Prof. Dr. Ali El-Armouche

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  • 2019 | Journal Article | Research Paper
    ​ ​Protein kinase/phosphatase balance mediates the effects of increased late sodium current on ventricular calcium cycling​
    Eiringhaus, J. ; Herting, J. ; Schatter, F. ; Nikolaev, V. O. ; Sprenger, J.; Wang, Y. & Köhn, M. et al.​ (2019) 
    Basic Research in Cardiology, 114(2) pp. 13​.​ DOI: https://doi.org/10.1007/s00395-019-0720-7 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​The reduced activity of PP-1α under redox stress condition is a consequence of GSH-mediated transient disulfide formation​
    Singh, S.; Lämmle, S.; Giese, H.; Kämmerer, S.; Meyer-Roxlau, S. ; Alfar, E. A. & Dihazi, H.  et al.​ (2018) 
    Scientific Reports, 8(1) art. 17711​.​ DOI: https://doi.org/10.1038/s41598-018-36267-6 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure​
    Fischer, T. H. ; Eiringhaus, J. ; Dybkova, N.; Saadatmand, A.; Pabel, S. ; Weber, S. & Wang, Y. et al.​ (2018) 
    European Journal of Heart Failure, 20(12) pp. 1673​-1685​.​ DOI: https://doi.org/10.1002/ejhf.1297 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper
    ​ ​Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction​
    Vettel, C. ; Lindner, M.; Dewenter, M. ; Lorenz, K.; Schanbacher, C.; Riedel, M. & Lämmle, S. et al.​ (2017) 
    Circulation Research, 120(1) pp. 120​-132​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.116.310069 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4​
    Perera, R. K. ; Fischer, T. H. ; Wagner, M.; Dewenter, M. ; Vettel, C. ; Bork, N. I. & Maier, L. S.  et al.​ (2017) 
    Scientific Reports, 7(1) art. 15222​.​ DOI: https://doi.org/10.1038/s41598-017-15632-x 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper
    ​ ​Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure​
    Dewenter, M. ; Neef, S.; Vettel, C. ; Lämmle, S.; Beushausen, C.; Zelarayan, L. C.   & Katz, S. et al.​ (2017) 
    Circulation: Heart Failure, 10(5) art. e003840​.​ DOI: https://doi.org/10.1161/CIRCHEARTFAILURE.117.003840 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper
    ​ ​Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity​
    Neef, S.; Heijman, J.; Otte, K.; Dewenter, M. ; Saadatmand, A. R.; Meyer-Roxlau, S.   & Antos, C. L. et al.​ (2017) 
    Naunyn-Schmiedeberg's Archives of Pharmacology, 390(8) pp. 857​-862​.​ DOI: https://doi.org/10.1007/s00210-017-1376-1 
    ​Details  DOI  PMID  PMC 
  • 2015 | Journal Article | Research Paper
    ​ ​Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation​
    Godier-Furnemont, A. F. G.; Tiburcy, M. ; Wagner, E. ; Dewenter, M. ; Laemmle, S.; El-Armouche, A.   & Lehnart, S. E.  et al.​ (2015) 
    Biomaterials, 60 pp. 82​-91​.​ DOI: https://doi.org/10.1016/j.biomaterials.2015.03.055 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper | 
    ​ ​I-1-deficiency negatively impacts survival in a cardiomyopathy mouse model​
    Friedrich, F. W.; Sotoud, H.; Geertz, B.; Weber, S.; Flenner, F.; Reischmann, S. & Eschenhagen, T.  et al.​ (2015) 
    IJC Heart & Vasculature, 8 pp. 87​-94​.​ DOI: https://doi.org/10.1016/j.ijcha.2015.05.010 
    ​Details  DOI  PMID  PMC 
  • 2015 | Journal Article | Research Paper
    ​ ​Microdomain switch of cGMP-regulated phosphodiesterases leads to ANP-induced augmentation of β-adrenoceptor-stimulated contractility in early cardiac hypertrophy​
    Perera, R. K. ; Sprenger, J. U.; Steinbrecher, J. H.; Hübscher, D. ; Lehnart, S. E. ; Abesser, M. & Schuh, K. et al.​ (2015) 
    Circulation Research, 116(8) pp. 1304​-1311​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.116.306082 
    ​Details  DOI  PMID  PMC 
  • 2014 | Journal Article | Research Paper
    ​ ​PDE2-mediated cAMP hydrolysis accelerates cardiac fibroblast to myofibroblast conversion and is antagonized by exogenous activation of cGMP signaling pathways​
    Vettel, C. ; Lämmle, S.; Ewens, S.; Cervirgen, C.; Emmons, J.; Ongherth, A. & Dewenter, M.  et al.​ (2014) 
    American Journal of Physiology - Heart and Circulatory Physiology, 306(8) pp. H1246​-H1252​.​ DOI: https://doi.org/10.1152/ajpheart.00852.2013 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper | 
    ​ ​Erythropoietin Responsive Cardiomyogenic Cells Contribute to Heart Repair Post Myocardial Infarction​
    Zafiriou, M. P. ; Noack, C. ; Unsoeld, B. W.; Didie, M. ; Pavlova, E.; Fischer, H. J.   & Reichardt, H. M.  et al.​ (2014) 
    STEM CELLS, 32(9) pp. 2480​-2491​.​ DOI: https://doi.org/10.1002/stem.1741 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper
    ​ ​Dopamine and Lipophilic Derivates Protect Cardiomyocytes against Cold Preservation Injury​
    Vettel, C.; Hottenrott, M. C.; Spindler, R.; Benck, U.; Schnuelle, P.; Tsagogiorgas, C. & Kraemer, B. et al.​ (2014) 
    Journal of Pharmacology and Experimental Therapeutics, 348(1) pp. 77​-85​.​ DOI: https://doi.org/10.1124/jpet.113.207001 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper
    ​ ​Paradoxical Effects on Force Generation after Efficient beta 1-Adrenoceptor Knockdown in Reconstituted Heart Tissue​
    Neuber, C.; Mueller, O. J.; Hansen, F. C.; Eder, A.; Witten, A.; Ruehle, F. & Stoll, M. et al.​ (2014) 
    Journal of Pharmacology and Experimental Therapeutics, 349(1) pp. 39​-46​.​ DOI: https://doi.org/10.1124/jpet.113.210898 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper
    ​ ​Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes​
    Slimane, Z. H.; Bedioune, I.; Lechene, P.; Varin, A.; Lefebvre, F.; Mateo, P. & Domergue-Dupont, V. et al.​ (2014) 
    Cardiovascular Research, 102(1) pp. 97​-106​.​ DOI: https://doi.org/10.1093/cvr/cvu029 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper | 
    ​ ​Enhanced Ca2+ influx through cardiac L-type Ca2+ channels maintains the systolic Ca2+ transient in early cardiac atrophy induced by mechanical unloading​
    Schwoerer, A. P.; Neef, S.; Broichhausen, I.; Jacubeit, J.; Tiburcy, M. ; Wagner, M. & Biermann, D. et al.​ (2013) 
    Pflügers Archiv - European Journal of Physiology, 465(12) pp. 1763​-1773​.​ DOI: https://doi.org/10.1007/s00424-013-1316-y 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper | 
    ​ ​The Four and a Half LIM-Domain 2 Controls Early Cardiac Cell Commitment and Expansion Via Regulating β-Catenin-Dependent Transcription​
    Renger, A.; Zafiriou, M.-P. ; Noack, C. ; Pavlova, E.; Becker, A. ; Sharkova, K. & Bergmann, M. W. et al.​ (2013) 
    Stem Cells, 31(5) pp. 928​-940​.​ DOI: https://doi.org/10.1002/stem.1332 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Parthenogenetic stem cells for tissue-engineered heart repair​
    Didie, M. ; Christalla, P.; Rubart, M.; Muppala, V. ; Doeker, S.; Unsoeld, B. W. & El-Armouche, A.  et al.​ (2013) 
    Journal of Clinical Investigation, 123(3) pp. 1285​-1298​.​ DOI: https://doi.org/10.1172/JCI66854 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in CaMKII delta-KO mice​
    Neef, S.; Sag, C. M.; Daut, M.; Baeumer, H.; Grefe, C.; El-Armouche, A.   & DeSantiago, J. et al.​ (2013) 
    Journal of Molecular and Cellular Cardiology, 59 pp. 107​-116​.​ DOI: https://doi.org/10.1016/j.yjmcc.2013.02.014 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper | 
    ​ ​Development of a Colorimetric and a Fluorescence Phosphatase-Inhibitor Assay Suitable for Drug Discovery Approaches​
    Sotoud, H.; Gribbon, P.; Ellinger, B.; Reinshagen, J.; Boknik, P.; Kattner, L. & El-Armouche, A.  et al.​ (2013) 
    Journal of Biomolecular Screening, 18(8) pp. 899​-909​.​ DOI: https://doi.org/10.1177/1087057113486000 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Preservation of left ventricular function and morphology in volume-loaded versus volume-unloaded heterotopic heart transplants​
    Didie, M. ; Biermann, D.; Buchert, R.; Hess, A.; Wittkoepper, K.; Christalla, P. & Doeker, S. et al.​ (2013) 
    American Journal of Physiology - Heart and Circulatory Physiology, 305(4) pp. H533​-H541​.​ DOI: https://doi.org/10.1152/ajpheart.00218.2013 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Phosphodiesterase-2 Is Up-Regulated in Human Failing Hearts and Blunts β-Adrenergic Responses in Cardiomyocytes​
    Mehel, H.; Emons, J.; Vettel, C. ; Wittköpper, K.; Seppelt, D.; Dewenter, M.   & Lutz, S.  et al.​ (2013) 
    Journal of the American College of Cardiology, 62(17) pp. 1596​-1606​.​ DOI: https://doi.org/10.1016/j.jacc.2013.05.057 
    ​Details  DOI  PMID  PMC  WoS 

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