Prof. Dr. Dr. med. Samuel Tobias Sossalla

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  • 2022 | Journal Article
    ​ ​Na v 1.8 Dysregulates Na and Ca Leading to Arrhythmias in Patients with Sleep-disordered Breathing​
    Lebek, S.; Hegner, P.; Hultsch, R.; Rohde, J.; Rupprecht, L.; Schmid, C. & Sossalla, S. T.  et al.​ (2022) 
    American Journal of Respiratory and Critical Care Medicine, art. rccm.202205-0981LE​.​ DOI: https://doi.org/10.1164/rccm.202205-0981LE 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Effects of Atrial Fibrillation on the Human Ventricle​
    Pabel, S. ; Knierim, M.; Stehle, T.; Alebrand, F.; Paulus, M.; Sieme, M. & Herwig, M. et al.​ (2022) 
    Circulation Research, 130(7) pp. 994​-1010​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.121.319718 
    ​Details  DOI 
  • 2022 | Journal Article
    ​ ​Atrial Fibrillation Burden Specifically Determines Human Ventricular Cellular Remodeling​
    Körtl, T.; Stehle, T.; Riedl, D.; Trausel, J.; Rebs, S. ; Pabel, S.   & Paulus, M. et al.​ (2022) 
    JACC: Clinical Electrophysiology, 8(11) pp. 1357​-1366​.​ DOI: https://doi.org/10.1016/j.jacep.2022.07.016 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​A mechanistic rationale for the investigation of sodium–glucose co‐transporter 2 inhibitors in heart failure with preserved ejection fraction. Letter regarding the article ‘Baseline characteristics of patients with heart failure with preserved ejection fraction in the EMPEROR‐Preserved trial’​
    Pabel, S. ; Hamdani, N. & Sossalla, S. ​ (2021) 
    European Journal of Heart Failure,.​ DOI: https://doi.org/10.1002/ejhf.2091 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Detrimental proarrhythmogenic interaction of Ca2+/calmodulin-dependent protein kinase II and NaV1.8 in heart failure​
    Bengel, P. ; Dybkova, N.; Tirilomis, P.; Ahmad, S. ; Hartmann, N. H. ; A. Mohamed, B. & Krekeler, M. C. et al.​ (2021) 
    Nature Communications, 12(1) art. 6586​.​ DOI: https://doi.org/10.1038/s41467-021-26690-1 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Empagliflozin improves endothelial and cardiomyocyte function in human heart failure with preserved ejection fraction via reduced pro-inflammatory-oxidative pathways and protein kinase Gα oxidation​
    Kolijn, D.; Pabel, S. ; Tian, Y.; Lódi, M.; Herwig, M.; Carrizzo, A. & Zhazykbayeva, S. et al.​ (2020) 
    Cardiovascular Research, 117(2) pp. 495​-507​.​ DOI: https://doi.org/10.1093/cvr/cvaa123 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Novel re-expression of L-type calcium channel Cav1.3 in left ventricles of failing human heart​
    Srivastava, U.; Jennings-Charles, R.; Qu, Y. S.; Sossalla, S. ; Chahine, M. & Boutjdir, M.​ (2020) 
    Heart Rhythm, 17(7) pp. 1193​-1197​.​ DOI: https://doi.org/10.1016/j.hrthm.2020.02.025 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​CaMKIIδC Drives Early Adaptive Ca 2+ Change and Late Eccentric Cardiac Hypertrophy​
    Ljubojevic-Holzer, S.; Herren, A. W.; Djalinac, N.; Voglhuber, J.; Morotti, S.; Holzer, M. & Wood, B. M. et al.​ (2020) 
    Circulation Research, 127(9) pp. 1159​-1178​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.120.316947 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Dantrolene reduces CaMKIIδC-mediated atrial arrhythmias​
    Pabel, S. ; Mustroph, J.; Stehle, T.; Lebek, S.; Dybkova, N.; Keyser, A. & Rupprecht, L. et al.​ (2020) 
    Europace, 22(7) pp. 1111​-1118​.​ DOI: https://doi.org/10.1093/europace/euaa079 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Contribution of the neuronal sodium channel NaV1.8 to sodium- and calcium-dependent cellular proarrhythmia​
    Bengel, P. ; Ahmad, S. ; Tirilomis, P.; Trum, M.; Dybkova, N.; Wagner, S.   & Maier, L. S.  et al.​ (2020) 
    Journal of Molecular and Cellular Cardiology, 144 pp. 35​-46​.​ DOI: https://doi.org/10.1016/j.yjmcc.2020.05.002 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Sacubitrilat reduces pro‐arrhythmogenic sarcoplasmic reticulum Ca 2+ leak in human ventricular cardiomyocytes of patients with end‐stage heart failure​
    Eiringhaus, J. ; Wünsche, C. M.; Tirilomis, P.; Herting, J. ; Bork, N.; Nikolaev, V. O.   & Hasenfuss, G.  et al.​ (2020) 
    ESC Heart Failure, 7(5) pp. 2992​-3002​.​ DOI: https://doi.org/10.1002/ehf2.12918 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper
    ​ ​Serelaxin alleviates cardiac fibrosis through inhibiting endothelial-to-mesenchymal transition via RXFP1​
    Wilhelmi, T.; Xu, X.; Tan, X.; Hulshoff, M. S.; Maamari, S.; Sossalla, S.   & Zeisberg, M.  et al.​ (2020) 
    Theranostics, 10(9) pp. 3905​-3924​.​ DOI: https://doi.org/10.7150/thno.38640 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Inhibition of NaV1.8 prevents atrial arrhythmogenesis in human and mice​
    Pabel, S. ; Ahmad, S. ; Tirilomis, P.; Stehle, T.; Mustroph, J.; Knierim, M. & Dybkova, N. et al.​ (2020) 
    Basic Research in Cardiology, 115(2).​ DOI: https://doi.org/10.1007/s00395-020-0780-8 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​A High-Throughput Method as a Diagnostic Tool for HIV Detection in Patient-Specific Induced Pluripotent Stem Cells Generated by Different Reprogramming Methods​
    Hübscher, D. ; Rebs, S. ; Haupt, L. ; Borchert, T. ; Guessoum, C. I.; Treu, F. & Köhne, S. et al.​ (2019) 
    Stem Cells International, 2019 pp. 1​-11​.​ DOI: https://doi.org/10.1155/2019/2181437 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper
    ​ ​Protein kinase/phosphatase balance mediates the effects of increased late sodium current on ventricular calcium cycling​
    Eiringhaus, J. ; Herting, J. ; Schatter, F. ; Nikolaev, V. O. ; Sprenger, J.; Wang, Y. & Köhn, M. et al.​ (2019) 
    Basic Research in Cardiology, 114(2) pp. 13​.​ DOI: https://doi.org/10.1007/s00395-019-0720-7 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis​
    Brandenburg, S. ; Pawlowitz, J.; Eikenbusch, B.; Peper, J.; Kohl, T. ; Mitronova, G. Y.   & Sossalla, S.  et al.​ (2019) 
    JCI insight, 4(12).​ DOI: https://doi.org/10.1172/jci.insight.127116 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​KLF15-Wnt–Dependent Cardiac Reprogramming Up-Regulates SHISA3 in the Mammalian Heart​
    Noack, C. ; Iyer, L. M. ; Liaw, N. Y. ; Schoger, E.; Khadjeh, S. ; Wagner, E.   & Woelfer, M. et al.​ (2019) 
    Journal of the American College of Cardiology, 74(14) pp. 1804​-1819​.​ DOI: https://doi.org/10.1016/j.jacc.2019.07.076 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​The functional consequences of sodium channel NaV1.8 in human left ventricular hypertrophy​
    Ahmad, S. ; Tirilomis, P.; Pabel, S. ; Dybkova, N.; Hartmann, N. ; Molina, C. E.   & Tirilomis, T.  et al.​ (2019) 
    ESC Heart Failure, 6(1) pp. 154​-163​.​ DOI: https://doi.org/10.1002/ehf2.12378 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | 
    ​ ​Inhibition of the Hypoxia-Inducible Factor 1α–Induced Cardiospecific HERNA1 Enhance-Templated RNA Protects From Heart Disease​
    Mirtschink, P.; Bischof, C.; Pham, M.-D.; Sharma, R.; Khadayate, S.; Rossi, G. & Fankhauser, N. et al.​ (2019) 
    Circulation, 139(24) pp. 2778​-2792​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.118.036769 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | 
    ​ ​Data on differential multivariable risk prediction of appropriate shock vs. competing mortality​
    Bergau, L.; Willems, R.; Sprenkeler, D. J; Fischer, T. H. ; Flevari, P.; Hasenfuß, G.   & Katsaras, D. et al.​ (2018) 
    Data in Brief, 21 pp. 2110​-2116​.​ DOI: https://doi.org/10.1016/j.dib.2018.11.025 
    ​Details  DOI  PMID  PMC 
  • 2018 | Research Data | Research Paper | 
    ​ ​Axial Tubule Junctions Activate Atrial Ca2+ Release across Species​
    Brandenburg, S. ; Pawlowitz, J.; Lehnart, S. E. ; Fakuade, F. E.; Kownatzki-Danger, D.; Kohl, T.  & Mitronova, G. Y.  et al.​ (2018)
     DOI: https://doi.org/10.3389/fphys.2018.01227 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article
    ​ ​Empagliflozin reduces Ca/calmodulin-dependent kinase II activity in isolated ventricular cardiomyocytes​
    Mustroph, J.; Wagemann, O.; Lücht, C. M.; Trum, M.; Hammer, K. P.; Sag, C. M. & Lebek, S. et al.​ (2018) 
    ESC Heart Failure, 5(4) pp. 642​-648​.​ DOI: https://doi.org/10.1002/ehf2.12336 
    ​Details  DOI 
  • 2018 | Journal Article | Research Paper
    ​ ​Empagliflozin directly improves diastolic function in human heart failure​
    Pabel, S. ; Wagner, S. ; Bollenberg, H.; Bengel, P. ; Kovács, Á.; Schach, C. & Tirilomis, P. et al.​ (2018) 
    European Journal of Heart Failure, 20(12) pp. 1690​-1700​.​ DOI: https://doi.org/10.1002/ejhf.1328 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart​
    Dybkova, N.; Ahmad, S. ; Pabel, S. ; Tirilomis, P.; Hartmann, N. ; Fischer, T. H   & Bengel, P.  et al.​ (2018) 
    Cardiovascular Research, 114(13) pp. 1728​-1737​.​ DOI: https://doi.org/10.1093/cvr/cvy152 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | 
    ​ ​Differential multivariable risk prediction of appropriate shock versus competing mortality - A prospective cohort study to estimate benefits from ICD therapy​
    Bergau, L.; Willems, R.; Sprenkeler, D. J.; Fischer, T. H. ; Flevari, P.; Hasenfuß, G.   & Katsaras, D. et al.​ (2018) 
    International Journal of Cardiology, 272 pp. 102​-107​.​ DOI: https://doi.org/10.1016/j.ijcard.2018.06.103 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression​
    Mohamed, B. A. ; Hartmann, N. ; Tirilomis, P.; Sekeres, K.; Li, W.; Neef, S. & Richter, C.  et al.​ (2018) 
    Science Translational Medicine, 10(458) art. eaan0724​.​ DOI: https://doi.org/10.1126/scitranslmed.aan0724 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure​
    Fischer, T. H. ; Eiringhaus, J. ; Dybkova, N.; Saadatmand, A.; Pabel, S. ; Weber, S. & Wang, Y. et al.​ (2018) 
    European Journal of Heart Failure, 20(12) pp. 1673​-1685​.​ DOI: https://doi.org/10.1002/ejhf.1297 
    ​Details  DOI  PMID  PMC 
  • 2017 | Conference Abstract
    ​ ​P1334 - The relevant role of SR Ca leak in the development of heart failure​
    Mohamed, B. A.; Kattner, L.; Guan, K. ; Lehnart, S. E. ; Luther, S. ; Sossalla, S.   & Hasenfuß, G.  et al.​ (2017)
    European Journal of Heart Failure, 19(Suppl. 1) ​Heart Failure 2017 and the 4th World Congress on Acute Heart Failure​, Paris.
    ​Details 
  • 2017 | Journal Article | Research Paper
    ​ ​PP1 activation as novel antiarrhythmic approach in human heart failure​
    Eiringhaus, J. ; Fischer, T. H. ; Kohn, M.; Wang, Y.; Maier, L. S. ; Hasenfuss, G.   & Sossalla, S. T. ​ (2017) 
    European Heart Journal, 38(suppl_1) art. P5841​.​ DOI: https://doi.org/10.1093/eurheartj/ehx493.P5841 
    ​Details  DOI 
  • 2017 | Journal Article | Overview
    ​ ​The Significance of the Late Na+ Current for Arrhythmia Induction and the Therapeutic Antiarrhythmic Potential of Ranolazine​
    Mason, F. E.   & Sossalla, S. ​ (2017) 
    Journal of Cardiovascular Pharmacology and Therapeutics, 22(1) pp. 40​-50​.​ DOI: https://doi.org/10.1177/1074248416644989 
    ​Details  DOI  WoS 
  • 2017 | Journal Article | Research Paper
    ​ ​Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction​
    Vettel, C. ; Lindner, M.; Dewenter, M. ; Lorenz, K.; Schanbacher, C.; Riedel, M. & Lämmle, S. et al.​ (2017) 
    Circulation Research, 120(1) pp. 120​-132​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.116.310069 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper
    ​ ​Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure​
    Dewenter, M. ; Neef, S.; Vettel, C. ; Lämmle, S.; Beushausen, C.; Zelarayan, L. C.   & Katz, S. et al.​ (2017) 
    Circulation: Heart Failure, 10(5) art. e003840​.​ DOI: https://doi.org/10.1161/CIRCHEARTFAILURE.117.003840 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article
    ​ ​Inhibition of Late Sodium Current as an Innovative Antiarrhythmic Strategy​
    Bengel, P. ; Ahmad, S.   & Sossalla, S. ​ (2017) 
    Current Heart Failure Reports, 14(3) pp. 179​-186​.​ DOI: https://doi.org/10.1007/s11897-017-0333-0 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy​
    Borchert, T. ; Hübscher, D. ; Guessoum, C. I. ; Lam, T. Lam, Tuan-Dinh D.; Ghadri, J. R.; Schellinger, I. N.   & Tiburcy, M.  et al.​ (2017) 
    Journal of the American College of Cardiology, 70(8) pp. 975​-991​.​ DOI: https://doi.org/10.1016/j.jacc.2017.06.061 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​The contractile adaption to preload depends on the amount of afterload​
    Schotola, H.; Sossalla, S. T. ; Renner, A.; Gummert, J.; Danner, B. C.; Schott, P. & Toischer, K. ​ (2017) 
    ESC Heart Failure,.​ DOI: https://doi.org/10.1002/ehf2.12164 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes​
    Streckfuss-Bömeke, K. ; Tiburcy, M. ; Fomin, A.; Luo, X.; Li, W.; Fischer, C. & Özcelik, C. et al.​ (2017) 
    Journal of Molecular and Cellular Cardiology, 113 pp. 9​-21​.​ DOI: https://doi.org/10.1016/j.yjmcc.2017.09.008 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article | Research Paper
    ​ ​Sex-dependent alterations of Ca2+ cycling in human cardiac hypertrophy and heart failure​
    Fischer, T. H. ; Herting, J. ; Eiringhaus, J. ; Pabel, S. ; Hartmann, N. H. ; Ellenberger, D.   & Friedrich, M.  et al.​ (2016) 
    EP Europace, 18(9) pp. 1440​-1448​.​ DOI: https://doi.org/10.1093/europace/euv313 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper
    ​ ​Inhibition of CaMKII Attenuates Progressing Disruption of Ca2+ Homeostasis Upon Left Ventricular Assist Device Implantation in Human Heart Failure​
    Fischer, T. H. ; Kleinwächter, A.; Herting, J. ; Eiringhaus, J. ; Hartmann, N. ; Renner, A. & Gummert, J. et al.​ (2016) 
    Artificial Organs, 40(8) pp. 719​-726​.​ DOI: https://doi.org/10.1111/aor.12677 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII​
    Fischer, T. H. ; Herting, J. ; Mason, F. E. ; Hartmann, N. ; Watanabe, S.; Nikolaev, V. O.   & Sprenger, J. U. et al.​ (2015) 
    Cardiovascular Research, 107(1) pp. 184​-196​.​ DOI: https://doi.org/10.1093/cvr/cvv153 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper
    ​ ​Enhanced late INa induces proarrhythmogenic SR Ca leak in a CaMKII-dependent manner​
    Sag, C. M.; Mallwitz, A.; Wagner, S. ; Hartmann, N. ; Schotola, H.; Fischer, T. H.   & Ungeheuer, N. et al.​ (2014) 
    Journal of Molecular and Cellular Cardiology, 76 pp. 94​-105​.​ DOI: https://doi.org/10.1016/j.yjmcc.2014.08.016 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Diabetes increases mortality after myocardial infarction by oxidizing CaMKII​
    Luo, M.; Guan, X.; Luczak, E. D.; Lang, D.; Kutschke, W.; Gao, Z. & Yang, J. et al.​ (2013) 
    Journal of Clinical Investigation, 123(3) pp. 1262​-1274​.​ DOI: https://doi.org/10.1172/JCI65268 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Phosphodiesterase-2 Is Up-Regulated in Human Failing Hearts and Blunts β-Adrenergic Responses in Cardiomyocytes​
    Mehel, H.; Emons, J.; Vettel, C. ; Wittköpper, K.; Seppelt, D.; Dewenter, M.   & Lutz, S.  et al.​ (2013) 
    Journal of the American College of Cardiology, 62(17) pp. 1596​-1606​.​ DOI: https://doi.org/10.1016/j.jacc.2013.05.057 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease​
    Toischer, K. ; Hartmann, N. ; Wagner, S. ; Fischer, T. H. ; Herting, J. ; Danner, B. C.   & Sag, C. M. et al.​ (2013) 
    Journal of Molecular and Cellular Cardiology, 61 pp. 111​-122​.​ DOI: https://doi.org/10.1016/j.yjmcc.2013.03.021 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Ranolazine Maintained Sinus Rhythm in a Patient with Refractory Symptomatic Atrial Fibrillation​
    Sossalla, S. ; Sohns, C.; Seegers, J.; Lüthje, L. ; Vollmann, D. & Zabel, M. ​ (2013) 
    Cardiovascular Therapeutics, 31(5) pp. 303​-306​.​ DOI: https://doi.org/10.1111/1755-5922.12017 
    ​Details  DOI  PMID  PMC  WoS 

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