Prof. Dr. Nils Brose

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  • 2015 | Journal Article
    ​ ​Mammalian Unc-13 homologues as possible regulators of neurotransmitter release​
    Betz, A. ; Telemenakis, I. ; Hofmann, K. & Brose, N. ​ (2015) 
    Biochemical Society transactions, 24(3) pp. 661​-666​.​ DOI: https://doi.org/10.1042/bst0240661 
    ​Details  DOI 
  • 2012 | Journal Article | Research Paper
    ​ ​The RacGAP β2-Chimaerin Selectively Mediates Axonal Pruning in the Hippocampus​
    Riccomagno, M. M.; Hurtado, A.; Wang, H.; Macopson, J. G. J.; Griner, E. M.; Betz, A.   & Brose, N.  et al.​ (2012) 
    Cell, 149(7) pp. 1594​-1606​.​ DOI: https://doi.org/10.1016/j.cell.2012.05.018 
    ​Details  DOI  PMID  PMC  WoS 
  • 2007 | Journal Article | Research Paper
    ​ ​Munc13-1 C1 domain activation lowers the energy barrier for synaptic vesicle fusion​
    Basu, J.; Betz, A. ; Brose, N.   & Rosenmund, C.​ (2007) 
    The Journal of neuroscience, 27(5) pp. 1200​-1210​.​ DOI: https://doi.org/10.1523/JNEUROSCI.4908-06.2007 
    ​Details  DOI  PMID  PMC  WoS 
  • 2007 | Journal Article | Research Paper
    ​ ​EphA4-Dependent axon guidance is mediated by the RacGAP alpha 2-chirnaerin​
    Wegmeyer, H.; Egea, J.; Rabe, N.; Gezelius, H.; Filosa, A.; Enjin, A. & Varoqueaux, F. et al.​ (2007) 
    Neuron, 55(5) pp. 756​-767​.​ DOI: https://doi.org/10.1016/j.neuron.2007.07.038 
    ​Details  DOI  PMID  PMC  WoS 
  • 2006 | Journal Article | Research Paper
    ​ ​Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose tolerance​
    Kwan, E. P.; Xie, L.; Sheu, L.; Nolan, C. J.; Prentki, M.; Betz, A.   & Brose, N.  et al.​ (2006) 
    Diabetes, 55(5) pp. 1421​-1429​.​ DOI: https://doi.org/10.2337/db05-1263 
    ​Details  DOI  PMID  PMC  WoS 
  • 2006 | Journal Article | Research Paper
    ​ ​Munc13-1 is required for the sustained release of insulin from pancreatic beta cells​
    Kang, L. J.; He, Z.; Xu, P Y; Fan, J. M.; Betz, A. ; Brose, N.   & Xu, T.​ (2006) 
    Cell Metabolism, 3(6) pp. 463​-468​.​ DOI: https://doi.org/10.1016/j.cmet.2006.04.012 
    ​Details  DOI  PMID  PMC  WoS 
  • 2006 | Conference Paper | Research Paper
    ​ ​Characterization of the Munc13-calmodulin interaction by photoaffinity labeling​
    Dimova, K.; Kawabe, H.; Betz, A. ; Brose, N.   & Jahn, O. ​ (2006)
    ​Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (11) (Vol. 1763). , Ecole Superieure Biotechnol, Strasbourg, FRANCE.
    Amsterdam​: Elsevier Science Bv. DOI: https://doi.org/10.1016/j.bbamcr.2006.09.017 
    ​Details  DOI  PMID  PMC  WoS 
  • 2004 | Review
    ​ ​Divergent and convergent signaling by the diacylglycerol second messenger pathway in mammals​
    Brose, N. ; Betz, A.  & Wegmeyer, H.​ (2004)
    Current Opinion in Neurobiology, 14​(3) pp. 328​-340​.​
    Current Biology Ltd. DOI: https://doi.org/10.1016/j.conb.2004.05.006 
    ​Details  DOI  PMID  PMC  WoS 
  • 2004 | Journal Article | Research Paper
    ​ ​Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing​
    Rossner, S.; Fuchsbrunner, K.; Lange-Dohna, C.; Hartlage-Rubsamen, M.; Bigl, V.; Betz, A.   & Reim, K. et al.​ (2004) 
    Journal of biological chemistry, 279(27) pp. 27841​-27844​.​ DOI: https://doi.org/10.1074/jbc.C400122200 
    ​Details  DOI  PMID  PMC  WoS 
  • 2002 | Journal Article | Research Paper
    ​ ​β Phorbol Ester- and Diacylglycerol-Induced Augmentation of Transmitter Release Is Mediated by Munc13s and Not by PKCs​
    Rhee, J.-S. ; Betz, A. ; Pyott, S.; Reim, K.; Varoqueaux, F.; Augustin, I. & Hesse, D. et al.​ (2002) 
    Cell, 108(1) pp. 121​-133​.​ DOI: https://doi.org/10.1016/S0092-8674(01)00635-3 
    ​Details  DOI  PMID  PMC  WoS 
  • 2001 | Journal Article | Research Paper
    ​ ​Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming​
    Betz, A. ; Thakur, P.; Junge, H. J.; Ashery, U.; Rhee, J.-S. ; Scheuss, V. & Rosenmund, C. et al.​ (2001) 
    Neuron, 30(1) pp. 183​-196​.​ DOI: https://doi.org/10.1016/S0896-6273(01)00272-0 
    ​Details  DOI  PMID  PMC  WoS 
  • 2000 | Journal Article | Research Paper
    ​ ​Munc13-1 acts as a priming factor for large dense-core vesicles in bovine chromaffin cells​
    Ashery, U.; Varoqueaux, F.; Voets, T.; Betz, A. ; Koch, H.; Neher, E.   & Brose, N.  et al.​ (2000) 
    EMBO Journal, 19(14) pp. 3586​-3596​.​ DOI: https://doi.org/10.1093/emboj/19.14.3586 
    ​Details  DOI  PMID  PMC  WoS 
  • 1999 | Journal Article | Research Paper
    ​ ​Differential expression of two novel Munc13 proteins in rat brain​
    Augustin, I.; Betz, A. ; Herrmann, C. ; Jo, T. & Brose, N. ​ (1999) 
    Biochemical Journal, 337 pp. 363​-371​.​ DOI: https://doi.org/10.1042/0264-6021:3370363 
    ​Details  DOI  PMID  PMC  WoS 
  • 1999 | Journal Article | Research Paper
    ​ ​Transient, phorbol ester-induced DOC2-Munc13 interactions in vivo​
    Duncan, R. R.; Betz, A. ; Shipston, M. J.; Brose, N.   & Chow, R. H.​ (1999) 
    Journal of Biological Chemistry, 274(39) pp. 27347​-27350​.​ DOI: https://doi.org/10.1074/jbc.274.39.27347 
    ​Details  DOI  PMID  PMC  WoS 
  • 1999 | Journal Article | Research Paper
    ​ ​An efficient method for infection of adrenal chromaffin cells using the Semliki Forest virus gene expression system​
    Ashery, U.; Betz, A. ; Brose, N. ; Rettig, J. & Xu, T.​ (1999) 
    European Journal of Cell Biology, 78(8) pp. 525​-532​.​ DOI: https://doi.org/10.1016/s0171-9335(99)80017-x 
    ​Details  DOI  PMID  PMC  WoS 
  • 1998 | Journal Article | Research Paper
    ​ ​Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release​
    Betz, A. ; Ashery, U.; Rickmann, M. ; Augustin, I.; Neher, E. ; Südhof, T. C. & Rettig, J. et al.​ (1998) 
    Neuron, 21(1) pp. 123​-136​.​ DOI: https://doi.org/10.1016/S0896-6273(00)80520-6 
    ​Details  DOI  PMID  PMC  WoS 
  • 1997 | Journal Article
    ​ ​Direct Interaction of the Rat unc-13 Homologue Munc13-1 with the N Terminus of Syntaxin​
    Okamoto, M.; Brose, N.   & Betz, A. ​ (1997) 
    Journal of biological chemistry, 272(4) pp. 2520​-2526​.​ DOI: https://doi.org/10.1074/jbc.272.4.2520 
    ​Details  DOI 

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