et al. ​Targeted disruption of Hspa4 gene leads to cardiac hypertrophy and fibrosis​. ​​Journal of Molecular and Cellular Cardiology. ​2012;​53​(4):​​459​-468​. ​doi:10.1016/j.yjmcc.2012.07.014. 
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  • 2011 Journal Article | Letter Note
    ​ ​Toischer K, Rokita AG, Unsoeld BW, Sossalla ST, Becker A, Seidler T, et al. ​Response to Letter Regarding Article, "Differential Cardiac Remodeling in Preload Versus Afterload"​. ​​Circulation. ​2011;​123​(16). ​doi:10.1161/CIRCULATIONAHA.110.017566. 
    Details  DOI  WoS 
  • 2011 Journal Article | Research Paper
    ​ ​Sossalla S, Schotola H, Schmitto JD, Toischer K, Sohns C, Schwoerer H, et al. ​Effects of different proton pump inhibitors on cardiac contractility in isolated human failing myocardium​. ​​Journal of Cardiovascular Surgery. ​2011;​52​(3):​​437​-444​. ​
    Details  PMID  PMC  WoS 
  • 2011 Conference Abstract
    ​ ​Neef S, Wittkoepper K, Brammen C, Sowa T, Zimmermann, Wolfram-Hubertus, Brown JH, et al. ​Ablation of Phosphatase-1-Inhibitor-1 is Detrimental in CaMKII Overexpression Despite Reduction of SR Ca2+Leak​. ​​Circulation. ​2011;​124​(21)
    Details  WoS 
  • 2011 Conference Abstract
    ​ ​Sossalla ST, Toischer K, Hartmann N, Schulte T, Wagner S, Hasenfuß G, et al. ​Pressure overload-induced hypertrophy and heart failure are associated with arrhythmic triggers caused by late INa​. ​​European Heart Journal. ​2011;​32​:997​-998​. ​
    Details  WoS 
  • 2011 Journal Article | Research Paper | 
    ​ ​Seidler T, Teucher N, Hellenkamp K, Unsoeld BW, Grebe C, Kramps P, et al. ​Limitations of FKBP12.6-directed treatment strategies for maladaptive cardiac remodeling and heart failure​. ​​Journal of Molecular and Cellular Cardiology. ​2011;​50​(1):​​33​-42​. ​doi:10.1016/j.yjmcc.2010.08.016. 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article | Research Paper | 
    ​ ​Sossalla S, Maurer U, Schotola H, Hartmann NH, Didie M, Zimmermann, Wolfram-Hubertus, et al. ​Diastolic dysfunction and arrhythmias caused by overexpression of CaMKII delta(C) can be reversed by inhibition of late Na+ current​. ​​Basic Research in Cardiology. ​2011;​106​(2):​​263​-272​. ​doi:10.1007/s00395-010-0136-x. 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article | Research Paper
    ​ ​Knöll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, et al. ​Telethonin Deficiency Is Associated With Maladaptation to Biomechanical Stress in the Mammalian Heart​. ​​Circulation Research. ​2011;​109​(7):​​758​-U153​. ​doi:10.1161/CIRCRESAHA.111.245787. 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article | Research Paper
    ​ ​Jacobshagen C, Belardinelli L, Hasenfuß G, Maier LS. ​Ranolazine for the Treatment of Heart Failure With Preserved Ejection Fraction: Background, Aims, and Design of the RALI-DHF Study​. ​​Clinical Cardiology. ​2011;​34​(7):​​426​-432​. ​doi:10.1002/clc.20897. 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Conference Abstract
    ​ ​Toischer K, Rokita AG, Unsoeld BW, Zhu W, Kararigas G, Regitz-Zagrosek V, et al. ​Differential cardiac remodeling in preload versus afterload​. ​​Stockholm, SWEDEN. ​European Heart Journal. ​2010;​31​
    Details  WoS 
  • 2010 Journal Article
    ​ ​Schott P, Jacobshagen C, Köhler J, Seidler T, Asif AR, Dihazi H, et al. ​Proteome changes in CaMKIIδC-overexpressing cardiac myocytes​. ​​Cardiovascular Pathology. ​2010;​19​(6):​​e241​-e250​. ​doi:10.1016/j.carpath.2009.11.005. 
    Details  DOI 
  • 2010 Journal Article | 
    ​ ​Silter M, Koegler H, Zieseniss A, Wilting J, Schaefer K, Toischer K, et al. ​Impaired Ca2+-handling in HIF-1 alpha(+/-) mice as a consequence of pressure overload​. ​​Pflügers Archiv - European Journal of Physiology. ​2010;​459​(4):​​569​-577​. ​doi:10.1007/s00424-009-0748-x. 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article | Research Paper | 
    ​ ​Jacobshagen C, Pelster T, Pax A, Horn W, Schmidt-Schweda S, Unsoeld BW, et al. ​Effects of mild hypothermia on hemodynamics in cardiac arrest survivors and isolated failing human myocardium​. ​​Clinical Research in Cardiology. ​2010;​99​(5):​​267​-276​. ​doi:10.1007/s00392-010-0113-2. 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article | Research Paper | 
    ​ ​Sossalla S, Kallmeyer B, Wagner S, Mazur M, Maurer U, Toischer K, et al. ​Altered Na+ Currents in Atrial Fibrillation Effects of Ranolazine on Arrhythmias and Contractility in Human Atrial Myocardium​. ​​Journal of the American College of Cardiology. ​2010;​55​(21):​​2330​-2342​. ​doi:10.1016/j.jacc.2009.12.055. 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article | Research Paper | 
    ​ ​Toischer K, Rokita AG, Unsoeld BW, Zhu W, Kararigas G, Sossalla S, et al. ​Differential Cardiac Remodeling in Preload Versus Afterload​. ​​Circulation. ​2010;​122​(10):​​993​-1003​. ​doi:10.1161/CIRCULATIONAHA.110.943431. 
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  • 2010 Journal Article | Research Paper
    ​ ​Neef S, Dybkova N, Sossalla S, Ort KR, Fluschnik N, Neumann K, et al. ​CaMKII-Dependent Diastolic SR Ca2+ Leak and Elevated Diastolic Ca2+ Levels in Right Atrial Myocardium of Patients With Atrial Fibrillation​. ​​Circulation Research. ​2010;​106​(6):​​1134​-1144​. ​doi:10.1161/CIRCRESAHA.109.203836. 
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  • 2010 Journal Article | Research Paper | 
    ​ ​Sossalla S, Fluschnik N, Schotola H, Ort KR, Neef S, Schulte T, et al. ​Inhibition of Elevated Ca2+/Calmodulin-Dependent Protein Kinase II Improves Contractility in Human Failing Myocardium​. ​​Circulation Research. ​2010;​107​(9):​​1150​-U215​. ​doi:10.1161/CIRCRESAHA.110.220418. 
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  • 2010 Journal Article | Research Paper
    ​ ​Knöll R, Kostin S, Klede S, Savvatis K, Klinge L, Stehle I, et al. ​A Common MLP (Muscle LIM Protein) Variant Is Associated With Cardiomyopathy​. ​​Circulation Research. ​2010;​106​(4):​​695​-704​. ​doi:10.1161/CIRCRESAHA.109.206243. 
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  • 2010 Journal Article | Research Paper | 
    ​ ​Wittoepper K, Fabritz L, Neef S, Ort KR, Grefe C, Unsoeld BW, et al. ​Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging​. ​​Journal of Clinical Investigation. ​2010;​120​(2):​​617​-626​. ​doi:10.1172/JCI40545. 
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  • 2009 Journal Article | Research Paper
    ​ ​Jacobshagen C, Pax A, Unsoeld BW, Seidler T, Schmidt-Schweda S, Hasenfuß G, et al. ​Effects of large volume, ice-cold intravenous fluid infusion on respiratory function in cardiac arrest survivors​. ​​Resuscitation. ​2009;​80​(11):​​1223​-1228​. ​doi:10.1016/j.resuscitation.2009.06.032. 
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  • 2009 Journal Article | Research Paper | 
    ​ ​Lehnart SE, Maier LS, Hasenfuß G. ​Abnormalities of calcium metabolism and myocardial contractility depression in the failing heart​. ​​Heart Failure Reviews. ​2009;​14​(4):​​213​-224​. ​doi:10.1007/s10741-009-9146-x. 
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  • 2008 Journal Article | Research Paper
    ​ ​Jacobshagen C, Kortlepel S, Unsoeld BW, Sowa T, Koegler H, Hasenfuß G, et al. ​Inhibition of PI3K improves contractility in alpha(1)-adrenergically stimulated myocardium​. ​​Frontiers in Bioscience. ​2008;​13​:​​6841​-6849​. ​doi:10.2741/3192. 
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  • 2008 Journal Article | Research Paper
    ​ ​Jacobshagen C, Grueber M, Teucher N, Schmidt AG, Unsoeld BW, Toischer K, et al. ​Celecoxib modulates hypertrophic signalling and prevents load-induced cardiac dysfunction​. ​​European Journal of Heart Failure. ​2008;​10​(4):​​334​-342​. ​doi:10.1016/j.ejheart.2008.02.013. 
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  • 2008 Journal Article | Research Paper
    ​ ​Lewinski D, Zhu D, Khafaga M, Kockskamper J, Maier LS, Hasenfuss G, et al. ​Frequency-dependence of the slow force response​. ​​Frontiers in Bioscience. ​2008;​13​:​​7202​-7209​. ​doi:10.2741/3222. 
    Details  DOI  PMID  PMC  WoS 
  • 2008 Journal Article | Research Paper
    ​ ​Sossalla S, Wagner S, Rasenack ECL, Ruff H, Weber SL, Schoendube FA, et al. ​Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts - Role of late sodium current and intracellular ion accumulation​. ​​Journal of Molecular and Cellular Cardiology. ​2008;​45​(1):​​32​-43​. ​doi:10.1016/j.yjmcc.2008.03.006. 
    Details  DOI  PMID  PMC  WoS 
  • 2008 Journal Article | Research Paper
    ​ ​Mauritz C, Schwanke K, Reppel M, Neef S, Katsirntaki K, Maier LS, et al. ​Generation of functional murine cardiac myocytes from induced pluripotent stem cells​. ​​Circulation. ​2008;​118​(5):​​507​-517​. ​doi:10.1161/CIRCULATIONAHA.108.778795. 
    Details  DOI  PMID  PMC  WoS 
  • 2008 Journal Article | Research Paper | 
    ​ ​Hasenfuß G, Maier LS. ​Mechanism of action of the new anti-ischemia drug ranolazine​. ​​Clinical Research in Cardiology. ​2008;​97​(4):​​222​-226​. ​doi:10.1007/s00392-007-0612-y. 
    Details  DOI  PMID  PMC  WoS 
  • 2007 Journal Article | Research Paper
    ​ ​Guan K, Wagner S, Unsoeld BW, Maier LS, Kaiser D, Hemmerlein B, et al. ​Generation of functional cardiomyocytes from adult mouse spermatogonial stem cells​. ​​Circulation Research. ​2007;​100​(11):​​1615​-1625​. ​doi:10.1161/01.RES.0000269182.22798.d9. 
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  • 2007 Journal Article | Research Paper
    ​ ​Schillinger W, Teucher N, Sossalla S, Kettlewell S, Werner C, Raddatz D, et al. ​Negative inotropy of the gastric proton pump inhibitor pantoprazole in myocardium from humans and rabbits - Evaluation of mechanisms​. ​​Circulation. ​2007;​116​(1):​​57​-66​. ​doi:10.1161/CIRCULATIONAHA.106.666008. 
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  • 2007 Review
    ​ ​Seidler T, Hasenfuß G, Maier LS. ​Targeting altered calcium physiology in the heart: Translational approaches to excitation, contraction, and transcription​ [book review]. ​​Physiology. ​2007;​22​(5):​​328​-334​. ​doi:10.1152/physiol.00015.2007. 
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  • 2006 Journal Article | Research Paper
    ​ ​Koegler H, Schott P, Toischer K, Milting H, Van PN, Kohlhaas M, et al. ​Relevance of brain natriuretic peptide in preload-dependent regulation of cardiac sarcoplasmic reticulum Ca2+ ATPase expression​. ​​Circulation. ​2006;​113​(23):​​2724​-2732​. ​doi:10.1161/CIRCULATIONAHA.105.608828. 
    Details  DOI  PMID  PMC  WoS 
  • 2006 Journal Article | Research Paper
    ​ ​Guan K, Nayernia K, Maier LS, Wagner S, Dressel R, Lee JH, et al. ​Pluripotency of spermatogonial stem cells from adult mouse testis​. ​​Nature. ​2006;​440​(7088):​​1199​-1203​. ​doi:10.1038/nature04697. 
    Details  DOI  PMID  PMC  WoS 
  • 2006 Journal Article | Research Paper
    ​ ​Wagner S, Dybkova N, Rasenack ECL, Jacobshagen C, Fabritz L, Kirchhof P, et al. ​Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels​. ​​Journal of Clinical Investigation. ​2006;​116​(12):​​3127​-3138​. ​doi:10.1172/JCI26620. 
    Details  DOI  PMID  PMC  WoS 
  • 2006 Journal Article | Research Paper
    ​ ​Schillinger W, Teucher N, Christians C, Kohlhaas M, Sossalla S, Van Nguyen P, et al. ​High intracellular Na+ preserves myocardial function at low heart rates in isolated myocardium from failing hearts​. ​​European Journal of Heart Failure. ​2006;​8​(7):​​673​-680​. ​doi:10.1016/j.ejheart.2006.01.013. 
    Details  DOI  PMID  PMC  WoS 
  • 2005 Conference Abstract
    ​ ​Guan K, Nayernia K, Maier LS, Wagner S, Wolf F, Li MY, et al. ​Adult mouse spermatogonial stem cells differentiate into cardiovascular lineages and generate functional cardiomyocytes​. ​ Scientific Meeting of the American-Heart-Association; ​Dallas, TX. ​Circulation Research. ​2005;​97​(11)
    Details  WoS 
  • 2003 Journal Article | Research Paper
    ​ ​Wagner S, Seidler T, Picht E, Maier LS, Kazanski V, Teucher N, et al. ​Na+-Ca2+ exchanger overexpression predisposes to reactive oxygen species-induced injury​. ​​Cardiovascular Research. ​2003;​60​(2):​​404​-412​. ​doi:10.1016/j.cardiores.2003.08.006. 
    Details  DOI  PMID  PMC  WoS 
  • 2002 Journal Article | Research Paper
    ​ ​Hasenfuß G, Maier LS, Hermann, Hans-Peter, Luers C, Hünlich M, Zeitz O, et al. ​Influence of pyruvate on contractile performance and Ca2+ cycling in isolated failing human myocardium​. ​​Circulation. ​2002;​105​(2):​​194​-199​. ​doi:10.1161/hc0202.102238. 
    Details  DOI  PMID  PMC  WoS 
  • 2001 Journal Article | Research Paper
    ​ ​Weisser J, Martin J, Bisping E, Maier LS, Beyersdorf F, Hasenfuß G, et al. ​Influence of mild hypothermia on myocardial contractility and circulatory function​. ​​Basic Research in Cardiology. ​2001;​96​(2):​​198​-205​. ​doi:10.1007/s003950170071. 
    Details  DOI  PMID  PMC  WoS 
  • 2000 Journal Article | Research Paper
    ​ ​Janssen PML, Zeitz O, Keweloh B, Siegel U, Maier LS, Barckhausen P, et al. ​Influence of cyclosporine A on contractile function, calcium handling, and energetics in isolated human and rabbit myocardium​. ​​Cardiovascular Research. ​2000;​47​(1):​​99​-107​. ​doi:10.1016/S0008-6363(00)00052-3. 
    Details  DOI  PMID  PMC  WoS 
  • 1999 Journal Article
    ​ ​Hasenfuß G, Schillinger W, Lehnart SE, Preuss M, Pieske B, Maier LS, et al. ​Relationship Between Na + -Ca 2+ –Exchanger Protein Levels and Diastolic Function of Failing Human Myocardium​. ​​Circulation. ​1999;​99​(5):​​641​-648​. ​doi:10.1161/01.CIR.99.5.641. 
    Details  DOI 
  • 1998 Journal Article
    ​ ​Schillinger W, Lehnart SE, Prestle J, Preuss M, Pieske B, Maier LS, et al. ​Influence of SR Ca2+-ATPase and Na+-Ca2+-exchanger on the force-frequency relation​. ​​Basic Research in Cardiology. ​1998;​93​(Supplement 1):​​38​-45​. ​doi:10.1007/s003950050208. 
    Details  DOI 
  • 1998 Journal Article | Research Paper
    ​ ​Schlotthauer K, Schattmann J, Bers DM, Maier LS, Schutt U, Minami K, et al. ​Frequency-dependent changes in contribution of SR Ca2+ to Ca2+ transients in failing human myocardium assessed with ryanodine​. ​​Journal of Molecular and Cellular Cardiology. ​1998;​30​(7):​​1285​-1294​. ​doi:10.1006/jmcc.1998.0690. 
    Details  DOI  PMID  PMC  WoS 

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