Prof. Dr. med. Lars Siegfried Maier

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  • 2022 | Journal Article
    ​ ​Na v 1.8 Dysregulates Na and Ca Leading to Arrhythmias in Patients with Sleep-disordered Breathing​
    Lebek, S.; Hegner, P.; Hultsch, R.; Rohde, J.; Rupprecht, L.; Schmid, C. & Sossalla, S. T.  et al.​ (2022) 
    American Journal of Respiratory and Critical Care Medicine, art. rccm.202205-0981LE​.​ DOI: https://doi.org/10.1164/rccm.202205-0981LE 
    ​Details  DOI 
  • 2022 | Journal Article
    ​ ​Atrial Fibrillation Burden Specifically Determines Human Ventricular Cellular Remodeling​
    Körtl, T.; Stehle, T.; Riedl, D.; Trausel, J.; Rebs, S. ; Pabel, S.   & Paulus, M. et al.​ (2022) 
    JACC: Clinical Electrophysiology, 8(11) pp. 1357​-1366​.​ DOI: https://doi.org/10.1016/j.jacep.2022.07.016 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Empagliflozin improves endothelial and cardiomyocyte function in human heart failure with preserved ejection fraction via reduced pro-inflammatory-oxidative pathways and protein kinase Gα oxidation​
    Kolijn, D.; Pabel, S. ; Tian, Y.; Lódi, M.; Herwig, M.; Carrizzo, A. & Zhazykbayeva, S. et al.​ (2020) 
    Cardiovascular Research, 117(2) pp. 495​-507​.​ DOI: https://doi.org/10.1093/cvr/cvaa123 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Dantrolene reduces CaMKIIδC-mediated atrial arrhythmias​
    Pabel, S. ; Mustroph, J.; Stehle, T.; Lebek, S.; Dybkova, N.; Keyser, A. & Rupprecht, L. et al.​ (2020) 
    Europace, 22(7) pp. 1111​-1118​.​ DOI: https://doi.org/10.1093/europace/euaa079 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Contribution of the neuronal sodium channel NaV1.8 to sodium- and calcium-dependent cellular proarrhythmia​
    Bengel, P. ; Ahmad, S. ; Tirilomis, P.; Trum, M.; Dybkova, N.; Wagner, S.   & Maier, L. S.  et al.​ (2020) 
    Journal of Molecular and Cellular Cardiology, 144 pp. 35​-46​.​ DOI: https://doi.org/10.1016/j.yjmcc.2020.05.002 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Inhibition of NaV1.8 prevents atrial arrhythmogenesis in human and mice​
    Pabel, S. ; Ahmad, S. ; Tirilomis, P.; Stehle, T.; Mustroph, J.; Knierim, M. & Dybkova, N. et al.​ (2020) 
    Basic Research in Cardiology, 115(2).​ DOI: https://doi.org/10.1007/s00395-020-0780-8 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​The functional consequences of sodium channel NaV1.8 in human left ventricular hypertrophy​
    Ahmad, S. ; Tirilomis, P.; Pabel, S. ; Dybkova, N.; Hartmann, N. ; Molina, C. E.   & Tirilomis, T.  et al.​ (2019) 
    ESC Heart Failure, 6(1) pp. 154​-163​.​ DOI: https://doi.org/10.1002/ehf2.12378 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article
    ​ ​Empagliflozin reduces Ca/calmodulin-dependent kinase II activity in isolated ventricular cardiomyocytes​
    Mustroph, J.; Wagemann, O.; Lücht, C. M.; Trum, M.; Hammer, K. P.; Sag, C. M. & Lebek, S. et al.​ (2018) 
    ESC Heart Failure, 5(4) pp. 642​-648​.​ DOI: https://doi.org/10.1002/ehf2.12336 
    ​Details  DOI 
  • 2018 | Journal Article | Research Paper
    ​ ​Empagliflozin directly improves diastolic function in human heart failure​
    Pabel, S. ; Wagner, S. ; Bollenberg, H.; Bengel, P. ; Kovács, Á.; Schach, C. & Tirilomis, P. et al.​ (2018) 
    European Journal of Heart Failure, 20(12) pp. 1690​-1700​.​ DOI: https://doi.org/10.1002/ejhf.1328 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart​
    Dybkova, N.; Ahmad, S. ; Pabel, S. ; Tirilomis, P.; Hartmann, N. ; Fischer, T. H   & Bengel, P.  et al.​ (2018) 
    Cardiovascular Research, 114(13) pp. 1728​-1737​.​ DOI: https://doi.org/10.1093/cvr/cvy152 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure​
    Fischer, T. H. ; Eiringhaus, J. ; Dybkova, N.; Saadatmand, A.; Pabel, S. ; Weber, S. & Wang, Y. et al.​ (2018) 
    European Journal of Heart Failure, 20(12) pp. 1673​-1685​.​ DOI: https://doi.org/10.1002/ejhf.1297 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper
    ​ ​PP1 activation as novel antiarrhythmic approach in human heart failure​
    Eiringhaus, J. ; Fischer, T. H. ; Kohn, M.; Wang, Y.; Maier, L. S. ; Hasenfuss, G.   & Sossalla, S. T. ​ (2017) 
    European Heart Journal, 38(suppl_1) art. P5841​.​ DOI: https://doi.org/10.1093/eurheartj/ehx493.P5841 
    ​Details  DOI 
  • 2017 | Journal Article | Research Paper
    ​ ​Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure​
    Dewenter, M. ; Neef, S.; Vettel, C. ; Lämmle, S.; Beushausen, C.; Zelarayan, L. C.   & Katz, S. et al.​ (2017) 
    Circulation: Heart Failure, 10(5) art. e003840​.​ DOI: https://doi.org/10.1161/CIRCHEARTFAILURE.117.003840 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article | Research Paper
    ​ ​Sex-dependent alterations of Ca2+ cycling in human cardiac hypertrophy and heart failure​
    Fischer, T. H. ; Herting, J. ; Eiringhaus, J. ; Pabel, S. ; Hartmann, N. H. ; Ellenberger, D.   & Friedrich, M.  et al.​ (2016) 
    EP Europace, 18(9) pp. 1440​-1448​.​ DOI: https://doi.org/10.1093/europace/euv313 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper
    ​ ​The combined effects of ranolazine and dronedarone on human atrial and ventricular electrophysiology​
    Hartmann, N. H. ; Mason, F. E. ; Braun, I.; Pabel, S. ; Voigt, N. ; Schotola, H. & Fischer, T. H.  et al.​ (2016) 
    Journal of Molecular and Cellular Cardiology, 94 pp. 95​-106​.​ DOI: https://doi.org/10.1016/j.yjmcc.2016.03.012 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper
    ​ ​Antiarrhythmic effects of dantrolene in human diseased cardiomyocytes​
    Hartmann, N. H. ; Pabel, S. ; Herting, J. ; Schatter, F. ; Renner, A.; Gummert, J. & Schotola, H. et al.​ (2016) 
    Heart Rhythm, 14(3) pp. 412​-419​.​ DOI: https://doi.org/10.1016/j.hrthm.2016.09.014 
    ​Details  DOI  PMID  PMC 
  • 2015 | Conference Abstract
    ​ ​Epigenetic balance of aberrant rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis​
    Xu, X. X.; Tan, X.; Tampe, B.; Liu, X.; Maier, L. S. ; Sossalla, S. T.   & Kalluri, R. et al.​ (2015)
    European Journal of Heart Failure, 17 
    Hoboken​: Wiley-blackwell.
    ​Details  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII​
    Fischer, T. H. ; Herting, J. ; Mason, F. E. ; Hartmann, N. ; Watanabe, S.; Nikolaev, V. O.   & Sprenger, J. U. et al.​ (2015) 
    Cardiovascular Research, 107(1) pp. 184​-196​.​ DOI: https://doi.org/10.1093/cvr/cvv153 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis​
    Xu, X.; Tan, X.; Tampe, B. ; Nyamsuren, G.; Liu, X.; Maier, L. S.   & Sossalla, S.  et al.​ (2015) 
    Cardiovascular Research, 105(3) pp. 279​-291​.​ DOI: https://doi.org/10.1093/cvr/cvv015 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper
    ​ ​Enhanced late INa induces proarrhythmogenic SR Ca leak in a CaMKII-dependent manner​
    Sag, C. M.; Mallwitz, A.; Wagner, S. ; Hartmann, N. ; Schotola, H.; Fischer, T. H.   & Ungeheuer, N. et al.​ (2014) 
    Journal of Molecular and Cellular Cardiology, 76 pp. 94​-105​.​ DOI: https://doi.org/10.1016/j.yjmcc.2014.08.016 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper | 
    ​ ​Effects of Ranolazine on Torsades de Pointes Tachycardias in a Healthy Isolated Rabbit Heart Model​
    Sossalla, S. T. ; Wallisch, N.; Toischer, K. ; Sohns, C.; Vollmann, D.; Seegers, J. & Luethje, L. et al.​ (2014) 
    Cardiovascular Therapeutics, 32(4) pp. 170​-177​.​ DOI: https://doi.org/10.1111/1755-5922.12078 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper | 
    ​ ​Ca2+/calmodulin-dependent protein kinase II equally induces sarcoplasmic reticulum Ca2+ leak in human ischaemic and dilated cardiomyopathy​
    Fischer, T. H. ; Eiringhaus, J. ; Dybkova, N.; Foerster, A.; Herting, J. ; Kleinwaechter, A. & Ljubojevic, S. et al.​ (2014) 
    European Journal of Heart Failure, 16(12) pp. 1292​-1300​.​ DOI: https://doi.org/10.1002/ejhf.163 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Conference Abstract
    ​ ​Phosphodiesterase-2 is upregulated in failing hearts and blunts beta-AR mediated chronotropic and inotropic effects​
    Vettel, C.; Mehel, H.; Emons, J.; Wittkoepper, K.; Dewenter, M.; Laemmle, S. & Seppelt, D. et al.​ (2013)
    Naunyn-Schmiedeberg s Archives of Pharmacology, 386 
    New york​: Springer.
    ​Details  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Diabetes increases mortality after myocardial infarction by oxidizing CaMKII​
    Luo, M.; Guan, X.; Luczak, E. D.; Lang, D.; Kutschke, W.; Gao, Z. & Yang, J. et al.​ (2013) 
    Journal of Clinical Investigation, 123(3) pp. 1262​-1274​.​ DOI: https://doi.org/10.1172/JCI65268 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Phosphodiesterase-2 Is Up-Regulated in Human Failing Hearts and Blunts β-Adrenergic Responses in Cardiomyocytes​
    Mehel, H.; Emons, J.; Vettel, C. ; Wittköpper, K.; Seppelt, D.; Dewenter, M.   & Lutz, S.  et al.​ (2013) 
    Journal of the American College of Cardiology, 62(17) pp. 1596​-1606​.​ DOI: https://doi.org/10.1016/j.jacc.2013.05.057 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease​
    Toischer, K. ; Hartmann, N. ; Wagner, S. ; Fischer, T. H. ; Herting, J. ; Danner, B. C.   & Sag, C. M. et al.​ (2013) 
    Journal of Molecular and Cellular Cardiology, 61 pp. 111​-122​.​ DOI: https://doi.org/10.1016/j.yjmcc.2013.03.021 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Ca2+/Calmodulin-Dependent Protein Kinase II and Protein Kinase A Differentially Regulate Sarcoplasmic Reticulum Ca2+ Leak in Human Cardiac Pathology​
    Fischer, T. H. ; Herting, J. ; Tirilomis, T. ; Renner, A.; Neef, S.; Toischer, K.   & Ellenberger, D.  et al.​ (2013) 
    Circulation, 128(9) pp. 970​-981​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.113.001746 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Overview | 
    ​ ​The ryanodine receptor leak: how a tattered receptor plunges the failing heart into crisis​
    Fischer, T. H. ; Maier, L. S.   & Sossalla, S. T. ​ (2013) 
    Heart Failure Reviews, 18(4) pp. 475​-483​.​ DOI: https://doi.org/10.1007/s10741-012-9339-6 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Overview | 
    ​ ​The late Na current as a therapeutic target: Where are we?​
    Maier, L. S.   & Sossalla, S. T. ​ (2013) 
    Journal of Molecular and Cellular Cardiology, 61 pp. 44​-50​.​ DOI: https://doi.org/10.1016/j.yjmcc.2013.03.001 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Conference Abstract
    ​ ​Afterload but not preload induces proliferation of cardiomyocytes and improves survival in cyclinD2-overexpressing mice​
    Toischer, K. ; Huenlich, M.; Zhang, W.; Reuter, S.; Maier, L. S. ; Sossalla, S. T.   & Field, L. J. et al.​ (2012)
    European Heart Journal, 33 , Munchen, GERMANY.
    Oxford​: Oxford Univ Press.
    ​Details  WoS 
  • 2012 | Journal Article | 
    ​ ​Mild metabolic acidosis impairs the beta-adrenergic response in isolated human failing myocardium​
    Schotola, H.; Toischer, K. ; Popov, A.-F.; Renner, A.; Schmitto, J. D.; Gummert, J. F. & Quintel, M. et al.​ (2012) 
    CRITICAL CARE, 16(4) art. R153​.​ DOI: https://doi.org/10.1186/cc11468 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article | Letter Note
    ​ ​Response to Letter Regarding Article, "Differential Cardiac Remodeling in Preload Versus Afterload"​
    Toischer, K. ; Rokita, A. G.; Unsoeld, B. W.; Sossalla, S. T. ; Becker, A.; Seidler, T. & Grebe, C. et al.​ (2011) 
    Circulation, 123(16).​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.110.017566 
    ​Details  DOI  WoS 
  • 2011 | Journal Article | Research Paper
    ​ ​Effects of different proton pump inhibitors on cardiac contractility in isolated human failing myocardium​
    Sossalla, S. ; Schotola, H.; Schmitto, J. D.; Toischer, K. ; Sohns, C.; Schwoerer, H. & Hasenfuß, G.  et al.​ (2011) 
    Journal of Cardiovascular Surgery, 52(3) pp. 437​-444​.​
    ​Details  PMID  PMC  WoS 
  • 2011 | Conference Abstract
    ​ ​Pressure overload-induced hypertrophy and heart failure are associated with arrhythmic triggers caused by late INa​
    Sossalla, S. T. ; Toischer, K. ; Hartmann, N.; Schulte, T.; Wagner, S.; Hasenfuß, G.   & Maier, L. S. ​ (2011)
    European Heart Journal, 32 pp. 997​-998. 
    Oxford​: Oxford Univ Press.
    ​Details  WoS 
  • 2011 | Journal Article | Research Paper | 
    ​ ​Diastolic dysfunction and arrhythmias caused by overexpression of CaMKII delta(C) can be reversed by inhibition of late Na+ current​
    Sossalla, S. ; Maurer, U.; Schotola, H.; Hartmann, N. H. ; Didie, M. ; Zimmermann, W.-H.   & Jacobshagen, C.  et al.​ (2011) 
    Basic Research in Cardiology, 106(2) pp. 263​-272​.​ DOI: https://doi.org/10.1007/s00395-010-0136-x 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | Research Paper | 
    ​ ​Altered Na+ Currents in Atrial Fibrillation Effects of Ranolazine on Arrhythmias and Contractility in Human Atrial Myocardium​
    Sossalla, S. ; Kallmeyer, B.; Wagner, S. ; Mazur, M.; Maurer, U.; Toischer, K.   & Schmitto, J. D. et al.​ (2010) 
    Journal of the American College of Cardiology, 55(21) pp. 2330​-2342​.​ DOI: https://doi.org/10.1016/j.jacc.2009.12.055 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | Research Paper | 
    ​ ​Differential Cardiac Remodeling in Preload Versus Afterload​
    Toischer, K. ; Rokita, A. G.; Unsoeld, B. W.; Zhu, W.; Kararigas, G.; Sossalla, S.   & Reuter, S. P. et al.​ (2010) 
    Circulation, 122(10) pp. 993​-1003​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.110.943431 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | Research Paper
    ​ ​CaMKII-Dependent Diastolic SR Ca2+ Leak and Elevated Diastolic Ca2+ Levels in Right Atrial Myocardium of Patients With Atrial Fibrillation​
    Neef, S.; Dybkova, N.; Sossalla, S. ; Ort, K. R.; Fluschnik, N.; Neumann, K. & Seipelt, R. et al.​ (2010) 
    Circulation Research, 106(6) pp. 1134​-1144​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.109.203836 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | Research Paper | 
    ​ ​Inhibition of Elevated Ca2+/Calmodulin-Dependent Protein Kinase II Improves Contractility in Human Failing Myocardium​
    Sossalla, S. ; Fluschnik, N.; Schotola, H.; Ort, K. R.; Neef, S.; Schulte, T. & Wittkoepper, K. et al.​ (2010) 
    Circulation Research, 107(9) pp. 1150​-U215​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.110.220418 
    ​Details  DOI  PMID  PMC  WoS 
  • 2008 | Journal Article | Research Paper
    ​ ​Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts - Role of late sodium current and intracellular ion accumulation​
    Sossalla, S. ; Wagner, S. ; Rasenack, E. C. L.; Ruff, H.; Weber, S. L.; Schoendube, F. A.   & Tirilomis, T.  et al.​ (2008) 
    Journal of Molecular and Cellular Cardiology, 45(1) pp. 32​-43​.​ DOI: https://doi.org/10.1016/j.yjmcc.2008.03.006 
    ​Details  DOI  PMID  PMC  WoS 
  • 2007 | Journal Article | Research Paper
    ​ ​Negative inotropy of the gastric proton pump inhibitor pantoprazole in myocardium from humans and rabbits - Evaluation of mechanisms​
    Schillinger, W. ; Teucher, N. ; Sossalla, S. ; Kettlewell, S.; Werner, C. ; Raddatz, D.   & Elgner, A. et al.​ (2007) 
    Circulation, 116(1) pp. 57​-66​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.106.666008 
    ​Details  DOI  PMID  PMC  WoS 
  • 2006 | Journal Article | Research Paper
    ​ ​High intracellular Na+ preserves myocardial function at low heart rates in isolated myocardium from failing hearts​
    Schillinger, W. ; Teucher, N. ; Christians, C.; Kohlhaas, M.; Sossalla, S. ; Van Nguyen, P. & Schmidt, A. G. et al.​ (2006) 
    European Journal of Heart Failure, 8(7) pp. 673​-680​.​ DOI: https://doi.org/10.1016/j.ejheart.2006.01.013 
    ​Details  DOI  PMID  PMC  WoS 

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