Prof. Dr. med. Lars Siegfried Maier

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  • 2020 | Journal Article | Research Paper | 
    ​ ​Inhibition of NaV1.8 prevents atrial arrhythmogenesis in human and mice​
    Pabel, S. ; Ahmad, S. ; Tirilomis, P.; Stehle, T.; Mustroph, J.; Knierim, M. & Dybkova, N. et al.​ (2020) 
    Basic Research in Cardiology, 115(2).​ DOI: https://doi.org/10.1007/s00395-020-0780-8 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​The functional consequences of sodium channel NaV1.8 in human left ventricular hypertrophy​
    Ahmad, S. ; Tirilomis, P.; Pabel, S. ; Dybkova, N.; Hartmann, N. ; Molina, C. E.   & Tirilomis, T.  et al.​ (2019) 
    ESC Heart Failure, 6(1) pp. 154​-163​.​ DOI: https://doi.org/10.1002/ehf2.12378 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4​
    Perera, R. K. ; Fischer, T. H. ; Wagner, M.; Dewenter, M. ; Vettel, C. ; Bork, N. I. & Maier, L. S.  et al.​ (2017) 
    Scientific Reports, 7(1) art. 15222​.​ DOI: https://doi.org/10.1038/s41598-017-15632-x 
    ​Details  DOI  PMID  PMC 
  • 2015 | Journal Article | Research Paper | 
    ​ ​In vivo model with targeted cAMP biosensor reveals changes in receptor-microdomain communication in cardiac disease​
    Sprenger, J. U.; Perera, R. K. ; Steinbrecher, J. H.; Lehnart, S. E. ; Maier, L. S. ; Hasenfuß, G.   & Nikolaev, V. O. ​ (2015) 
    Nature Communications, 6 art. 6965​.​ DOI: https://doi.org/10.1038/ncomms7965 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Overview | 
    ​ ​CaMKII regulation of cardiac K channels​
    Mustroph, J.; Maier, L. S.   & Wagner, S.​ (2014) 
    Frontiers in Pharmacology, 5 art. 20​.​ DOI: https://doi.org/10.3389/fphar.2014.00020 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper | 
    ​ ​Effects of Ranolazine on Torsades de Pointes Tachycardias in a Healthy Isolated Rabbit Heart Model​
    Sossalla, S. T. ; Wallisch, N.; Toischer, K. ; Sohns, C.; Vollmann, D.; Seegers, J. & Luethje, L. et al.​ (2014) 
    Cardiovascular Therapeutics, 32(4) pp. 170​-177​.​ DOI: https://doi.org/10.1111/1755-5922.12078 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper | 
    ​ ​Ca2+/calmodulin-dependent protein kinase II equally induces sarcoplasmic reticulum Ca2+ leak in human ischaemic and dilated cardiomyopathy​
    Fischer, T. H. ; Eiringhaus, J. ; Dybkova, N.; Foerster, A.; Herting, J. ; Kleinwaechter, A. & Ljubojevic, S. et al.​ (2014) 
    European Journal of Heart Failure, 16(12) pp. 1292​-1300​.​ DOI: https://doi.org/10.1002/ejhf.163 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper | 
    ​ ​Enhanced Ca2+ influx through cardiac L-type Ca2+ channels maintains the systolic Ca2+ transient in early cardiac atrophy induced by mechanical unloading​
    Schwoerer, A. P.; Neef, S.; Broichhausen, I.; Jacubeit, J.; Tiburcy, M. ; Wagner, M. & Biermann, D. et al.​ (2013) 
    Pflügers Archiv - European Journal of Physiology, 465(12) pp. 1763​-1773​.​ DOI: https://doi.org/10.1007/s00424-013-1316-y 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper | 
    ​ ​Ionizing radiation regulates cardiac Ca handling via increased ROS and activated CaMKII​
    Sag, C. M.; Wolff, H. A.; Neumann, K.; Opiela, M.-K.; Zhang, J.; Steuer, F. & Sowa, T. et al.​ (2013) 
    Basic Research in Cardiology, 108(6) art. 385​.​ DOI: https://doi.org/10.1007/s00395-013-0385-6 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Overview | 
    ​ ​The Ca-calmodulin dependent kinase II: A promising target for future antiarrhythmic therapies?​
    Fischer, T. H. ; Neef, S. & Maier, L. S. ​ (2013) 
    Journal of Molecular and Cellular Cardiology, 58 pp. 182​-187​.​ DOI: https://doi.org/10.1016/j.yjmcc.2012.11.003 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Overview | 
    ​ ​The ryanodine receptor leak: how a tattered receptor plunges the failing heart into crisis​
    Fischer, T. H. ; Maier, L. S.   & Sossalla, S. T. ​ (2013) 
    Heart Failure Reviews, 18(4) pp. 475​-483​.​ DOI: https://doi.org/10.1007/s10741-012-9339-6 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Letter Note | 
    ​ ​The German CPU Registry: Comparison of troponin positive to troponin negative patients​
    Maier, L. S. ; Darius, H.; Giannitsis, E.; Erbel, R.; Haude, M.; Hamm, C. & Hasenfuß, G.  et al.​ (2013) 
    International Journal of Cardiology, 168(2) pp. 1651​-1653​.​ DOI: https://doi.org/10.1016/j.ijcard.2013.03.009 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Overview | 
    ​ ​The late Na current as a therapeutic target: Where are we?​
    Maier, L. S.   & Sossalla, S. T. ​ (2013) 
    Journal of Molecular and Cellular Cardiology, 61 pp. 44​-50​.​ DOI: https://doi.org/10.1016/j.yjmcc.2013.03.001 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article | Overview | 
    ​ ​New Treatment Options for Late Na Current, Arrhythmias, and Diastolic Dysfunction​
    Maier, L. S. ​ (2012) 
    Current Heart Failure Reports, 9(3) pp. 183​-191​.​ DOI: https://doi.org/10.1007/s11897-012-0099-3 
    ​Details  DOI 
  • 2012 | Journal Article | 
    ​ ​Mild metabolic acidosis impairs the beta-adrenergic response in isolated human failing myocardium​
    Schotola, H.; Toischer, K. ; Popov, A.-F.; Renner, A.; Schmitto, J. D.; Gummert, J. F. & Quintel, M. et al.​ (2012) 
    CRITICAL CARE, 16(4) art. R153​.​ DOI: https://doi.org/10.1186/cc11468 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article | Research Paper | 
    ​ ​Limitations of FKBP12.6-directed treatment strategies for maladaptive cardiac remodeling and heart failure​
    Seidler, T. ; Teucher, N. ; Hellenkamp, K. ; Unsoeld, B. W.; Grebe, C.; Kramps, P. & Schotola, H. et al.​ (2011) 
    Journal of Molecular and Cellular Cardiology, 50(1) pp. 33​-42​.​ DOI: https://doi.org/10.1016/j.yjmcc.2010.08.016 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article | Research Paper | 
    ​ ​Diastolic dysfunction and arrhythmias caused by overexpression of CaMKII delta(C) can be reversed by inhibition of late Na+ current​
    Sossalla, S. ; Maurer, U.; Schotola, H.; Hartmann, N. H. ; Didie, M. ; Zimmermann, W.-H.   & Jacobshagen, C.  et al.​ (2011) 
    Basic Research in Cardiology, 106(2) pp. 263​-272​.​ DOI: https://doi.org/10.1007/s00395-010-0136-x 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | 
    ​ ​Impaired Ca2+-handling in HIF-1 alpha(+/-) mice as a consequence of pressure overload​
    Silter, M.; Koegler, H.; Zieseniss, A.; Wilting, J.; Schaefer, K. ; Toischer, K.   & Rokita, A. G. et al.​ (2010) 
    Pflügers Archiv - European Journal of Physiology, 459(4) pp. 569​-577​.​ DOI: https://doi.org/10.1007/s00424-009-0748-x 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | Research Paper | 
    ​ ​Effects of mild hypothermia on hemodynamics in cardiac arrest survivors and isolated failing human myocardium​
    Jacobshagen, C. ; Pelster, T.; Pax, A.; Horn, W.; Schmidt-Schweda, S.; Unsoeld, B. W. & Seidler, T.  et al.​ (2010) 
    Clinical Research in Cardiology, 99(5) pp. 267​-276​.​ DOI: https://doi.org/10.1007/s00392-010-0113-2 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | Research Paper | 
    ​ ​Altered Na+ Currents in Atrial Fibrillation Effects of Ranolazine on Arrhythmias and Contractility in Human Atrial Myocardium​
    Sossalla, S. ; Kallmeyer, B.; Wagner, S. ; Mazur, M.; Maurer, U.; Toischer, K.   & Schmitto, J. D. et al.​ (2010) 
    Journal of the American College of Cardiology, 55(21) pp. 2330​-2342​.​ DOI: https://doi.org/10.1016/j.jacc.2009.12.055 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | Research Paper | 
    ​ ​Differential Cardiac Remodeling in Preload Versus Afterload​
    Toischer, K. ; Rokita, A. G.; Unsoeld, B. W.; Zhu, W.; Kararigas, G.; Sossalla, S.   & Reuter, S. P. et al.​ (2010) 
    Circulation, 122(10) pp. 993​-1003​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.110.943431 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | Research Paper | 
    ​ ​Inhibition of Elevated Ca2+/Calmodulin-Dependent Protein Kinase II Improves Contractility in Human Failing Myocardium​
    Sossalla, S. ; Fluschnik, N.; Schotola, H.; Ort, K. R.; Neef, S.; Schulte, T. & Wittkoepper, K. et al.​ (2010) 
    Circulation Research, 107(9) pp. 1150​-U215​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.110.220418 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | Research Paper | 
    ​ ​Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging​
    Wittoepper, K.; Fabritz, L.; Neef, S.; Ort, K. R.; Grefe, C.; Unsoeld, B. W. & Kirchhof, P. et al.​ (2010) 
    Journal of Clinical Investigation, 120(2) pp. 617​-626​.​ DOI: https://doi.org/10.1172/JCI40545 
    ​Details  DOI  PMID  PMC  WoS 
  • 2009 | Journal Article | Research Paper | 
    ​ ​Abnormalities of calcium metabolism and myocardial contractility depression in the failing heart​
    Lehnart, S. E. ; Maier, L. S.   & Hasenfuß, G. ​ (2009) 
    Heart Failure Reviews, 14(4) pp. 213​-224​.​ DOI: https://doi.org/10.1007/s10741-009-9146-x 
    ​Details  DOI  PMID  PMC  WoS 
  • 2008 | Journal Article | Research Paper | 
    ​ ​Mechanism of action of the new anti-ischemia drug ranolazine​
    Hasenfuß, G.   & Maier, L. S. ​ (2008) 
    Clinical Research in Cardiology, 97(4) pp. 222​-226​.​ DOI: https://doi.org/10.1007/s00392-007-0612-y 
    ​Details  DOI  PMID  PMC  WoS 

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