RG Hasenfuß (Transition zur Herzinsuffizienz)

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  • 2024 | Journal Article
    ​ ​Non-invasive analysis of contractility during identical maturations revealed two phenotypes in ventricular but not in atrial iPSC-CM​
    Rapöhn, M.; Cyganek, L.; Voigt, N.; Hasenfuß, G.; Lehnart, S. E & Wegener, J. W​ (2024) 
    American Journal of Physiology. Heart and Circulatory Physiology,.​ DOI: https://doi.org/10.1152/ajpheart.00527.2023 
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  • 2024 | Journal Article
    ​ ​Epicardial adipose tissue as an independent predictor of long-term outcome in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement​
    Schulz, A.; Beuthner, B. E.; Böttiger, Z. M.; Gersch, S. S.; Lange, T.; Gronwald, J. & Evertz, R. et al.​ (2024) 
    Clinical Research in Cardiology,.​ DOI: https://doi.org/10.1007/s00392-024-02387-5 
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  • 2024 | Journal Article
    ​ ​Preclinical evaluation of CRISPR-based therapies for Noonan syndrome caused by deep-intronic LZTR1 variants​
    Knauer, C.; Haltern, H.; Schoger, E.; Kügler, S.; Roos, L.; Zelarayán, L. C. & Hasenfuss, G. et al.​ (2024) 
    Molecular Therapy - Nucleic Acids, 35(1) art. 102123​.​ DOI: https://doi.org/10.1016/j.omtn.2024.102123 
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  • 2024 | Journal Article
    ​ ​Low-flow in aortic valve stenosis patients with reduced ejection fraction does not depend on left ventricular function​
    Gersch, S.; Lange, T.; Beuthner, B. E.; Elkenani, M.; Paul, N.; Schnelle, M. & Zeisberg, E. et al.​ (2024) 
    Clinical Research in Cardiology,.​ DOI: https://doi.org/10.1007/s00392-023-02372-4 
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  • 2024 | Journal Article
    ​ ​Histological assessment of cardiac amyloidosis in patients undergoing transcatheter aortic valve replacement​
    Beuthner, B. E.; Elkenani, M.; Evert, K.; Mustroph, J.; Jacob, C. F.; Paul, N. B. & Beißbarth, T. et al.​ (2024) 
    ESC Heart Failure, art. ehf2.14709​.​ DOI: https://doi.org/10.1002/ehf2.14709 
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  • 2023 | Journal Article | 
    ​ ​Low levels of circulating methylated IRX3 are related to worse outcome after transcatheter aortic valve implantation in patients with severe aortic stenosis​
    Kanwischer, L.; Xu, X.; Saifuddin, A. B.; Maamari, S.; Tan, X.; Alnour, F. & Tampe, B. et al.​ (2023) 
    Clinical Epigenetics, 15(1) art. 149​.​ DOI: https://doi.org/10.1186/s13148-023-01561-2 
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  • 2023 | Journal Article | 
    ​ ​Molecular and Functional Relevance of NaV1.8-Induced Atrial Arrhythmogenic Triggers in a Human SCN10A Knock-Out Stem Cell Model​
    Hartmann, N.; Knierim, M.; Maurer, W.; Dybkova, N.; Hasenfuß, G.; Sossalla, S. & Streckfuss-Bömeke, K.​ (2023) 
    International Journal of Molecular Sciences, 24(12) art. 10189​.​ DOI: https://doi.org/10.3390/ijms241210189 
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  • 2023 | Preprint
    ​ ​LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome​
    Busley, A. V.; Gutiérrez-Gutiérrez, Ó.; Hammer, E.; Steinegger, M.; Böhmer, L.; Schroeder, H.& Kleinsorge, M. et al.​ (2023). DOI: https://doi.org/10.1101/2023.01.10.523203 
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  • 2023 | Journal Article | 
    ​ ​DNA Methylation Analysis Identifies Novel Epigenetic Loci in Dilated Murine Heart upon Exposure to Volume Overload​
    Xu, X.; Elkenani, M.; Tan, X.; Hain, J. katharina; Cui, B.; Schnelle, M. & Hasenfuss, G.  et al.​ (2023) 
    International Journal of Molecular Sciences, 24(6) pp. 5885​.​ DOI: https://doi.org/10.3390/ijms24065885 
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  • 2023 | Journal Article | 
    ​ ​The DZHK research platform: maximisation of scientific value by enabling access to health data and biological samples collected in cardiovascular clinical studies​
    Hoffmann, J.; Hanß, S.; Kraus, M.; Schaller, J.; Schäfer, C.; Stahl, D. & Anker, S. D. et al.​ (2023) 
    Clinical Research in Cardiology,.​ DOI: https://doi.org/10.1007/s00392-023-02177-5 
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  • 2023 | Journal Article
    ​ ​A dual-targeted drug inhibits cardiac ryanodine receptor Ca 2+ leak but activates SERCA2a Ca 2+ uptake​
    Wegener, J. W.; Mitronova, G. Y.; ElShareif, L.; Quentin, C.; Belov, V.; Pochechueva, T. & Hasenfuss, G. et al.​ (2023) 
    Life Science Alliance, 7(2) art. e202302278​.​ DOI: https://doi.org/10.26508/lsa.202302278 
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  • 2023 | Journal Article
    ​ ​An Alternative Mechanism of Subcellular Iron Uptake Deficiency in Cardiomyocytes​
    Dai, Y.; Ignatyeva, N.; Xu, H.; Wali, R.; Toischer, K.; Brandenburg, S. & Lenz, C. et al.​ (2023) 
    Circulation Research, art. CIRCRESAHA.122.321157​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.122.321157 
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  • 2023 | Journal Article | 
    ​ ​Aortic valve calcification and myocardial fibrosis determine outcome following transcatheter aortic valve replacement​
    Evertz, R.; Hub, S.; Beuthner, B. E.; Backhaus, S. J.; Lange, T.; Schulz, A. & Toischer, K. et al.​ (2023) 
    ESC Heart Failure, art. ehf2.14307​.​ DOI: https://doi.org/10.1002/ehf2.14307 
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  • 2023 | Preprint
    ​ ​Secreted-Frizzled-Related Protein 5 Modulates Calcium Handling in Human Ipsc-Cardiomyocytes​
    Weber, F.; Klas, S.; Hindmarsh, V.; Salinas, G.; Toischer, K.; Hasenfuss, G.& Cyganek, L.​ (2023). DOI: https://doi.org/10.2139/ssrn.4544232 
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  • 2023 | Journal Article | 
    ​ ​Metabolomic Profiling in Patients with Different Hemodynamic Subtypes of Severe Aortic Valve Stenosis​
    Bengel, P.; Elkenani, M.; Beuthner, B. E.; Pietzner, M.; Mohamed, B. A.; Pollok-Kopp, B. & Krätzner, R. et al.​ (2023) 
    Biomolecules, 13(1) pp. 95​.​ DOI: https://doi.org/10.3390/biom13010095 
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  • 2022 | Journal Article | Research Paper | 
    ​ ​Hemodynamic stress-induced cardiac remodelling is not modulated by ablation of phosphodiesterase 4D interacting protein​
    Mohamed, B. A. ; Elkenani, M.; Mobarak, S.; Marques Rodrigues, D.; Annamalai, K.; Schnelle, M.   & Bader, M. et al.​ (2022) 
    Journal of Cellular and Molecular Medicine, 26(16) pp. 4440​-4452​.​ DOI: https://doi.org/10.1111/jcmm.17468 
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  • 2022 | Journal Article | 
    ​ ​Functional and structural reverse myocardial remodeling following transcatheter aortic valve replacement: a prospective cardiovascular magnetic resonance study​
    Lange, T.; Backhaus, S. J.; Beuthner, B. E.; Topci, R.; Rigorth, K.-R.; Kowallick, J. T. & Evertz, R. et al.​ (2022) 
    Journal of Cardiovascular Magnetic Resonance, 24(1) art. 45​.​ DOI: https://doi.org/10.1186/s12968-022-00874-0 
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  • 2022 | Journal Article | Research Paper
    ​ ​Modulatorische Einheiten bei Herzinsuffizienz​
    Hasenfuß, G. P. ; Kaul, A.; Lehnart, S. E. ; Linke, W. A. ; Zelarayan, L. C.   & Zimmermann, W.-H. ​ (2022) 
    Der Kardiologe, 16(2) pp. 109​-114​.​ DOI: https://doi.org/10.1007/s12181-022-00540-w 
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  • 2022 | Journal Article
    ​ ​Dysferlin facilitates the de novo biogenesis of tubular membranes in hypertrophic remodelling​
    Paulke, N.; Amlaz, S.; Fleischhacker, C.; Kohl, T.; Kownatzki-Danger, D.; Hasenfuss, G.   & Lehnart, S.  et al.​ (2022) 
    European Heart Journal, 43(Suppl. 2).​ DOI: https://doi.org/10.1093/eurheartj/ehac544.2944 
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  • 2022 | Journal Article | Research Paper | 
    ​ ​Effects of Atrial Fibrillation on the Human Ventricle​
    Pabel, S. ; Knierim, M.; Stehle, T.; Alebrand, F.; Paulus, M.; Sieme, M. & Herwig, M. et al.​ (2022) 
    Circulation Research, 130(7) pp. 994​-1010​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.121.319718 
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  • 2022 | Journal Article | Research Paper | 
    ​ ​A junctional cAMP compartment regulates rapid Ca2+ signaling in atrial myocytes​
    Brandenburg, S. ; Pawlowitz, J.; Steckmeister, V.; Subramanian, H.; Uhlenkamp, D.; Scardigli, M. & Mushtaq, M. et al.​ (2022) 
    Journal of Molecular and Cellular Cardiology, 165 pp. 141​-157​.​ DOI: https://doi.org/10.1016/j.yjmcc.2022.01.003 
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  • 2022 | Journal Article | 
    ​ ​Doxorubicin induces cardiotoxicity in a pluripotent stem cell model of aggressive B cell lymphoma cancer patients​
    Haupt, L. P.; Rebs, S.; Maurer, W.; Hübscher, D.; Tiburcy, M.; Pabel, S. & Maus, A. et al.​ (2022) 
    Basic Research in Cardiology, 117(1) art. 13​.​ DOI: https://doi.org/10.1007/s00395-022-00918-7 
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  • 2022 | Journal Article | 
    ​ ​Direct proteomic and high-resolution microscopy biopsy analysis identifies distinct ventricular fates in severe aortic stenosis​
    Brandenburg, S. ; Drews, L.; Schönberger, H.-L.; Jacob, C. F.; Paulke, N. J.; Beuthner, B. E. & Topci, R. et al.​ (2022) 
    Journal of Molecular and Cellular Cardiology, 173 pp. 1​-15​.​ DOI: https://doi.org/10.1016/j.yjmcc.2022.08.363 
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  • 2022 | Journal Article | Research Paper | 
    ​ ​Different activation of MAPKs and Akt/GSK3β after preload vs. afterload elevation​
    Hartmann, N. ; Preuß, L.; Mohamed, B. A. ; Schnelle, M. ; Renner, A.; Hasenfuß, G.   & Toischer, K. ​ (2022) 
    ESC Heart Failure, 9(3) pp. 1823​-1831​.​ DOI: https://doi.org/10.1002/ehf2.13877 
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  • 2021 | Journal Article | Research Paper | 
    ​ ​The RyR2-R2474S Mutation Sensitizes Cardiomyocytes and Hearts to Catecholaminergic Stress-Induced Oxidation of the Mitochondrial Glutathione Pool​
    Wegener, J. W.; Wagdi, A.; Wagner, E.; Katschinski, D. M.; Hasenfuß, G. ; Brügmann, T.   & Lehnart, S. E. ​ (2021) 
    Frontiers in Physiology, 12.​ DOI: https://doi.org/10.3389/fphys.2021.777770 
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  • 2021 | Journal Article | Research Paper
    ​ ​Exercise-Stress Real-time Cardiac Magnetic Resonance Imaging for Non-Invasive Characterisation of Heart Failure with Preserved Ejection Fraction: The HFpEF Stress Trial​
    Backhaus, S. J; Lange, T.; George, E. F; Hellenkamp, K. ; Gertz, R. J; Billing, M. & Wachter, R.  et al.​ (2021) 
    Circulation,.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.120.051542 
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  • 2021 | Journal Article | Research Paper
    ​ ​Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations​
    Fomin, A.; Gärtner, A.; Cyganek, L. ; Tiburcy, M. ; Tuleta, I.; Wellers, L. & Folsche, L. et al.​ (2021) 
    Science Translational Medicine, 13(618).​ DOI: https://doi.org/10.1126/scitranslmed.abd3079 
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Detrimental proarrhythmogenic interaction of Ca2+/calmodulin-dependent protein kinase II and NaV1.8 in heart failure​
    Bengel, P. ; Dybkova, N.; Tirilomis, P.; Ahmad, S. ; Hartmann, N. H. ; A. Mohamed, B. & Krekeler, M. C. et al.​ (2021) 
    Nature Communications, 12(1) art. 6586​.​ DOI: https://doi.org/10.1038/s41467-021-26690-1 
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  • 2021 | Journal Article | Research Paper
    ​ ​Non‐negative blind deconvolution for signal processing in a CRISPR‐edited iPSC‐cardiomyocyte model of dilated cardiomyopathy​
    Xu, H.; Wali, R.; Cheruiyot, C.; Bodenschatz, J.; Hasenfuss, G. ; Janshoff, A.   & Habeck, M.  et al.​ (2021) 
    FEBS Letters,.​ DOI: https://doi.org/10.1002/1873-3468.14189 
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  • 2021 | Journal Article | Research Paper
    ​ ​Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes​
    Peper, J.; Kownatzki-Danger, D.; Weninger, G.; Seibertz, F.; Pronto, J. R. D.; Sutanto, H. & Pacheu-Grau, D. et al.​ (2021) 
    Circulation Research, 128(6).​ DOI: https://doi.org/10.1161/CIRCRESAHA.119.316547 
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  • 2021 | Journal Article | Research Paper
    ​ ​cAMP Imaging at Ryanodine Receptors Reveals β2-Adrenoceptor Driven Arrhythmias​
    Berisha, F.; Götz, K.; Wegener, J. W.; Brandenburg, S. ; Subramanian, H.; Molina, C. E. & Rueffer, A. et al.​ (2021) 
    Circulation Research,.​ DOI: https://doi.org/10.1161/CIRCRESAHA.120.318234 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Impact of myocardial fibrosis on left ventricular remodelling, recovery, and outcome after transcatheter aortic valve implantation in different haemodynamic subtypes of severe aortic stenosis​
    Puls, M.; Beuthner, B. E.; Topci, R.; Vogelgesang, A.; Bleckmann, A.; Sitte, M. & Lange, T. et al.​ (2020) 
    European Heart Journal, 41(20) pp. 1903​-1914​.​ DOI: https://doi.org/10.1093/eurheartj/ehaa033 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Interdisciplinary Research on Aortic Valve Stenosis: A Longitudinal Collection of Biospecimens and Clinical Data of Patients Undergoing Transcatheter Aortic Valve Replacement​
    Beuthner, B. E. C.; Topci, R.; Derks, M.; Franke, T.; Seelke, S.; Puls, M. & Schuster, A. et al.​ (2020) 
    Open Journal of Bioresources, 7.​ DOI: https://doi.org/10.5334/ojb.65 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Inhibition of NaV1.8 prevents atrial arrhythmogenesis in human and mice​
    Pabel, S. ; Ahmad, S. ; Tirilomis, P.; Stehle, T.; Mustroph, J.; Knierim, M. & Dybkova, N. et al.​ (2020) 
    Basic Research in Cardiology, 115(2).​ DOI: https://doi.org/10.1007/s00395-020-0780-8 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Bi-allelic missense disease-causing variants in RPL3L associate neonatal dilated cardiomyopathy with muscle-specific ribosome biogenesis​
    Ganapathi, M.; Argyriou, L.; Martínez-Azorín, F.; Morlot, S.; Yigit, G. ; Lee, T. M. & Auber, B. et al.​ (2020) 
    Human Genetics, 139(11) pp. 1443​-1454​.​ DOI: https://doi.org/10.1007/s00439-020-02188-6 
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  • 2020 | Journal Article
    ​ ​Integrated Ca 2+ flux and AFM force analysis in human iPSC-derived cardiomyocytes​
    Malkovskiy, A. V.; Ignatyeva, N.; Dai, Y.; Hasenfuss, G. ; Rajadas, J. & Ebert, A. ​ (2020) 
    Biological Chemistry, 402(1) pp. 113​-121​.​ DOI: https://doi.org/10.1515/hsz-2020-0212 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Troponin destabilization impairs sarcomere-cytoskeleton interactions in iPSC-derived cardiomyocytes from dilated cardiomyopathy patients​
    Dai, Y.; Amenov, A.; Ignatyeva, N.; Koschinski, A.; Xu, H.; Soong, P. L.   & Tiburcy, M.  et al.​ (2020) 
    Scientific Reports, 10(1) art. 209​.​ DOI: https://doi.org/10.1038/s41598-019-56597-3 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Sacubitrilat reduces pro‐arrhythmogenic sarcoplasmic reticulum Ca 2+ leak in human ventricular cardiomyocytes of patients with end‐stage heart failure​
    Eiringhaus, J. ; Wünsche, C. M.; Tirilomis, P.; Herting, J. ; Bork, N.; Nikolaev, V. O.   & Hasenfuss, G.  et al.​ (2020) 
    ESC Heart Failure, 7(5) pp. 2992​-3002​.​ DOI: https://doi.org/10.1002/ehf2.12918 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​CRISPLD1: a novel conserved target in the transition to human heart failure​
    Khadjeh, S. ; Hindmarsh, V.; Weber, F.; Cyganek, L. ; Vidal, R. O. ; Torkieh, S. & Streckfuss-Bömeke, K.  et al.​ (2020) 
    Basic Research in Cardiology, 115(3).​ DOI: https://doi.org/10.1007/s00395-020-0784-4 
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  • 2020 | Journal Article | Research Paper
    ​ ​Intronic CRISPR Repair in a Preclinical Model of Noonan Syndrome–Associated Cardiomyopathy​
    Hanses, U.; Kleinsorge, M.; Roos, L.; Yigit, G. ; Li, Y. ; Barbarics, B. & El-Battrawy, I. et al.​ (2020) 
    Circulation, 142(11) pp. 1059​-1076​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.119.044794 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Real-time cardiovascular magnetic resonance T1 and extracellular volume fraction mapping for tissue characterisation in aortic stenosis​
    Backhaus, S. J. ; Lange, T.; Beuthner, B. E.; Topci, R.; Wang, X.; Kowallick, J. T.   & Lotz, J.  et al.​ (2020) 
    Journal of Cardiovascular Magnetic Resonance, 22(1) pp. 46​.​ DOI: https://doi.org/10.1186/s12968-020-00632-0 
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Assessing the role of extracellular signal‐regulated kinases 1 and 2 in volume overload‐induced cardiac remodelling​
    Jochmann, S.; Elkenani, M.; Mohamed, B. A.; Buchholz, E.; Lbik, D.; Binder, L. & Lorenz, K. et al.​ (2019) 
    ESC Heart Failure, 6(5) pp. 1015​-1026​.​ DOI: https://doi.org/10.1002/ehf2.12497 
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  • 2019 | Conference Paper
    ​ ​P5998The Phosphodiesterase 4D interacting protein averts volume overload - but not pressure overload-induced pathological myocardial remodeling​
    Mohamed, B. A.; Elkenani, M.; Jakubiczka-Smorag, J.; Bader, M.; Hasenfuss, G.   & Toischer, K. ​ (2019)
    European Heart Journal, 40(Suppl. 1) ​ESC Congress 2019 together with World Congress of Cardiology​, Paris. DOI: https://doi.org/10.1093/eurheartj/ehz746.0719 
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  • 2019 | Conference Paper
    ​ ​P3829 Antiarrhythmic effects of Sacubitrilat (LBQ657) on Ca2+ homeostasis in ventricular cardiomyocytes​
    Eiringhaus, J.; Wuensche, C.; Herting, J.; Hasenfuss, G. ; Sossalla, S.   & Fischer, T. ​ (2019)
    European Heart Journal, 40(Suppl. 1) ​ESC Congress 2019 together with World Congress of Cardiology​, Paris. DOI: https://doi.org/10.1093/eurheartj/ehz745.0671 
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  • 2019 | Conference Paper
    ​ ​1180 Cardiomyocyte-specific deletion of Brd4 induces hypertrophic cardiomyopathy and suggests a novel function for the chromatin reader as co-repressor in the healthy heart​
    Lbik, D.; Buchholz, E.; Mohamed, B.; Fischer, A. ; Hasenfuss, G.   & Toischer, K. ​ (2019)
    European Heart Journal, 40(Suppl. 1) ​ESC Congress 2019 together with World Congress of Cardiology​, Paris. DOI: https://doi.org/10.1093/eurheartj/ehz748.0022 
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  • 2019 | Conference Paper
    ​ ​P1621m6A RNA-methylation in the progression of heart failure​
    Buchholz, E.; Berulava, T.; Ellerdashvilli, V.; Pena, T.; Lbik, D.; Mohamed, B. & Sloan, K. et al.​ (2019)
    European Heart Journal, 40(Suppl. 1) ​ESC Congress 2019 together with World Congress of Cardiology​, Paris. DOI: https://doi.org/10.1093/eurheartj/ehz748.0380 
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Changes in m6A RNA methylation contribute to heart failure progression by modulating translation​
    Berulava, T.; Buchholz, E.; Elerdashvili, V.; Pena, T.; Islam, M. R.; Lbik, D. & Mohamed, B. A.  et al.​ (2019) 
    European Journal of Heart Failure, 22(1) pp. 54​-66​.​ DOI: https://doi.org/10.1002/ejhf.1672 
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Genetic deletion of calcium/calmodulin-dependent protein kinase type II delta does not mitigate adverse myocardial remodeling in volume-overloaded hearts​
    Mohamed, B. A. ; Elkenani, M.; Jakubiczka-Smorag, J. ; Buchholz, E.; Koszewa, S.; Lbik, D. & Schnelle, M.  et al.​ (2019) 
    Scientific Reports, 9(1) art. 9889​.​ DOI: https://doi.org/10.1038/s41598-019-46332-3 
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  • 2019 | Journal Article | Research Paper
    ​ ​Protein kinase/phosphatase balance mediates the effects of increased late sodium current on ventricular calcium cycling​
    Eiringhaus, J. ; Herting, J. ; Schatter, F. ; Nikolaev, V. O. ; Sprenger, J.; Wang, Y. & Köhn, M. et al.​ (2019) 
    Basic Research in Cardiology, 114(2) pp. 13​.​ DOI: https://doi.org/10.1007/s00395-019-0720-7 
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  • 2019 | Journal Article | Research Paper
    ​ ​Endothelial Leptin Receptor Deletion Promotes Cardiac Autophagy and Angiogenesis Following Pressure Overload by Suppressing Akt/mTOR Signaling​
    Gogiraju, R.; Hubert, A.; Fahrer, J.; Straub, B. K.; Brandt, M.; Wenzel, P. & Münzel, T. et al.​ (2019) 
    Circulation: Heart Failure, 12(1).​ DOI: https://doi.org/10.1161/CIRCHEARTFAILURE.118.005622 
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis​
    Brandenburg, S. ; Pawlowitz, J.; Eikenbusch, B.; Peper, J.; Kohl, T. ; Mitronova, G. Y.   & Sossalla, S.  et al.​ (2019) 
    JCI insight, 4(12).​ DOI: https://doi.org/10.1172/jci.insight.127116 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​KLF15-Wnt–Dependent Cardiac Reprogramming Up-Regulates SHISA3 in the Mammalian Heart​
    Noack, C. ; Iyer, L. M. ; Liaw, N. Y. ; Schoger, E.; Khadjeh, S. ; Wagner, E.   & Woelfer, M. et al.​ (2019) 
    Journal of the American College of Cardiology, 74(14) pp. 1804​-1819​.​ DOI: https://doi.org/10.1016/j.jacc.2019.07.076 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper
    ​ ​Proteasome-Dependent Regulation of Distinct Metabolic States During Long-Term Culture of Human iPSC-Derived Cardiomyocytes​
    Ebert, A. ; Joshi, A. U.; Andorf, S.; Dai, Y.; Sampathkumar, S.; Chen, H. & Li, Y. et al.​ (2019) 
    Circulation Research, 125(1) pp. 90​-103​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.118.313973 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​NADPH oxidase-4 promotes eccentric cardiac hypertrophy in response to volume overload​
    Schnelle, M. ; Sawyer, I.; Anilkumar, N.; Mohamed, B. A. ; Richards, D. A.; Toischer, K.   & Zhang, M. et al.​ (2019) 
    Cardiovascular Research, 117(1) pp. 178​-187​.​ DOI: https://doi.org/10.1093/cvr/cvz331 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​The functional consequences of sodium channel NaV1.8 in human left ventricular hypertrophy​
    Ahmad, S. ; Tirilomis, P.; Pabel, S. ; Dybkova, N.; Hartmann, N. ; Molina, C. E.   & Tirilomis, T.  et al.​ (2019) 
    ESC Heart Failure, 6(1) pp. 154​-163​.​ DOI: https://doi.org/10.1002/ehf2.12378 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​CD8+-T Cells With Specificity for a Model Antigen in Cardiomyocytes Can Become Activated After Transverse Aortic Constriction but Do Not Accelerate Progression to Heart Failure​
    Gröschel, C.; Sasse, A.; Monecke, S.; Röhrborn, C.; Elsner, L.; Didié, M. & Reupke, V. et al.​ (2018) 
    Frontiers in Immunology, 9 art. 2665​.​ DOI: https://doi.org/10.3389/fimmu.2018.02665 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Empagliflozin directly improves diastolic function in human heart failure​
    Pabel, S. ; Wagner, S. ; Bollenberg, H.; Bengel, P. ; Kovács, Á.; Schach, C. & Tirilomis, P. et al.​ (2018) 
    European Journal of Heart Failure, 20(12) pp. 1690​-1700​.​ DOI: https://doi.org/10.1002/ejhf.1328 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart​
    Iyer, L. M ; Nagarajan, S. ; Woelfer, M.; Schoger, E.; Khadjeh, S. ; Zafiriou, M. P.   & Kari, V.  et al.​ (2018) 
    Nucleic Acids Research, 46(6) pp. 2850​-2867​.​ DOI: https://doi.org/10.1093/nar/gky049 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart​
    Dybkova, N.; Ahmad, S. ; Pabel, S. ; Tirilomis, P.; Hartmann, N. ; Fischer, T. H   & Bengel, P.  et al.​ (2018) 
    Cardiovascular Research, 114(13) pp. 1728​-1737​.​ DOI: https://doi.org/10.1093/cvr/cvy152 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​Deep phenotyping of human induced pluripotent stem cell–derived atrial and ventricular cardiomyocytes​
    Cyganek, L. ; Tiburcy, M. ; Sekeres, K.; Gerstenberg, K.; Bohnenberger, H. ; Lenz, C.   & Henze, S.  et al.​ (2018) 
    JCI Insight, 3(12) art. e99941​.​ DOI: https://doi.org/10.1172/jci.insight.99941 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure​
    Fischer, T. H. ; Eiringhaus, J. ; Dybkova, N.; Saadatmand, A.; Pabel, S. ; Weber, S. & Wang, Y. et al.​ (2018) 
    European Journal of Heart Failure, 20(12) pp. 1673​-1685​.​ DOI: https://doi.org/10.1002/ejhf.1297 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Electromechanical vortex filaments during cardiac fibrillation​
    Christoph, J. ; Chebbok, M. ; Richter, C. ; Schröder-Schetelig, J. ; Bittihn, P.; Stein, S. & Uzelac, I. et al.​ (2018) 
    Nature, 555(7698) pp. 667​-672​.​ DOI: https://doi.org/10.1038/nature26001 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression​
    Mohamed, B. A. ; Hartmann, N. ; Tirilomis, P.; Sekeres, K.; Li, W.; Neef, S. & Richter, C.  et al.​ (2018) 
    Science Translational Medicine, 10(458) art. eaan0724​.​ DOI: https://doi.org/10.1126/scitranslmed.aan0724 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis​
    Xu, X.; Tan, X.; Tampe, B. ; Wilhelmi, T.; Hulshoff, M. S.; Saito, S. & Moser, T.  et al.​ (2018) 
    Nature Communications, 9(1) art. 3509​.​ DOI: https://doi.org/10.1038/s41467-018-05766-5 
    ​Details  DOI  PMID  PMC 
  • 2017 | Conference Abstract
    ​ ​P1334 - The relevant role of SR Ca leak in the development of heart failure​
    Mohamed, B. A.; Kattner, L.; Guan, K. ; Lehnart, S. E. ; Luther, S. ; Sossalla, S.   & Hasenfuß, G.  et al.​ (2017)
    European Journal of Heart Failure, 19(Suppl. 1) ​Heart Failure 2017 and the 4th World Congress on Acute Heart Failure​, Paris.
    ​Details 
  • 2017 | Journal Article | Research Paper
    ​ ​B-catenin/TCF7L2 signaling orchestrates initiation of pathological hypertrophic cardiac remodeling by inducing chromatin modifications​
    Iyer, L. M. ; Noack, C.; Nagarajan, S.; Woelfer, M.; Schoger, E.; Pang, S. T. & Kari, V.  et al.​ (2017) 
    European Heart Journal, 38(suppl_1) art. P4479​.​ DOI: https://doi.org/10.1093/eurheartj/ehx504.P4479 
    ​Details  DOI 
  • 2017 | Journal Article | Research Paper
    ​ ​PP1 activation as novel antiarrhythmic approach in human heart failure​
    Eiringhaus, J. ; Fischer, T. H. ; Kohn, M.; Wang, Y.; Maier, L. S. ; Hasenfuss, G.   & Sossalla, S. T. ​ (2017) 
    European Heart Journal, 38(suppl_1) art. P5841​.​ DOI: https://doi.org/10.1093/eurheartj/ehx493.P5841 
    ​Details  DOI 
  • 2017 | Journal Article | Research Paper
    ​ ​Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair​
    Tiburcy, M. ; Hudson, J. E.; Balfanz, P.; Schlick, S.; Meyer, T. ; Chang Liao, M.-L. & Levent, E. et al.​ (2017) 
    Circulation, 135(19) pp. 1832​-1847​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.116.024145 
    ​Details  DOI 
  • 2017 | Conference Abstract
    ​ ​P41 - Studying beta-adrenergic signalling in a patient-specific induced pluripotent stem cell model for Takotsubo syndrome​
    Hübscher, D.; Borchert, T.; Lam, D.; Guessoum, C. I.; Templin, C.; Hasenfuß, G.   & Streckfuß-Bömeke, K.​ (2017)
    European Journal of Heart Failure, 19(Suppl. 1) ​Heart Failure 2017 and the 4th World Congress on Acute Heart Failure​, Paris.
    ​Details 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes​
    Streckfuss-Bömeke, K. ; Tiburcy, M. ; Fomin, A.; Luo, X.; Li, W.; Fischer, C. & Özcelik, C. et al.​ (2017) 
    Journal of Molecular and Cellular Cardiology, 113 pp. 9​-21​.​ DOI: https://doi.org/10.1016/j.yjmcc.2017.09.008 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​T helper cells with specificity for an antigen in cardiomyocytes promote pressure overload-induced progression from hypertrophy to heart failure​
    Gröschel, C. ; Sasse, A. ; Röhrborn, C. ; Monecke, S. ; Didié, M. ; Elsner, L.   & Kruse, V.  et al.​ (2017) 
    Scientific Reports, 7(1) art. 15998​.​ DOI: https://doi.org/10.1038/s41598-017-16147-1 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4​
    Perera, R. K. ; Fischer, T. H. ; Wagner, M.; Dewenter, M. ; Vettel, C. ; Bork, N. I. & Maier, L. S.  et al.​ (2017) 
    Scientific Reports, 7(1) art. 15222​.​ DOI: https://doi.org/10.1038/s41598-017-15632-x 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Cardiomyocyte proliferation prevents failure in pressure overload but not volume overload​
    Toischer, K. ; Zhu, W.; Hünlich, M.; Mohamed, B. A.; Khadjeh, S.; Reuter, S. P. & Schäfer, K.  et al.​ (2017) 
    Journal of Clinical Investigation, 127(12) pp. 4285​-4296​.​ DOI: https://doi.org/10.1172/JCI81870 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy​
    Borchert, T. ; Hübscher, D. ; Guessoum, C. I. ; Lam, T. Lam, Tuan-Dinh D.; Ghadri, J. R.; Schellinger, I. N.   & Tiburcy, M.  et al.​ (2017) 
    Journal of the American College of Cardiology, 70(8) pp. 975​-991​.​ DOI: https://doi.org/10.1016/j.jacc.2017.06.061 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article | Research Paper
    ​ ​Axial tubule junctions control rapid calcium signaling in atria​
    Brandenburg, S. ; Kohl, T. ; Williams, G. S. B.; Gusev, K.; Wagner, E. ; Rog-Zielinska, E. A. & Hebisch, E. et al.​ (2016) 
    Journal of Clinical Investigation, 126(10) pp. 3999​-4015​.​ DOI: https://doi.org/10.1172/JCI88241 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper | 
    ​ ​Cardiac-specific succinate dehydrogenase deficiency in Barth syndrome​
    Dudek, J. ; Cheng, I.-F. ; Chowdhury, A. ; Wozny, K.; Balleininger, M.; Reinhold, R.   & Grunau, S.  et al.​ (2016) 
    EMBO Molecular Medicine, 8(2) pp. 139​-154​.​ DOI: https://doi.org/10.15252/emmm.201505644 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article | Research Paper
    ​ ​The combined effects of ranolazine and dronedarone on human atrial and ventricular electrophysiology​
    Hartmann, N. H. ; Mason, F. E. ; Braun, I.; Pabel, S. ; Voigt, N. ; Schotola, H. & Fischer, T. H.  et al.​ (2016) 
    Journal of Molecular and Cellular Cardiology, 94 pp. 95​-106​.​ DOI: https://doi.org/10.1016/j.yjmcc.2016.03.012 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper
    ​ ​Antiarrhythmic effects of dantrolene in human diseased cardiomyocytes​
    Hartmann, N. H. ; Pabel, S. ; Herting, J. ; Schatter, F. ; Renner, A.; Gummert, J. & Schotola, H. et al.​ (2016) 
    Heart Rhythm, 14(3) pp. 412​-419​.​ DOI: https://doi.org/10.1016/j.hrthm.2016.09.014 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article | Research Paper | 
    ​ ​Molecular and structural transition mechanisms in long-term volume overload​
    Mohamed, B. A. ; Schnelle, M. ; Khadjeh, S. ; Lbik, D.; Herwig, M.; Linke, W. A.   & Hasenfuß, G.  et al.​ (2016) 
    European Journal of Heart Failure, 18(4) pp. 362​-371​.​ DOI: https://doi.org/10.1002/ejhf.465 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper
    ​ ​Sex-dependent alterations of Ca2+ cycling in human cardiac hypertrophy and heart failure​
    Fischer, T. H. ; Herting, J. ; Eiringhaus, J. ; Pabel, S. ; Hartmann, N. H. ; Ellenberger, D.   & Friedrich, M.  et al.​ (2016) 
    EP Europace, 18(9) pp. 1440​-1448​.​ DOI: https://doi.org/10.1093/europace/euv313 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper
    ​ ​Endothelial deletion of protein tyrosine phosphatase-1B protects against pressure overload-induced heart failure in mice​
    Gogiraju, R.; Schroeter, M. R. ; Bochenek, M. L.; Hubert, A.; Muenzel, T.; Hasenfuß, G.   & Schaefer, K. ​ (2016) 
    Cardiovascular Research, 111(3) pp. 204​-216​.​ DOI: https://doi.org/10.1093/cvr/cvw101 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper | 
    ​ ​In vivo model with targeted cAMP biosensor reveals changes in receptor-microdomain communication in cardiac disease​
    Sprenger, J. U.; Perera, R. K. ; Steinbrecher, J. H.; Lehnart, S. E. ; Maier, L. S. ; Hasenfuß, G.   & Nikolaev, V. O. ​ (2015) 
    Nature Communications, 6 art. 6965​.​ DOI: https://doi.org/10.1038/ncomms7965 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII​
    Fischer, T. H. ; Herting, J. ; Mason, F. E. ; Hartmann, N. ; Watanabe, S.; Nikolaev, V. O.   & Sprenger, J. U. et al.​ (2015) 
    Cardiovascular Research, 107(1) pp. 184​-196​.​ DOI: https://doi.org/10.1093/cvr/cvv153 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis​
    Xu, X.; Tan, X.; Tampe, B. ; Nyamsuren, G.; Liu, X.; Maier, L. S.   & Sossalla, S.  et al.​ (2015) 
    Cardiovascular Research, 105(3) pp. 279​-291​.​ DOI: https://doi.org/10.1093/cvr/cvv015 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​p63RhoGEF regulates auto- and paracrine signaling in cardiac fibroblasts​
    Ongherth, A.; Pasch, S.; Wuertz, C. M. ; Nowak, K.; Kittana, N.; Weis, C. A. & Jatho, A.  et al.​ (2015) 
    Journal of Molecular and Cellular Cardiology, 88 pp. 39​-54​.​ DOI: https://doi.org/10.1016/j.yjmcc.2015.09.009 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper | 
    ​ ​Ca2+/calmodulin-dependent protein kinase II equally induces sarcoplasmic reticulum Ca2+ leak in human ischaemic and dilated cardiomyopathy​
    Fischer, T. H. ; Eiringhaus, J. ; Dybkova, N.; Foerster, A.; Herting, J. ; Kleinwaechter, A. & Ljubojevic, S. et al.​ (2014) 
    European Journal of Heart Failure, 16(12) pp. 1292​-1300​.​ DOI: https://doi.org/10.1002/ejhf.163 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Editorial Contribution (Editorial, Introduction, Epilogue) | 
    ​ ​Special Issue "Novel Perspectives on Heart Failure'​
    Hasenfuß, G.   & Heusch, G.​ (2013) 
    Basic Research in Cardiology, 108(4) art. 355​.​ DOI: https://doi.org/10.1007/s00395-013-0355-z 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Comparative study of human-induced pluripotent stem cells derived from bone marrow cells, hair keratinocytes, and skin fibroblasts​
    Streckfuss-Boemeke, K. ; Wolf, F.; Azizian, A. ; Stauske, M.; Tiburcy, M. ; Wagner, S.   & Huebscher, D.  et al.​ (2013) 
    European heart journal, 34(33) pp. 2618​-2629​.​ DOI: https://doi.org/10.1093/eurheartj/ehs203 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease​
    Toischer, K. ; Hartmann, N. ; Wagner, S. ; Fischer, T. H. ; Herting, J. ; Danner, B. C.   & Sag, C. M. et al.​ (2013) 
    Journal of Molecular and Cellular Cardiology, 61 pp. 111​-122​.​ DOI: https://doi.org/10.1016/j.yjmcc.2013.03.021 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Ca2+/Calmodulin-Dependent Protein Kinase II and Protein Kinase A Differentially Regulate Sarcoplasmic Reticulum Ca2+ Leak in Human Cardiac Pathology​
    Fischer, T. H. ; Herting, J. ; Tirilomis, T. ; Renner, A.; Neef, S.; Toischer, K.   & Ellenberger, D.  et al.​ (2013) 
    Circulation, 128(9) pp. 970​-981​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.113.001746 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​RAnoLazIne for the Treatment of Diastolic Heart Failure in Patients With Preserved Ejection Fraction: ​The RALI-DHF Proof-of-Concept Study​
    Maier, L. S. ; Layug, B.; Karwatowska-Prokopczuk, E.; Belardinelli, L.; Lee, S.; Sander, J. & Lang, C. et al.​ (2013) 
    JACC: Heart Failure, 1(2) pp. 115​-122​.​ DOI: https://doi.org/10.1016/j.jchf.2012.12.002 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article | Research Paper
    ​ ​Stimulated Emission Depletion Live-Cell Super-Resolution Imaging Shows Proliferative Remodeling of T-Tubule Membrane Structures After Myocardial Infarction​
    Wagner, E. ; Lauterbach, M. A.; Kohl, T. ; Westphal, V. ; Williams, G. S. B.; Steinbrecher, J. H. & Streich, J.-H. et al.​ (2012) 
    Circulation Research, 111(4) pp. 402​-414​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.112.274530 
    ​Details  DOI  PMID  PMC  WoS 

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