Prof. Dr. Tim Friede

 
Staff Status
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  • 2024 Journal Article | Research Paper | 
    ​ ​Investigating the heterogeneity of "study twins"​
    Röver, C.   & Friede, T. ​ (2024) 
    Biometrical Journal66(6) art. e202300387​.​ DOI: https://doi.org/10.1002/bimj.202300387 
    Details  DOI  arXiv 
  • 2024 Journal Article | 
    ​ ​Survival analysis for AdVerse events with VarYing follow-up times (SAVVY): summary of findings and assessment of existing guidelines​
    Rufibach, K.; Beyersmann, J.; Friede, T. ; Schmoor, C. & Stegherr, R.​ (2024) 
    Trials25(1) art. 353​.​ DOI: https://doi.org/10.1186/s13063-024-08186-7 
    Details  DOI 
  • 2024 Journal Article | 
    ​ ​Health economic evaluation of blended collaborative care for older multimorbid heart failure patients: study protocol​
    Derendorf, L.; Stock, S.; Simic, D.; Shukri, A.; Zelenak, C.; Nagel, J. & Friede, T.  et al.​ (2024) 
    Cost Effectiveness and Resource Allocation22(1) art. 29​.​ DOI: https://doi.org/10.1186/s12962-024-00535-2 
    Details  DOI 
  • 2024 Journal Article | 
    ​ ​How trace plots help interpret meta-analysis results​
    Röver, C. ; Rindskopf, D. & Friede, T. ​ (2024) 
    Research Synthesis Methods15(3) art. jrsm.1693​.​ DOI: https://doi.org/10.1002/jrsm.1693 
    Details  DOI  PMID  PMC  Preprint 
  • 2024 Journal Article | 
    ​ ​Bayesian random‐effects meta‐analysis with empirical heterogeneity priors for application in health technology assessment with very few studies​
    Lilienthal, J.; Sturtz, S.; Schürmann, C.; Maiworm, M.; Röver, C. ; Friede, T.   & Bender, R.​ (2024) 
    Research Synthesis Methods15(2) art. jrsm.1685​.​ DOI: https://doi.org/10.1002/jrsm.1685 
    Details  DOI  PMID  PMC 
  • 2024 Journal Article
    ​ ​Electrocardiographic Risk Stratification in Primary Prophylactic Implantable Cardioverter Defibrillator Patients: Can Future Arrhythmias Correlating with Sudden Cardiac Death Be Predicted?​
    Zabel, M. & Friede, T. ​ (2024) 
    Europace, art. euae133​.​ DOI: https://doi.org/10.1093/europace/euae133 
    Details  DOI 
  • 2024 Journal Article
    ​ ​Transition from asymptomatic to symptomatic systolic chronic heart failure: rationale and design of TransitionCHF​
    Sandek, A.; Edelmann, F.; Gertler, C.; Friede, T. ; Wachter, R. & Hasenfuß, G.​ (2024) 
    ESC Heart Failure, art. ehf2.14783​.​ DOI: https://doi.org/10.1002/ehf2.14783 
    Details  DOI 
  • 2024 Journal Article
    ​ ​Stress and Multiple Sclerosis – Systematic review and meta-analysis of the association with disease onset, relapse risk and disability progression​
    von Drathen, S.; Heesen, C.; Gold, S. M.; Peper, J.; Rahn, A. C.; Ramien, C. & Magyari, M. et al.​ (2024) 
    Brain, Behavior, and Immunity,.​ DOI: https://doi.org/10.1016/j.bbi.2024.06.004 
    Details  DOI 
  • 2024 Journal Article
    ​ ​Randomized investigation of the MitraClip device in heart failure: Design and rationale of the RESHAPE‐HF2 trial design​
    Anker, S. D.; Friede, T. ; von Bardeleben, R. S.; Butler, J.; Fatima, K.; Diek, M. & Heinrich, J. et al.​ (2024) 
    European Journal of Heart Failure, art. ejhf.3247​.​ DOI: https://doi.org/10.1002/ejhf.3247 
    Details  DOI 
  • 2024 Journal Article
    ​ ​A diagnostic phase III/IV seamless design to investigate the diagnostic accuracy and clinical effectiveness using the example of HEDOS and HEDOS II​
    Pepić, A.; Stark, M.; Friede, T. ; Kopp-Schneider, A.; Calderazzo, S.; Reichert, M. & Wolf, M. et al.​ (2024) 
    Statistical Methods in Medical Research, art. 09622802241227951​.​ DOI: https://doi.org/10.1177/09622802241227951 
    Details  DOI 
  • 2024 Journal Article
    ​ ​Methods for non-proportional hazards in clinical trials: A systematic review​
    Bardo, M.; Huber, C.; Benda, N.; Brugger, J.; Fellinger, T.; Galaune, V. & Heinz, J. et al.​ (2024) 
    Statistical Methods in Medical Research, art. 09622802241242325​.​ DOI: https://doi.org/10.1177/09622802241242325 
    Details  DOI 
  • 2024 Journal Article
    ​ ​OPTINOFA – Intelligenter Assistenzdienst zur strukturierten Ersteinschätzung in der Notaufnahme​
    Nyoungui, E.; Karg, M. V.; Wieckenberg, M.; Esslinger, K.; Schmucker, M.; Reiswich, A. & Antweiler, K. L. et al.​ (2024) 
    Medizinische Klinik - Intensivmedizin und Notfallmedizin,.​ DOI: https://doi.org/10.1007/s00063-024-01126-y 
    Details  DOI 
  • 2024 Journal Article
    ​ ​Percutaneous repair of moderate‐to‐severe or severe functional mitral regurgitation in patients with symptomatic heart failure: Baseline characteristics of patients in the RESHAPE‐HF2 trial and comparison to COAPT and MITRA‐FR trials​
    Anker, S. D.; Friede, T. ; von Bardeleben, R. S.; Butler, J.; Khan, M. S.; Diek, M. & Heinrich, J. et al.​ (2024) 
    European Journal of Heart Failure, art. ejhf.3286​.​ DOI: https://doi.org/10.1002/ejhf.3286 
    Details  DOI 
  • 2023 Journal Article | 
    ​ ​Adherence enhancing interventions for pharmacological and oxygen therapy in patients with COPD: protocol for a systematic review and component network meta-analyses​
    Ammous, O.; Andreas, S.; Friede, T. ; Kampo, R.; Schwarz, S.; Wollsching-Strobel, M. & Salem, S. et al.​ (2023) 
    Systematic Reviews12(1) art. 159​.​ DOI: https://doi.org/10.1186/s13643-023-02326-x 
    Details  DOI 
  • 2023 Journal Article | Research Paper
    ​ ​Development of an interprofessional person-centred care concept for persons with care needs living in their own homes ( interprof HOME): study protocol for a mixed-methods study​
    Tetzlaff, B.; Scherer, M.; Balzer, K.; Steyer, L.; Köpke, S.; Friede, T.   & Maurer, I. et al.​ (2023) 
    BMJ Open13(7) art. e069597​.​ DOI: https://doi.org/10.1136/bmjopen-2022-069597 
    Details  DOI 
  • 2023 Journal Article | Research Paper | 
    ​ ​Evaluating an app for digital medical history taking in urgent care practices: study protocol of the cluster-randomized interventional trial ‘DASI’​
    Noack, E. M. ; Zajontz, D.; Friede, T. ; Antweiler, K.; Hummers, E. ; Schmidt, T. & Roddewig, L. et al.​ (2023) 
    BMC Primary Care24(1) art. 108​.​ DOI: https://doi.org/10.1186/s12875-023-02065-x 
    Details  DOI  PMID  PMC 
  • 2023 Journal Article | 
    ​ ​Summarizing empirical information on between‐study heterogeneity for Bayesian random‐effects meta‐analysis​
    Röver, C.; Sturtz, S.; Lilienthal, J.; Bender, R. & Friede, T. ​ (2023) 
    Statistics in Medicine42(14) art. sim.9731​.​ DOI: https://doi.org/10.1002/sim.9731 
    Details  DOI  PMID  PMC  Preprint 
  • 2023 Journal Article | 
    ​ ​Integrated care for older multimorbid heart failure patients: protocol for the ESCAPE randomized trial and cohort study​
    Zelenak, C.; Nagel, J.; Bersch, K.; Derendorf, L.; Doyle, F.; Friede, T.   & Herbeck Belnap, B. et al.​ (2023) 
    ESC Heart Failure10(3) art. ehf2.14294​.​ DOI: https://doi.org/10.1002/ehf2.14294 
    Details  DOI 
  • 2023 Journal Article | 
    ​ ​Using the bayesmeta R package for Bayesian random-effects meta-regression​
    Röver, C.   & Friede, T. ​ (2023) 
    Computer Methods and Programs in Biomedicine229 art. 107303​.​ DOI: https://doi.org/10.1016/j.cmpb.2022.107303 
    Details  DOI  PMID  PMC  Preprint 
  • 2023 Journal Article
    ​ ​Cost-Effectiveness of Inter-Professional Collaboration to Reduce Hospitalisations in Nursing Home Residents: Results from the German Interprof ACT Trial​
    Muntendorf, L.-K.; Balzer, K.; Friede, T. ; Hummers, E. ; König, H.-H.; Müller, C. A.   & Scherer, M. et al.​ (2023) 
    International Journal of Integrated Care23(2) pp. 8​.​ DOI: https://doi.org/10.5334/ijic.7001 
    Details  DOI  PMID  PMC 
  • 2023 Journal Article
    ​ ​The impact of healthcare systems on the clinical diagnosis and disease-modifying treatment usage in relapse-onset multiple sclerosis: a real-world perspective in five registries across Europe​
    Nicholas, R.; Rodgers, J.; Witts, J.; Lerede, A.; Friede, T. ; Hillert, J. & Forsberg, L. et al.​ (2023) 
    Therapeutic Advances in Neurological Disorders16 art. 17562864231198963​.​ DOI: https://doi.org/10.1177/17562864231198963 
    Details  DOI 
  • 2023 Journal Article
    ​ ​Postpartum relapse risk in multiple sclerosis: a systematic review and meta-analysis​
    Schubert, C.; Steinberg, L.; Peper, J.; Ramien, C.; Hellwig, K.; Köpke, S. & Solari, A. et al.​ (2023) 
    Journal of Neurology, Neurosurgery & Psychiatry, art. jnnp-2022-330533​.​ DOI: https://doi.org/10.1136/jnnp-2022-330533 
    Details  DOI 
  • 2023 Journal Article
    ​ ​Time to disability milestones and annualized relapse rates in NMOSD and MOGAD​
    Duchow, A.; Bellmann‐Strobl, J.; Friede, T. ; Aktas, O.; Angstwurm, K.; Ayzenberg, I. & Berthele, A. et al.​ (2023) 
    Annals of Neurology, art. ana.26858​.​ DOI: https://doi.org/10.1002/ana.26858 
    Details  DOI 
  • 2023 Journal Article
    ​ ​QRS complex and T wave planarity for the efficacy prediction of automatic implantable defibrillators​
    Hnatkova, K.; Andršová, I.; Novotný, T.; Vanderberk, B.; Sprenkeler, D.; Junttila, J. & Reichlin, T. et al.​ (2023) 
    Heart, pp. heartjnl-2023-322878​.​ DOI: https://doi.org/10.1136/heartjnl-2023-322878 
    Details  DOI 
  • 2023 Journal Article
    ​ ​The consequences of neglected confounding and interactions in mixed‐effects meta‐regression: An illustrative example​
    Knop, E. S.; Pauly, M.; Friede, T.   & Welz, T.​ (2023) 
    Research Synthesis Methods, art. jrsm.1643​.​ DOI: https://doi.org/10.1002/jrsm.1643 
    Details  DOI 
  • 2023 Journal Article
    ​ ​On the role of benchmarking data sets and simulations in method comparison studies​
    Friedrich, S. & Friede, T. ​ (2023) 
    Biometrical Journal, art. 2200212​.​ DOI: https://doi.org/10.1002/bimj.202200212 
    Details  DOI 
  • 2023 Journal Article
    ​ ​High levels of perivascular inflammation and active demyelinating lesions at time of death associated with rapidly progressive multiple sclerosis disease course: a retrospective post‐mortem cohort study​
    Nicholas, R.; Magliozzi, R.; Marastoni, D.; Howell, O.; Roncaroli, F.; Muraro, P. & Reynolds, R. et al.​ (2023) 
    Annals of Neurology, art. ana.26870​.​ DOI: https://doi.org/10.1002/ana.26870 
    Details  DOI 
  • 2023 Journal Article
    ​ ​Mobile health interventions in multiple sclerosis: A systematic review​
    Heesen, C.; Berger, T.; Riemann-Lorenz, K.; Krause, N.; Friede, T. ; Pöttgen, J. & Meyer, B. et al.​ (2023) 
    Multiple Sclerosis Journal, art. 13524585231201089​.​ DOI: https://doi.org/10.1177/13524585231201089 
    Details  DOI 
  • 2023 Journal Article
    ​ ​Interim decision making in seamless trial designs: An application in an adaptive dose‐finding study in a rare kidney disease​
    Papachristofi, O.; Bornkamp, B.; Wright, M. & Friede, T. ​ (2023) 
    Pharmaceutical Statistics, art. pst.2335​.​ DOI: https://doi.org/10.1002/pst.2335 
    Details  DOI 
  • 2023 Journal Article
    ​ ​Internet-delivered cognitive behavioural therapy programme to reduce depressive symptoms in patients with multiple sclerosis: a multicentre, randomised, controlled, phase 3 trial​
    Gold, S. M; Friede, T. ; Meyer, B.; Moss-Morris, R.; Hudson, J.; Asseyer, S. & Bellmann-Strobl, J. et al.​ (2023) 
    The Lancet Digital Health5(10) pp. e668​-e678​.​ DOI: https://doi.org/10.1016/S2589-7500(23)00109-7 
    Details  DOI 
  • 2023 Journal Article
    ​ ​Effect of Intravenous Iron Replacement on Recurrent Heart Failure Hospitalizations and Cardiovascular Mortality in Patients with Heart Failure and Iron Deficiency: A Bayesian Meta‐Analysis​
    Anker, S. D.; Shahzeb Khan, M.; Butler, J.; von Haehling, S.; Jankowska, E. A; Ponikowski, P. & Friede, T. ​ (2023) 
    European Journal of Heart Failure, art. ejhf.2860​.​ DOI: https://doi.org/10.1002/ejhf.2860 
    Details  DOI 
  • 2023 Journal Article
    ​ ​Association of health behaviour and clinical manifestation in early multiple sclerosis in Germany – Baseline characteristics of the POWER@MS1 randomised controlled trial​
    Krause, N.; Derad, C.; von Glasenapp, B.; Riemann-Lorenz, K.; Temmes, H.; van de Loo, M. & Friede, T.  et al.​ (2023) 
    Multiple Sclerosis and Related Disorders79 pp. 105043​.​ DOI: https://doi.org/10.1016/j.msard.2023.105043 
    Details  DOI 
  • 2023 Journal Article
    ​ ​Challenges in developing and validating machine learning models for TAVI mortality risk prediction: reply​
    Leha, A.; Huber, C.; Friede, T. ; Bauer, T.; Beckmann, A.; Bekeredjian, R. & Bleiziffer, S. et al.​ (2023) 
    European Heart Journal - Digital Health5(1) pp. 3​-5​.​ DOI: https://doi.org/10.1093/ehjdh/ztad065 
    Details  DOI 
  • 2023 Journal Article
    ​ ​Confidence intervals for discrete data in clinical research by VivekPradhan, Ashis K.Gangopadhyay, Sandeep M.Menon, CynthiaBasu, TathagataBanerjee.Boca Raton, FL: Chapman & Hall/CRC Press. 2022. 240 pages. ISBN: 9781138048980 (hbk). ISBN 9781315169859 (ebk). List price: £99.99​
    Friede, T. ​ (2023) 
    Biometrical Journal, art. 2300026​.​ DOI: https://doi.org/10.1002/bimj.202300026 
    Details  DOI 
  • 2023 Journal Article
    ​ ​Adjusting for publication bias in meta‐analysis via inverse probability weighting using clinical trial registries​
    Huang, A.; Morikawa, K.; Friede, T.   & Hattori, S.​ (2023) 
    Biometrics, art. biom.13822​.​ DOI: https://doi.org/10.1111/biom.13822 
    Details  DOI 
  • 2023 Journal Article
    ​ ​Accounting for time dependency in meta‐analyses of concordance probability estimates​
    Schmid, M.; Friede, T. ; Klein, N. & Weinhold, L.​ (2023) 
    Research Synthesis Methods, art. jrsm.1655​.​ DOI: https://doi.org/10.1002/jrsm.1655 
    Details  DOI 
  • 2023 Journal Article
    ​ ​Coping with Information Loss and the Use of Auxiliary Sources of Data: A Report from the NISS Ingram Olkin Forum Series on Unplanned Clinical Trial Disruptions​
    Calderazzo, S.; Tarima, S.; Reid, C.; Flournoy, N.; Friede, T. ; Geller, N. & Rosenberger, J. L et al.​ (2023) 
    Statistics in Biopharmaceutical Research, pp. 1​-17​.​ DOI: https://doi.org/10.1080/19466315.2023.2211023 
    Details  DOI 
  • 2023 Journal Article
    ​ ​Efficacy of Ferric carboxymaltose in heart failure with iron deficiency: an individual patient data meta-analysis​
    Ponikowski, P.; Mentz, R. J; Hernandez, A. F; Butler, J.; Khan, M. S.; van Veldhuisen, D. J & Roubert, B. et al.​ (2023) 
    European Heart Journal, art. ehad586​.​ DOI: https://doi.org/10.1093/eurheartj/ehad586 
    Details  DOI 
  • 2023 Journal Article
    ​ ​Blinded sample size recalculation in multiple composite population designs with normal data and baseline adjustments​
    Gera, R. G. & Friede, T. ​ (2023) 
    Biometrical Journal, art. 2000326​.​ DOI: https://doi.org/10.1002/bimj.202000326 
    Details  DOI 
  • 2023 Journal Article
    ​ ​Development and validation of explainable machine learning models for risk of mortality in transcatheter aortic valve implantation: TAVI risk machine scores​
    Leha, A.; Huber, C.; Friede, T. ; Bauer, T.; Beckmann, A.; Bekeredjian, R. & Bleiziffer, S. et al.​ (2023) 
    European Heart Journal - Digital Health4(3) pp. 225​-235​.​ DOI: https://doi.org/10.1093/ehjdh/ztad021 
    Details  DOI 
  • 2023 Journal Article | 
    ​ ​Verknüpfung von randomisierten kontrollierten Studien und Real World Data​
    Friede, T. ; Röver, C. & Mathes, T.​ (2023) 
    Prävention und Gesundheitsförderung,.​ DOI: https://doi.org/10.1007/s11553-023-01016-9 
    Details  DOI 
  • 2023 Journal Article
    ​ ​Supervised exercise training in patients with advanced heart failure and left ventricular assist device: A multicentre randomized controlled trial ( Ex‐VAD trial)​
    Feuerstein, A.; Schoenrath, F.; Belyavskiy, E.; Knierim, J.; Friede, T. ; Placzek, M.   & Bach, D. et al.​ (2023) 
    European Journal of Heart Failure, art. ejhf.3032​.​ DOI: https://doi.org/10.1002/ejhf.3032 
    Details  DOI 
  • 2023 Journal Article | Research Paper | 
    ​ ​Cluster randomised trial of a complex interprofessional intervention (interprofACT) to reduce hospital admission of nursing home residents​
    Mazur, A. ; Tetzlaff, B.; Mallon, T.; Hesjedal-Streller, B.; Weiß, V.; Scherer, M. & Köpke, S. et al.​ (2023) 
    Age and Ageing52(3).​ DOI: https://doi.org/10.1093/ageing/afad022 
    Details  DOI  PMID  PMC 
  • 2022 Journal Article | Research Paper | 
    ​ ​A straightforward meta-analysis approach for oncology phase I dose-finding studies​
    Röver, C. ; Ursino, M.; Zohar, S. & Friede, T. ​ (2022) 
    Statistics in Medicine41(20) art. sim.9484​.​ DOI: https://doi.org/10.1002/sim.9484 
    Details  DOI  PMID  PMC  Preprint 
  • 2022 Journal Article | Research Paper | 
    ​ ​Double arcsine transform not appropriate for meta‐analysis​
    Röver, C.   & Friede, T. ​ (2022) 
    Research Synthesis Methods13(5) art. jrsm.1591​.​ DOI: https://doi.org/10.1002/jrsm.1591 
    Details  DOI  Preprint 
  • 2022 Journal Article | 
    ​ ​Blinded sample size recalculation in adaptive enrichment designs​
    Placzek, M.   & Friede, T. ​ (2022) 
    Biometrical Journal65(2) art. bimj.202000345​.​ DOI: https://doi.org/10.1002/bimj.202000345 
    Details  DOI 
  • 2022 Journal Article | Research Paper | 
    ​ ​Implementation, mechanisms of change and contextual factors of a complex intervention to improve interprofessional collaboration and the quality of medical care for nursing home residents: study protocol of the process evaluation of the interprof ACT intervention package​
    Steyer, L.; Kortkamp, C.; Müller, C. ; Tetzlaff, B.; Fleischmann, N. ; Weber, C. E. & Scherer, M. et al.​ (2022) 
    Trials23(1) art. 561​.​ DOI: https://doi.org/10.1186/s13063-022-06476-6 
    Details  DOI 
  • 2022 Journal Article | Research Paper | 
    ​ ​Immunotherapy for people with clinically isolated syndrome or relapsing-remitting multiple sclerosis: treatment response by demographic, clinical, and biomarker subgroups (PROMISE)—a systematic review protocol​
    Lehnert, T.; Köpke, S.; Rio, J.; Chard, D.; Fittipaldo, A. V.; Heesen, C. & Rahn, A. C. et al.​ (2022) 
    Systematic Reviews11(1) art. 134​.​ DOI: https://doi.org/10.1186/s13643-022-01997-2 
    Details  DOI 
  • 2022 Journal Article | Research Paper | 
    ​ ​COPD mortality and exacerbations in the placebo group of clinical trials over two decades: a systematic review and meta-regression​
    Andreas, S.; Röver, C. ; Heinz, J.; Taube, C. & Friede, T. ​ (2022) 
    ERJ Open Research8(1) art. 00261-2021​.​ DOI: https://doi.org/10.1183/23120541.00261-2021 
    Details  DOI 
  • 2022 Preprint
    ​ ​MetaStan: An R package for Bayesian (model-based) meta-analysis using Stan​
    Kürsad Günhan, B.; Röver, C.  & Friede, T. ​ (2022)
    Details  arXiv 
  • 2022 Journal Article | 
    ​ ​Development and Validation of a Predictive Model for Toxicity of Neoadjuvant Chemoradiotherapy in Rectal Cancer in the CAO/ARO/AIO-04 Phase III Trial​
    Diefenhardt, M.; Martin, D.; Ludmir, E. B.; Fleischmann, M.; Hofheinz, R.-D.; Ghadimi, M.   & Kosmala, R. et al.​ (2022) 
    Cancers14(18) pp. 4425​.​ DOI: https://doi.org/10.3390/cancers14184425 
    Details  DOI 
  • 2022 Journal Article | 
    ​ ​Improving the statistical power of economic experiments using adaptive designs​
    Jobjörnsson, S.; Schaak, H.; Musshoff, O.   & Friede, T. ​ (2022) 
    Experimental Economics,.​ DOI: https://doi.org/10.1007/s10683-022-09773-8 
    Details  DOI 
  • 2022 Journal Article
    ​ ​Patiromer for the management of hyperkalemia in heart failure with reduced ejection fraction: the DIAMOND trial​
    Butler, J.; Anker, S. D. ; Lund, L. H.; Coats, A. J. S.; Filippatos, G.; Siddiqi, T. J. & Friede, T.  et al.​ (2022) 
    European Heart Journal, art. ehac401​.​ DOI: https://doi.org/10.1093/eurheartj/ehac401 
    Details  DOI 
  • 2022 Journal Article
    ​ ​Robustness of outcomes in trials evaluating sodium–glucose co‐transporter 2 inhibitors for heart failure​
    Usman, M. S.; Khan, M. S.; Fonarow, G. C.; Greene, S. J.; Friede, T. ; Vaduganathan, M. & Filippatos, G. et al.​ (2022) 
    ESC Heart Failure,.​ DOI: https://doi.org/10.1002/ehf2.13785 
    Details  DOI 
  • 2022 Journal Article
    ​ ​Improving pediatric multiple sclerosis interventional phase III study design: a meta-analysis​
    Graves, J. S.; Thomas, M.; Li, J.; Shah, A. R.; Goodyear, A.; Lange, M. R. & Schmidli, H. et al.​ (2022) 
    Therapeutic Advances in Neurological Disorders15 pp. 175628642110704​.​ DOI: https://doi.org/10.1177/17562864211070449 
    Details  DOI 
  • 2022 Journal Article
    ​ ​Regularization approaches in clinical biostatistics: A review of methods and their applications​
    Friedrich, S.; Groll, A.; Ickstadt, K.; Kneib, T.; Pauly, M.; Rahnenführer, J. & Friede, T. ​ (2022) 
    Statistical Methods in Medical Research, art. 096228022211335​.​ DOI: https://doi.org/10.1177/09622802221133557 
    Details  DOI 
  • 2022 Journal Article
    ​ ​Minimal Clinically Important Difference for Six-minute Walk Test in Patients with HFrEF and Iron Deficiency​
    Khan, M. S.; Anker, S. D.; Friede, T. ; Jankowska, E. A.; Metra, M.; Piña, I. L & Coats, A. J. et al.​ (2022) 
    Journal of Cardiac Failure,.​ DOI: https://doi.org/10.1016/j.cardfail.2022.10.423 
    Details  DOI 
  • 2022 Journal Article
    ​ ​Managing neuropsychological impairment in multiple sclerosis – Controlled study on a standardized metacognitive intervention (MaTiMS)​
    Pöttgen, J.; Friede, T. ; Lau, S.; Gold, S. M.; Letsch, C.; Bender, G. & Flachenecker, P. et al.​ (2022) 
    Multiple Sclerosis and Related Disorders59 art. S2211034822002024​.​ DOI: https://doi.org/10.1016/j.msard.2022.103687 
    Details  DOI 
  • 2022 Journal Article
    ​ ​A Guide to Selecting Flexible Survival Models to Inform Economic Evaluations of Cancer Immunotherapies​
    Palmer, S.; Borget, I.; Friede, T. ; Husereau, D.; Karnon, J.; Kearns, B. & Medin, E. et al.​ (2022) 
    Value in Health,.​ DOI: https://doi.org/10.1016/j.jval.2022.07.009 
    Details  DOI 
  • 2022 Journal Article
    ​ ​Disease-modifying treatments for multiple sclerosis have not affected the incidence of neoplasms in clinical trials over 3 decades: a meta-analysis with meta-regression​
    Papadopoulos, D.; Gklinos, P.; Psarros, G.; Drellia, K.; Delicha, E. M.; Friede, T.   & Mitsikostas, D. D. et al.​ (2022) 
    Journal of Neurology,.​ DOI: https://doi.org/10.1007/s00415-021-10932-9 
    Details  DOI 
  • 2022 Journal Article
    ​ ​Responder analysis for improvement in six‐minute walk test with ferric carboxymaltose in patients with heart failure with reduced ejection fraction and iron deficiency​
    Anker, S. D.; Ponikowski, P.; Khan, M. S.; Friede, T. ; Jankowska, E. A.; Fabien, V. & Goehring, U. et al.​ (2022) 
    European Journal of Heart Failure,.​ DOI: https://doi.org/10.1002/ejhf.2491 
    Details  DOI 
  • 2022 Journal Article
    ​ ​Health status improvement with ferric carboxymaltose in heart failure with reduced ejection fraction and iron deficiency​
    Butler, J.; Khan, M. S.; Friede, T. ; Jankowska, E. A.; Fabien, V.; Goehring, U. & Dorigotti, F. et al.​ (2022) 
    European Journal of Heart Failure,.​ DOI: https://doi.org/10.1002/ejhf.2478 
    Details  DOI 
  • 2022 Journal Article | 
    ​ ​A machine learning algorithm for electrocardiographic fQRS quantification validated on multi-center data​
    Villa, A.; Vandenberk, B.; Kenttä, T.; Ingelaere, S.; Huikuri, H. V; Zabel, M. & Friede, T.  et al.​ (2022) 
    Scientific Reports12(1) art. 6783​.​ DOI: https://doi.org/10.1038/s41598-022-10452-0 
    Details  DOI 
  • 2022 Journal Article
    ​ ​Sample size calculation for the augmented logrank test in randomized clinical trials​
    Hattori, S.; Komukai, S. & Friede, T. ​ (2022) 
    Statistics in Medicine,.​ DOI: https://doi.org/10.1002/sim.9374 
    Details  DOI 
  • 2022 Journal Article
    ​ ​Improving adaptive seamless designs through Bayesian optimization​
    Richter, J.; Friede, T.   & Rahnenführer, J.​ (2022) 
    Biometrical Journal,.​ DOI: https://doi.org/10.1002/bimj.202000389 
    Details  DOI 
  • 2022 Journal Article | 
    ​ ​Authors’ response: on the role of data, statistics and decisions in a pandemic​
    Jahn, B.; Friedrich, S.; Behnke, J.; Engel, J.; Garczarek, U.; Münnich, R. & Pauly, M. et al.​ (2022) 
    AStA Advances in Statistical Analysis,.​ DOI: https://doi.org/10.1007/s10182-022-00460-w 
    Details  DOI 
  • 2022 Journal Article | 
    ​ ​On the role of data, statistics and decisions in a pandemic​
    Jahn, B.; Friedrich, S.; Behnke, J.; Engel, J.; Garczarek, U.; Münnich, R. & Pauly, M. et al.​ (2022) 
    Advances in Statistical Analysis,.​ DOI: https://doi.org/10.1007/s10182-022-00439-7 
    Details  DOI 
  • 2021 Lecture | 
    ​ ​Statistik in der klinischen Forschung​
    Friede, T. ​ (2021)
    Künstliche Intelligenz, Data Science und Gesellschaft; 2021-12-21​, Göttingen.
    Details 
  • 2021 Journal Article | Research Paper | 
    ​ ​Classification of Companion Diagnostics: A New Framework for Biomarker-Driven Patient Selection​
    Huber, C.; Friede, T. ; Stingl, J. & Benda, N.​ (2021) 
    Therapeutic Innovation & Regulatory Science56(2) pp. 244​-254​.​ DOI: https://doi.org/10.1007/s43441-021-00352-2 
    Details  DOI 
  • 2021 Journal Article | Research Paper
    ​ ​Herbal treatment with uva ursi extract versus fosfomycin in women with uncomplicated urinary tract infection in primary care: a randomized controlled trial​
    Gágyor, I. ; Hummers, E. ; Schmiemann, G.; Friede, T. ; Pfeiffer, S.; Afshar, K. & Bleidorn, J.​ (2021) 
    Clinical Microbiology and Infection27(10) pp. 1441​-1447​.​ DOI: https://doi.org/10.1016/j.cmi.2021.05.032 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | 
    ​ ​Subgroup identification in individual participant data meta-analysis using model-based recursive partitioning​
    Huber, C.; Benda, N. & Friede, T. ​ (2021) 
    Advances in Data Analysis and Classification16(3) pp. 797​-815​.​ DOI: https://doi.org/10.1007/s11634-021-00458-3 
    Details  DOI 
  • 2021 Journal Article | 
    ​ ​Is there a role for statistics in artificial intelligence?​
    Friedrich, S.; Antes, G.; Behr, S.; Binder, H.; Brannath, W.; Dumpert, F. & Ickstadt, K. et al.​ (2021) 
    Advances in Data Analysis and Classification16(4) pp. 823​-846​.​ DOI: https://doi.org/10.1007/s11634-021-00455-6 
    Details  DOI 
  • 2021 Journal Article | Research Paper | 
    ​ ​Survival analysis for AdVerse events with VarYing follow-up times (SAVVY)—estimation of adverse event risks​
    Stegherr, R.; Schmoor, C.; Beyersmann, J.; Rufibach, K.; Jehl, V.; Brückner, A. & Eisele, L. et al.​ (2021) 
    Trials22(1) art. 420​.​ DOI: https://doi.org/10.1186/s13063-021-05354-x 
    Details  DOI 
  • 2021 Journal Article | Research Paper | 
    ​ ​Phase I dose-escalation oncology trials with sequential multiple schedules​
    Günhan, B. K.; Weber, S.; Seroutou, A. & Friede, T. ​ (2021) 
    BMC Medical Research Methodology21(1) art. 69​.​ DOI: https://doi.org/10.1186/s12874-021-01218-9 
    Details  DOI 
  • 2021 Journal Article | 
    ​ ​Identification of subgroup effect with an individual participant data meta-analysis of randomised controlled trials of three different types of therapist-delivered care in low back pain​
    Mistry, D.; Friede, T. ; Lamb, S. E.; Stallard, N.; Underwood, M.; Patel, S. & Hee, S. W.​ (2021) 
    BMC Musculoskeletal Disorders22(1) art. 191​.​ DOI: https://doi.org/10.1186/s12891-021-04028-8 
    Details  DOI 
  • 2021 Journal Article | Research Paper
    ​ ​Exercise-Stress Real-time Cardiac Magnetic Resonance Imaging for Non-Invasive Characterisation of Heart Failure with Preserved Ejection Fraction: The HFpEF Stress Trial​
    Backhaus, S. J; Lange, T.; George, E. F; Hellenkamp, K. ; Gertz, R. J; Billing, M. & Wachter, R.  et al.​ (2021) 
    Circulation,.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.120.051542 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | 
    ​ ​Bounds for the weight of external data in shrinkage estimation​
    Röver, C.   & Friede, T. ​ (2021) 
    Biometrical Journal63(5) pp. 1131​-1143​.​ DOI: https://doi.org/10.1002/bimj.202000227 
    Details  DOI 
  • 2021 Journal Article | Research Paper | 
    ​ ​Acute respiratory infections in an adult refugee population: an observational study​
    Jablonka, A.; Dopfer, C.; Happle, C.; Shalabi, A.; Wetzke, M.; Hummers, E.   & Friede, T.  et al.​ (2021) 
    npj Primary Care Respiratory Medicine31(1).​ DOI: https://doi.org/10.1038/s41533-021-00261-9 
    Details  DOI 
  • 2021 Journal Article | 
    ​ ​Chances and challenges of a long-term data repository in multiple sclerosis: 20th birthday of the German MS registry​
    Ohle, L.-M.; Ellenberger, D. ; Flachenecker, P.; Friede, T. ; Haas, J.; Hellwig, K. & Parciak, T. et al.​ (2021) 
    Scientific Reports11(1) art. 13340​.​ DOI: https://doi.org/10.1038/s41598-021-92722-x 
    Details  DOI 
  • 2021 Journal Article
    ​ ​Study protocol for a randomised controlled trial of a web-based behavioural lifestyle programme for emPOWERment in early Multiple Sclerosis (POWER@MS1)​
    Krause, N.; Riemann-Lorenz, K.; Steffen, T.; Rahn, A. C.; Pöttgen, J.; Stellmann, J.-P. & Köpke, S. et al.​ (2021) 
    BMJ Open11(2) pp. e041720​.​ DOI: https://doi.org/10.1136/bmjopen-2020-041720 
    Details  DOI 
  • 2021 Journal Article | Research Paper | 
    ​ ​Patient delay and benefit of timely reperfusion in ST-segment elevation myocardial infarction​
    Scholz, K. H.; Meyer, T.; Lengenfelder, B.; Vahlhaus, C.; Tongers, J.; Schnupp, S. & Burckhard, R. et al.​ (2021) 
    Open Heart8(1) pp. e001650​.​ DOI: https://doi.org/10.1136/openhrt-2021-001650 
    Details  DOI 
  • 2021 Journal Article
    ​ ​Percutaneous Mitral Valve Annuloplasty in Patients With Secondary Mitral Regurgitation and Severe Left Ventricular Enlargement​
    Anker, S. D.; Starling, R. C.; Khan, M. S.; Friede, T. ; Filippatos, G.; Lindenfeld, J. & Stephan von Bardeleben, R. et al.​ (2021) 
    JACC Heart Failure9(6) pp. 453​-462​.​ DOI: https://doi.org/10.1016/j.jchf.2021.03.002 
    Details  DOI 
  • 2021 Journal Article
    ​ ​Random-effects meta-analysis of Phase I dose-finding studies using stochastic process priors​
    Ursino, M.; Röver, C.; Zohar, S. & Friede, T. ​ (2021) 
    The Annals of Applied Statistics15(1).​ DOI: https://doi.org/10.1214/20-AOAS1390 
    Details  DOI 
  • 2021 Journal Article
    ​ ​Noninferiority trials: What's clinically (ir)relevant?​
    Falk, V. & Friede, T. ​ (2021) 
    Journal of Thoracic and Cardiovascular Surgery161(6) pp. 2119​-2123​.​ DOI: https://doi.org/10.1016/j.jtcvs.2020.03.168 
    Details  DOI 
  • 2021 Journal Article
    ​ ​Development and evaluation of an interactive web-based decision-making programme on relapse management for people with multiple sclerosis (POWER@MS2)—study protocol for a randomised controlled trial​
    Rahn, A. C.; Wenzel, L.; Icks, A.; Stahmann, A.; Scheiderbauer, J.; Grentzenberg, K. & Vomhof, M. et al.​ (2021) 
    Trials22(1).​ DOI: https://doi.org/10.1186/s13063-021-05059-1 
    Details  DOI 
  • 2021 Journal Article | 
    ​ ​Design aspects of COVID‐19 treatment trials: Improving probability and time of favorable events​
    Beyersmann, J.; Friede, T.   & Schmoor, C.​ (2021) 
    Biometrical Journal64(3) pp. 440​-460​.​ DOI: https://doi.org/10.1002/bimj.202000359 
    Details  DOI 
  • 2021 Journal Article | Erratum
    ​ ​Correction to: Development and evaluation of an interactive web-based decision-making programme on relapse management for people with multiple sclerosis (POWER@MS2)—study protocol for a randomised controlled trial​
    Rahn, A. C.; Wenzel, L.; Icks, A.; Stahmann, A.; Scheiderbauer, J.; Grentzenberg, K. & Vomhof, M. et al.​ (2021) 
    Trials22(1).​ DOI: https://doi.org/10.1186/s13063-021-05152-5 
    Details  DOI 
  • 2021 Journal Article
    ​ ​Estimating and comparing adverse event probabilities in the presence of varying follow‐up times and competing events​
    Stegherr, R.; Schmoor, C.; Lübbert, M.; Friede, T.   & Beyersmann, J.​ (2021) 
    Pharmaceutical Statistics,.​ DOI: https://doi.org/10.1002/pst.2130 
    Details  DOI 
  • 2021 Conference Abstract
    ​ ​Chemoradiotherapy plus induction or consolidation chemotherapy as total neoadjuvant therapy for locally advanced rectal cancer: Final results of the CAO/ ARO/ AIO-12 randomized phase 2 trial​
    Fokas, E.; Schlenska-Lange, A.; Polat, B.; Klautke, G.; Grabenbauer, G.; Fietkau, R. & Kuhnt, T. et al.​ (2021)
    Strahlentherapie und Onkologie197(Suppl. 1) pp. S7​-S8. ​27. Jahrestagung der Deutschen Gesellschaft für Radioonkologie​, virtuell.
    Details 
  • 2021 Conference Abstract
    ​ ​The impact of smoking cessation on multiple sclerosis disease progression​
    Rodgers, W. J.; Friede, T. ; Vonberg, F. W.; Constantinescu, C. S.; Coles, A.; Chataway, J. & Emsley, H. et al.​ (2021)
    Multiple Sclerosis Journal27(Suppl. 2) pp. 41​-42. ​37th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS 2021)​, virtual.
    Details  WoS 
  • 2021 Conference Abstract
    ​ ​TNT in rectal cancer: Final results of the CAO/ARO/AIO-12 randomized phase 2 trial​
    Fokas, E.; Schlenska-Lange, A.; Polat, B.; Klautke, G.; Fietkau, R.; Kuhnt, T. & Brunner, T. et al.​ (2021)
    Radiotherapy and Oncology161(Suppl. 1) pp. S199​-S200. ​CARO 2021, Transforming Care in Radiation Medicine​, virtual.
    Details  WoS 
  • 2021 Conference Abstract
    ​ ​Using historical relapse rates for the design of an innovative Phase 3 study with ofatumumab and siponimod in paediatric multiple sclerosis​
    Gärtner, J. ; Thomas, M.; Li, J.; Karlsson, G.; Schmidli, H.; Haring, D. A. & Friede, T.  et al.​ (2021)
    Multiple Sclerosis Journal27(Suppl. 2) pp. 195​-196. ​37th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS 2021)​, virtual.
    Details  WoS 
  • 2021 Conference Abstract
    ​ ​Treatment patterns of patients with aggressive MS in a cohort of early retirees​
    Fneish, F.; Frahm, N.; Ellenberger, D.; Flachenecker, P.; Friede, T. ; Kleinschnitz, C. & Krefting, D.  et al.​ (2021)
    Multiple Sclerosis Journal27(Suppl. 2) pp. 711​-712. ​37th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS 2021)​, virtual.
    Details  WoS 
  • 2021 Journal Article
    ​ ​Using clinical trial registries to inform Copas selection model for publication bias in meta‐analysis​
    Huang, A.; Komukai, S.; Friede, T.   & Hattori, S.​ (2021) 
    Research Synthesis Methods12(5) pp. 658​-673​.​ DOI: https://doi.org/10.1002/jrsm.1506 
    Details  DOI 
  • 2021 Journal Article | 
    ​ ​Validation of a Prospective Urinalysis-Based Prediction Model for ICU Resources and Outcome of COVID-19 Disease: A Multicenter Cohort Study​
    Gross, O. ; Moerer, O. ; Rauen, T.; Böckhaus, J.; Hoxha, E.; Jörres, A. & Kamm, M. et al.​ (2021) 
    Journal of Clinical Medicine10(14) pp. 3049​.​ DOI: https://doi.org/10.3390/jcm10143049 
    Details  DOI 
  • 2021 Journal Article
    ​ ​Reduced Clostridioides difficile infections in hospitalised older people through multiple quality improvement strategies​
    Dohrendorf, C. M.; Unkel, S.; Scheithauer, S. ; Kaase, M.; Meier, V.; Fenz, D. & Sasse, J. et al.​ (2021) 
    Age and Ageing50(6) pp. 2123​-2132​.​ DOI: https://doi.org/10.1093/ageing/afab169 
    Details  DOI 
  • 2021 Journal Article
    ​ ​A potential for seamless designs in diagnostic research could be identified​
    Vach, W.; Bibiza, E.; Gerke, O.; Bossuyt, P. M.; Friede, T.   & Zapf, A. ​ (2021) 
    Journal of Clinical Epidemiology129 pp. 51​-59​.​ DOI: https://doi.org/10.1016/j.jclinepi.2020.09.019 
    Details  DOI 
  • 2021 Journal Article
    ​ ​Patiromer for the management of hyperkalaemia in patients receiving renin–angiotensin–aldosterone system inhibitors for heart failure: design and rationale of the DIAMOND trial​
    Butler, J.; Anker, S. D.; Siddiqi, T. J.; Coats, A. J.; Dorigotti, F.; Filippatos, G. & Friede, T.  et al.​ (2021) 
    European Journal of Heart Failure,.​ DOI: https://doi.org/10.1002/ejhf.2386 
    Details  DOI 
  • 2021 Journal Article
    ​ ​The impact of smoking cessation on multiple sclerosis disease progression​
    Rodgers, J.; Friede, T. ; Vonberg, F. W; Constantinescu, C. S; Coles, A.; Chataway, J. & Duddy, M. et al.​ (2021) 
    Brain,.​ DOI: https://doi.org/10.1093/brain/awab385 
    Details  DOI 
  • 2021 Journal Article
    ​ ​Effect of Carillon Mitral Contour System on patient‐reported outcomes in functional mitral regurgitation: an individual participant data meta‐analysis​
    Khan, M. S.; Friede, T. ; Anker, S. D. & Butler, J.​ (2021) 
    ESC Heart Failure8(3) pp. 1885​-1891​.​ DOI: https://doi.org/10.1002/ehf2.13301 
    Details  DOI 
  • 2021 Journal Article
    ​ ​Influence of individual, illness and environmental factors on place of death among people with neurodegenerative diseases: a retrospective, observational, comparative cohort study​
    Nicholas, R.; Nicholas, E.; Hannides, M.; Gautam, V.; Friede, T.   & Koffman, J.​ (2021) 
    BMJ Supportive & Palliative Care, pp. bmjspcare-2021-003105​.​ DOI: https://doi.org/10.1136/bmjspcare-2021-003105 
    Details  DOI 
  • 2021 Journal Article | 
    ​ ​On weakly informative prior distributions for the heterogeneity parameter in Bayesian random‐effects meta‐analysis​
    Röver, C. ; Bender, R.; Dias, S.; Schmid, C. H.; Schmidli, H.; Sturtz, S. & Weber, S. et al.​ (2021) 
    Research Synthesis Methods,.​ DOI: https://doi.org/10.1002/jrsm.1475 
    Details  DOI 
  • 2021 Journal Article | 
    ​ ​A confidence interval robust to publication bias for random‐effects meta‐analysis of few studies​
    Henmi, M.; Hattori, S. & Friede, T. ​ (2021) 
    Research Synthesis Methods,.​ DOI: https://doi.org/10.1002/jrsm.1482 
    Details  DOI 
  • 2021 Journal Article
    ​ ​Functional outcomes with Carillon device over 1 year in patients with functional mitral regurgitation of Grades 2+ to 4+: results from the REDUCE‐FMR trial​
    Khan, M. S.; Siddiqi, T. J.; Butler, J.; Friede, T. ; Levy, W. C.; Witte, K. K. & Lipiecki, J. et al.​ (2021) 
    ESC Heart Failure8(2) pp. 872​-878​.​ DOI: https://doi.org/10.1002/ehf2.13273 
    Details  DOI 
  • 2020 Journal Article | Research Paper | 
    ​ ​Effects of strategies to improve general practitioner-nurse collaboration and communication in regard to hospital admissions of nursing home residents (interprof ACT): study protocol for a cluster randomised controlled trial​
    Müller, C.; Hesjedal-Streller, B.; Fleischmann, N.; Tetzlaff, B.; Mallon, T.; Scherer, M. & Köpke, S. et al.​ (2020) 
    Trials21(1).​ DOI: https://doi.org/10.1186/s13063-020-04736-x 
    Details  DOI 
  • 2020 Journal Article | 
    ​ ​Repeating noninvasive risk stratification improves prediction of outcome in ICD patients.​
    Vandenberk, B.; Floré, V.; Röver, C.; Vos, M. A; Dunnink, A.; Leftheriotis, D. & Friede, T.  et al.​ (2020) 
    Annals of Noninvasive Electrocardiology25(6) art. e12794​.​ DOI: https://doi.org/10.1111/anec.12794 
    Details  DOI  PMID  PMC 
  • 2020 Lecture | 
    ​ ​Klinische Forschung in Zeiten von Corona​
    Friede, T. ​ (2020)
    Ein Virus verändert die Welt: Göttinger Wissenschaftler*innen zur Corona-Pandemie; 2020-05-05​, virtuell.
    Details 
  • 2020 Journal Article | 
    ​ ​Prognostic significance of emergency department bypass in stable and unstable patients with ST-segment elevation myocardial infarction​
    Scholz, K. H.; Jacobshagen, C. ; Lengenfelder, B.; Jung, J.; Fleischmann, C.; Moehlis, H. & Olbrich, H. G et al.​ (2020) 
    European Heart Journal - Acute Cardiovascular Care9(1, Suppl.) pp. 34​-44​.​ DOI: https://doi.org/10.1177/2048872618813907 
    Details  DOI  PMID  PMC 
  • 2020 Journal Article | 
    ​ ​Antibody signatures in patients with histopathologically defined multiple sclerosis patterns​
    Stork, L.; Ellenberger, D.; Ruprecht, K.; Reindl, M.; Beißbarth, T. ; Friede, T.   & Kümpfel, T. et al.​ (2020) 
    Acta Neuropathologica139(3) pp. 547​-564​.​ DOI: https://doi.org/10.1007/s00401-019-02120-x 
    Details  DOI  PMID  PMC 
  • 2020 Journal Article
    ​ ​Application of the Reverse Fragility Index to Statistically Nonsignificant Randomized Clinical Trial Results​
    Khan, M. S.; Fonarow, G. C.; Friede, T. ; Lateef, N.; Khan, S. U.; Anker, S. D.   & Harrell, F. E. et al.​ (2020) 
    JAMA Network Open3(8) pp. e2012469​.​ DOI: https://doi.org/10.1001/jamanetworkopen.2020.12469 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Exact change point detection with improved power in small‐sample binomial sequences​
    Ellenberger, D. ; Lausen, B. & Friede, T. ​ (2020) 
    Biometrical Journal63(3) pp. 558​-574​.​ DOI: https://doi.org/10.1002/bimj.201900273 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Survival analysis for AdVerse events with VarYing follow‐up times (SAVVY): Rationale and statistical concept of a meta‐analytic study​
    Stegherr, R.; Beyersmann, J.; Jehl, V.; Rufibach, K.; Leverkus, F.; Schmoor, C. & Friede, T. ​ (2020) 
    Biometrical Journal63(3) pp. 650​-670​.​ DOI: https://doi.org/10.1002/bimj.201900347 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Simvastatin add-on to escitalopram in patients with comorbid obesity and major depression (SIMCODE): study protocol of a multicentre, randomised, double-blind, placebo-controlled trial​
    Otte, C.; Chae, W. R.; Nowacki, J.; Kaczmarczyk, M.; Piber, D.; Roepke, S. & Märschenz, S. et al.​ (2020) 
    BMJ Open10(12) pp. e040119​.​ DOI: https://doi.org/10.1136/bmjopen-2020-040119 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Predicting menstrual bleeding patterns with levonorgestrel-releasing intrauterine systems​
    Frenz, A.-K.; Ahlers, C.; Beckert, V.; Gerlinger, C. & Friede, T. ​ (2020) 
    The European Journal of Contraception & Reproductive Health Care26(1) pp. 48​-57​.​ DOI: https://doi.org/10.1080/13625187.2020.1843015 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Conducting clinical trials in heart failure during (and after) the COVID-19 pandemic: an Expert Consensus Position Paper from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)​
    Anker, S. D ; Butler, J.; Khan, M. S.; Abraham, W. T; Bauersachs, J. ; Bocchi, E. & Bozkurt, B. et al.​ (2020) 
    European Heart Journal41(22) pp. 2109​-2117​.​ DOI: https://doi.org/10.1093/eurheartj/ehaa461 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Adaptive seamless clinical trials using early outcomes for treatment or subgroup selection: Methods, simulation model and their implementation in R​
    Friede, T. ; Stallard, N. & Parsons, N.​ (2020) 
    Biometrical Journal62(5) pp. 1264​-1283​.​ DOI: https://doi.org/10.1002/bimj.201900020 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Efficacy and safety of SGLT2 inhibitors in heart failure: systematic review and meta‐analysis​
    Butler, J.; Usman, M. S.; Khan, M. S.; Greene, S. J.; Friede, T. ; Vaduganathan, M. & Filippatos, G. et al.​ (2020) 
    ESC Heart Failure7(6) pp. 3298​-3309​.​ DOI: https://doi.org/10.1002/ehf2.13169 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Role of the proportion of sudden cardiac death to mortality for clinical effectiveness of primary prevention ICDs​
    Zabel, M. ; Friede, T. ; Huikuri, H.; Malik, M. & Willems, R.​ (2020) 
    European Heart Journal41(47) pp. 4527​-4528​.​ DOI: https://doi.org/10.1093/eurheartj/ehaa630 
    Details  DOI 
  • 2020 Journal Article | Research Paper | 
    ​ ​Strategies to reduce antibiotic use in women with uncomplicated urinary tract infection in primary care: protocol of a systematic review and meta-analysis including individual patient data​
    Heinz, J. ; Röver, C. ; Furaijat, G.; Kaußner, Y.; Hummers, E. ; Debray, T. & Hay, A. D et al.​ (2020) 
    BMJ Open10(10) pp. e035883​.​ DOI: https://doi.org/10.1136/bmjopen-2019-035883 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Shrinkage Estimation for Dose–Response Modeling in Phase II Trials With Multiple Schedules​
    Günhan, B. K. ; Meyvisch, P. & Friede, T. ​ (2020) 
    Statistics in Biopharmaceutical Research, pp. 1​-13​.​ DOI: https://doi.org/10.1080/19466315.2020.1850519 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Reporting and interpretation of subgroup analyses in heart failure randomized controlled trials​
    Khan, M. S.; Khan, M. A. A.; Irfan, S.; Siddiqi, T. J.; Greene, S. J.; Anker, S. D.   & Sreenivasan, J. et al.​ (2020) 
    ESC Heart Failure8(1) pp. 26​-36​.​ DOI: https://doi.org/10.1002/ehf2.13122 
    Details  DOI 
  • 2020 Journal Article | 
    ​ ​Blinded sample size reestimation for negative binomial regression with baseline adjustment​
    Zapf, A. ; Asendorf, T. ; Anten, C.; Mütze, T.   & Friede, T. ​ (2020) 
    Statistics in Medicine39(14) pp. 1980​-1998​.​ DOI: https://doi.org/10.1002/sim.8525 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Self-diagnosed COVID-19 in people with multiple sclerosis: a community-based cohort of the UK MS Register​
    Evangelou, N.; Garjani, A.; dasNair, R.; Hunter, R.; Tuite-Dalton, K. A; Craig, E. M & Rodgers, W. J et al.​ (2020) 
    Journal of Neurology, Neurosurgery & Psychiatry92(1) pp. 107​-109​.​ DOI: https://doi.org/10.1136/jnnp-2020-324449 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Efficient Adaptive Designs for Clinical Trials of Interventions for COVID-19​
    Stallard, N.; Hampson, L.; Benda, N.; Brannath, W.; Burnett, T.; Friede, T.   & Kimani, P. K. et al.​ (2020) 
    Statistics in Biopharmaceutical Research12(4) pp. 483​-497​.​ DOI: https://doi.org/10.1080/19466315.2020.1790415 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Clinical Trials Impacted by the COVID-19 Pandemic: Adaptive Designs to the Rescue?​
    Kunz, C. U.; Jörgens, S.; Bretz, F.; Stallard, N.; Van Lancker, K.; Xi, D. & Zohar, S. et al.​ (2020) 
    Statistics in Biopharmaceutical Research12(4) pp. 461​-477​.​ DOI: https://doi.org/10.1080/19466315.2020.1799857 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Causal inference methods for small non-randomized studies: Methods and an application in COVID-19​
    Friedrich, S.   & Friede, T. ​ (2020) 
    Contemporary Clinical Trials99 pp. 106213​.​ DOI: https://doi.org/10.1016/j.cct.2020.106213 
    Details  DOI 
  • 2020 Journal Article | 
    ​ ​Sample size recalculation in multicenter randomized controlled clinical trials based on noncomparative data​
    Harden, M.   & Friede, T. ​ (2020) 
    Biometrical Journal62(5) pp. 1284​-1299​.​ DOI: https://doi.org/10.1002/bimj.201900138 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Blinded continuous information monitoring of recurrent event endpoints with time trends in clinical trials​
    Mütze, T. ; Salem, S.; Benda, N.; Schmidli, H. & Friede, T. ​ (2020) 
    Statistics in Medicine39(27) pp. 3968​-3985​.​ DOI: https://doi.org/10.1002/sim.8702 
    Details  DOI 
  • 2020 Journal Article | 
    ​ ​A systematic review and meta‐analysis of published cases reveals the natural disease history in multiple sulfatase deficiency​
    Schlotawa, L.; Preiskorn, J.; Ahrens‐Nicklas, R.; Schiller, S. ; Adang, L. A.; Gärtner, J.   & Friede, T. ​ (2020) 
    Journal of Inherited Metabolic Disease43(6) pp. 1288​-1297​.​ DOI: https://doi.org/10.1002/jimd.12282 
    Details  DOI 
  • 2020 Journal Article | 
    ​ ​Impact of COVID-19 outbreak on regional STEMI care in Germany​
    Scholz, K. H.; Lengenfelder, B.; Thilo, C.; Jeron, A.; Stefanow, S.; Janssens, U. & Bauersachs, J.  et al.​ (2020) 
    Clinical Research in Cardiology109(12) pp. 1511​-1521​.​ DOI: https://doi.org/10.1007/s00392-020-01703-z 
    Details  DOI 
  • 2020 Journal Article | 
    ​ ​A Bayesian time‐to‐event pharmacokinetic model for phase I dose‐escalation trials with multiple schedules​
    Günhan, B. K. ; Weber, S. & Friede, T. ​ (2020) 
    Statistics in Medicine39(27) pp. 3986​-4000​.​ DOI: https://doi.org/10.1002/sim.8703 
    Details  DOI 
  • 2020 Journal Article | 
    ​ ​Precise variant interpretation, phenotype ascertainment, and genotype–phenotype correlation of children in the EARLY PRO‐TECT Alport trial​
    Boeckhaus, J.; Hoefele, J.; Riedhammer, K. M.; Tönshoff, B.; Ehren, R.; Pape, L. & Latta, K. et al.​ (2020) 
    Clinical Genetics99(1) pp. 143​-156​.​ DOI: https://doi.org/10.1111/cge.13861 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Multiple Sklerose in Deutschland: aktualisierte Auswertungen des MS-Registers der DMSG 2014–2018​
    Flachenecker, P.; Eichstädt, K.; Berger, K.; Ellenberger, D. ; Friede, T. ; Haas, J. & Kleinschnitz, C. et al.​ (2020) 
    Fortschritte der Neurologie · Psychiatrie88(07) pp. 436​-450​.​ DOI: https://doi.org/10.1055/a-0985-4124 
    Details  DOI 
  • 2020 Journal Article
    ​ ​First international meeting of early career investigators: Current opportunities, challenges and horizon in critical care nutrition research​
    Stoppe, C.; van Gassel, R.; Jonckheer, J.; Garcia Velasquez, M. E.; Di Girolamo, F. G.; Chapela, S. P. & Wichansawakun, S. et al.​ (2020) 
    Clinical Nutrition40 pp. 92​-100​.​ DOI: https://doi.org/10.1016/j.clnesp.2020.09.006 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Longitudinal Assessment of Multiple Sclerosis with the Brain‐Age Paradigm​
    Cole, J. H.; Raffel, J.; Friede, T. ; Eshaghi, A.; Brownlee, W. J.; Chard, D. & De Stefano, N. et al.​ (2020) 
    Annals of Neurology88(1) pp. 93​-105​.​ DOI: https://doi.org/10.1002/ana.25746 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Long-term effects of a standardized feedback-driven quality improvement program for timely reperfusion therapy in regional STEMI care networks​
    Scholz, K. H.; Lengenfelder, B.; Jacobshagen, C. ; Fleischmann, C.; Moehlis, H.; Olbrich, H. G & Jung, J. et al.​ (2020) 
    European Heart Journal. Acute Cardiovascular Care,.​ DOI: https://doi.org/10.1177/2048872620907323 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Sporadic Creutzfeldt-Jakob Disease among Physicians, Germany, 1993–2018​
    Hermann, P. ; Treig, J.; Unkel, S. ; Goebel, S. ; Bunck, T. ; Jünemann, M. & Friede, T.  et al.​ (2020) 
    Emerging Infectious Diseases26(8).​ DOI: https://doi.org/10.3201/eid2608.191159 
    Details  DOI 
  • 2020 Journal Article | Research Paper | 
    ​ ​Factors Influencing the Frequency of Airway Infections in Underage Refugees: A Retrospective, Cross Sectional Study​
    Müller, F. ; Hummers, E. ; Hillermann, N.; Dopfer, C.; Jablonka, A.; Friede, T.   & Simmenroth, A.  et al.​ (2020) 
    International Journal of Environmental Research and Public Health17(18) pp. 6823​.​ DOI: https://doi.org/10.3390/ijerph17186823 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Data monitoring committees for clinical trials evaluating treatments of COVID-19​
    Mütze, T.   & Friede, T. ​ (2020) 
    Contemporary Clinical Trials98 pp. 106154​.​ DOI: https://doi.org/10.1016/j.cct.2020.106154 
    Details  DOI 
  • 2020 Journal Article | 
    ​ ​Clinical effectiveness of primary prevention implantable cardioverter-defibrillators: results of the EU-CERT-ICD controlled multicentre cohort study​
    Zabel, M.; Willems, R.; Lubinski, A.; Bauer, A.; Brugada, J.; Conen, D. & Flevari, P. et al.​ (2020) 
    European Heart Journal41(36) pp. 3437​-3447​.​ DOI: https://doi.org/10.1093/eurheartj/ehaa226 
    Details  DOI 
  • 2020 Journal Article | Research Paper
    ​ ​Electrocardiogram as a predictor of survival without appropriate shocks in primary prophylactic ICD patients: A retrospective multi-center study​
    Pelli, A.; Kenttä, T. V.; Junttila, M. J.; Bergau, L.; Zabel, M.; Malik, M. & Reichlin, T. et al.​ (2020) 
    International Journal of Cardiology309 pp. 78​-83​.​ DOI: https://doi.org/10.1016/j.ijcard.2020.03.024 
    Details  DOI  PMID  PMC 
  • 2019 Journal Article | 
    ​ ​Over three decades study populations in progressive multiple sclerosis have become older and more disabled, but have lower on-trial progression rates: A systematic review and meta-analysis of 43 randomised placebo-controlled trials​
    Nicholas, R. S; Han, E.; Raffel, J.; Chataway, J. & Friede, T. ​ (2019) 
    Multiple Sclerosis Journal25(11) pp. 1462​-1471​.​ DOI: https://doi.org/10.1177/1352458518794063 
    Details  DOI 
  • 2019 Journal Article | 
    ​ ​Group sequential designs for negative binomial outcomes​
    Mütze, T. ; Glimm, E.; Schmidli, H. & Friede, T. ​ (2019) 
    Statistical Methods in Medical Research28(8) pp. 2326​-2347​.​ DOI: https://doi.org/10.1177/0962280218773115 
    Details  DOI 
  • 2019 Journal Article | 
    ​ ​Modelling and sample size reestimation for longitudinal count data with incomplete follow up​
    Asendorf, T. ; Henderson, R.; Schmidli, H. & Friede, T. ​ (2019) 
    Statistical Methods in Medical Research28(1) pp. 117​-133​.​ DOI: https://doi.org/10.1177/0962280217715664 
    Details  DOI 
  • 2019 Journal Article
    ​ ​Blinded sample size reestimation in event‐driven clinical trials: Methods and an application in multiple sclerosis​
    Friede, T. ; Pohlmann, H. & Schmidli, H.​ (2019) 
    Pharmaceutical Statistics18(3) pp. 351​-365​.​ DOI: https://doi.org/10.1002/pst.1927 
    Details  DOI 
  • 2019 Journal Article | 
    ​ ​Exercise training in patients with a left ventricular assist device (Ex‐VAD): rationale and design of a multicentre, prospective, assessor‐blinded, randomized, controlled trial​
    Bobenko, A.; Schoenrath, F.; Knierim, J. H.; Friede, T. ; Verheyen, N.; Mehra, M. R. & Haykowsky, M. et al.​ (2019) 
    European Journal of Heart Failure21(9) pp. 1152​-1159​.​ DOI: https://doi.org/10.1002/ejhf.1431 
    Details  DOI 
  • 2019 Journal Article
    ​ ​Severe heart failure and the need for mechanical circulatory support and heart transplantation in pediatric patients with myocarditis: Results from the prospective multicenter registry “MYKKE”​
    Schubert, S.; Opgen‐Rhein, B.; Boehne, M.; Weigelt, A.; Wagner, R.; Müller, G. & Rentzsch, A. et al.​ (2019) 
    Pediatric Transplantation23(7) art. e13548​.​ DOI: https://doi.org/10.1111/petr.13548 
    Details  DOI 
  • 2019 Journal Article | 
    ​ ​Dynamically borrowing strength from another study through shrinkage estimation​
    Röver, C.   & Friede, T. ​ (2019) 
    Statistical Methods in Medical Research29(1) pp. 293​-308​.​ DOI: https://doi.org/10.1177/0962280219833079 
    Details  DOI 
  • 2019 Journal Article
    ​ ​Appropriate Shocks and Mortality in Patients With Versus Without Diabetes With Prophylactic Implantable Cardioverter Defibrillators​
    Junttila, M. J.; Pelli, A.; Kenttä, T. V.; Friede, T. ; Willems, R.; Bergau, L.   & Malik, M. et al.​ (2019) 
    Diabetes Care43(1) pp. 196​-200​.​ DOI: https://doi.org/10.2337/dc19-1014 
    Details  DOI 
  • 2019 Journal Article
    ​ ​OC-0501 Chemo-RT plus induction or consolidation chemotherapy for rectal cancer: a randomised phase 2 trial​
    Fokas, E.; Allgäuer, M.; Polat, B.; Klautke, G.; Grabenbauer, G.; Fietkau, R. & Kuhnt, T. et al.​ (2019) 
    Radiotherapy and Oncology133 pp. S257​-S258​.​ DOI: https://doi.org/10.1016/S0167-8140(19)30921-1 
    Details  DOI 
  • 2019 Journal Article
    ​ ​Improved description of clinical features of multiple sulfatase deficiency: A meta-analysis of published cases​
    Schlotawa, L.; Preiskorn, J.; Ahrens-Nicklas, R.; Adang, L. A.; Gärtner, J.   & Friede, T. ​ (2019) 
    Molecular Genetics and Metabolism126(2) pp. S131​.​ DOI: https://doi.org/10.1016/j.ymgme.2018.12.337 
    Details  DOI 
  • 2019 Journal Article | 
    ​ ​Present criteria for prophylactic ICD implantation: Insights from the EU-CERT-ICD (Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in EUrope) project​
    Zabel, M. ; Schlögl, S.; Lubinski, A.; Svendsen, J. H.; Bauer, A.; Arbelo, E. & Brusich, S. et al.​ (2019) 
    Journal of Electrocardiology57 pp. S34​-S39​.​ DOI: https://doi.org/10.1016/j.jelectrocard.2019.09.001 
    Details  DOI 
  • 2019 Journal Article | 
    ​ ​Random‐effects meta‐analysis of few studies involving rare events​
    Günhan, B. K. ; Röver, C.   & Friede, T. ​ (2019) 
    Research Synthesis Methods11(1) pp. 74​-90​.​ DOI: https://doi.org/10.1002/jrsm.1370 
    Details  DOI 
  • 2019 Journal Article | 
    ​ ​Decline of COPD exacerbations in clinical trials over two decades – a systematic review and meta-regression​
    Andreas, S. ; Röver, C. ; Heinz, J. ; Straube, S. ; Watz, H. & Friede, T. ​ (2019) 
    Respiratory Research20(1).​ DOI: https://doi.org/10.1186/s12931-019-1163-2 
    Details  DOI 
  • 2019 Journal Article | 
    ​ ​Adaptive trial designs in diagnostic accuracy research​
    Zapf, A.; Stark, M.; Gerke, O.; Ehret, C.; Benda, N.; Bossuyt, P. & Deeks, J. et al.​ (2019) 
    Statistics in Medicine39(5) pp. 591​-601​.​ DOI: https://doi.org/10.1002/sim.8430 
    Details  DOI 
  • 2019 Journal Article | 
    ​ ​Likelihood-based random-effects meta-analysis with few studies: empirical and simulation studies​
    Seide, S. E.; Röver, C.   & Friede, T. ​ (2019) 
    BMC Medical Research Methodology19(1) art. 16​.​ DOI: https://doi.org/10.1186/s12874-018-0618-3 
    Details  DOI  PMID  PMC 
  • 2019 Journal Article | 
    ​ ​Semi‐parametric analysis of overdispersed count and metric data with varying follow‐up times: Asymptotic theory and small sample approximations​
    Konietschke, F.; Friede, T.   & Pauly, M.​ (2019) 
    Biometrical Journal61(3) pp. 616​-629​.​ DOI: https://doi.org/10.1002/bimj.201800027 
    Details  DOI  PMID  PMC 
  • 2019 Journal Article | 
    ​ ​ROCK-ALS: Protocol for a Randomized, Placebo-Controlled, Double-Blind Phase IIa Trial of Safety, Tolerability and Efficacy of the Rho Kinase (ROCK) Inhibitor Fasudil in Amyotrophic Lateral Sclerosis​
    Lingor, P.; Weber, M.; Camu, W.; Friede, T. ; Hilgers, R.; Leha, A. & Neuwirth, C. et al.​ (2019) 
    Frontiers in Neurology10 art. 293​.​ DOI: https://doi.org/10.3389/fneur.2019.00293 
    Details  DOI  PMID  PMC 
  • 2019 Journal Article | 
    ​ ​Rationale and design of the EU-CERT-ICD prospective study: comparative effectiveness of prophylactic ICD implantation​
    Zabel, M.; Sticherling, C.; Willems, R.; Lubinski, A.; Bauer, A.; Bergau, L. & Braunschweig, F. et al.​ (2019) 
    ESC Heart Failure6(1) pp. 182​-193​.​ DOI: https://doi.org/10.1002/ehf2.12367 
    Details  DOI  PMID  PMC 
  • 2019 Journal Article
    ​ ​A conditional error function approach for adaptive enrichment designs with continuous endpoints​
    Placzek, M.   & Friede, T. ​ (2019) 
    Statistics in Medicine38(17) pp. 3105​-3122​.​ DOI: https://doi.org/10.1002/sim.8154 
    Details  DOI 
  • 2019 Journal Article | 
    ​ ​A comparison of subgroup identification methods in clinical drug development: Simulation study and regulatory considerations​
    Huber, C.; Benda, N. & Friede, T. ​ (2019) 
    Pharmaceutical Statistics18(5) pp. 600​-626​.​ DOI: https://doi.org/10.1002/pst.1951 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | 
    ​ ​Data on differential multivariable risk prediction of appropriate shock vs. competing mortality​
    Bergau, L.; Willems, R.; Sprenkeler, D. J; Fischer, T. H. ; Flevari, P.; Hasenfuß, G.   & Katsaras, D. et al.​ (2018) 
    Data in Brief21 pp. 2110​-2116​.​ DOI: https://doi.org/10.1016/j.dib.2018.11.025 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | 
    ​ ​Contribution to the discussion of "When should meta-analysis avoid making hidden normality assumptions?": A Bayesian perspective.​
    Röver, C.   & Friede, T. ​ (2018) 
    Biometrical Journal,.​ DOI: https://doi.org/10.1002/bimj.201800179 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | 
    ​ ​Model averaging for robust extrapolation in evidence synthesis​
    Röver, C. ; Wandel, S. & Friede, T. ​ (2018) 
    Statistics in Medicine,.​ DOI: https://doi.org/10.1002/sim.7991 
    Details  DOI 
  • 2018 Report
    ​ ​KMU-innovativ-13: Validierung eines cfDNA – basierten diagnostischen Tests zur frühzeitigen Erkennung von Transplantatschädigungen bei Nierentransplantationen: ​Teilprojekt 2 : Schlussbericht (Teilprojekt 2) für das Projekt : Projektlaufzeit: 01.02.2015 bis 31.01.2018 (bis 31.03.2018 nach Verlängerung)​
    Oellerich, M.; Beißbarth, T. ; Friede, T. ; Kramer, F. ; Ellenberger, D.  & Asendorf, T. ​ (2018)
    Details 
  • 2018 Journal Article
    ​ ​Blinded continuous monitoring in clinical trials with recurrent event endpoints​
    Friede, T. ; Häring, D. A. & Schmidli, H.​ (2018) 
    Pharmaceutical Statistics18(1) pp. 54​-64​.​ DOI: https://doi.org/10.1002/pst.1907 
    Details  DOI 
  • 2018 Journal Article
    ​ ​Sample size re‐estimation for clinical trials with longitudinal negative binomial counts including time trends​
    Asendorf, T. ; Henderson, R.; Schmidli, H. & Friede, T. ​ (2018) 
    Statistics in Medicine38(9) pp. 1503​-1528​.​ DOI: https://doi.org/10.1002/sim.8061 
    Details  DOI 
  • 2018 Journal Article
    ​ ​dfpk: An R-package for Bayesian dose-finding designs using pharmacokinetics (PK) for phase I clinical trials​
    Toumazi, A.; Comets, E.; Alberti, C.; Friede, T. ; Lentz, F.; Stallard, N. & Zohar, S. et al.​ (2018) 
    Computer Methods and Programs in Biomedicine157 pp. 163​-177​.​ DOI: https://doi.org/10.1016/j.cmpb.2018.01.023 
    Details  DOI 
  • 2018 Journal Article
    ​ ​Methods for evidence synthesis in the case of very few studies​
    Bender, R.; Koch, A.; Kuss, O.; Schlattmann, P.; Schwarzer, G.; Skipka, G. & Friede, T. ​ (2018) 
    Research Synthesis Methods9(3) pp. 382​-392​.​ DOI: https://doi.org/10.1002/jrsm.1297 
    Details  DOI 
  • 2018 Journal Article | 
    ​ ​Group sequential designs with robust semiparametric recurrent event models​
    Mütze, T. ; Glimm, E.; Schmidli, H. & Friede, T. ​ (2018) 
    Statistical Methods in Medical Research28(8) pp. 2385​-2403​.​ DOI: https://doi.org/10.1177/0962280218780538 
    Details  DOI 
  • 2018 Journal Article
    ​ ​Symptomatology and symptomatic treatment in multiple sclerosis: Results from a nationwide MS registry​
    Rommer, P. S.; Eichstädt, K.; Ellenberger, D. ; Flachenecker, P.; Friede, T. ; Haas, J. & Kleinschnitz, C. et al.​ (2018) 
    Multiple Sclerosis Journal25(12) pp. 1641​-1652​.​ DOI: https://doi.org/10.1177/1352458518799580 
    Details  DOI 
  • 2018 Journal Article
    ​ ​Echocardiographic Estimation of Mean Pulmonary Artery Pressure: A Comparison of Different Approaches to Assign the Likelihood of Pulmonary Hypertension​
    Hellenkamp, K. ; Unsöld, B.; Mushemi-Blake, S.; Shah, A. M.; Friede, T. ; Hasenfuß, G.   & Seidler, T. ​ (2018) 
    Journal of the American Society of Echocardiography31(1) pp. 89​-98​.​ DOI: https://doi.org/10.1016/j.echo.2017.09.009 
    Details  DOI 
  • 2018 Journal Article
    ​ ​Reclassifying Acute Respiratory Distress Syndrome​
    Maiolo, G.; Collino, F.; Vasques, F.; Rapetti, F.; Tonetti, T. ; Romitti, F.   & Cressoni, M. et al.​ (2018) 
    American Journal of Respiratory and Critical Care Medicine197(12) pp. 1586​-1595​.​ DOI: https://doi.org/10.1164/rccm.201709-1804OC 
    Details  DOI 
  • 2018 Journal Article
    ​ ​Treatment of fatigue in amyotrophic lateral sclerosis/motor neuron disease​
    Gibbons, C.; Pagnini, F.; Friede, T.   & Young, C. A​ (2018) 
    Cochrane Database of Systematic Reviews,.​ DOI: https://doi.org/10.1002/14651858.CD011005.pub2 
    Details  DOI 
  • 2018 Journal Article | 
    ​ ​A dose finding design for seizure reduction in neonates​
    Ursino, M.; Yuan, Y.; Alberti, C.; Comets, E.; Favrais, G.; Friede, T.   & Lentz, F. et al.​ (2018) 
    Journal of the Royal Statistical Society: Series C (Applied Statistics)68(2) pp. 427​-444​.​ DOI: https://doi.org/10.1111/rssc.12289 
    Details  DOI 
  • 2018 Journal Article
    ​ ​A standardised frankincense extract reduces disease activity in relapsing-remitting multiple sclerosis (the SABA phase IIa trial)​
    Stürner, K. H.; Stellmann, J.-P.; Dörr, J.; Paul, F.; Friede, T. ; Schammler, S. & Reinhardt, S. et al.​ (2018) 
    Journal of Neurology, Neurosurgery & Psychiatry89(4) pp. 330​-338​.​ DOI: https://doi.org/10.1136/jnnp-2017-317101 
    Details  DOI 
  • 2018 Journal Article
    ​ ​Randomised controlled trial of a self-guided online fatigue intervention in multiple sclerosis​
    Pöttgen, J.; Moss-Morris, R.; Wendebourg, J.-M.; Feddersen, L.; Lau, S.; Köpke, S. & Meyer, B. et al.​ (2018) 
    Journal of Neurology, Neurosurgery & Psychiatry89(9) pp. 970​-976​.​ DOI: https://doi.org/10.1136/jnnp-2017-317463 
    Details  DOI 
  • 2018 Journal Article
    ​ ​Baseline predictors for progression 4 years after Parkinson's disease diagnosis in the De Novo Parkinson Cohort (DeNoPa)​
    Mollenhauer, B. ; Zimmermann, J.; Sixel‐Döring, F.; Focke, N. K. ; Wicke, T.; Ebentheuer, J. & Schaumburg, M. et al.​ (2018) 
    Movement Disorders34(1) pp. 67​-77​.​ DOI: https://doi.org/10.1002/mds.27492 
    Details  DOI 
  • 2018 Journal Article | 
    ​ ​Sample size calculation in multi-centre clinical trials​
    Harden, M. & Friede, T. ​ (2018) 
    BMC Medical Research Methodology18(1) art. 156​.​ DOI: https://doi.org/10.1186/s12874-018-0602-y 
    Details  DOI 
  • 2018 Journal Article
    ​ ​Decreasing longitudinal use of glucocorticosteroids in multiple sclerosis​
    Ellenberger, D. ; Eichstädt, K.; Flachenecker, P.; Friede, T. ; Haas, J.; Kleinschnitz, C. & Pöhlau, D. et al.​ (2018) 
    Multiple Sclerosis and Related Disorders25 pp. 173​-174​.​ DOI: https://doi.org/10.1016/j.msard.2018.07.040 
    Details  DOI 
  • 2018 Journal Article | 
    ​ ​Robustness of testing procedures for confirmatory subpopulation analyses based on a continuous biomarker​
    Graf, A. C.; Wassmer, G.; Friede, T. ; Gera, R. G.   & Posch, M.​ (2018) 
    Statistical Methods in Medical Research28(6) pp. 1879​-1892​.​ DOI: https://doi.org/10.1177/0962280218777538 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | 
    ​ ​Recent advances in methodology for clinical trials in small populations: the InSPiRe project.​
    Friede, T. ; Posch, M.; Zohar, S.; Alberti, C.; Benda, N.; Comets, E. & Day, S. et al.​ (2018) 
    Orphanet Journal of Rare Diseases13 art. 186​.​ DOI: https://doi.org/10.1186/s13023-018-0919-y 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | Research Paper | 
    ​ ​Reducing antibiotic use for uncomplicated urinary tract infection in general practice by treatment with uva-ursi (REGATTA) – a double-blind, randomized, controlled comparative effectiveness trial​
    Afshar, K.; Fleischmann, N.; Schmiemann, G.; Bleidorn, J.; Hummers-Pradier, E. ; Friede, T.   & Wegscheider, K. et al.​ (2018) 
    BMC Complementary and Alternative Medicine18(1) art. 203​.​ DOI: https://doi.org/10.1186/s12906-018-2266-x 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article
    ​ ​Impact of treatment delay on mortality in ST-segment elevation myocardial infarction (STEMI) patients presenting with and without haemodynamic instability: results from the German prospective, multicentre FITT-STEMI trial​
    Scholz, K. H.; Maier, S. K G; Maier, L. S; Lengenfelder, B.; Jacobshagen, C. ; Jung, J. & Fleischmann, C. et al.​ (2018) 
    European Heart Journal39(13) pp. 1065​-1074​.​ DOI: https://doi.org/10.1093/eurheartj/ehy004 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | 
    ​ ​On estimands and the analysis of adverse events in the presence of varying follow‐up times within the benefit assessment of therapies​
    Unkel, S.; Amiri, M.; Benda, N.; Beyersmann, J.; Knoerzer, D.; Kupas, K. & Langer, F. et al.​ (2018) 
    Pharmaceutical Statistics18(2) pp. 166​-183​.​ DOI: https://doi.org/10.1002/pst.1915 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | 
    ​ ​Insights into permanent pacemaker implantation following TAVR in a real-world cohort​
    Tichelbäcker, T.; Bergau, L.; Puls, M.; Friede, T. ; Mütze, T.; Maier, L. S. & Frey, N. et al.​ (2018) 
    PLoS One13(10) art. e0204503​.​ DOI: https://doi.org/10.1371/journal.pone.0204503 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | 
    ​ ​A design-by-treatment interaction model for network meta-analysis and meta-regression with integrated nested Laplace approximations​
    Günhan, B. K. ; Friede, T.   & Held, L.​ (2018) 
    Research Synthesis Methods9(2) pp. 179​-194​.​ DOI: https://doi.org/10.1002/jrsm.1285 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article
    ​ ​Differences in the Reponses to Apheresis Therapy of Patients With 3 Histopathologically Classified Immunopathological Patterns of Multiple Sclerosis​
    Stork, L.; Ellenberger, D. ; Beißbarth, T. ; Friede, T. ; Lucchinetti, C. F.; Brück, W.   & Metz, I. ​ (2018) 
    JAMA Neurology75(4) pp. 428​-435​.​ DOI: https://doi.org/10.1001/jamaneurol.2017.4842 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | 
    ​ ​Differential multivariable risk prediction of appropriate shock versus competing mortality - A prospective cohort study to estimate benefits from ICD therapy​
    Bergau, L.; Willems, R.; Sprenkeler, D. J.; Fischer, T. H. ; Flevari, P.; Hasenfuß, G.   & Katsaras, D. et al.​ (2018) 
    International Journal of Cardiology272 pp. 102​-107​.​ DOI: https://doi.org/10.1016/j.ijcard.2018.06.103 
    Details  DOI  PMID  PMC 
  • 2017 Journal Article | 
    ​ ​Patient-reported outcomes and survival in multiple sclerosis: A 10-year retrospective cohort study using the Multiple Sclerosis Impact Scale-29.​
    Raffel, J.; Wallace, A.; Gveric, D.; Reynolds, R.; Friede, T.   & Nicholas, R.​ (2017) 
    PLoS medicine14(7) art. e1002346​.​ DOI: https://doi.org/10.1371/journal.pmed.1002346 
    Details  DOI  PMID  PMC 
  • 2017 Journal Article | 
    ​ ​Meta-analysis of two studies in the presence of heterogeneity with applications in rare diseases.​
    Friede, T. ; Röver, C. ; Wandel, S. & Neuenschwander, B.​ (2017) 
    Biometrical journal. Biometrische Zeitschrift59(4) pp. 658​-671​.​ DOI: https://doi.org/10.1002/bimj.201500236 
    Details  DOI  PMID  PMC 
  • 2017 Journal Article
    ​ ​Blinded sample size re-estimation in three-arm trials with ‘gold standard’ design​
    Mütze, T.   & Friede, T. ​ (2017) 
    Statistics in Medicine36(23) pp. 3636​-3653​.​ DOI: https://doi.org/10.1002/sim.7356 
    Details  DOI 
  • 2017 Book Chapter
    ​ ​Information Flows in Patient-Oriented Online Media and Scientific Research​
    Makedonski, P. ; Friede, T. ; Grabowski, J. ; Koschack, J.  & Himmel, W. ​ (2017)
    In:​Fu, Xiaoming; Luo, J. D.; Boos, Margarete​ (Eds.), Social Network Analysis – Interdisciplinary Approaches and Case Studies pp. 341​-363. ​Boca Raton: ​CRC Press.
    Details 
  • 2017 Journal Article
    ​ ​Dose-finding methods for Phase I clinical trials using pharmacokinetics in small populations​
    Ursino, M.; Zohar, S.; Lentz, F.; Alberti, C.; Friede, T. ; Stallard, N. & Comets, E.​ (2017) 
    Biometrical Journal59(4) pp. 804​-825​.​ DOI: https://doi.org/10.1002/bimj.201600084 
    Details  DOI 
  • 2017 Journal Article
    ​ ​Sample size re-estimation incorporating prior information on a nuisance parameter​
    Mütze, T. ; Schmidli, H. & Friede, T. ​ (2017) 
    Pharmaceutical Statistics17(2) pp. 126​-143​.​ DOI: https://doi.org/10.1002/pst.1837 
    Details  DOI 
  • 2017 Journal Article | 
    ​ ​Sex differences in outcomes of primary prevention implantable cardioverter-defibrillator therapy: combined registry data from eleven European countries​
    Sticherling, C.; Arendacka, B.; Svendsen, J. H.; Wijers, S.; Friede, T. ; Stockinger, J. & Dommasch, M. et al.​ (2017) 
    EP Europace20(6) pp. 963​-970​.​ DOI: https://doi.org/10.1093/europace/eux176 
    Details  DOI 
  • 2017 Journal Article
    ​ ​Meta-analytic-predictive use of historical variance data for the design and analysis of clinical trials​
    Schmidli, H.; Neuenschwander, B. & Friede, T. ​ (2017) 
    Computational Statistics & Data Analysis113 pp. 100​-110​.​ DOI: https://doi.org/10.1016/j.csda.2016.08.007 
    Details  DOI  WoS 
  • 2017 Journal Article | 
    ​ ​Discrete Approximation of a Mixture Distribution via Restricted Divergence​
    Roever, C.   & Friede, T. ​ (2017) 
    Journal of Computational and Graphical Statistics26(1) pp. 217​-222​.​ DOI: https://doi.org/10.1080/10618600.2016.1276840 
    Details  DOI  WoS 
  • 2017 Journal Article
    ​ ​Immunotherapies in neuromyelitis optica spectrum disorder: efficacy and predictors of response​
    Stellmann, J.-P.; Krumbholz, M.; Friede, T. ; Gahlen, A.; Borisow, N.; Fischer, K. & Hellwig, K. et al.​ (2017) 
    Journal of Neurology, Neurosurgery & Psychiatry88(8) pp. 639​-647​.​ DOI: https://doi.org/10.1136/jnnp-2017-315603 
    Details  DOI 
  • 2017 Journal Article
    ​ ​Control conditions for randomised trials of behavioural interventions in psychiatry: a decision framework​
    Gold, S. M; Enck, P.; Hasselmann, H.; Friede, T. ; Hegerl, U.; Mohr, D. C & Otte, C.​ (2017) 
    The Lancet Psychiatry4(9) pp. 725​-732​.​ DOI: https://doi.org/10.1016/S2215-0366(17)30153-0 
    Details  DOI 
  • 2017 Journal Article
    ​ ​Predictors of mortality and ICD shock therapy in primary prophylactic ICD patients-A systematic review and meta-analysis.​
    Bergau, L.; Tichelbäcker, T.; Kessel, B.; Lüthje, L.; Fischer, T. H.; Friede, T.   & Zabel, M.​ (2017) 
    PloS one12(10) art. e0186387​.​ DOI: https://doi.org/10.1371/journal.pone.0186387 
    Details  DOI  PMID  PMC 
  • 2017 Journal Article | 
    ​ ​Using phase II data for the analysis of phase III studies: An application in rare diseases​
    Wandel, S.; Neuenschwander, B.; Roever, C.   & Friede, T. ​ (2017) 
    Clinical Trials14(3) pp. 277​-285​.​ DOI: https://doi.org/10.1177/1740774517699409 
    Details  DOI  PMID  PMC  WoS 
  • 2017 Journal Article | 
    ​ ​T-wave loop area from a pre-implant 12-lead ECG is associated with appropriate ICD shocks​
    Seegers, J.; Hnatkova, K.; Friede, T. ; Malik, M. & Zabel, M.​ (2017) 
    PLoS ONE12(3) art. e0173868​.​ DOI: https://doi.org/10.1371/journal.pone.0173868 
    Details  DOI  PMID  PMC  WoS 
  • 2017 Review
    ​ ​Pharmacological Approaches to the Management of Secondary Progressive Multiple Sclerosis​
    Nandoskar, A.; Raffel, J.; Scalfari, A. S.; Friede, T.  & Nicholas, R. S.​ (2017)
    Drugs, 77​(8) pp. 885​-910​.​
    Adis Int Ltd. DOI: https://doi.org/10.1007/s40265-017-0726-0 
    Details  DOI  PMID  PMC  WoS 
  • 2017 Journal Article
    ​ ​Toward evidence-based diagnosis of myocarditis in children and adolescents: Rationale, design, and first baseline data of MYKKE, a multicenter registry and study platform​
    Messroghli, D. R.; Pickardt, T.; Fischer, M.; Opgen-Rhein, B.; Papakostas, K.; Bocker, D. & Jakob, A. et al.​ (2017) 
    American Heart Journal187 pp. 133​-144​.​ DOI: https://doi.org/10.1016/j.ahj.2017.02.027 
    Details  DOI  PMID  PMC  WoS 
  • 2017 Review
    ​ ​Independent academic Data Monitoring Committees for clinical trials in cardiovascular and cardiometabolic diseases​
    Filippatos, G. S.; de Graeff, P.; Bax, J. J.; Borg, J.-J.; Cleland, J. G. F.; Dargie, H. J.& Flather, M. et al.​ (2017)
    European Journal of Heart Failure, 19​(4) pp. 449​-456​.​
    Wiley. DOI: https://doi.org/10.1002/ejhf.761 
    Details  DOI  PMID  PMC  WoS 
  • 2017 Journal Article
    ​ ​Do we consent to rules of consent and confidentiality?​
    Wegscheider, K. & Friede, T. ​ (2017) 
    Biometrical Journal59(2) pp. 235​-239​.​ DOI: https://doi.org/10.1002/bimj.201600150 
    Details  DOI  PMID  PMC  WoS 
  • 2017 Journal Article | 
    ​ ​Blinded versus unblinded estimation of a correlation coefficient to inform interim design adaptations​
    Kunz, C. U.; Stallard, N.; Parsons, N.; Todd, S. & Friede, T. ​ (2017) 
    Biometrical Journal59(2) pp. 344​-357​.​ DOI: https://doi.org/10.1002/bimj.201500233 
    Details  DOI  PMID  PMC  WoS 
  • 2017 Journal Article | 
    ​ ​Meta-analysis of few small studies in orphan diseases​
    Friede, T. ; Roever, C. ; Wandel, S. & Neuenschwander, B.​ (2017) 
    Research Synthesis Methods8(1) pp. 79​-91​.​ DOI: https://doi.org/10.1002/jrsm.1217 
    Details  DOI  PMID  PMC  WoS 
  • 2017 Journal Article
    ​ ​Doxycycline in early CJD: a double-blinded randomised phase II and observational study​
    Varges, D. A.; Manthey, H.; Heinemann, U.; Ponto, C.; Schmitz, M.; Schulz-Schaeffer, W. J. & Krasnianski, A. et al.​ (2017) 
    Journal of Neurology Neurosurgery & Psychiatry88(2) pp. 119​-125​.​ DOI: https://doi.org/10.1136/jnnp-2016-313541 
    Details  DOI  PMID  PMC  WoS 
  • 2017 Review
    ​ ​Advances and unmet needs in genetic, basic and clinical science in Alport syndrome: report from the 2015 International Workshop on Alport Syndrome​
    Gross, O.; Kashtan, C. E.; Rheault, M. N.; Flinter, F.; Savige, J.; Miner, J. H.& Torra, R. et al.​ (2017)
    Nephrology Dialysis Transplantation, 32​(6) pp. 916​-924​.​
    Oxford Univ Press. DOI: https://doi.org/10.1093/ndt/gfw095 
    Details  DOI  PMID  PMC  WoS 
  • 2017 Journal Article
    ​ ​Clinical trials with nested subgroups: Analysis, sample size determination and internal pilot studies​
    Placzek, M.   & Friede, T. ​ (2017) 
    Statistical Methods in Medical Research27(11) pp. 3286​-3303​.​ DOI: https://doi.org/10.1177/0962280217696116 
    Details  DOI 
  • 2016 Conference Abstract
    ​ ​Apheresis therapy in multiple sclerosis patients with histopathologically classified immunopathological patterns​
    Stork, L.; Ellenberger, D. ; Beißbarth, T. ; Friede, T. ; Lucchinetti, C.; Brück, W.   & Metz, I. ​ (2016)
    Multiple Sclerosis Journal22 , London, ENGLAND.
    London​: Sage Publications Ltd.
    Details  WoS 
  • 2016 Journal Article
    ​ ​Results of medial patellofemoral ligament reconstruction compared with trochleoplasty plus individual extensor apparatus balancing in patellar instability caused by severe trochlear dysplasia: a systematic review and meta-analysis​
    Balcarek, P. ; Rehn, S.; Howells, N. R.; Eldridge, J. D.; Kita, K.; Dejour, D. & Nelitz, M. et al.​ (2016) 
    Knee Surgery, Sports Traumatology, Arthroscopy25(12) pp. 3869​-3877​.​ DOI: https://doi.org/10.1007/s00167-016-4365-x 
    Details  DOI 
  • 2016 Conference Abstract
    ​ ​Value of microvolt T-wave alternans assessed by ergometer and pacing as predictor for shock and mortality in a large ICD cohort​
    Bergau, L.; Flevari, P.; Willems, R.; Tuinenburg, A. E.; Vos, M. A.; Munoz-Exposito, P. & Fischer, T. H. et al.​ (2016)
    European Heart Journal37 pp. 304​-305. , Rome, ITALY.
    Oxford​: Oxford Univ Press.
    Details  WoS 
  • 2016 Journal Article | 
    ​ ​EFSPI/PSI working group on data sharing: accessing and working with pharmaceutical clinical trial patient level datasets – a primer for academic researchers​
    Sudlow, R.; Branson, J.; Friede, T. ; Morgan, D. & Whately-Smith, C.​ (2016) 
    BMC Medical Research Methodology16(S1).​ DOI: https://doi.org/10.1186/s12874-016-0171-x 
    Details  DOI 
  • 2016 Conference Abstract
    ​ ​Gender differences in the outcome of primary preventive implantable defibrillator therapy-data from the EU-CERT ICD study​
    Sticherling, C.; Svendsen, J. H.; Arendacka, B.; Wijers, S.; Stockinger, J.; Schmidt, G. & Merkely, B. et al.​ (2016)
    European Heart Journal37 pp. 693​-694. , Rome, ITALY.
    Oxford​: Oxford Univ Press.
    Details  WoS 
  • 2016 Conference Abstract
    ​ ​Efficacy of immunotherapies and predictors of therapy response in neuromyelitis optica spectrum disorders: analysis of 397 treatment years from 150 patients​
    Stellmann, J.-P.; Krumbholz, M.; Friede, T. ; Trebst, C. & Kleiter, I.​ (2016)
    Multiple Sclerosis Journal22 ​32nd Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS)​, London, ENGLAND.
    London​: Sage Publications Ltd.
    Details  WoS 
  • 2016 Conference Abstract
    ​ ​Increased multiple sclerosis impact scale-29 score is associated with reduced survival in multiple sclerosis​
    Wallace, A. C.; Raffel, J.; Reynolds, R.; Friede, T.   & Nicholas, R.​ (2016)
    Multiple Sclerosis Journal22 pp. 455​-456. ​32nd Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS)​, London, ENGLAND.
    London​: Sage Publications Ltd.
    Details  WoS 
  • 2016 Journal Article
    ​ ​A studentized permutation test for three-arm trials in the ‘gold standard’ design​
    Mütze, T. ; Konietschke, F. ; Munk, A.   & Friede, T. ​ (2016) 
    Statistics in Medicine36(6) pp. 883​-898​.​ DOI: https://doi.org/10.1002/sim.7176 
    Details  DOI 
  • 2016 Research Data | 
    ​ ​Data from: T-wave loop area from a pre-implant 12-lead ECG is associated with appropriate ICD shocks​
    Seegers, J.; Hnatkova, K.; Friede, T. ; Malik, M.& Zabel, M.​ (2016)
     DOI: https://doi.org/10.3249/ugoe-data-1 
    Details  DOI 
  • 2016 Journal Article | Research Paper | 
    ​ ​Sex difference in appropriate shocks but not mortality during long-term follow-up in patients with implantable cardioverter-defibrillators​
    Seegers, J.; Conen, D.; Jung, K. ; Bergau, L. ; Dorenkamp, M.; Luethje, L.   & Sohns, C. et al.​ (2016) 
    EP Europace18(8) pp. 1194​-1202​.​ DOI: https://doi.org/10.1093/europace/euv361 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Journal Article | Research Paper | 
    ​ ​Prediction of Appropriate Shocks Using 24-Hour Holter Variables and T-Wave Alternans After First Implantable Cardioverter-Defibrillator Implantation in Patients With Ischemic or Nonischemic Cardiomyopathy​
    Seegers, J.; Bergau, L. ; Exposito, P. M.; Bauer, A.; Fischer, T. H. ; Luethje, L.   & Hasenfuß, G.  et al.​ (2016) 
    The American Journal of Cardiology118(1) pp. 86​-94​.​ DOI: https://doi.org/10.1016/j.amjcard.2016.04.016 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Journal Article | 
    ​ ​Serum peptide reactivities may distinguish neuromyelitis optica subgroups and multiple sclerosis​
    Metz, I. ; Beißbarth, T. ; Ellenberger, D. ; Pache, F.; Stork, L.; Ringelstein, M. & Aktas, O. et al.​ (2016) 
    Neurology: Neuroimmunology & Neuroinflammation3(2) art. e204​.​ DOI: https://doi.org/10.1212/NXI.0000000000000204 
    Details  DOI  PMID  PMC 
  • 2016 Journal Article
    ​ ​An Unconditional Test for Change Point Detection in Binary Sequences with Applications to Clinical Registries​
    Ellenberger, D.   & Friede, T. ​ (2016) 
    Methods of Information in Medicine55(4) pp. 367​-372​.​ DOI: https://doi.org/10.3414/ME15-02-0020 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Review | 
    ​ ​Systematic reviews in paediatric multiple sclerosis and Creutzfeldt-Jakob disease exemplify shortcomings in methods used to evaluate therapies in rare conditions​
    Unkel, S.; Roever, C. ; Stallard, N.; Benda, N.; Posch, M.; Zohar, S.& Friede, T. ​ (2016)
    Orphanet Journal of Rare Diseases, 11​.​
    Biomed Central Ltd. DOI: https://doi.org/10.1186/s13023-016-0402-6 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Journal Article | Research Paper
    ​ ​Design and analysis of three-arm trials with negative binomially distributed endpoints​
    Muetze, T. ; Munk, A.   & Friede, T. ​ (2016) 
    Statistics in Medicine35(4) pp. 505​-521​.​ DOI: https://doi.org/10.1002/sim.6738 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Journal Article | 
    ​ ​Peripheral Nerve Dysfunction in Middle-Aged Subjects Born with Thalidomide Embryopathy​
    Nicotra, A.; Newman, C.; Johnson, M.; Eremin, O.; Friede, T. ; Malik, O. & Nicholas, R.​ (2016) 
    PLoS ONE11(4) art. e0152902​.​ DOI: https://doi.org/10.1371/journal.pone.0152902 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Journal Article | 
    ​ ​Evidence synthesis for count distributions based on heterogeneous and incomplete aggregated data​
    Roever, C. ; Andreas, S. & Friede, T. ​ (2016) 
    Biometrical Journal58(1) pp. 170​-185​.​ DOI: https://doi.org/10.1002/bimj.201300288 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Journal Article
    ​ ​Monitoring of 30 marker candidates in early Parkinson disease as progression markers​
    Mollenhauer, B. ; Zimmermann, J.; Sixel-Döring, F.; Focke, N. K. ; Wicke, T.; Ebentheuer, J. & Schaumburg, M. et al.​ (2016) 
    Neurology87(2) pp. 168​-177​.​ DOI: https://doi.org/10.1212/WNL.0000000000002651 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Review | 
    ​ ​Gender Differences in Appropriate Shocks and Mortality among Patients with Primary Prophylactic Implantable Cardioverter-Defibrillators: Systematic Review and Meta-Analysis​
    Conen, D.; Arendacka, B.; Roever, C. ; Bergau, L.; Munoz, P.; Wijers, S.& Sticherling, C. et al.​ (2016)
    PLoS ONE, 11​(9).​
    Public Library Science. DOI: https://doi.org/10.1371/journal.pone.0162756 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Review
    ​ ​Back schools for the treatment of chronic low back pain: possibility of benefit but no convincing evidence after 47 years of research-systematic review and meta-analysis​
    Straube, S.; Harden, M.; Schroeder, H.; Arendacka, B.; Fan, X.; Moore, R. A.& Friede, T. ​ (2016)
    Pain, 157​(10) pp. 2160​-2172​.​
    Lippincott Williams & Wilkins. DOI: https://doi.org/10.1097/j.pain.0000000000000640 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Journal Article | Letter Note
    ​ ​The N-MOmentum trial: Building momentum to advance trial methodology in a rare disease​
    Chataway, J. & Friede, T. ​ (2016) 
    Multiple Sclerosis Journal22(7) pp. 852​-853​.​ DOI: https://doi.org/10.1177/1352458516643399 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Journal Article
    ​ ​Improving clinical trials for cardiovascular diseases: a position paper from the Cardiovascular Round Table of the European Society of Cardiology​
    Jackson, N.; Atar, D.; Borentain, M.; Breithardt, G.; van Eickels, M.; Endres, M. & Fraass, U. et al.​ (2016) 
    European Heart Journal37(9) pp. 747​-U16​.​ DOI: https://doi.org/10.1093/eurheartj/ehv213 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Journal Article | 
    ​ ​Methods for identification and confirmation of targeted subgroups in clinical trials: A systematic review​
    Ondra, T.; Dmitrienko, A.; Friede, T. ; Graf, A.; Miller, F.; Stallard, N. & Posch, M.​ (2016) 
    Journal of Biopharmaceutical Statistics26(1) pp. 99​-119​.​ DOI: https://doi.org/10.1080/10543406.2015.1092034 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Journal Article
    ​ ​Evaluation of dysphagia by novel real-time MRI​
    Olthoff, A. ; Carstens, P.-O. ; Zhang, S.; von Fintel, E. ; Friede, T. ; Lotz, J.   & Frahm, J.  et al.​ (2016) 
    Neurology87(20) pp. 2132​-2138​.​ DOI: https://doi.org/10.1212/WNL.0000000000003337 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Conference Paper
    ​ ​Automated characterization of cell tracks and classification by using their position coordinates and velocity components​
    Islam, S.; Nietert, M. M. ; Haberl, M.; Friede, T.   & Beißbarth, T. ​ (2015)
    ​Computational Models in Biology and Medicine​, Leipzig.
    Details 
  • 2015 Conference Abstract
    ​ ​Risk stratification of ICD patients for appropriate shock and mortality in a multi-centre cohort. The EU-TrigTreat study​
    Bergau, L.; Willems, R.; Tuinenburg, A. E.; Vos, M. A.; Flevari, P.; Sohns, C. & Roever, C.  et al.​ (2015)
    European Heart Journal36 pp. 8​-9. , London, ENGLAND.
    Oxford​: Oxford Univ Press.
    Details  WoS 
  • 2015 Conference Abstract
    ​ ​Validation of the German version of the multiple sclerosis work difficulties questionnaire (MSWDQ)​
    Ellenberger, D. ; Friede, T. ; Sterz, C. & Flachenecker, P.​ (2015)
    Multiple Sclerosis Journal21 ​31st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS)​, Barcelona, SPAIN.
    London​: Sage Publications Ltd.
    Details  WoS 
  • 2015 Conference Abstract
    ​ ​Development and validation of employment-specific assessment instruments in German MS patients​
    Flachenecker, P.; Sterz, C.; Ellenberger, D. ; Meissner, H.; Gusowski, K. & Friede, T. ​ (2015)
    Multiple Sclerosis Journal21 ​31st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS)​, Barcelona, SPAIN.
    London​: Sage Publications Ltd.
    Details  WoS 
  • 2015 Journal Article | 
    ​ ​Regression to the Mean and Predictors of MRI Disease Activity in RRMS Placebo Cohorts - Is There a Place for Baseline-to-Treatment Studies in MS?​
    Stellmann, J.-P.; Stuerner, K. H.; Young, K. L.; Siemonsen, S.; Friede, T.   & Heesen, C.​ (2015) 
    PLoS ONE10(2) art. e0116559​.​ DOI: https://doi.org/10.1371/journal.pone.0116559 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article
    ​ ​Memorandum "Open Metadata"​
    Dugas, M.; Joeckel, K.-H.; Friede, T. ; Gefeller, O.; Kieser, M.; Marschollek, M.   & Ammenwerth, E. et al.​ (2015) 
    METHODS OF INFORMATION IN MEDICINE54(4) pp. 376​-378​.​ DOI: https://doi.org/10.3414/ME15-05-0007 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article
    ​ ​Cerebrospinal Fluid Apolipoprotein E Concentration and Progression of Alzheimer's Disease​
    Schmidt, C. D.; Gerlach, N.; Peter, C.; Gherib, K.; Lange, K.; Friede, T.   & Zerr, I.​ (2015) 
    Journal of Alzheimer s Disease43(4) pp. 1229​-1236​.​ DOI: https://doi.org/10.3233/JAD-141581 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article
    ​ ​Patients characteristics influencing the longitudinal utilization of steroids in multiple sclerosis - an observational study​
    Rommer, P. S.; Buckow, K.; Ellenberger, D. ; Friede, T. ; Pitschnau-Michel, D.; Fuge, J. & Stueve, O. et al.​ (2015) 
    European Journal of Clinical Investigation45(6) pp. 587​-593​.​ DOI: https://doi.org/10.1111/eci.12450 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article
    ​ ​Anticholinergics for urinary symptoms in multiple sclerosis (Withdrawn Paper. 2015, Art. no. CD004193)​
    Nicholas, R. S.; Friede, T. ; Hollis, S. & Young, C. A.​ (2015) 
    COCHRANE DATABASE OF SYSTEMATIC REVIEWS,(6) art. CD004193​.​ DOI: https://doi.org/10.1002/14651858.CD004193.pub3 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article | 
    ​ ​POINT AND INTERVAL ESTIMATORS OF THE TARGET DOSE IN CLINICAL DOSE-FINDING STUDIES WITH ACTIVE CONTROL​
    Helms, H.-J.; Benda, N. & Friede, T. ​ (2015) 
    Journal of Biopharmaceutical Statistics25(5) pp. 939​-957​.​ DOI: https://doi.org/10.1080/10543406.2014.920343 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article | 
    ​ ​Hartung-Knapp-Sidik-Jonkman approach and its modification for random-effects meta-analysis with few studies​
    Roever, C. ; Knapp, G. & Friede, T. ​ (2015) 
    BMC Medical Research Methodology15 art. 99​.​ DOI: https://doi.org/10.1186/s12874-015-0091-1 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article
    ​ ​Baseline CSF/Serum-Ratio of Apolipoprotein E and Rate of Differential Decline in Alzheimer's Disease​
    Schmidt, C. D.; Gerlach, N.; Schmitz, M.; Thom, T.; Kramer, K.; Friede, T.   & Zerr, I.​ (2015) 
    Journal of Alzheimer s Disease48(1) pp. 189​-196​.​ DOI: https://doi.org/10.3233/JAD-150286 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Review
    ​ ​A systematic review identifies shortcomings in the reporting of crossover trials in chronic painful conditions​
    Straube, S.; Werny, B.& Friede, T. ​ (2015)
    Journal of Clinical Epidemiology, 68​(12) pp. 1496​-1503​.​
    Elsevier Science Inc. DOI: https://doi.org/10.1016/j.jclinepi.2015.04.006 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article | 
    ​ ​Flexible selection of a single treatment incorporating short-term endpoint information in a phase II/III clinical trial​
    Stallard, N.; Kunz, C. U.; Todd, S.; Parsons, N. & Friede, T. ​ (2015) 
    Statistics in Medicine34(23) pp. 3104​-3115​.​ DOI: https://doi.org/10.1002/sim.6567 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article | 
    ​ ​A Comparison of Methods for Treatment Selection in Seamless Phase II/III Clinical Trials Incorporating Information on Short-Term Endpoints​
    Kunz, C. U.; Friede, T. ; Parsons, N.; Todd, S. & Stallard, N.​ (2015) 
    Journal of Biopharmaceutical Statistics25(1) pp. 170​-189​.​ DOI: https://doi.org/10.1080/10543406.2013.840646 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article | Research Paper | 
    ​ ​Scientific Versus Experiential Evidence: Discourse Analysis of the Chronic Cerebrospinal Venous Insufficiency Debate in a Multiple Sclerosis Forum.​
    Koschack, J. ; Weibezahl, L.; Friede, T. ; Himmel, W. ; Makedonski, F. D.   & Grabowski, J. ​ (2015) 
    Journal of medical Internet research17(7) art. e159​.​ DOI: https://doi.org/10.2196/jmir.4103 
    Details  DOI  PMID  PMC 
  • 2015 Review | 
    ​ ​Changing EDSS Progression in Placebo Cohorts in Relapsing MS: A Systematic Review and Meta-Regression​
    Roever, C. ; Nicholas, R.; Straube, S.& Friede, T. ​ (2015)
    PLoS ONE, 10​(9).​
    Public Library Science. DOI: https://doi.org/10.1371/journal.pone.0137052 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Conference Paper
    ​ ​Arbeitsplatz-basiertes Assessment im Medizinstudium: Ist eine Multilevel-Analyse sinnvoll?​
    Himmel, W. ; Gemperli, A. & Rogausch, A.​ (2014)
    In:Friede, Tim; Hilgers, Reinhard; Minkenberg, Ralf​ (Eds.), ​KSFE 2014: Proceedings pp. 115​-124. ​18. Konferenz der SAS-Anwender in Forschung und Entwicklung​, Göttingen.
    Aachen​: Shaker.
    Details 
  • 2014 Conference Abstract
    ​ ​Sex related differences in T2 lesion load in pediatric multiple sclerosis patients​
    Hummel, H. M. ; Huppke, P.; Friede, T. ; Ellenberger, D.   & Gaertner, J. ​ (2014)
    Multiple Sclerosis Journal20 pp. 397​-398. , Boston, MA.
    London​: Sage Publications Ltd.
    Details  WoS 
  • 2014 Journal Article | 
    ​ ​Sources of Information and Behavioral Patterns in Online Health Forums: Observational Study (vol 16, e10, 2014)​
    Sudau, F.; Friede, T. ; Grabowski, J. ; Koschack, J. ; Makedonski, F. D.   & Himmel, W. ​ (2014) 
    Journal of Medical Internet Research16(1) art. e39​.​ DOI: https://doi.org/10.2196/jmir.3280 
    Details  DOI  WoS 
  • 2014 Journal Article
    ​ ​Plasma prion protein concentration and progression of Alzheimer disease​
    Schmidt, C. D.; Becker, H.; Peter, C.; Lange, K.; Friede, T.   & Zerr, I.​ (2014) 
    Prion8(2) pp. 210​-214​.​ DOI: https://doi.org/10.4161/pri.27964 
    Details  DOI  WoS 
  • 2014 Journal Article
    ​ ​Guest Editors' Introduction​
    Friede, T. ; Henderson, R. & Hougaard, P.​ (2014) 
    Statistics in Medicine33(30) pp. 5221​-5222​.​ DOI: https://doi.org/10.1002/sim.6362 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper | 
    ​ ​Sources of Information and Behavioral Patterns in Online Health Forums: Observational Study​
    Sudau, F.; Friede, T. ; Grabowski, J. ; Koschack, J. ; Makedonski, F. D.   & Himmel, W. ​ (2014) 
    Journal of Medical Internet Research16(1) art. e10​.​ DOI: https://doi.org/10.2196/jmir.2875 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper | 
    ​ ​Safety relevant knowledge of orally anticoagulated patients without self-monitoring: a baseline survey in primary care​
    Chenot, J.-F.; Thanh Duc Hua, T. D. H.; Abu Abed, M.; Schneider-Rudt, H.; Friede, T. ; Schneider, S. & Vormfelde, S. V.​ (2014) 
    BMC Family Practice15 art. 104​.​ DOI: https://doi.org/10.1186/1471-2296-15-104 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | 
    ​ ​Work-related outcomes in randomised placebo-controlled pain trials: a systematic review and meta-analysis​
    Wolf, I.; Friede, T. ; Hallier, E. & Straube, S.​ (2014) 
    Journal of Occupational Medicine and Toxicology9 art. 25​.​ DOI: https://doi.org/10.1186/1745-6673-9-25 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | 
    ​ ​Efficacy of Ambroxol lozenges for pharyngitis: a meta-analysis​
    Chenot, J.-F.; Weber, P. & Friede, T. ​ (2014) 
    BMC Family Practice15 art. 45​.​ DOI: https://doi.org/10.1186/1471-2296-15-45 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | 
    ​ ​Data-driven treatment selection for seamless phase II/III trials incorporating early-outcome data​
    Kunz, C. U.; Friede, T. ; Parsons, N.; Todd, S. & Stallard, N.​ (2014) 
    Pharmaceutical Statistics13(4) pp. 238​-246​.​ DOI: https://doi.org/10.1002/pst.1619 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article
    ​ ​CR1 is potentially associated with rate of decline in sporadic Alzheimer's disease​
    Schmidt, C. D.; Wolff, M.; von Ahsen, N.; Lange, K.; Friede, T.   & Zerr, I.​ (2014) 
    Journal of Clinical Neuroscience21(10) pp. 1705​-1708​.​ DOI: https://doi.org/10.1016/j.jocn.2014.03.015 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article
    ​ ​ADAPTIVE DESIGNS FOR CONFIRMATORY CLINICAL TRIALS WITH SUBGROUP SELECTION​
    Stallard, N.; Hamborg, T.; Parsons, N. & Friede, T. ​ (2014) 
    Journal of Biopharmaceutical Statistics24(1) pp. 168​-187​.​ DOI: https://doi.org/10.1080/10543406.2013.857238 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article
    ​ ​Blinded sample size re-estimation in crossover bioequivalence trials​
    Golkowski, D.; Friede, T.   & Kieser, M.​ (2014) 
    Pharmaceutical Statistics13(3) pp. 157​-162​.​ DOI: https://doi.org/10.1002/pst.1617 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | 
    ​ ​Interleukin-2 receptor antagonists for pediatric liver transplant recipients: A systematic review and meta-analysis of controlled studies​
    Crins, N. D.; Roever, C. ; Goralczyk, A. D. & Friede, T. ​ (2014) 
    Pediatric Transplantation18(8) pp. 839​-850​.​ DOI: https://doi.org/10.1111/petr.12362 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | 
    ​ ​Primum non nocere: shared informed decision making in low back pain - a pilot cluster randomised trial​
    Patel, S.; Ngunjiri, A.; Hee, S. W.; Yang, Y.; Brown, S.; Friede, T.   & Griffiths, F. et al.​ (2014) 
    BMC Musculoskeletal Disorders15 art. 282​.​ DOI: https://doi.org/10.1186/1471-2474-15-282 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | 
    ​ ​Multiple sclerosis registries in Europe - results of a systematic survey​
    Flachenecker, P.; Buckow, K.; Pugliatti, M.; Kes, V. B.; Battaglia, M. A.; Boyko, A. & Confavreux, C. et al.​ (2014) 
    Multiple Sclerosis Journal20(11) pp. 1523​-1532​.​ DOI: https://doi.org/10.1177/1352458514528760 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | 
    ​ ​Design and Development of a Decision Support Package for Low Back Pain​
    Patel, S.; Ngunjiri, A.; Sandhu, H.; Griffiths, F.; Thistlewaite, J.; Brown, S. & Friede, T.  et al.​ (2014) 
    Arthritis Care & Research66(6) pp. 925​-933​.​ DOI: https://doi.org/10.1002/acr.22252 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper
    ​ ​Clinical presentation of pediatric multiple sclerosis before puberty​
    Huppke, B. ; Ellenberger, D. ; Rosewich, H. ; Friede, T. ; Gärtner, J.   & Huppke, P. ​ (2014) 
    European Journal of Neurology21(3) pp. 441​-446​.​ DOI: https://doi.org/10.1111/ene.12327 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper
    ​ ​Educating Orally Anticoagulated Patients in Drug Safety A Cluster-Randomized Study in General Practice​
    Vormfelde, S. V.; Abu Abed, M.; Hua, T. D.; Schneider, S.; Friede, T.   & Chenot, J.-F.​ (2014) 
    Deutsches Ärzteblatt international111(37) pp. 607​-614​.​ DOI: https://doi.org/10.3238/arztebl.2014.0607 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | 
    ​ ​Spline-based procedures for dose-finding studies with active control​
    Helms, H.-J.; Benda, N.; Zinserling, J.; Kneib, T.   & Friede, T. ​ (2014) 
    Statistics in Medicine34(2) pp. 232​-248​.​ DOI: https://doi.org/10.1002/sim.6320 
    Details  DOI  PMID  PMC 
  • 2013 Conference Abstract
    ​ ​Comparison of disability scores and annualised relapse rates as trial outcomes in randomized, placebo controlled trials in relapsing multiple sclerosis: a systematic review​
    Roever, C. ; Nicholas, R.; Steinvorth, S.; Straube, S. & Friede, T. ​ (2013)
    Multiple Sclerosis Journal19(11) pp. 498​-499. ​29th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis / 18th Annual Conference of Rehabilitation in MS​, Copenhagen, DENMARK.
    London​: Sage Publications Ltd.
    Details  WoS 
  • 2013 Journal Article
    ​ ​A conditional error function approach for subgroup selection in adaptive clinical trials (vol 31, pg 4309, 2012)​
    Friede, T. ; Parsons, N. & Stallard, N.​ (2013) 
    Statistics in Medicine32(14) pp. 2513​-2514​.​ DOI: https://doi.org/10.1002/sim.5759 
    Details  DOI  WoS 
  • 2013 Conference Abstract
    ​ ​Using the internet in the management of multiple sclerosis: an overview of the evidence available​
    Schilling, J.; Friede, T.   & Straube, S.​ (2013)
    Multiple Sclerosis Journal19(11) pp. 302​-303. ​29th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis / 18th Annual Conference of Rehabilitation in MS​, Copenhagen, DENMARK.
    London​: Sage Publications Ltd.
    Details  WoS 
  • 2013 Journal Article | 
    ​ ​Study protocol: improving patient choice in treating Low back pain (IMPACT-LBP): a randomised controlled trial of a decision support package for use in physical therapy (vol 12, 52, 2011)​
    Patel, S.; Brown, S.; Friede, T. ; Griffiths, F.; Lord, J.; Ngunjiri, A. & Thistlethwaite, J. et al.​ (2013) 
    BMC Musculoskeletal Disorders14 art. 158​.​ DOI: https://doi.org/10.1186/1471-2474-14-158 
    Details  DOI  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​Design and semiparametric analysis of non-inferiority trials with active and placebo control for censored time-to-event data​
    Kombrink, K.; Munk, A.   & Friede, T. ​ (2013) 
    Statistics in Medicine32(18) pp. 3055​-3066​.​ DOI: https://doi.org/10.1002/sim.5769 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​Adhesion maturation of neutrophils on nanoscopically presented platelet glycoprotein Ibα​
    Kruss, S.; Erpenbeck, L.; Amschler, K.; Mundinger, T. A. ; Boehm, H.; Helms, H.-J. & Friede, T.  et al.​ (2013) 
    ACS Nano7(11) pp. 9984​-9996​.​ DOI: https://doi.org/10.1021/nn403923h 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article
    ​ ​Assessment of statistical significance and clinical relevance​
    Kieser, M.; Friede, T.   & Gondan, M.​ (2013) 
    Statistics in Medicine32(10) pp. 1707​-1719​.​ DOI: https://doi.org/10.1002/sim.5634 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Review
    ​ ​Systematic Review of Randomized Controlled Trials of Clinical Prediction Rules for Physical Therapy in Low Back Pain​
    Patel, S.; Psychol, C.; Friede, T. ; Froud, R.; Evans, D. W.& Underwood, M.​ (2013)
    Spine, 38​(9) pp. 762​-769​.​
    Lippincott Williams & Wilkins. DOI: https://doi.org/10.1097/BRS.0b013e31827b158f 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | 
    ​ ​Explaining temporal trends in annualised relapse rates in placebo groups of randomised controlled trials in relapsing multiple sclerosis: systematic review and meta-regression​
    Steinvorth, S. M.; Roever, C. ; Schneider, S.; Nicholas, R.; Straube, S. & Friede, T. ​ (2013) 
    Multiple Sclerosis Journal19(12) pp. 1580​-1586​.​ DOI: https://doi.org/10.1177/1352458513481009 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article
    ​ ​Blinded and unblinded internal pilot study designs for clinical trials with count data​
    Schneider, S.; Schmidli, H. & Friede, T. ​ (2013) 
    Biometrical Journal55(4) pp. 617​-633​.​ DOI: https://doi.org/10.1002/bimj.201200189 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article
    ​ ​Blinded sample size re-estimation for recurrent event data with time trends​
    Schneider, S.; Schmidli, H. & Friede, T. ​ (2013) 
    Statistics in Medicine32(30) pp. 5448​-5457​.​ DOI: https://doi.org/10.1002/sim.5977 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article
    ​ ​Robustness of methods for blinded sample size re-estimation with overdispersed count data​
    Schneider, S.; Schmidli, H. & Friede, T. ​ (2013) 
    Statistics in Medicine32(21) pp. 3623​-3635​.​ DOI: https://doi.org/10.1002/sim.5800 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article
    ​ ​Blinded sample size re-estimation in superiority and noninferiority trials: bias versus variance in variance estimation​
    Friede, T.   & Kieser, M.​ (2013) 
    Pharmaceutical Statistics12(3) pp. 141​-146​.​ DOI: https://doi.org/10.1002/pst.1564 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article
    ​ ​Cross cultural evaluation of the Warwick-Edinburgh mental well-being scale (WEMWBS) -a mixed methods study​
    Taggart, F.; Friede, T. ; Weich, S.; Clarke, A.; Johnson, M. A. & Stewart-Brown, S.​ (2013) 
    Health and Quality of Life Outcomes11 art. 27​.​ DOI: https://doi.org/10.1186/1477-7525-11-27 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper | 
    ​ ​Therapeutic Apheresis in Pediatric Patients with Acute CNS Inflammatory Demyelinating Disease​
    Koziolek, M. J. ; Friede, T. ; Ellenberger, D. ; Sigler, M. ; Huppke, B. ; Gärtner, J.   & Mueller, G.-A.  et al.​ (2013) 
    Blood Purification36(2) pp. 92​-97​.​ DOI: https://doi.org/10.1159/000354077 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Journal Article | 
    ​ ​Safety and Efficacy of the ACE-Inhibitor Ramipril in Alport Syndrome: The Double-Blind, Randomized, Placebo-Controlled, Multicenter Phase III EARLY PRO-TECT Alport Trial in Pediatric Patients​
    Gross, O.; Friede, T. ; Hilgers, R.; Görlitz, A.; Gavénis, K.; Ahmed, R. & Dürr, U.​ (2012) 
    ISRN Pediatrics2012 pp. 1​-6​.​ DOI: https://doi.org/10.5402/2012/436046 
    Details  DOI  PMID  PMC 
  • 2012 Journal Article
    ​ ​Assess, compare and enhance the status of Persons with Multiple Sclerosis (MS) in Europe: a European Register for MS​
    Pugliatti, M.; Eskic, D.; Mikolcic, T.; Pitschnau-Michel, D.; Myhr, K.-M.; Sastre-Garriga, J. & Otero, S. et al.​ (2012) 
    Acta Neurologica Scandinavica126 pp. 24​-30​.​ DOI: https://doi.org/10.1111/ane.12024 
    Details  DOI  WoS 
  • 2012 Journal Article
    ​ ​Blinded continuous monitoring of nuisance parameters in clinical trials​
    Friede, T.   & Miller, F.​ (2012) 
    Journal of the Royal Statistical Society Series C (Applied Statistics)61 pp. 601​-618​.​ DOI: https://doi.org/10.1111/j.1467-9876.2011.01029.x 
    Details  DOI  WoS 
  • 2012 Journal Article
    ​ ​An R package for implementing simulations for seamless phase II/III clinical trials using early outcomes for treatment selection​
    Parsons, N.; Friede, T. ; Todd, S.; Marquez, E. V.; Chataway, J.; Nicholas, R. & Stallard, N.​ (2012) 
    Computational Statistics & Data Analysis56(5) pp. 1150​-1160​.​ DOI: https://doi.org/10.1016/j.csda.2010.10.027 
    Details  DOI  WoS 
  • 2012 Conference Abstract
    ​ ​Time trends in baseline characteristics and eligibility criteria in trials in relapsing mutliple sclerosis - a systematic review and meta-analysis​
    Steinvorth, S. M.; Nicholas, R.; Roever, C. ; Schneider, S.; Straube, S. & Friede, T. ​ (2012)
    Multiple Sclerosis Journal18 pp. 474​-475. ​28th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis​, Lyon, FRANCE.
    London​: Sage Publications Ltd.
    Details  WoS 
  • 2012 Conference Abstract
    ​ ​Calcineurin Inhibitor Sparing with Mycophenolate Mofetil in Liver Transplant Recipients: A Systematic Review and Meta-Analysis​
    Goralczyk, A. D.; Abu-Ajaj, W.; Bari, N.; Lorf, T.; Ramadori, G.; Friede, T.   & Obed, A.​ (2012)
    Transplantation Journal94(10) 
    Philadelphia​: Lippincott Williams & Wilkins.
    Details  WoS 
  • 2012 Journal Article
    ​ ​Early angiotensin-converting enzyme inhibition in Alport syndrome delays renal failure and improves life expectancy​
    Gross, O.; Licht, C.; Anders, H.-J.; Hoppe, B.; Beck, B.; Toenshoff, B. & Hoecker, B. et al.​ (2012) 
    Kidney International81(5) pp. 494​-501​.​ DOI: https://doi.org/10.1038/ki.2011.407 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Journal Article | Research Paper | 
    ​ ​Rationale, objectives, and design of the EUTrigTreat clinical study: a prospective observational study for arrhythmia risk stratification and assessment of interrelationships among repolarization markers and genotype​
    Seegers, J.; Vos, M. A.; Flevari, P.; Willems, R.; Sohns, C.; Vollmann, D. & Luethje, L.  et al.​ (2012) 
    EP Europace14(3) pp. 416​-422​.​ DOI: https://doi.org/10.1093/europace/eur352 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Conference Paper
    ​ ​A conditional error function approach for subgroup selection in adaptive clinical trials​
    Friede, T. ; Parsons, N. & Stallard, N.​ (2012)
    Statistics in Medicine31(30) pp. 4309​-4320. ​32nd Annual Conference of the International-Society-for-Clinical-Biostatistics​, Ontario, CANADA.
    Hoboken​: Wiley-blackwell. DOI: https://doi.org/10.1002/sim.5541 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Review
    ​ ​Calcineurin Inhibitor Sparing With Mycophenolate Mofetil in Liver Transplantion: A Systematic Review of Randomized Controlled Trials​
    Goralczyk, A. D.; Bari, N.; Abu-Ajaj, W.; Lorf, T.; Ramadori, G.; Friede, T.  & Obed, A.​ (2012)
    American Journal of Transplantation, 12​(10) pp. 2601​-2607​.​
    Wiley-blackwell. DOI: https://doi.org/10.1111/j.1600-6143.2012.04157.x 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Review | 
    ​ ​Time-patterns of annualized relapse rates in randomized placebo-controlled clinical trials in relapsing multiple sclerosis: A systematic review and meta-analysis​
    Nicholas, R.; Straube, S.; Schmidli, H.; Pfeiffer, S.& Friede, T. ​ (2012)
    Multiple Sclerosis Journal, 18​(9) pp. 1290​-1296​.​
    Sage Publications Ltd. DOI: https://doi.org/10.1177/1352458511435715 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Conference Paper
    ​ ​Considerations on what constitutes a 'qualified statistician' in regulatory guidelines​
    Gerlinger, C.; Edler, L.; Friede, T. ; Kieser, M.; Nakas, C. T.; Schumacher, M. & Seldrup, J. et al.​ (2012)
    Statistics in Medicine31(11-12) pp. 1303​-1305. ​31st Annual Conference of the International-Society-for-Clinical-Biostatistics​, Montpellier, FRANCE.
    Hoboken​: Wiley-blackwell. DOI: https://doi.org/10.1002/sim.4345 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article | Letter Note
    ​ ​Planning and analysis of three-arm non-inferiority trials with binary endpoints​
    Kieser, M. & Friede, T. ​ (2011) 
    Statistics in Medicine30(3).​ DOI: https://doi.org/10.1002/sim.4113 
    Details  DOI  WoS 
  • 2011 Conference Abstract
    ​ ​Interleukin 2 Receptor Antagonists for Liver Transplant Recipients: A Systematic Review and Meta-Analysis of Controlled Trials​
    Goralczyk, A. D.; Hauke, N.; Bari, N.; Lorf, T.; Friede, T.   & Obed, A.​ (2011)
    Liver Transplantation17(6) pp. S262​-S263. ​Joint International Congress of ILTS, ELITA, and LICAGE​, Valencia, SPAIN.
    Malden​: Wiley-blackwell.
    Details  WoS 
  • 2011 Journal Article | 
    ​ ​Software tools for implementing simulation studies in adaptive seamless designs: introducing R package ASD​
    Parsons, N.; Friede, T. ; Todd, S. & Stallard, N.​ (2011) 
    Trials12(Suppl 1) pp. A8​.​ DOI: https://doi.org/10.1186/1745-6215-12-S1-A8 
    Details  DOI 
  • 2011 Journal Article | 
    ​ ​Reporting FDR analogous confidence intervals for the log fold change of differentially expressed genes​
    Jung, K. ; Friede, T.   & Beißbarth, T. ​ (2011) 
    BMC Bioinformatics12 art. 288​.​ DOI: https://doi.org/10.1186/1471-2105-12-288 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article | 
    ​ ​Warwick-Edinburgh Mental Well-being Scale (WEMWBS): Validated for teenage school students in England and Scotland. A mixed methods assessment​
    Clarke, A.; Friede, T. ; Putz, R.; Ashdown, J.; Martin, S.; Blake, A. & Adi, Y. et al.​ (2011) 
    BMC Public Health11 art. 487​.​ DOI: https://doi.org/10.1186/1471-2458-11-487 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article | 
    ​ ​Trends in annualized relapse rates in relapsing-remitting multiple sclerosis and consequences for clinical trial design​
    Nicholas, R.; Straube, S.; Schmidli, H.; Schneider, S. & Friede, T. ​ (2011) 
    Multiple Sclerosis Journal17(10) pp. 1211​-1217​.​ DOI: https://doi.org/10.1177/1352458511406309 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article
    ​ ​Sample Size Reassessment in Non-inferiority Trials​
    Friede, T.   & Kieser, M.​ (2011) 
    METHODS OF INFORMATION IN MEDICINE50(3) pp. 237​-243​.​ DOI: https://doi.org/10.3414/ME09-01-0063 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article | 
    ​ ​A novel adaptive design strategy increases the efficiency of clinical trials in secondary progressive multiple sclerosis​
    Chataway, J.; Nicholas, R.; Todd, S.; Miller, D. H.; Parsons, N.; Valdes-Marquez, E. & Stallard, N. et al.​ (2011) 
    MULTIPLE SCLEROSIS17(1) pp. 81​-88​.​ DOI: https://doi.org/10.1177/1352458510382129 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Review
    ​ ​Systematic review of sonographic chronic cerebrospinal venous insufficiency findings in multiple sclerosis​
    Thapar, A.; Lane, T.; Nicholas, R.; Friede, T. ; Ellis, M.; Assenheim, J.& Franklin, I. J. et al.​ (2011)
    Phlebology The Journal of Venous Disease, 26​(8) pp. 319​-325​.​
    Royal Soc Medicine Press Ltd. DOI: https://doi.org/10.1258/phleb.2011.011098 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article | Research Paper | 
    ​ ​Practice nursed-based, individual and video-assisted patient education in oral anticoagulation - Protocol of a cluster-randomized controlled trial​
    Hua, T. D.; Vormfelde, S. V.; Abu Abed, M.; Schneider-Rudt, H.; Sobotta, P.; Friede, T.   & Chenot, J.-F.​ (2011) 
    BMC Family Practice12 art. 17​.​ DOI: https://doi.org/10.1186/1471-2296-12-17 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Conference Paper
    ​ ​Designing a seamless phase II/III clinical trial using early outcomes for treatment selection: An application in multiple sclerosis​
    Friede, T. ; Parsons, N.; Stallard, N.; Todd, S.; Marquez, E. V.; Chataway, J. & Nicholas, R.​ (2011)
    Statistics in Medicine30(13) pp. 1528​-1540. , Biopharm & Hlth Grp French Soc Stat, Paris, FRANCE.
    Hoboken​: Wiley-blackwell. DOI: https://doi.org/10.1002/sim.4202 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Review | 
    ​ ​Development of oral immunomodulatory agents in the management of multiple sclerosis​
    Nicholas, R.; Giannetti, P.; Alsanousi, A.; Friede, T.  & Muraro, P. A.​ (2011)
    Drug Design Development and Therapy, 5​ pp. 255​-274​.​
    Dove Medical Press Ltd. DOI: https://doi.org/10.2147/DDDT.S10498 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article | 
    ​ ​Study protocol: Improving patient choice in treating low back pain (IMPACT - LBP): A randomised controlled trial of a decision support package for use in physical therapy​
    Patel, S.; Brown, S.; Friede, T. ; Griffiths, F.; Lord, J.; Ngunjiri, A. & Thistlethwaite, J. et al.​ (2011) 
    BMC Musculoskeletal Disorders12 art. 52​.​ DOI: https://doi.org/10.1186/1471-2474-12-52 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article
    ​ ​Aspects of Modernizing Drug Development Using Clinical Scenario Planning and Evaluation​
    Benda, N.; Branson, M.; Maurer, W. & Friede, T. ​ (2010) 
    DRUG INFORMATION JOURNAL44(3) pp. 299​-315​.​
    Details  WoS 
  • 2010 Journal Article
    ​ ​Blinded Sample Size Recalculation in Noninferiority Trials: A Case Study in Dermatology​
    Friede, T.   & Stammer, H.​ (2010) 
    DRUG INFORMATION JOURNAL44(5) pp. 599​-607​.​
    Details  WoS 
  • 2010 Journal Article
    ​ ​Refinement of the Clinical Scenario Evaluation Framework for Assessment of Competing Development Strategies With an Application to Multiple Sclerosis​
    Friede, T. ; Nicholas, R.; Stallard, N.; Todd, S.; Parsons, N.; Valdes-Marquez, E. & Chataway, J.​ (2010) 
    DRUG INFORMATION JOURNAL44(6) pp. 713​-718​.​
    Details  WoS 
  • 2010 Journal Article
    ​ ​Perspectives on the Use of Adaptive Designs in Clinical Trials. Part II. Panel Discussion​
    Benda, N.; Brannath, W.; Bretz, F.; Burger, H.-U.; Friede, T. ; Maurer, W. & Wang, S.​ (2010) 
    Journal of Biopharmaceutical Statistics20(6) art. PII 929076459​.​ DOI: https://doi.org/10.1080/10543406.2010.514447 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article
    ​ ​Blinded Sample Size Reestimation with Negative Binomial Counts in Superiority and Non-inferiority Trials​
    Friede, T.   & Schmidli, H.​ (2010) 
    Methods of Information in Medicine49(6) pp. 618​-624​.​ DOI: https://doi.org/10.3414/ME09-02-0060 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Conference Paper | 
    ​ ​Blinded sample size reestimation with count data: Methods and applications in multiple sclerosis​
    Friede, T.   & Schmidli, H.​ (2010)
    Statistics in Medicine29(10) pp. 1145​-1156. ​Annual Conference on Statistical Issues in Clinical Trials-Early, Translational and Proof of Concept Studies - The Go/No Go Decisions​, Philadelphia, PA.
    Malden​: Wiley-blackwell. DOI: https://doi.org/10.1002/sim.3861 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Review
    ​ ​Bladder symptoms in multiple sclerosis: a review of pathophysiology and management​
    Nicholas, R.; Young, C. A.& Friede, T. ​ (2010)
    Expert Opinion on Drug Safety, 9​(6) pp. 905​-915​.​
    Informa Healthcare. DOI: https://doi.org/10.1517/14740338.2010.501793 
    Details  DOI  PMID  PMC  WoS 
  • 2004 Journal Article | Letter Note
    ​ ​Culture collections of algae: Increasing accessibility and exploring algal biodiversity - Preface​
    Fried, T. ; Day, J. G. & Preisig, H. R.​ (2004) 
    Nova Hedwigia79(1-2).​
    Details  WoS 

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