RG Sossalla (Kardiovaskuläre experimentelle Elektrophysiologie und Bildgebung)

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  • 2023 Journal Article
    ​ ​An Alternative Mechanism of Subcellular Iron Uptake Deficiency in Cardiomyocytes​
    Dai, Y.; Ignatyeva, N.; Xu, H.; Wali, R.; Toischer, K.; Brandenburg, S. & Lenz, C. et al.​ (2023) 
    Circulation Research, art. CIRCRESAHA.122.321157​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.122.321157 
    Details  DOI  PMID  PMC 
  • 2022 Journal Article
    ​ ​Na v 1.8 Dysregulates Na and Ca Leading to Arrhythmias in Patients with Sleep-disordered Breathing​
    Lebek, S.; Hegner, P.; Hultsch, R.; Rohde, J.; Rupprecht, L.; Schmid, C. & Sossalla, S. T.  et al.​ (2022) 
    American Journal of Respiratory and Critical Care Medicine, art. rccm.202205-0981LE​.​ DOI: https://doi.org/10.1164/rccm.202205-0981LE 
    Details  DOI 
  • 2019 Conference Paper
    ​ ​P3829 Antiarrhythmic effects of Sacubitrilat (LBQ657) on Ca2+ homeostasis in ventricular cardiomyocytes​
    Eiringhaus, J.; Wuensche, C.; Herting, J.; Hasenfuss, G. ; Sossalla, S.   & Fischer, T. ​ (2019)
    European Heart Journal40(Suppl. 1) ​ESC Congress 2019 together with World Congress of Cardiology​, Paris. DOI: https://doi.org/10.1093/eurheartj/ehz745.0671 
    Details  DOI 
  • 2019 Journal Article | Research Paper
    ​ ​Arzneimittelinteraktionen, die man kennen muss!​
    Voigt, N. ; Ort, K.   & Sossalla, S. ​ (2019) 
    Deutsche medizinische Wochenschrift144(04) pp. 264​-275​.​ DOI: https://doi.org/10.1055/a-0160-8413 
    Details  DOI  PMID  PMC 
  • 2019 Journal Article | Research Paper
    ​ ​Protein kinase/phosphatase balance mediates the effects of increased late sodium current on ventricular calcium cycling​
    Eiringhaus, J. ; Herting, J. ; Schatter, F. ; Nikolaev, V. O. ; Sprenger, J.; Wang, Y. & Köhn, M. et al.​ (2019) 
    Basic Research in Cardiology114(2) pp. 13​.​ DOI: https://doi.org/10.1007/s00395-019-0720-7 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | Research Paper
    ​ ​Empagliflozin directly improves diastolic function in human heart failure​
    Pabel, S. ; Wagner, S. ; Bollenberg, H.; Bengel, P. ; Kovács, Á.; Schach, C. & Tirilomis, P. et al.​ (2018) 
    European Journal of Heart Failure20(12) pp. 1690​-1700​.​ DOI: https://doi.org/10.1002/ejhf.1328 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | Research Paper
    ​ ​Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart​
    Dybkova, N.; Ahmad, S. ; Pabel, S. ; Tirilomis, P.; Hartmann, N. ; Fischer, T. H   & Bengel, P.  et al.​ (2018) 
    Cardiovascular Research114(13) pp. 1728​-1737​.​ DOI: https://doi.org/10.1093/cvr/cvy152 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | Research Paper
    ​ ​Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression​
    Mohamed, B. A. ; Hartmann, N. ; Tirilomis, P.; Sekeres, K.; Li, W.; Neef, S. & Richter, C.  et al.​ (2018) 
    Science Translational Medicine10(458) art. eaan0724​.​ DOI: https://doi.org/10.1126/scitranslmed.aan0724 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | Research Paper
    ​ ​Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure​
    Fischer, T. H. ; Eiringhaus, J. ; Dybkova, N.; Saadatmand, A.; Pabel, S. ; Weber, S. & Wang, Y. et al.​ (2018) 
    European Journal of Heart Failure20(12) pp. 1673​-1685​.​ DOI: https://doi.org/10.1002/ejhf.1297 
    Details  DOI  PMID  PMC 
  • 2017 Conference Abstract
    ​ ​P1334 - The relevant role of SR Ca leak in the development of heart failure​
    Mohamed, B. A.; Kattner, L.; Guan, K. ; Lehnart, S. E. ; Luther, S. ; Sossalla, S.   & Hasenfuß, G.  et al.​ (2017)
    European Journal of Heart Failure19(Suppl. 1) ​Heart Failure 2017 and the 4th World Congress on Acute Heart Failure​, Paris.
    Details 
  • 2017 Journal Article | Research Paper
    ​ ​PP1 activation as novel antiarrhythmic approach in human heart failure​
    Eiringhaus, J. ; Fischer, T. H. ; Kohn, M.; Wang, Y.; Maier, L. S. ; Hasenfuss, G.   & Sossalla, S. T. ​ (2017) 
    European Heart Journal38(suppl_1) art. P5841​.​ DOI: https://doi.org/10.1093/eurheartj/ehx493.P5841 
    Details  DOI 
  • 2017 Journal Article | Overview
    ​ ​The Significance of the Late Na+ Current for Arrhythmia Induction and the Therapeutic Antiarrhythmic Potential of Ranolazine​
    Mason, F. E.   & Sossalla, S. ​ (2017) 
    Journal of Cardiovascular Pharmacology and Therapeutics22(1) pp. 40​-50​.​ DOI: https://doi.org/10.1177/1074248416644989 
    Details  DOI  WoS 
  • 2017 Journal Article | Research Paper
    ​ ​Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction​
    Vettel, C. ; Lindner, M.; Dewenter, M. ; Lorenz, K.; Schanbacher, C.; Riedel, M. & Lämmle, S. et al.​ (2017) 
    Circulation Research120(1) pp. 120​-132​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.116.310069 
    Details  DOI  PMID  PMC 
  • 2017 Journal Article | Research Paper
    ​ ​Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure​
    Dewenter, M. ; Neef, S.; Vettel, C. ; Lämmle, S.; Beushausen, C.; Zelarayan, L. C.   & Katz, S. et al.​ (2017) 
    Circulation: Heart Failure10(5) art. e003840​.​ DOI: https://doi.org/10.1161/CIRCHEARTFAILURE.117.003840 
    Details  DOI  PMID  PMC 
  • 2016 Journal Article | Research Paper
    ​ ​Sex-dependent alterations of Ca2+ cycling in human cardiac hypertrophy and heart failure​
    Fischer, T. H. ; Herting, J. ; Eiringhaus, J. ; Pabel, S. ; Hartmann, N. H. ; Ellenberger, D.   & Friedrich, M.  et al.​ (2016) 
    EP Europace18(9) pp. 1440​-1448​.​ DOI: https://doi.org/10.1093/europace/euv313 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Journal Article | Research Paper
    ​ ​Inhibition of CaMKII Attenuates Progressing Disruption of Ca2+ Homeostasis Upon Left Ventricular Assist Device Implantation in Human Heart Failure​
    Fischer, T. H. ; Kleinwächter, A.; Herting, J. ; Eiringhaus, J. ; Hartmann, N. ; Renner, A. & Gummert, J. et al.​ (2016) 
    Artificial Organs40(8) pp. 719​-726​.​ DOI: https://doi.org/10.1111/aor.12677 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Journal Article | Research Paper
    ​ ​The combined effects of ranolazine and dronedarone on human atrial and ventricular electrophysiology​
    Hartmann, N. H. ; Mason, F. E. ; Braun, I.; Pabel, S. ; Voigt, N. ; Schotola, H. & Fischer, T. H.  et al.​ (2016) 
    Journal of Molecular and Cellular Cardiology94 pp. 95​-106​.​ DOI: https://doi.org/10.1016/j.yjmcc.2016.03.012 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Journal Article | Research Paper
    ​ ​Antiarrhythmic effects of dantrolene in human diseased cardiomyocytes​
    Hartmann, N. H. ; Pabel, S. ; Herting, J. ; Schatter, F. ; Renner, A.; Gummert, J. & Schotola, H. et al.​ (2016) 
    Heart Rhythm14(3) pp. 412​-419​.​ DOI: https://doi.org/10.1016/j.hrthm.2016.09.014 
    Details  DOI  PMID  PMC 
  • 2015 Journal Article | Research Paper
    ​ ​Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII​
    Fischer, T. H. ; Herting, J. ; Mason, F. E. ; Hartmann, N. ; Watanabe, S.; Nikolaev, V. O.   & Sprenger, J. U. et al.​ (2015) 
    Cardiovascular Research107(1) pp. 184​-196​.​ DOI: https://doi.org/10.1093/cvr/cvv153 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article | Research Paper
    ​ ​Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis​
    Xu, X.; Tan, X.; Tampe, B. ; Nyamsuren, G.; Liu, X.; Maier, L. S.   & Sossalla, S.  et al.​ (2015) 
    Cardiovascular Research105(3) pp. 279​-291​.​ DOI: https://doi.org/10.1093/cvr/cvv015 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper
    ​ ​Enhanced late INa induces proarrhythmogenic SR Ca leak in a CaMKII-dependent manner​
    Sag, C. M.; Mallwitz, A.; Wagner, S. ; Hartmann, N. ; Schotola, H.; Fischer, T. H.   & Ungeheuer, N. et al.​ (2014) 
    Journal of Molecular and Cellular Cardiology76 pp. 94​-105​.​ DOI: https://doi.org/10.1016/j.yjmcc.2014.08.016 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​Diabetes increases mortality after myocardial infarction by oxidizing CaMKII​
    Luo, M.; Guan, X.; Luczak, E. D.; Lang, D.; Kutschke, W.; Gao, Z. & Yang, J. et al.​ (2013) 
    Journal of Clinical Investigation123(3) pp. 1262​-1274​.​ DOI: https://doi.org/10.1172/JCI65268 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​Phosphodiesterase-2 Is Up-Regulated in Human Failing Hearts and Blunts β-Adrenergic Responses in Cardiomyocytes​
    Mehel, H.; Emons, J.; Vettel, C. ; Wittköpper, K.; Seppelt, D.; Dewenter, M.   & Lutz, S.  et al.​ (2013) 
    Journal of the American College of Cardiology62(17) pp. 1596​-1606​.​ DOI: https://doi.org/10.1016/j.jacc.2013.05.057 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease​
    Toischer, K. ; Hartmann, N. ; Wagner, S. ; Fischer, T. H. ; Herting, J. ; Danner, B. C.   & Sag, C. M. et al.​ (2013) 
    Journal of Molecular and Cellular Cardiology61 pp. 111​-122​.​ DOI: https://doi.org/10.1016/j.yjmcc.2013.03.021 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​Ca2+/Calmodulin-Dependent Protein Kinase II and Protein Kinase A Differentially Regulate Sarcoplasmic Reticulum Ca2+ Leak in Human Cardiac Pathology​
    Fischer, T. H. ; Herting, J. ; Tirilomis, T. ; Renner, A.; Neef, S.; Toischer, K.   & Ellenberger, D.  et al.​ (2013) 
    Circulation128(9) pp. 970​-981​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.113.001746 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​Ranolazine Maintained Sinus Rhythm in a Patient with Refractory Symptomatic Atrial Fibrillation​
    Sossalla, S. ; Sohns, C.; Seegers, J.; Lüthje, L. ; Vollmann, D. & Zabel, M. ​ (2013) 
    Cardiovascular Therapeutics31(5) pp. 303​-306​.​ DOI: https://doi.org/10.1111/1755-5922.12017 
    Details  DOI  PMID  PMC  WoS 

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