Prof. Dr. Niels Grabe

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  • 2023 Book Chapter
    ​ ​Reusing Biomedical Data as Agreed – Towards Structured Metadata for Data Use Agreements​
    Bönisch, C.; Hanß, S.; Spicher, N. ; Sax, U.  & Krefting, D. ​ (2023)
    In:​Röhrig, Rainer; Grabe, Niels; Haag, Martin; Hübner, Ursula; Sax, Ulrich; Schmidt, Carsten Oliver; Sedlmayr, Martin, et al.​ (Eds.), German Medical Data Sciences 2023 – Science. Close to People. : Proceedings of the 68th Annual Meeting of the German Association of Medical Informatics, Biometry, and Epidemiology e.V. (gmds) 2023 in Heilbronn, Germany. ​IOS Press. DOI: https://doi.org/10.3233/SHTI230690 
    Details  DOI 
  • 2019 Journal Article | Research Paper
    ​ ​Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas​
    Rapp, C.; Dettling, S.; Liu, F.; Ull, A. T.; Warta, R.; Jungk, C. & Roesch, S. et al.​ (2019) 
    Clinical Cancer Research25(17) pp. 5260​-5270​.​ DOI: https://doi.org/10.1158/1078-0432.CCR-19-0389 
    Details  DOI  PMID  PMC 
  • 2019 Journal Article | Research Paper
    ​ ​Robust and accurate quantification of biomarkers of immune cells in lung cancer micro-environment using deep convolutional neural networks​
    Aprupe, L.; Litjens, G.; Brinker, T. J.; van der Laak, J. & Grabe, N. ​ (2019) 
    PeerJ7 art. e6335​.​ DOI: https://doi.org/10.7717/peerj.6335 
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  • 2019 Journal Article
    ​ ​Identification and regulation of the long non-coding RNA Heat2 in heart failure​
    Boeckel, J.-N.; Perret, M. F.; Glaser, S. F.; Seeger, T.; Heumüller, A. W.; Chen, W. & John, D. et al.​ (2019) 
    Journal of Molecular and Cellular Cardiology126 pp. 13​-22​.​ DOI: https://doi.org/10.1016/j.yjmcc.2018.11.004 
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  • 2018 Journal Article | Research Paper
    ​ ​Digitale Pathologie in der Immunonkologie – Aktuelle Chancen und Herausforderungen: ​Überblick zur Analyse von Immunzellinfiltraten mittels Whole Slide Imaging​
    Grabe, N. ; Roth, W. & Foersch, S.​ (2018) 
    Der Pathologe39(6) pp. 539​-545​.​ DOI: https://doi.org/10.1007/s00292-018-0540-9 
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  • 2018 Journal Article | Research Paper
    ​ ​Altered density, composition and microanatomical distribution of infiltrating immune cells in cutaneous squamous cell carcinoma of organ transplant recipients​
    Strobel, S. B.; Safferling, K.; Lahrmann, B.; Hoffmann, J. H.; Enk, A. H.; Hadaschik, E. N. & Grabe, N.  et al.​ (2018) 
    British Journal of Dermatology179(2) pp. 405​-412​.​ DOI: https://doi.org/10.1111/bjd.16477 
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  • 2018 Journal Article | Research Paper
    ​ ​Skin Cancer Classification Using Convolutional Neural Networks: Systematic Review​
    Brinker, T. J.; Hekler, A.; Utikal, J. S.; Grabe, N. ; Schadendorf, D.; Klode, J. & Berking, C. et al.​ (2018) 
    Journal of Medical Internet Research20(10) art. e11936​.​ DOI: https://doi.org/10.2196/11936 
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  • 2018 Journal Article | Research Paper
    ​ ​High numbers of PDCD1 (PD-1)-positive T cells and B2M mutations in microsatellite-unstable colorectal cancer​
    Janikovits, J.; Müller, M.; Krzykalla, J.; Körner, S.; Echterdiek, F.; Lahrmann, B. & Grabe, N.  et al.​ (2018) 
    OncoImmunology7(2) art. e1390640​.​ DOI: https://doi.org/10.1080/2162402X.2017.1390640 
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  • 2018 Journal Article | Research Paper
    ​ ​Tumor Cell Load and Heterogeneity Estimation From Diffusion-Weighted MRI Calibrated With Histological Data: an Example From Lung Cancer​
    Yin, Y.; Sedlaczek, O.; Muller, B.; Warth, A.; Gonzalez-Vallinas, M.; Lahrmann, B. & Grabe, N.  et al.​ (2018) 
    IEEE Transactions on Medical Imaging37(1) pp. 35​-46​.​ DOI: https://doi.org/10.1109/TMI.2017.2698525 
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  • 2018 Journal Article | Research Paper
    ​ ​Identification of CRKII, CFL1, CNTN1, NME2, and TKT as Novel and Frequent T-Cell Targets in Human IDH-Mutant Glioma​
    Dettling, S.; Stamova, S.; Warta, R.; Schnölzer, M.; Rapp, C.; Rathinasamy, A. & Reuss, D. et al.​ (2018) 
    Clinical Cancer Research24(12) pp. 2951​-2962​.​ DOI: https://doi.org/10.1158/1078-0432.CCR-17-1839 
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  • 2018 Journal Article | Research Paper
    ​ ​Teledermatology: Comparison of Store-and-Forward Versus Live Interactive Video Conferencing​
    Brinker, T. J.; Hekler, A.; von Kalle, C.; Schadendorf, D.; Esser, S.; Berking, C. & Zacher, M. T. et al.​ (2018) 
    Journal of Medical Internet Research20(10) art. e11871​.​ DOI: https://doi.org/10.2196/11871 
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  • 2018 Journal Article | Research Paper
    ​ ​Comparison of the Reverse-Remodeling Effect of Pharmacological Soluble Guanylate Cyclase Activation With Pressure Unloading in Pathological Myocardial Left Ventricular Hypertrophy​
    Ruppert, M.; Korkmaz-Icöz, S.; Li, S.; Brlecic, P.; Németh, B. T.; Oláh, A. & Horváth, E. M. et al.​ (2018) 
    Frontiers in Physiology9 art. 1869​.​ DOI: https://doi.org/10.3389/fphys.2018.01869 
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  • 2018 Journal Article | Research Paper
    ​ ​Cortactin expression: Association with disease progression and survival in oral squamous cell carcinoma​
    Horn, D.; Gross, M.; Dyckhoff, G.; Fuchs, J.; Grabe, N. ; Weichert, W. & Herpel, E. et al.​ (2018) 
    Head & Neck40(12) pp. 2685​-2694​.​ DOI: https://doi.org/10.1002/hed.25515 
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  • 2018 Journal Article | Research Paper
    ​ ​Astrocytic glutamine synthetase is expressed in the neuronal somatic layers and down-regulated proportionally to neuronal loss in the human epileptic hippocampus​
    Papageorgiou, I. E.; Valous, N. A.; Lahrmann, B.; Janova, H.; Klaft, Z.-J.; Koch, A. & Schneider, U. C et al.​ (2018) 
    Glia66(5) pp. 920​-933​.​ DOI: https://doi.org/10.1002/glia.23292 
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  • 2017 Journal Article | Research Paper
    ​ ​MAGE expression in head and neck squamous cell carcinoma primary tumors, lymph node metastases and respective recurrences-implications for immunotherapy​
    Laban, S.; Giebel, G.; Klümper, N.; Schröck, A.; Doescher, J.; Spagnoli, G. & Thierauf, J. et al.​ (2017) 
    Oncotarget8(9) pp. 14719​-14735​.​ DOI: https://doi.org/10.18632/oncotarget.14830 
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  • 2017 Journal Article | Research Paper
    ​ ​106 Three-dimensional agent-based modeling of the human epidermal structure and barrier function with realistic cell morphology​
    Stamatas, G.; Sütterlin, T.; Tsingos, E.; Bensaci, J. & Grabe, N. ​ (2017) 
    Journal of Investigative Dermatology137(10) pp. S211​.​ DOI: https://doi.org/10.1016/j.jid.2017.07.416 
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  • 2017 Journal Article | Research Paper
    ​ ​Identification of T cell target antigens in glioblastoma stem-like cells using an integrated proteomics-based approach in patient specimens​
    Rapp, C.; Warta, R.; Stamova, S.; Nowrouzi, A.; Geisenberger, C.; Gal, Z. & Roesch, S. et al.​ (2017) 
    Acta Neuropathologica134(2) pp. 297​-316​.​ DOI: https://doi.org/10.1007/s00401-017-1702-1 
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  • 2016 Journal Article | Research Paper
    ​ ​In-depth tissue profiling using multiplexed immunohistochemical consecutive staining on single slide​
    Remark, R.; Merghoub, T.; Grabe, N. ; Litjens, G.; Damotte, D.; Wolchok, J. D. & Merad, M. et al.​ (2016) 
    Science Immunology1(1) art. aaf6925​.​ DOI: https://doi.org/10.1126/sciimmunol.aaf6925 
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  • 2016 Journal Article | Research Paper
    ​ ​Spatial intratumoral heterogeneity of proliferation in immunohistochemical images of solid tumors​
    Valous, N. A.; Lahrmann, B.; Halama, N.; Bergmann, F.; Jäger, D. & Grabe, N. ​ (2016) 
    Medical Physics43(6) pp. 2936​-2947​.​ DOI: https://doi.org/10.1118/1.4949003 
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  • 2016 Journal Article | Research Paper
    ​ ​Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients​
    Halama, N.; Zoernig, I.; Berthel, A.; Kahlert, C.; Klupp, F.; Suarez-Carmona, M. & Suetterlin, T. et al.​ (2016) 
    Cancer Cell29(4) pp. 587​-601​.​ DOI: https://doi.org/10.1016/j.ccell.2016.03.005 
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  • 2016 Journal Article | Research Paper
    ​ ​Combined Treatment of ATRA with Epigenetic Drugs Increases Aggressiveness of Glioma Xenografts​
    Schmoch, T.; Gal, Z.; Mock, A.; Mossemann, J.; Lahrmann, B.; Grabe, N.   & Schmezer, P. et al.​ (2016) 
    Anticancer Research36(4) pp. 1489​-1496​.​
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  • 2016 Journal Article | Research Paper
    ​ ​Transcriptomic analysis of aggressive meningiomas identifies PTTG1 and LEPR as prognostic biomarkers independent of WHO grade​
    Schmidt, M.; Mock, A.; Jungk, C.; Sahm, F.; Ull, A. T.; Warta, R. & Lamszus, K. et al.​ (2016) 
    Oncotarget7(12) pp. 14551​-14568​.​ DOI: https://doi.org/10.18632/oncotarget.7396 
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  • 2016 Journal Article | Research Paper
    ​ ​Low density of FOXP3-positive T cells in normal colonic mucosa is related to the presence of beta2-microglobulin mutations in Lynch syndrome-associated colorectal cancer​
    Echterdiek, F.; Janikovits, J.; Staffa, L.; Müller, M.; Lahrmann, B.; Frühschütz, M. & Hartog, B. et al.​ (2016) 
    OncoImmunology5(2) art. e1075692​.​ DOI: https://doi.org/10.1080/2162402X.2015.1075692 
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  • 2016 Journal Article | Research Paper
    ​ ​Directed random walks and constraint programming reveal active pathways in hepatocyte growth factor signaling​
    Kittas, A.; Delobelle, A.; Schmitt, S.; Breuhahn, K.; Guziolowski, C. & Grabe, N. ​ (2016) 
    The FEBS Journal283(2) pp. 350​-360​.​ DOI: https://doi.org/10.1111/febs.13580 
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  • 2016 Conference Paper
    ​ ​Abstract A085: Immune evasion and PD-1-positive T cell infiltration in DNA mismatch repair-deficient colorectal cancer​
    Kloor, M.; Janikovits, J.; Krzykalla, J.; Benner, A.; Grabe, N. ; Echterdiek, F. & Mueller, M. et al.​ (2016)
    pp. A085​-A085. ​Second CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival​, New York, NY. DOI: https://doi.org/10.1158/2326-6066.IMM2016-A085 
    Details  DOI 
  • 2016 Journal Article | Research Paper
    ​ ​Patch-Based Nonlinear Image Registration for Gigapixel Whole Slide Images​
    Lotz, J. ; Olesch, J.; Muller, B.; Polzin, T.; Galuschka, P.; Lotz, J. M. & Heldmann, S. et al.​ (2016) 
    IEEE Transactions on Bio-Medical Engineering63(9) pp. 1812​-1819​.​ DOI: https://doi.org/10.1109/TBME.2015.2503122 
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  • 2016 Journal Article | Research Paper
    ​ ​Reduced Microvascular Density in Omental Biopsies of Children with Chronic Kidney Disease​
    Burkhardt, D.; Bartosova, M.; Schaefer, B.; Grabe, N. ; Lahrmann, B.; Nasser, H. & Freise, C. et al.​ (2016) 
    PLoS One11(11) art. e0166050​.​ DOI: https://doi.org/10.1371/journal.pone.0166050 
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  • 2016 Journal Article | Research Paper
    ​ ​Identification of immunotherapeutic targets by genomic profiling of rectal NET metastases​
    Koşaloğlu, Z.; Zörnig, I.; Halama, N.; Kaiser, I.; Buchhalter, I.; Grabe, N.   & Eils, R. et al.​ (2016) 
    OncoImmunology5(11) art. e1213931​.​ DOI: https://doi.org/10.1080/2162402X.2016.1213931 
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  • 2016 Journal Article | Research Paper
    ​ ​LOC283731 promoter hypermethylation prognosticates survival after radiochemotherapy in IDH1 wild-type glioblastoma patients​
    Mock, A.; Geisenberger, C.; Orlik, C.; Warta, R.; Schwager, C.; Jungk, C. & Dutruel, C. et al.​ (2016) 
    International Journal of Cancer139(2) pp. 424​-432​.​ DOI: https://doi.org/10.1002/ijc.30069 
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  • 2015 Journal Article | Research Paper
    ​ ​Role of NR1I2 (pregnane X receptor) polymorphisms in head and neck squamous cell carcinoma​
    Reuter, T.; Warta, R.; Theile, D.; Meid, A. D.; Rigalli, J. P.; Mogler, C. & Herpel, E. et al.​ (2015) 
    Naunyn-Schmiedeberg's Archives of Pharmacology388(11) pp. 1141​-1150​.​ DOI: https://doi.org/10.1007/s00210-015-1150-1 
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  • 2015 Journal Article | Research Paper
    ​ ​Loss of SOX2 expression induces cell motility via vimentin up-regulation and is an unfavorable risk factor for survival of head and neck squamous cell carcinoma​
    Bayo, P.; Jou, A.; Stenzinger, A.; Shao, C.; Gross, M.; Jensen, A. & Grabe, N.  et al.​ (2015) 
    Molecular Oncology9(8) pp. 1704​-1719​.​ DOI: https://doi.org/10.1016/j.molonc.2015.05.006 
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  • 2015 Journal Article | Research Paper
    ​ ​Molecular profiling of long-term survivors identifies a subgroup of glioblastoma characterized by chromosome 19/20 co-gain​
    Geisenberger, C.; Mock, A.; Warta, R.; Rapp, C.; Schwager, C.; Korshunov, A. & Nied, A.-K. et al.​ (2015) 
    Acta Neuropathologica130(3) pp. 419​-434​.​ DOI: https://doi.org/10.1007/s00401-015-1427-y 
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  • 2015 Journal Article | Research Paper
    ​ ​Characterization of Skin Aging-Associated Secreted Proteins (SAASP) Produced by Dermal Fibroblasts Isolated from Intrinsically Aged Human Skin​
    Waldera Lupa, D. M.; Kalfalah, F.; Safferling, K.; Boukamp, P.; Poschmann, G.; Volpi, E. & Götz-Rösch, C. et al.​ (2015) 
    Journal of Investigative Dermatology135(8) pp. 1954​-1968​.​ DOI: https://doi.org/10.1038/jid.2015.120 
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  • 2015 Journal Article | Research Paper
    ​ ​CytoASP: a Cytoscape app for qualitative consistency reasoning, prediction and repair in biological networks​
    Kittas, A.; Barozet, A.; Sereshti, J.; Grabe, N.   & Tsoka, S.​ (2015) 
    BMC Systems Biology9(1) pp. 34​.​ DOI: https://doi.org/10.1186/s12918-015-0179-6 
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  • 2015 Journal Article | Research Paper
    ​ ​Phosphorylation of AKT(Ser473) serves as an independent prognostic marker for radiosensitivity in advanced head and neck squamous cell carcinoma​
    Freudlsperger, C.; Horn, D.; Weißfuß, S.; Weichert, W.; Weber, K.-J.; Saure, D. & Sharma, S. et al.​ (2015) 
    International Journal of Cancer136(12) pp. 2775​-2785​.​ DOI: https://doi.org/10.1002/ijc.29328 
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  • 2015 Journal Article | Research Paper
    ​ ​High S100A8 and S100A12 protein expression is a favorable prognostic factor for survival of oropharyngeal squamous cell carcinoma​
    Funk, S.; Mark, R.; Bayo, P.; Flechtenmacher, C.; Grabe, N. ; Angel, P. & Plinkert, P. K. et al.​ (2015) 
    International Journal of Cancer136(9) pp. 2037​-2046​.​ DOI: https://doi.org/10.1002/ijc.29262 
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  • 2015 Journal Article | Research Paper
    ​ ​Regulation and function of Myb-binding protein 1A (MYBBP1A) in cellular senescence and pathogenesis of head and neck cancer​
    George, B.; Horn, D.; Bayo, P.; Zaoui, K.; Flechtenmacher, C.; Grabe, N.   & Plinkert, P. et al.​ (2015) 
    Cancer Letters358(2) pp. 191​-199​.​ DOI: https://doi.org/10.1016/j.canlet.2014.12.042 
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  • 2015 Journal Article | Research Paper
    ​ ​Prognostic significance of spontaneous antibody responses against tumor-associated antigens in malignant melanoma patients​
    Zörnig, I.; Halama, N.; Lorenzo Bermejo, J.; Ziegelmeier, C.; Dickes, E.; Migdoll, A. & Kaiser, I. et al.​ (2015) 
    International Journal of Cancer136(1) pp. 138​-151​.​ DOI: https://doi.org/10.1002/ijc.28980 
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  • 2015 Journal Article | Research Paper
    ​ ​Mismatch repair-deficient crypt foci in Lynch syndrome--molecular alterations and association with clinical parameters​
    Staffa, L.; Echterdiek, F.; Nelius, N.; Benner, A.; Werft, W.; Lahrmann, B. & Grabe, N.  et al.​ (2015) 
    PLoS One10(3) art. e0121980​.​ DOI: https://doi.org/10.1371/journal.pone.0121980 
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  • 2014 Journal Article | Research Paper
    ​ ​Pathogenic role of the eight probably/possibly carcinogenic HPV types 26, 53, 66, 67, 68, 70, 73 and 82 in cervical cancer​
    Halec, G.; Alemany, L.; Lloveras, B.; Schmitt, M.; Alejo, M.; Bosch, F. X. & Tous, S. et al.​ (2014) 
    The Journal of Pathology234(4) pp. 441​-451​.​ DOI: https://doi.org/10.1002/path.4405 
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  • 2014 Journal Article | Research Paper
    ​ ​Aberrant self-renewal and quiescence contribute to the aggressiveness of glioblastoma​
    Campos, B.; Gal, Z.; Baader, A.; Schneider, T.; Sliwinski, C.; Gassel, K. & Bageritz, J. et al.​ (2014) 
    The Journal of Pathology234(1) pp. 23​-33​.​ DOI: https://doi.org/10.1002/path.4366 
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  • 2014 Journal Article | Research Paper
    ​ ​Antiproliferative efficacies but minor drug transporter inducing effects of paclitaxel, cisplatin, or 5-fluorouracil in a murine xenograft model for head and neck squamous cell carcinoma​
    Theile, D.; Gal, Z.; Warta, R.; Rigalli, J. P.; Lahrmann, B.; Grabe, N.   & Herold-Mende, C. et al.​ (2014) 
    Cancer Biology & Therapy15(4) pp. 436​-442​.​ DOI: https://doi.org/10.4161/cbt.27632 
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  • 2014 Journal Article | Research Paper
    ​ ​Association of drug transporter expression with mortality and progression-free survival in stage IV head and neck squamous cell carcinoma​
    Warta, R.; Theile, D.; Mogler, C.; Herpel, E.; Grabe, N. ; Lahrmann, B. & Plinkert, P. K. et al.​ (2014) 
    PLoS One9(9) art. e108908​.​ DOI: https://doi.org/10.1371/journal.pone.0108908 
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  • 2013 Journal Article | Research Paper
    ​ ​Wound healing revised: a novel reepithelialization mechanism revealed by in vitro and in silico models​
    Safferling, K.; Sütterlin, T.; Westphal, K.; Ernst, C.; Breuhahn, K.; James, M. & Jäger, D. et al.​ (2013) 
    The Journal of Cell Biology203(4) pp. 691​-709​.​ DOI: https://doi.org/10.1083/jcb.201212020 
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  • 2013 Journal Article | Research Paper
    ​ ​Identification of oropharyngeal squamous cell carcinomas with active HPV16 involvement by immunohistochemical analysis of the retinoblastoma protein pathway​
    Holzinger, D.; Flechtenmacher, C.; Henfling, N.; Kaden, I.; Grabe, N. ; Lahrmann, B. & Schmitt, M. et al.​ (2013) 
    International Journal of Cancer133(6) pp. 1389​-1399​.​ DOI: https://doi.org/10.1002/ijc.28142 
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  • 2013 Journal Article | Research Paper
    ​ ​HPV-related methylation signature predicts survival in oropharyngeal squamous cell carcinomas​
    Kostareli, E.; Holzinger, D.; Bogatyrova, O.; Hielscher, T.; Wichmann, G.; Keck, M. & Lahrmann, B. et al.​ (2013) 
    The Journal of Clinical Investigation123(6) pp. 2488​-2501​.​ DOI: https://doi.org/10.1172/JCI67010 
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  • 2013 Journal Article | Research Paper
    ​ ​Sequence mutations of the substrate binding pocket of stem cell factor and multidrug resistance protein ABCG2 in renal cell cancer: a possible link to treatment resistance​
    Zoernig, I.; Ziegelmeier, C.; Lahrmann, B.; Grabe, N. ; Jäger, D. & Halama, N.​ (2013) 
    Oncology Reports29(5) pp. 1697​-1700​.​ DOI: https://doi.org/10.3892/or.2013.2324 
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  • 2013 Journal Article | Research Paper
    ​ ​Hepatic metastases of colorectal cancer are rather homogeneous but differ from primary lesions in terms of immune cell infiltration​
    Halama, N.; Spille, A.; Lerchl, T.; Brand, K.; Herpel, E.; Welte, S. & Keim, S. et al.​ (2013) 
    OncoImmunology2(4) art. e24116​.​ DOI: https://doi.org/10.4161/onci.24116 
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  • 2013 Journal Article | Research Paper
    ​ ​Multistage histopathological image segmentation of Iba1-stained murine microglias in a focal ischemia model: methodological workflow and expert validation​
    Valous, N. A.; Lahrmann, B.; Zhou, W.; Veltkamp, R. & Grabe, N. ​ (2013) 
    Journal of Neuroscience Methods213(2) pp. 250​-262​.​ DOI: https://doi.org/10.1016/j.jneumeth.2012.12.017 
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  • 2013 Journal Article | Research Paper
    ​ ​Submaxillary gland androgen-regulated protein 3A expression is an unfavorable risk factor for the survival of oropharyngeal squamous cell carcinoma patients after surgery​
    Koffler, J.; Holzinger, D.; Sanhueza, G. A.; Flechtenmacher, C.; Zaoui, K.; Lahrmann, B. & Grabe, N.  et al.​ (2013) 
    European Archives of Oto-Rhino-Laryngology and Head & Neck270(4) pp. 1493​-1500​.​ DOI: https://doi.org/10.1007/s00405-012-2201-6 
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  • 2013 Journal Article | Research Paper
    ​ ​Bridging the scales: semantic integration of quantitative SBML in graphical multi-cellular models and simulations with EPISIM and COPASI​
    Sütterlin, T.; Kolb, C.; Dickhaus, H.; Jäger, D. & Grabe, N. ​ (2013) 
    Bioinformatics29(2) pp. 223​-229​.​ DOI: https://doi.org/10.1093/bioinformatics/bts659 
    Details  DOI  PMID  PMC 
  • 2013 Journal Article | Research Paper
    ​ ​Postischemic brain infiltration of leukocyte subpopulations differs among murine permanent and transient focal cerebral ischemia models​
    Zhou, W.; Liesz, A.; Bauer, H.; Sommer, C.; Lahrmann, B.; Valous, N. & Grabe, N.  et al.​ (2013) 
    Brain Pathology23(1) pp. 34​-44​.​ DOI: https://doi.org/10.1111/j.1750-3639.2012.00614.x 
    Details  DOI  PMID  PMC 
  • 2013 Journal Article | Research Paper
    ​ ​Semantic focusing allows fully automated single-layer slide scanning of cervical cytology slides​
    Lahrmann, B.; Valous, N. A.; Eisenmann, U.; Wentzensen, N. & Grabe, N. ​ (2013) 
    PLoS One8(4) art. e61441​.​ DOI: https://doi.org/10.1371/journal.pone.0061441 
    Details  DOI  PMID  PMC 
  • 2013 Journal Article | Research Paper
    ​ ​Stathmin regulates keratinocyte proliferation and migration during cutaneous regeneration​
    Schmitt, S.; Safferling, K.; Westphal, K.; Hrabowski, M.; Müller, U.; Angel, P. & Wiechert, L. et al.​ (2013) 
    PLoS One8(9) art. e75075​.​ DOI: https://doi.org/10.1371/journal.pone.0075075 
    Details  DOI  PMID  PMC 
  • 2012 Journal Article | Research Paper
    ​ ​Expression analysis of aldehyde dehydrogenase 1A1 (ALDH1A1) in colon and rectal cancer in association with prognosis and response to chemotherapy​
    Kahlert, C.; Gaitzsch, E.; Steinert, G.; Mogler, C.; Herpel, E.; Hoffmeister, M. & Jansen, L. et al.​ (2012) 
    Annals of Surgical Oncology19(13) pp. 4193​-4201​.​ DOI: https://doi.org/10.1245/s10434-012-2518-9 
    Details  DOI  PMID  PMC 
  • 2012 Journal Article | Research Paper
    ​ ​In silico accelerated identification of structurally conserved CD8+ and CD4+ T-cell epitopes in high-risk HPV types​
    Gupta, S. K.; Srivastava, M.; Akhoon, B. A.; Gupta, S. K. & Grabe, N. ​ (2012) 
    Infection Genetics and Evolution12(7) pp. 1513​-1518​.​ DOI: https://doi.org/10.1016/j.meegid.2012.02.022 
    Details  DOI  PMID  PMC 
  • 2012 Journal Article | Research Paper
    ​ ​Automatic generation of causal networks linking growth factor stimuli to functional cell state changes​
    Guziolowski, C.; Kittas, A.; Dittmann, F. & Grabe, N. ​ (2012) 
    The FEBS Journal279(18) pp. 3462​-3474​.​ DOI: https://doi.org/10.1111/j.1742-4658.2012.08616.x 
    Details  DOI  PMID  PMC 
  • 2012 Journal Article | Research Paper
    ​ ​Sequential metastases of colorectal cancer: Immunophenotypes and spatial distributions of infiltrating immune cells in relation to time and treatments​
    Keim, S.; Zoernig, I.; Spille, A.; Lahrmann, B.; Brand, K.; Herpel, E. & Grabe, N.  et al.​ (2012) 
    OncoImmunology1(5) pp. 593​-599​.​ DOI: https://doi.org/10.4161/onci.20179 
    Details  DOI  PMID  PMC 
  • 2012 Journal Article | Research Paper
    ​ ​The local immunological microenvironment in colorectal cancer as a prognostic factor for treatment decisions in the clinic: The way ahead​
    Halama, N.; Zoernig, I.; Grabe, N.   & Jaeger, D.​ (2012) 
    OncoImmunology1(1) pp. 62​-66​.​ DOI: https://doi.org/10.4161/onci.1.1.18460 
    Details  DOI  PMID  PMC 
  • 2012 Conference Paper
    ​ ​Abstract 396: Sequential metastases of colorectal cancer: Treatment, immunophenotypes and spatial distributions of infiltrating immune cells​
    Halama, N.; Keim, S.; Zoernig, I.; Schirmacher, P.; Grabe, N.   & Jaeger, D.​ (2012)
    ​Proceedings pp. 396​-396. ​AACR 103rd Annual Meeting 2012​, Chicago, IL. DOI: https://doi.org/10.1158/1538-7445.AM2012-396 
    Details  DOI 
  • 2012 Conference Paper
    ​ ​Abstract 4923: Understanding cancer invasion by the systems biological analysis of collective cell migration in 3D tissue models​
    Grabe, N. ; Safferling, K.; Westphal, K.; Guziolowski, C.; Kittas, A.; Ernst, C. & Halama, N. et al.​ (2012)
    pp. 4923​-4923. ​AACR 103rd Annual Meeting​, Chicago, IL. DOI: https://doi.org/10.1158/1538-7445.AM2012-4923 
    Details  DOI 
  • 2011 Journal Article | Research Paper
    ​ ​Localization and density of immune cells in the invasive margin of human colorectal cancer liver metastases are prognostic for response to chemotherapy​
    Halama, N.; Michel, S.; Kloor, M.; Zoernig, I.; Benner, A.; Spille, A. & Pommerencke, T. et al.​ (2011) 
    Cancer Research71(17) pp. 5670​-5677​.​ DOI: https://doi.org/10.1158/0008-5472.CAN-11-0268 
    Details  DOI  PMID  PMC 
  • 2011 Journal Article | Research Paper
    ​ ​Aberrant expression of retinoic acid signaling molecules influences patient survival in astrocytic gliomas​
    Campos, B.; Centner, F.-S.; Bermejo, J. L.; Ali, R.; Dorsch, K.; Wan, F. & Felsberg, J. et al.​ (2011) 
    The American Journal of Pathology178(5) pp. 1953​-1964​.​ DOI: https://doi.org/10.1016/j.ajpath.2011.01.051 
    Details  DOI  PMID  PMC 
  • 2011 Journal Article | Research Paper
    ​ ​Association of stem cell-related markers and survival in astrocytic gliomas​
    Wan, F.; Herold-Mende, C.; Campos, B.; Centner, F.-S.; Dictus, C.; Becker, N. & Devens, F. et al.​ (2011) 
    Biomarkers16(2) pp. 136​-143​.​ DOI: https://doi.org/10.3109/1354750X.2010.536256 
    Details  DOI  PMID  PMC 
  • 2011 Journal Article | Research Paper
    ​ ​Natural killer cells are scarce in colorectal carcinoma tissue despite high levels of chemokines and cytokines​
    Halama, N.; Braun, M.; Kahlert, C.; Spille, A.; Quack, C.; Rahbari, N. & Koch, M. et al.​ (2011) 
    Clinical Cancer Research17(4) pp. 678​-689​.​ DOI: https://doi.org/10.1158/1078-0432.CCR-10-2173 
    Details  DOI  PMID  PMC 
  • 2011 Journal Article | Research Paper
    ​ ​Expression of nuclear receptor corepressors and class I histone deacetylases in astrocytic gliomas​
    Campos, B.; Bermejo, J. L.; Han, L.; Felsberg, J.; Ahmadi, R.; Grabe, N.   & Reifenberger, G. et al.​ (2011) 
    Cancer Science102(2) pp. 387​-392​.​ DOI: https://doi.org/10.1111/j.1349-7006.2010.01792.x 
    Details  DOI  PMID  PMC 
  • 2011 Conference Paper
    ​ ​Abstract 795: Patterns of T-cell distribution at the invasive margin of colorectal cancer liver metastases: Downstream recruitment of T cells and spatial heterogeneity​
    Halama, N.; Zoernig, I.; Spille, A.; Schirmacher, P.; Brand, K.; Falk, C. & Grabe, N.  et al.​ (2011)
    ​Proceedings pp. 795​-795. ​AACR 102nd Annual Meeting 2011​, Orlando, FL. DOI: https://doi.org/10.1158/1538-7445.AM2011-795 
    Details  DOI 
  • 2011 Journal Article | Research Paper
    ​ ​A comparison of dacron versus Flocked nylon swabs for anal cytology specimen collection​
    Gage, J. C; Ghosh, A.; Borgonovo, S.; Follansbee, S.; Wentzensen, N.; Gravitt, P. E. & Grabe, N.  et al.​ (2011) 
    Acta Cytologica55(4) pp. 364​-367​.​ DOI: https://doi.org/10.1159/000329488 
    Details  DOI  PMID  PMC 
  • 2011 Journal Article | Research Paper
    ​ ​Automatic tumor-stroma separation in fluorescence TMAs enables the quantitative high-throughput analysis of multiple cancer biomarkers​
    Lahrmann, B.; Halama, N.; Sinn, H.-P.; Schirmacher, P.; Jaeger, D. & Grabe, N. ​ (2011) 
    PLoS One6(12) art. e28048​.​ DOI: https://doi.org/10.1371/journal.pone.0028048 
    Details  DOI  PMID  PMC 
  • 2010 Journal Article | Research Paper
    ​ ​Quantification of prognostic immune cell markers in colorectal cancer using whole slide imaging tumor maps​
    Halama, N.; Zoernig, I.; Spille, A.; Michel, S.; Kloor, M.; Grauling-Halama, S. & Westphal, K. et al.​ (2010) 
    Analytical and Quantitative Cytology and Histology32(6) pp. 333​-340​.​
    Details  PMID  PMC 
  • 2010 Journal Article | Research Paper
    ​ ​Robust gridding of TMAs after whole-slide imaging using template matching​
    Lahrmann, B.; Halama, N.; Westphal, K.; Ernst, C.; Elsawaf, Z.; Sinn, P. & Bosch, F. X. et al.​ (2010) 
    Cytometry. Part A77(12) pp. 1169​-1176​.​ DOI: https://doi.org/10.1002/cyto.a.20949 
    Details  DOI  PMID  PMC 
  • 2010 Journal Article | Research Paper
    ​ ​Spatial quantification and classification of skin response following perturbation using organotypic skin cultures​
    Pommerencke, T.; Westphal, K.; Ernst, C.; Safferling, K.; Dickhaus, H.; Steinberg, T. & Tomakidi, P. et al.​ (2010) 
    Bioinformatics26(21) pp. 2760​-2766​.​ DOI: https://doi.org/10.1093/bioinformatics/btq525 
    Details  DOI  PMID  PMC 
  • 2010 Journal Article | Research Paper
    ​ ​Impaired skin regeneration and remodeling after cutaneous injury and chemically induced hyperplasia in taps-transgenic mice​
    Hildenbrand, M.; Rhiemeier, V.; Hartenstein, B.; Lahrmann, B.; Grabe, N. ; Angel, P. & Hess, J.​ (2010) 
    Journal of Investigative Dermatology130(7) pp. 1922​-1930​.​ DOI: https://doi.org/10.1038/jid.2010.54 
    Details  DOI  PMID  PMC 
  • 2010 Conference Paper
    ​ ​Abstract 1917: Immunological Tumor Maps: a Landscape of Infiltrating Immune Cells in Colorectal Cancer Based on Complete Tissue Section Analyses​
    Halama, N.; Zoernig, I.; Foged, N. T.; Schirmacher, P.; Jaeger, D. & Grabe, N. ​ (2010)
    ​Proceedings pp. 1917​-1917. ​AACR 101st Annual Meeting 2010​, Washington, DC. DOI: https://doi.org/10.1158/1538-7445.AM10-1917 
    Details  DOI 
  • 2010 Journal Article | Research Paper
    ​ ​A virtual microscopy system to scan, evaluate and archive biomarker enhanced cervical cytology slides​
    Grabe, N. ; Lahrmann, B.; Pommerencke, T.; von Knebel Doeberitz, M.; Reuschenbach, M. & Wentzensen, N.​ (2010) 
    Cellular Oncology32(1-2) pp. 109​-119​.​ DOI: https://doi.org/10.3233/CLO-2009-0508 
    Details  DOI  PMID  PMC 
  • 2009 Journal Article | Research Paper
    ​ ​Estimation of immune cell densities in immune cell conglomerates: an approach for high-throughput quantification​
    Halama, N.; Zoernig, I.; Spille, A.; Westphal, K.; Schirmacher, P.; Jaeger, D. & Grabe, N. ​ (2009) 
    PLoS One4(11) art. e7847​.​ DOI: https://doi.org/10.1371/journal.pone.0007847 
    Details  DOI  PMID  PMC 
  • 2009 Journal Article | Research Paper
    ​ ​Modeling multi-cellular behavior in epidermal tissue homeostasis via finite state machines in multi-agent systems​
    Sütterlin, T.; Huber, S.; Dickhaus, H. & Grabe, N. ​ (2009) 
    Bioinformatics25(16) pp. 2057​-2063​.​ DOI: https://doi.org/10.1093/bioinformatics/btp361 
    Details  DOI  PMID  PMC 
  • 2009 Journal Article | Research Paper
    ​ ​From virtual microscopy to systems pathology: a meeting report of the 1st European workshop on tissue imaging and analysis, Heidelberg, Germany, 13-14 February 2009​
    Grabe, N.   & Schirmacher, P.​ (2009) 
    Virchows Archiv455(2) pp. 193​-196​.​ DOI: https://doi.org/10.1007/s00428-009-0810-2 
    Details  DOI  PMID  PMC 
  • 2008 Journal Article | Research Paper
    ​ ​Connective-Tissue Fibroblasts Established on Micropillar Interfaces are Pivotal for Epithelial-Tissue Morphogenesis​
    Mussig, E.; Steinberg, T.; Schulz, S.; Spatz, J. P.; Ulmer, J.; Grabe, N.   & Kohl, A. et al.​ (2008) 
    Advanced Functional Materials18(19) pp. 2919​-2929​.​ DOI: https://doi.org/10.1002/adfm.200800381 
    Details  DOI 
  • 2007 Journal Article | Research Paper
    ​ ​Reconstructing protein networks of epithelial differentiation from histological sections​
    Grabe, N. ; Pommerencke, T.; Steinberg, T.; Dickhaus, H. & Tomakidi, P.​ (2007) 
    Bioinformatics23(23) pp. 3200​-3208​.​ DOI: https://doi.org/10.1093/bioinformatics/btm504 
    Details  DOI  PMID  PMC 
  • 2007 Journal Article | Research Paper
    ​ ​Simulating psoriasis by altering transit amplifying cells​
    Grabe, N.   & Neuber, K.​ (2007) 
    Bioinformatics23(11) pp. 1309​-1312​.​ DOI: https://doi.org/10.1093/bioinformatics/btm042 
    Details  DOI  PMID  PMC 
  • 2007 Journal Article | Research Paper
    ​ ​Early keratinocyte differentiation on micropillar interfaces​
    Steinberg, T.; Schulz, S.; Spatz, J. P.; Grabe, N. ; Mussig, E.; Kohl, A. & Komposch, G. et al.​ (2007) 
    Nano Letters7(2) pp. 287​-294​.​ DOI: https://doi.org/10.1021/nl062271z 
    Details  DOI  PMID  PMC 
  • 2005 Journal Article | Research Paper
    ​ ​A multicellular systems biology model predicts epidermal morphology, kinetics and Ca2+ flow​
    Grabe, N.   & Neuber, K.​ (2005) 
    Bioinformatics21(17) pp. 3541​-3547​.​ DOI: https://doi.org/10.1093/bioinformatics/bti585 
    Details  DOI  PMID  PMC 
  • 2004 Journal Article | Research Paper
    ​ ​Highly specific prediction of phosphorylation sites in proteins​
    Koenig, M. & Grabe, N. ​ (2004) 
    Bioinformatics20(18) pp. 3620​-3627​.​ DOI: https://doi.org/10.1093/bioinformatics/bth455 
    Details  DOI  PMID  PMC 

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