RG Toischer (Kardiales Remodeling)

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  • 2024 | Journal Article
    ​ ​Low-flow in aortic valve stenosis patients with reduced ejection fraction does not depend on left ventricular function​
    Gersch, S.; Lange, T.; Beuthner, B. E.; Elkenani, M.; Paul, N.; Schnelle, M. & Zeisberg, E. et al.​ (2024) 
    Clinical Research in Cardiology,.​ DOI: https://doi.org/10.1007/s00392-023-02372-4 
    ​Details  DOI  PMID  PMC 
  • 2024 | Journal Article
    ​ ​Histological assessment of cardiac amyloidosis in patients undergoing transcatheter aortic valve replacement​
    Beuthner, B. E.; Elkenani, M.; Evert, K.; Mustroph, J.; Jacob, C. F.; Paul, N. B. & Beißbarth, T. et al.​ (2024) 
    ESC Heart Failure, art. ehf2.14709​.​ DOI: https://doi.org/10.1002/ehf2.14709 
    ​Details  DOI  PMID  PMC 
  • 2023 | Journal Article | 
    ​ ​DNA Methylation Analysis Identifies Novel Epigenetic Loci in Dilated Murine Heart upon Exposure to Volume Overload​
    Xu, X.; Elkenani, M.; Tan, X.; Hain, J. katharina; Cui, B.; Schnelle, M. & Hasenfuss, G.  et al.​ (2023) 
    International Journal of Molecular Sciences, 24(6) pp. 5885​.​ DOI: https://doi.org/10.3390/ijms24065885 
    ​Details  DOI 
  • 2023 | Journal Article
    ​ ​Regulatory roles of the N6-methyladenosine demethylase FTO in cardiac remodeling​
    Annamalai, K.; Buchholz, E.; Castro, R.; Panyam, N.; Fischer, A. & Toischer, K.​ (2023) 
    European Heart Journal, 44(Supplement 2).​ DOI: https://doi.org/10.1093/eurheartj/ehad655.3143 
    ​Details  DOI 
  • 2023 | Journal Article
    ​ ​An Alternative Mechanism of Subcellular Iron Uptake Deficiency in Cardiomyocytes​
    Dai, Y.; Ignatyeva, N.; Xu, H.; Wali, R.; Toischer, K.; Brandenburg, S. & Lenz, C. et al.​ (2023) 
    Circulation Research, art. CIRCRESAHA.122.321157​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.122.321157 
    ​Details  DOI  PMID  PMC 
  • 2023 | Journal Article | 
    ​ ​Aortic valve calcification and myocardial fibrosis determine outcome following transcatheter aortic valve replacement​
    Evertz, R.; Hub, S.; Beuthner, B. E.; Backhaus, S. J.; Lange, T.; Schulz, A. & Toischer, K. et al.​ (2023) 
    ESC Heart Failure, art. ehf2.14307​.​ DOI: https://doi.org/10.1002/ehf2.14307 
    ​Details  DOI  PMID  PMC 
  • 2023 | Preprint
    ​ ​Secreted-Frizzled-Related Protein 5 Modulates Calcium Handling in Human Ipsc-Cardiomyocytes​
    Weber, F.; Klas, S.; Hindmarsh, V.; Salinas, G.; Toischer, K.; Hasenfuss, G.& Cyganek, L.​ (2023). DOI: https://doi.org/10.2139/ssrn.4544232 
    ​Details  DOI 
  • 2023 | Journal Article | 
    ​ ​Metabolomic Profiling in Patients with Different Hemodynamic Subtypes of Severe Aortic Valve Stenosis​
    Bengel, P.; Elkenani, M.; Beuthner, B. E.; Pietzner, M.; Mohamed, B. A.; Pollok-Kopp, B. & Krätzner, R. et al.​ (2023) 
    Biomolecules, 13(1) pp. 95​.​ DOI: https://doi.org/10.3390/biom13010095 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Hemodynamic stress-induced cardiac remodelling is not modulated by ablation of phosphodiesterase 4D interacting protein​
    Mohamed, B. A. ; Elkenani, M.; Mobarak, S.; Marques Rodrigues, D.; Annamalai, K.; Schnelle, M.   & Bader, M. et al.​ (2022) 
    Journal of Cellular and Molecular Medicine, 26(16) pp. 4440​-4452​.​ DOI: https://doi.org/10.1111/jcmm.17468 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | 
    ​ ​Functional and structural reverse myocardial remodeling following transcatheter aortic valve replacement: a prospective cardiovascular magnetic resonance study​
    Lange, T.; Backhaus, S. J.; Beuthner, B. E.; Topci, R.; Rigorth, K.-R.; Kowallick, J. T. & Evertz, R. et al.​ (2022) 
    Journal of Cardiovascular Magnetic Resonance, 24(1) art. 45​.​ DOI: https://doi.org/10.1186/s12968-022-00874-0 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | 
    ​ ​Direct proteomic and high-resolution microscopy biopsy analysis identifies distinct ventricular fates in severe aortic stenosis​
    Brandenburg, S. ; Drews, L.; Schönberger, H.-L.; Jacob, C. F.; Paulke, N. J.; Beuthner, B. E. & Topci, R. et al.​ (2022) 
    Journal of Molecular and Cellular Cardiology, 173 pp. 1​-15​.​ DOI: https://doi.org/10.1016/j.yjmcc.2022.08.363 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Different activation of MAPKs and Akt/GSK3β after preload vs. afterload elevation​
    Hartmann, N. ; Preuß, L.; Mohamed, B. A. ; Schnelle, M. ; Renner, A.; Hasenfuß, G.   & Toischer, K. ​ (2022) 
    ESC Heart Failure, 9(3) pp. 1823​-1831​.​ DOI: https://doi.org/10.1002/ehf2.13877 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Detrimental proarrhythmogenic interaction of Ca2+/calmodulin-dependent protein kinase II and NaV1.8 in heart failure​
    Bengel, P. ; Dybkova, N.; Tirilomis, P.; Ahmad, S. ; Hartmann, N. H. ; A. Mohamed, B. & Krekeler, M. C. et al.​ (2021) 
    Nature Communications, 12(1) art. 6586​.​ DOI: https://doi.org/10.1038/s41467-021-26690-1 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Epigenetic gene expression links heart failure to memory impairment​
    Islam, M. R.; Lbik, D.; Sakib, M S.; Maximilian Hofmann, R.; Berulava, T.; Jiménez Mausbach, M. & Cha, J. et al.​ (2021) 
    EMBO Molecular Medicine, 13(3).​ DOI: https://doi.org/10.15252/emmm.201911900 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Impact of myocardial fibrosis on left ventricular remodelling, recovery, and outcome after transcatheter aortic valve implantation in different haemodynamic subtypes of severe aortic stenosis​
    Puls, M.; Beuthner, B. E.; Topci, R.; Vogelgesang, A.; Bleckmann, A.; Sitte, M. & Lange, T. et al.​ (2020) 
    European Heart Journal, 41(20) pp. 1903​-1914​.​ DOI: https://doi.org/10.1093/eurheartj/ehaa033 
    ​Details  DOI  PMID  PMC 
  • 2020 | Preprint
    ​ ​Epigenetic gene-expression links heart failure to memory impairment​
    Islam, R.; Lbik, D.; Sakib, S.; Hofmann, R. M.; Berulava, T.; Mausbach, M. J.& Cha, J. et al.​ (2020). DOI: https://doi.org/10.1101/2020.01.22.915637 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Interdisciplinary Research on Aortic Valve Stenosis: A Longitudinal Collection of Biospecimens and Clinical Data of Patients Undergoing Transcatheter Aortic Valve Replacement​
    Beuthner, B. E. C.; Topci, R.; Derks, M.; Franke, T.; Seelke, S.; Puls, M. & Schuster, A. et al.​ (2020) 
    Open Journal of Bioresources, 7.​ DOI: https://doi.org/10.5334/ojb.65 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper
    ​ ​Dysferlin links excitation-contraction coupling to structure and maintenance of the cardiac transverse-axial tubule system​
    Hofhuis, J. ; Bersch, K.; Wagner, S. ; Molina, C. E. ; Fakuade, F. E.; Iyer, L. M.   & Streckfuß-Bömeke, K.  et al.​ (2020) 
    Europace, 22(7) pp. 1119​-1131​.​ DOI: https://doi.org/10.1093/europace/euaa093 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Preclinical evidence for the therapeutic value of TBX5 normalization in arrhythmia control​
    Rathjens, F. S. ; Blenkle, A.; Iyer, L. M. ; Renger, A.; Syeda, F.; Noack, C.   & Jungmann, A. et al.​ (2020) 
    Cardiovascular Research,.​ DOI: https://doi.org/10.1093/cvr/cvaa239 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​CRISPLD1: a novel conserved target in the transition to human heart failure​
    Khadjeh, S. ; Hindmarsh, V.; Weber, F.; Cyganek, L. ; Vidal, R. O. ; Torkieh, S. & Streckfuss-Bömeke, K.  et al.​ (2020) 
    Basic Research in Cardiology, 115(3).​ DOI: https://doi.org/10.1007/s00395-020-0784-4 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Real-time cardiovascular magnetic resonance T1 and extracellular volume fraction mapping for tissue characterisation in aortic stenosis​
    Backhaus, S. J. ; Lange, T.; Beuthner, B. E.; Topci, R.; Wang, X.; Kowallick, J. T.   & Lotz, J.  et al.​ (2020) 
    Journal of Cardiovascular Magnetic Resonance, 22(1) pp. 46​.​ DOI: https://doi.org/10.1186/s12968-020-00632-0 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Assessing the role of extracellular signal‐regulated kinases 1 and 2 in volume overload‐induced cardiac remodelling​
    Jochmann, S.; Elkenani, M.; Mohamed, B. A.; Buchholz, E.; Lbik, D.; Binder, L. & Lorenz, K. et al.​ (2019) 
    ESC Heart Failure, 6(5) pp. 1015​-1026​.​ DOI: https://doi.org/10.1002/ehf2.12497 
    ​Details  DOI  PMID  PMC 
  • 2019 | Conference Paper
    ​ ​P5998The Phosphodiesterase 4D interacting protein averts volume overload - but not pressure overload-induced pathological myocardial remodeling​
    Mohamed, B. A.; Elkenani, M.; Jakubiczka-Smorag, J.; Bader, M.; Hasenfuss, G.   & Toischer, K. ​ (2019)
    European Heart Journal, 40(Suppl. 1) ​ESC Congress 2019 together with World Congress of Cardiology​, Paris. DOI: https://doi.org/10.1093/eurheartj/ehz746.0719 
    ​Details  DOI 
  • 2019 | Conference Paper
    ​ ​1180 Cardiomyocyte-specific deletion of Brd4 induces hypertrophic cardiomyopathy and suggests a novel function for the chromatin reader as co-repressor in the healthy heart​
    Lbik, D.; Buchholz, E.; Mohamed, B.; Fischer, A. ; Hasenfuss, G.   & Toischer, K. ​ (2019)
    European Heart Journal, 40(Suppl. 1) ​ESC Congress 2019 together with World Congress of Cardiology​, Paris. DOI: https://doi.org/10.1093/eurheartj/ehz748.0022 
    ​Details  DOI 
  • 2019 | Conference Paper
    ​ ​P1621m6A RNA-methylation in the progression of heart failure​
    Buchholz, E.; Berulava, T.; Ellerdashvilli, V.; Pena, T.; Lbik, D.; Mohamed, B. & Sloan, K. et al.​ (2019)
    European Heart Journal, 40(Suppl. 1) ​ESC Congress 2019 together with World Congress of Cardiology​, Paris. DOI: https://doi.org/10.1093/eurheartj/ehz748.0380 
    ​Details  DOI 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Changes in m6A RNA methylation contribute to heart failure progression by modulating translation​
    Berulava, T.; Buchholz, E.; Elerdashvili, V.; Pena, T.; Islam, M. R.; Lbik, D. & Mohamed, B. A.  et al.​ (2019) 
    European Journal of Heart Failure, 22(1) pp. 54​-66​.​ DOI: https://doi.org/10.1002/ejhf.1672 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Genetic deletion of calcium/calmodulin-dependent protein kinase type II delta does not mitigate adverse myocardial remodeling in volume-overloaded hearts​
    Mohamed, B. A. ; Elkenani, M.; Jakubiczka-Smorag, J. ; Buchholz, E.; Koszewa, S.; Lbik, D. & Schnelle, M.  et al.​ (2019) 
    Scientific Reports, 9(1) art. 9889​.​ DOI: https://doi.org/10.1038/s41598-019-46332-3 
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  • 2019 | Journal Article | Research Paper
    ​ ​Proteasome-Dependent Regulation of Distinct Metabolic States During Long-Term Culture of Human iPSC-Derived Cardiomyocytes​
    Ebert, A. ; Joshi, A. U.; Andorf, S.; Dai, Y.; Sampathkumar, S.; Chen, H. & Li, Y. et al.​ (2019) 
    Circulation Research, 125(1) pp. 90​-103​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.118.313973 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​NADPH oxidase-4 promotes eccentric cardiac hypertrophy in response to volume overload​
    Schnelle, M. ; Sawyer, I.; Anilkumar, N.; Mohamed, B. A. ; Richards, D. A.; Toischer, K.   & Zhang, M. et al.​ (2019) 
    Cardiovascular Research, 117(1) pp. 178​-187​.​ DOI: https://doi.org/10.1093/cvr/cvz331 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​CD8+-T Cells With Specificity for a Model Antigen in Cardiomyocytes Can Become Activated After Transverse Aortic Constriction but Do Not Accelerate Progression to Heart Failure​
    Gröschel, C.; Sasse, A.; Monecke, S.; Röhrborn, C.; Elsner, L.; Didié, M. & Reupke, V. et al.​ (2018) 
    Frontiers in Immunology, 9 art. 2665​.​ DOI: https://doi.org/10.3389/fimmu.2018.02665 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia​
    Chowdhury, A. ; Aich, A. ; Jain, G.; Wozny, K.; Lüchtenborg, C.; Hartmann, M.   & Bernhard, O.  et al.​ (2018) 
    Cell Reports, 25(3) pp. 561​-570.e6​.​ DOI: https://doi.org/10.1016/j.celrep.2018.09.057 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart​
    Iyer, L. M ; Nagarajan, S. ; Woelfer, M.; Schoger, E.; Khadjeh, S. ; Zafiriou, M. P.   & Kari, V.  et al.​ (2018) 
    Nucleic Acids Research, 46(6) pp. 2850​-2867​.​ DOI: https://doi.org/10.1093/nar/gky049 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression​
    Mohamed, B. A. ; Hartmann, N. ; Tirilomis, P.; Sekeres, K.; Li, W.; Neef, S. & Richter, C.  et al.​ (2018) 
    Science Translational Medicine, 10(458) art. eaan0724​.​ DOI: https://doi.org/10.1126/scitranslmed.aan0724 
    ​Details  DOI  PMID  PMC 
  • 2017 | Conference Abstract
    ​ ​P1334 - The relevant role of SR Ca leak in the development of heart failure​
    Mohamed, B. A.; Kattner, L.; Guan, K. ; Lehnart, S. E. ; Luther, S. ; Sossalla, S.   & Hasenfuß, G.  et al.​ (2017)
    European Journal of Heart Failure, 19(Suppl. 1) ​Heart Failure 2017 and the 4th World Congress on Acute Heart Failure​, Paris.
    ​Details 
  • 2017 | Journal Article | Research Paper
    ​ ​B-catenin/TCF7L2 signaling orchestrates initiation of pathological hypertrophic cardiac remodeling by inducing chromatin modifications​
    Iyer, L. M. ; Noack, C.; Nagarajan, S.; Woelfer, M.; Schoger, E.; Pang, S. T. & Kari, V.  et al.​ (2017) 
    European Heart Journal, 38(suppl_1) art. P4479​.​ DOI: https://doi.org/10.1093/eurheartj/ehx504.P4479 
    ​Details  DOI 
  • 2017 | Journal Article | Research Paper
    ​ ​Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair​
    Tiburcy, M. ; Hudson, J. E.; Balfanz, P.; Schlick, S.; Meyer, T. ; Chang Liao, M.-L. & Levent, E. et al.​ (2017) 
    Circulation, 135(19) pp. 1832​-1847​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.116.024145 
    ​Details  DOI 
  • 2017 | Journal Article | Research Paper | 
    ​ ​T helper cells with specificity for an antigen in cardiomyocytes promote pressure overload-induced progression from hypertrophy to heart failure​
    Gröschel, C. ; Sasse, A. ; Röhrborn, C. ; Monecke, S. ; Didié, M. ; Elsner, L.   & Kruse, V.  et al.​ (2017) 
    Scientific Reports, 7(1) art. 15998​.​ DOI: https://doi.org/10.1038/s41598-017-16147-1 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Cardiomyocyte proliferation prevents failure in pressure overload but not volume overload​
    Toischer, K. ; Zhu, W.; Hünlich, M.; Mohamed, B. A.; Khadjeh, S.; Reuter, S. P. & Schäfer, K.  et al.​ (2017) 
    Journal of Clinical Investigation, 127(12) pp. 4285​-4296​.​ DOI: https://doi.org/10.1172/JCI81870 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​The contractile adaption to preload depends on the amount of afterload​
    Schotola, H.; Sossalla, S. T. ; Renner, A.; Gummert, J.; Danner, B. C.; Schott, P. & Toischer, K. ​ (2017) 
    ESC Heart Failure,.​ DOI: https://doi.org/10.1002/ehf2.12164 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article | Research Paper | 
    ​ ​Cardiac-specific succinate dehydrogenase deficiency in Barth syndrome​
    Dudek, J. ; Cheng, I.-F. ; Chowdhury, A. ; Wozny, K.; Balleininger, M.; Reinhold, R.   & Grunau, S.  et al.​ (2016) 
    EMBO Molecular Medicine, 8(2) pp. 139​-154​.​ DOI: https://doi.org/10.15252/emmm.201505644 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article | Research Paper | 
    ​ ​Molecular and structural transition mechanisms in long-term volume overload​
    Mohamed, B. A. ; Schnelle, M. ; Khadjeh, S. ; Lbik, D.; Herwig, M.; Linke, W. A.   & Hasenfuß, G.  et al.​ (2016) 
    European Journal of Heart Failure, 18(4) pp. 362​-371​.​ DOI: https://doi.org/10.1002/ejhf.465 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper | 
    ​ ​Inducible Knock-Down of the Mineralocorticoid Receptor in Mice Disturbs Regulation of the Renin-Angiotensin-Aldosterone System and Attenuates Heart Failure Induced by Pressure Overload​
    Montes-Cobos, E. ; Li, X. ; Fischer, H. J. ; Sasse, A. ; Kügler, S. ; Didié, M.   & Toischer, K.  et al.​ (2015) 
    PLOS ONE, 10(11) art. e0143954​.​ DOI: https://doi.org/10.1371/journal.pone.0143954 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​p63RhoGEF regulates auto- and paracrine signaling in cardiac fibroblasts​
    Ongherth, A.; Pasch, S.; Wuertz, C. M. ; Nowak, K.; Kittana, N.; Weis, C. A. & Jatho, A.  et al.​ (2015) 
    Journal of Molecular and Cellular Cardiology, 88 pp. 39​-54​.​ DOI: https://doi.org/10.1016/j.yjmcc.2015.09.009 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper | 
    ​ ​Effects of Ranolazine on Torsades de Pointes Tachycardias in a Healthy Isolated Rabbit Heart Model​
    Sossalla, S. T. ; Wallisch, N.; Toischer, K. ; Sohns, C.; Vollmann, D.; Seegers, J. & Luethje, L. et al.​ (2014) 
    Cardiovascular Therapeutics, 32(4) pp. 170​-177​.​ DOI: https://doi.org/10.1111/1755-5922.12078 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease​
    Toischer, K. ; Hartmann, N. ; Wagner, S. ; Fischer, T. H. ; Herting, J. ; Danner, B. C.   & Sag, C. M. et al.​ (2013) 
    Journal of Molecular and Cellular Cardiology, 61 pp. 111​-122​.​ DOI: https://doi.org/10.1016/j.yjmcc.2013.03.021 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Ca2+/Calmodulin-Dependent Protein Kinase II and Protein Kinase A Differentially Regulate Sarcoplasmic Reticulum Ca2+ Leak in Human Cardiac Pathology​
    Fischer, T. H. ; Herting, J. ; Tirilomis, T. ; Renner, A.; Neef, S.; Toischer, K.   & Ellenberger, D.  et al.​ (2013) 
    Circulation, 128(9) pp. 970​-981​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.113.001746 
    ​Details  DOI  PMID  PMC  WoS 

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