Prof. Dr. med. Lars Siegfried Maier

 
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  • 2016 Journal Article | Research Paper
    ​ ​Sex-dependent alterations of Ca2+ cycling in human cardiac hypertrophy and heart failure​
    Fischer, T. H. ; Herting, J. ; Eiringhaus, J. ; Pabel, S. ; Hartmann, N. H. ; Ellenberger, D.   & Friedrich, M.  et al.​ (2016) 
    EP Europace18(9) pp. 1440​-1448​.​ DOI: https://doi.org/10.1093/europace/euv313 
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  • 2016 Journal Article | Research Paper
    ​ ​The combined effects of ranolazine and dronedarone on human atrial and ventricular electrophysiology​
    Hartmann, N. H. ; Mason, F. E. ; Braun, I.; Pabel, S. ; Voigt, N. ; Schotola, H. & Fischer, T. H.  et al.​ (2016) 
    Journal of Molecular and Cellular Cardiology94 pp. 95​-106​.​ DOI: https://doi.org/10.1016/j.yjmcc.2016.03.012 
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  • 2015 Conference Abstract
    ​ ​Epigenetic balance of aberrant rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis​
    Xu, X. X.; Tan, X.; Tampe, B.; Liu, X.; Maier, L. S. ; Sossalla, S. T.   & Kalluri, R. et al.​ (2015)
    European Journal of Heart Failure17 
    Hoboken​: Wiley-blackwell.
    Details  WoS 
  • 2015 Journal Article | Research Paper
    ​ ​Sensing Cardiac Electrical Activity With a Cardiac Myocyte-Targeted Optogenetic Voltage Indicator​
    Chang Liao, M.-L.; Boer, T. P. de; Mutoh, H.; Raad, N.; Richter, C. ; Wagner, E.   & Downie, B. R. et al.​ (2015) 
    Circulation Research117(5) pp. 401​-412​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.117.306143 
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  • 2015 Journal Article | Research Paper
    ​ ​Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII​
    Fischer, T. H. ; Herting, J. ; Mason, F. E. ; Hartmann, N. ; Watanabe, S.; Nikolaev, V. O.   & Sprenger, J. U. et al.​ (2015) 
    Cardiovascular Research107(1) pp. 184​-196​.​ DOI: https://doi.org/10.1093/cvr/cvv153 
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  • 2015 Journal Article | Research Paper
    ​ ​The German CPU Registry: Dyspnea independently predicts negative short-term outcome in patients admitted to German Chest Pain Units​
    Hellenkamp, K. ; Darius, H.; Giannitsis, E.; Erbel, R.; Haude, M.; Hamm, C. & Hasenfuß, G.  et al.​ (2015) 
    International Journal of Cardiology181 pp. 88​-95​.​ DOI: https://doi.org/10.1016/j.ijcard.2014.11.199 
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  • 2015 Journal Article | Research Paper
    ​ ​Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis​
    Xu, X.; Tan, X.; Tampe, B. ; Nyamsuren, G.; Liu, X.; Maier, L. S.   & Sossalla, S.  et al.​ (2015) 
    Cardiovascular Research105(3) pp. 279​-291​.​ DOI: https://doi.org/10.1093/cvr/cvv015 
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  • 2015 Journal Article | Research Paper | 
    ​ ​In vivo model with targeted cAMP biosensor reveals changes in receptor-microdomain communication in cardiac disease​
    Sprenger, J. U.; Perera, R. K. ; Steinbrecher, J. H.; Lehnart, S. E. ; Maier, L. S. ; Hasenfuß, G.   & Nikolaev, V. O. ​ (2015) 
    Nature Communications6 art. 6965​.​ DOI: https://doi.org/10.1038/ncomms7965 
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  • 2014 Conference Abstract
    ​ ​Ryanodine receptor calcium leak contributes to statin-induced myopathy​
    Tiburcy, M. ; Engel, G.; Sanders, S.-J.; Sowa, T.; Maier, L. S.   & Zimmermann, W.-H. ​ (2014)
    Naunyn-Schmiedeberg s Archives of Pharmacology387 , Hannover, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2014 Journal Article | Research Paper
    ​ ​Urocortin 2 stimulates nitric oxide production in ventricular myocytes via Akt- and PKA-mediated phosphorylation of eNOS at serine 1177​
    Walther, S.; Pluteanu, F.; Renz, S.; Nikonova, Y.; Maxwell, J. T.; Yang, L.-Z. & Schmidt, K. et al.​ (2014) 
    AJP Heart and Circulatory Physiology307(5) pp. H689​-H700​.​ DOI: https://doi.org/10.1152/ajpheart.00694.2013 
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  • 2014 Journal Article | Overview | 
    ​ ​CaMKII regulation of cardiac K channels​
    Mustroph, J.; Maier, L. S.   & Wagner, S.​ (2014) 
    Frontiers in Pharmacology5 art. 20​.​ DOI: https://doi.org/10.3389/fphar.2014.00020 
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  • 2014 Journal Article | Overview
    ​ ​Experimental Antiarrhythmic Targets: CaMKII Inhibition - Ready for Clinical Evaluation?​
    Maier, L. S. ​ (2014) 
    Current Medicinal Chemistry21(11) pp. 1299​-1307​.​ DOI: https://doi.org/10.2174/09298673113209990171 
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  • 2014 Journal Article | Research Paper
    ​ ​NADPH oxidase 2 mediates angiotensin II-dependent cellular arrhythmias via PKA and CaMKII​
    Wagner, S.; Dantz, C.; Flebbe, H.; Azizian, A.; Sag, C. M.; Engels, S. & Moellencamp, J. et al.​ (2014) 
    Journal of Molecular and Cellular Cardiology75 pp. 206​-215​.​ DOI: https://doi.org/10.1016/j.yjmcc.2014.07.011 
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  • 2014 Journal Article | Research Paper
    ​ ​Enhanced late INa induces proarrhythmogenic SR Ca leak in a CaMKII-dependent manner​
    Sag, C. M.; Mallwitz, A.; Wagner, S. ; Hartmann, N. ; Schotola, H.; Fischer, T. H.   & Ungeheuer, N. et al.​ (2014) 
    Journal of Molecular and Cellular Cardiology76 pp. 94​-105​.​ DOI: https://doi.org/10.1016/j.yjmcc.2014.08.016 
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  • 2014 Journal Article | Research Paper
    ​ ​Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction​
    Unsoeld, B. W.; Kaul, A.; Sbroggi, M.; Schubert, C.; Regitz-Zagrosek, V.; Brancaccio, M. & Damilano, F. et al.​ (2014) 
    Cardiovascular Research101(1) pp. 97​-107​.​ DOI: https://doi.org/10.1093/cvr/cvt235 
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  • 2014 Journal Article | Research Paper | 
    ​ ​Effects of Ranolazine on Torsades de Pointes Tachycardias in a Healthy Isolated Rabbit Heart Model​
    Sossalla, S. T. ; Wallisch, N.; Toischer, K. ; Sohns, C.; Vollmann, D.; Seegers, J. & Luethje, L. et al.​ (2014) 
    Cardiovascular Therapeutics32(4) pp. 170​-177​.​ DOI: https://doi.org/10.1111/1755-5922.12078 
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  • 2014 Journal Article | Research Paper
    ​ ​Tubulin polymerization disrupts cardiac beta-adrenergic regulation of late I-Na​
    Dybkova, N.; Wagner, S.; Backs, J.; Hund, T. J.; Mohler, P. J.; Sowa, T. & Nikolaev, V. O.  et al.​ (2014) 
    Cardiovascular Research103(1) pp. 168​-177​.​ DOI: https://doi.org/10.1093/cvr/cvu120 
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  • 2014 Journal Article | Research Paper | 
    ​ ​Ca2+/calmodulin-dependent protein kinase II equally induces sarcoplasmic reticulum Ca2+ leak in human ischaemic and dilated cardiomyopathy​
    Fischer, T. H. ; Eiringhaus, J. ; Dybkova, N.; Foerster, A.; Herting, J. ; Kleinwaechter, A. & Ljubojevic, S. et al.​ (2014) 
    European Journal of Heart Failure16(12) pp. 1292​-1300​.​ DOI: https://doi.org/10.1002/ejhf.163 
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  • 2013 Conference Abstract
    ​ ​Phosphodiesterase-2 is upregulated in failing hearts and blunts beta-AR mediated chronotropic and inotropic effects​
    Vettel, C.; Mehel, H.; Emons, J.; Wittkoepper, K.; Dewenter, M.; Laemmle, S. & Seppelt, D. et al.​ (2013)
    Naunyn-Schmiedeberg s Archives of Pharmacology386 
    New york​: Springer.
    Details  WoS 
  • 2013 Journal Article | Research Paper | 
    ​ ​Enhanced Ca2+ influx through cardiac L-type Ca2+ channels maintains the systolic Ca2+ transient in early cardiac atrophy induced by mechanical unloading​
    Schwoerer, A. P.; Neef, S.; Broichhausen, I.; Jacubeit, J.; Tiburcy, M. ; Wagner, M. & Biermann, D. et al.​ (2013) 
    Pflügers Archiv - European Journal of Physiology465(12) pp. 1763​-1773​.​ DOI: https://doi.org/10.1007/s00424-013-1316-y 
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  • 2013 Journal Article | Research Paper | 
    ​ ​Ionizing radiation regulates cardiac Ca handling via increased ROS and activated CaMKII​
    Sag, C. M.; Wolff, H. A.; Neumann, K.; Opiela, M.-K.; Zhang, J.; Steuer, F. & Sowa, T. et al.​ (2013) 
    Basic Research in Cardiology108(6) art. 385​.​ DOI: https://doi.org/10.1007/s00395-013-0385-6 
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  • 2013 Journal Article | Overview
    ​ ​Redox Regulation of Sodium and Calcium Handling​
    Wagner, S.; Rokita, A. G.; Anderson, M. E. & Maier, L. S. ​ (2013) 
    Antioxidants & Redox Signaling18(9) pp. 1063​-1077​.​ DOI: https://doi.org/10.1089/ars.2012.4818 
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  • 2013 Journal Article | Research Paper
    ​ ​While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in CaMKII delta-KO mice​
    Neef, S.; Sag, C. M.; Daut, M.; Baeumer, H.; Grefe, C.; El-Armouche, A.   & DeSantiago, J. et al.​ (2013) 
    Journal of Molecular and Cellular Cardiology59 pp. 107​-116​.​ DOI: https://doi.org/10.1016/j.yjmcc.2013.02.014 
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  • 2013 Journal Article | Overview
    ​ ​Role of oxidants on calcium and sodium movement in healthy and diseased cardiac myocytes​
    Sag, C. M.; Wagner, S.   & Maier, L. S. ​ (2013) 
    Free Radical Biology and Medicine63 pp. 338​-349​.​ DOI: https://doi.org/10.1016/j.freeradbiomed.2013.05.035 
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  • 2013 Journal Article | Research Paper
    ​ ​Diabetes increases mortality after myocardial infarction by oxidizing CaMKII​
    Luo, M.; Guan, X.; Luczak, E. D.; Lang, D.; Kutschke, W.; Gao, Z. & Yang, J. et al.​ (2013) 
    Journal of Clinical Investigation123(3) pp. 1262​-1274​.​ DOI: https://doi.org/10.1172/JCI65268 
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  • 2013 Journal Article | Overview | 
    ​ ​The Ca-calmodulin dependent kinase II: A promising target for future antiarrhythmic therapies?​
    Fischer, T. H. ; Neef, S. & Maier, L. S. ​ (2013) 
    Journal of Molecular and Cellular Cardiology58 pp. 182​-187​.​ DOI: https://doi.org/10.1016/j.yjmcc.2012.11.003 
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  • 2013 Journal Article | Research Paper
    ​ ​Oxidized Ca2+/Calmodulin-Dependent Protein Kinase II Triggers Atrial Fibrillation​
    Purohit, A.; Rokita, A. G.; Guan, X.; Chen, B.; Koval, O. M.; Voigt, N.   & Neef, S. et al.​ (2013) 
    Circulation128(16) pp. 1748​-1757​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.113.003313 
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  • 2013 Journal Article | Research Paper
    ​ ​Phosphodiesterase-2 Is Up-Regulated in Human Failing Hearts and Blunts β-Adrenergic Responses in Cardiomyocytes​
    Mehel, H.; Emons, J.; Vettel, C. ; Wittköpper, K.; Seppelt, D.; Dewenter, M.   & Lutz, S.  et al.​ (2013) 
    Journal of the American College of Cardiology62(17) pp. 1596​-1606​.​ DOI: https://doi.org/10.1016/j.jacc.2013.05.057 
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  • 2013 Journal Article | Overview
    ​ ​Novel aspects of excitation-contraction coupling in heart failure​
    Neef, S. & Maier, L. S. ​ (2013) 
    Basic Research in Cardiology108(4) art. 360​.​ DOI: https://doi.org/10.1007/s00395-013-0360-2 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​Comparative study of human-induced pluripotent stem cells derived from bone marrow cells, hair keratinocytes, and skin fibroblasts​
    Streckfuss-Boemeke, K. ; Wolf, F.; Azizian, A. ; Stauske, M.; Tiburcy, M. ; Wagner, S.   & Huebscher, D.  et al.​ (2013) 
    European heart journal34(33) pp. 2618​-2629​.​ DOI: https://doi.org/10.1093/eurheartj/ehs203 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease​
    Toischer, K. ; Hartmann, N. ; Wagner, S. ; Fischer, T. H. ; Herting, J. ; Danner, B. C.   & Sag, C. M. et al.​ (2013) 
    Journal of Molecular and Cellular Cardiology61 pp. 111​-122​.​ DOI: https://doi.org/10.1016/j.yjmcc.2013.03.021 
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  • 2013 Journal Article | Editorial Contribution (Editorial, Introduction, Epilogue)
    ​ ​Small conductance Ca-activated K channel: Small but powerful proarrhythmogenic?​
    Wagner, S. & Maier, L. S. ​ (2013) 
    Heart Rhythm10(6) pp. 899​-900​.​ DOI: https://doi.org/10.1016/j.hrthm.2013.02.002 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​Ca2+/Calmodulin-Dependent Protein Kinase II and Protein Kinase A Differentially Regulate Sarcoplasmic Reticulum Ca2+ Leak in Human Cardiac Pathology​
    Fischer, T. H. ; Herting, J. ; Tirilomis, T. ; Renner, A.; Neef, S.; Toischer, K.   & Ellenberger, D.  et al.​ (2013) 
    Circulation128(9) pp. 970​-981​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.113.001746 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Overview | 
    ​ ​The ryanodine receptor leak: how a tattered receptor plunges the failing heart into crisis​
    Fischer, T. H. ; Maier, L. S.   & Sossalla, S. T. ​ (2013) 
    Heart Failure Reviews18(4) pp. 475​-483​.​ DOI: https://doi.org/10.1007/s10741-012-9339-6 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Letter Note | 
    ​ ​The German CPU Registry: Comparison of troponin positive to troponin negative patients​
    Maier, L. S. ; Darius, H.; Giannitsis, E.; Erbel, R.; Haude, M.; Hamm, C. & Hasenfuß, G.  et al.​ (2013) 
    International Journal of Cardiology168(2) pp. 1651​-1653​.​ DOI: https://doi.org/10.1016/j.ijcard.2013.03.009 
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  • 2013 Journal Article | Research Paper
    ​ ​RAnoLazIne for the Treatment of Diastolic Heart Failure in Patients With Preserved Ejection Fraction: ​The RALI-DHF Proof-of-Concept Study​
    Maier, L. S. ; Layug, B.; Karwatowska-Prokopczuk, E.; Belardinelli, L.; Lee, S.; Sander, J. & Lang, C. et al.​ (2013) 
    JACC: Heart Failure1(2) pp. 115​-122​.​ DOI: https://doi.org/10.1016/j.jchf.2012.12.002 
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  • 2013 Journal Article | Overview | 
    ​ ​The late Na current as a therapeutic target: Where are we?​
    Maier, L. S.   & Sossalla, S. T. ​ (2013) 
    Journal of Molecular and Cellular Cardiology61 pp. 44​-50​.​ DOI: https://doi.org/10.1016/j.yjmcc.2013.03.001 
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  • 2012 Conference Abstract
    ​ ​Afterload but not preload induces proliferation of cardiomyocytes and improves survival in cyclinD2-overexpressing mice​
    Toischer, K. ; Huenlich, M.; Zhang, W.; Reuter, S.; Maier, L. S. ; Sossalla, S. T.   & Field, L. J. et al.​ (2012)
    European Heart Journal33 , Munchen, GERMANY.
    Oxford​: Oxford Univ Press.
    Details  WoS 
  • 2012 Conference Abstract
    ​ ​Comparative studies of human induced pluripotent stem cells derived from bone marrow cells, hair keratinocytes and skin fibroblasts​
    Guan, K. ; Streckfuss-Bömeke, K. ; Wolf, F.; Azizian, A.; Stauske, M.; Tiburcy, M.   & Wagner, S. et al.​ (2012)
    European Heart Journal33 pp. 21​-22. , Munchen, GERMANY.
    Oxford​: Oxford Univ Press.
    Details  WoS 
  • 2012 Journal Article | 
    ​ ​Mild metabolic acidosis impairs the beta-adrenergic response in isolated human failing myocardium​
    Schotola, H.; Toischer, K. ; Popov, A.-F.; Renner, A.; Schmitto, J. D.; Gummert, J. F. & Quintel, M. et al.​ (2012) 
    CRITICAL CARE16(4) art. R153​.​ DOI: https://doi.org/10.1186/cc11468 
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  • 2012 Journal Article | Research Paper
    ​ ​Leptin promotes the mobilization of vascular progenitor cells and neovascularization by NOX2-mediated activation of MMP9​
    Schroeter, M. R. ; Stein, S.; Heida, N.-M.; Leifheit-Nestler, M. ; Cheng, I.-F. ; Gogiraju, R. & Christiansen, H. et al.​ (2012) 
    Cardiovascular Research93(1) pp. 170​-180​.​ DOI: https://doi.org/10.1093/cvr/cvr275 
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  • 2012 Journal Article | Research Paper
    ​ ​Targeted disruption of Hspa4 gene leads to cardiac hypertrophy and fibrosis​
    Mohamed, B. A. ; Barakat, A. Z.; Zimmermann, W.-H. ; Bittner, R. E.; Muehlfeld, C.; Huenlich, M.   & Engel, W. et al.​ (2012) 
    Journal of Molecular and Cellular Cardiology53(4) pp. 459​-468​.​ DOI: https://doi.org/10.1016/j.yjmcc.2012.07.014 
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  • 2011 Journal Article | Letter Note
    ​ ​Response to Letter Regarding Article, "Differential Cardiac Remodeling in Preload Versus Afterload"​
    Toischer, K. ; Rokita, A. G.; Unsoeld, B. W.; Sossalla, S. T. ; Becker, A.; Seidler, T. & Grebe, C. et al.​ (2011) 
    Circulation123(16).​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.110.017566 
    Details  DOI  WoS 
  • 2011 Journal Article | Research Paper
    ​ ​Effects of different proton pump inhibitors on cardiac contractility in isolated human failing myocardium​
    Sossalla, S. ; Schotola, H.; Schmitto, J. D.; Toischer, K. ; Sohns, C.; Schwoerer, H. & Hasenfuß, G.  et al.​ (2011) 
    Journal of Cardiovascular Surgery52(3) pp. 437​-444​.​
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  • 2011 Conference Abstract
    ​ ​Ablation of Phosphatase-1-Inhibitor-1 is Detrimental in CaMKII Overexpression Despite Reduction of SR Ca2+Leak​
    Neef, S.; Wittkoepper, K.; Brammen, C.; Sowa, T.; Zimmermann, W.-H. ; Brown, J. H. & Maier, L. S.  et al.​ (2011)
    Circulation124(21) 
    Philadelphia​: Lippincott Williams & Wilkins.
    Details  WoS 
  • 2011 Conference Abstract
    ​ ​Pressure overload-induced hypertrophy and heart failure are associated with arrhythmic triggers caused by late INa​
    Sossalla, S. T. ; Toischer, K. ; Hartmann, N.; Schulte, T.; Wagner, S.; Hasenfuß, G.   & Maier, L. S. ​ (2011)
    European Heart Journal32 pp. 997​-998. 
    Oxford​: Oxford Univ Press.
    Details  WoS 
  • 2011 Journal Article | Research Paper | 
    ​ ​Limitations of FKBP12.6-directed treatment strategies for maladaptive cardiac remodeling and heart failure​
    Seidler, T. ; Teucher, N. ; Hellenkamp, K. ; Unsoeld, B. W.; Grebe, C.; Kramps, P. & Schotola, H. et al.​ (2011) 
    Journal of Molecular and Cellular Cardiology50(1) pp. 33​-42​.​ DOI: https://doi.org/10.1016/j.yjmcc.2010.08.016 
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  • 2011 Journal Article | Research Paper | 
    ​ ​Diastolic dysfunction and arrhythmias caused by overexpression of CaMKII delta(C) can be reversed by inhibition of late Na+ current​
    Sossalla, S. ; Maurer, U.; Schotola, H.; Hartmann, N. H. ; Didie, M. ; Zimmermann, W.-H.   & Jacobshagen, C.  et al.​ (2011) 
    Basic Research in Cardiology106(2) pp. 263​-272​.​ DOI: https://doi.org/10.1007/s00395-010-0136-x 
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  • 2011 Journal Article | Research Paper
    ​ ​Telethonin Deficiency Is Associated With Maladaptation to Biomechanical Stress in the Mammalian Heart​
    Knöll, R.; Linke, W. A. ; Zou, P.; Miocic, S.; Kostin, S.; Buyandelger, B. & Ku, C.-H. et al.​ (2011) 
    Circulation Research109(7) pp. 758​-U153​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.111.245787 
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  • 2011 Journal Article | Research Paper
    ​ ​Ranolazine for the Treatment of Heart Failure With Preserved Ejection Fraction: Background, Aims, and Design of the RALI-DHF Study​
    Jacobshagen, C. ; Belardinelli, L.; Hasenfuß, G.   & Maier, L. S. ​ (2011) 
    Clinical Cardiology34(7) pp. 426​-432​.​ DOI: https://doi.org/10.1002/clc.20897 
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  • 2010 Conference Abstract
    ​ ​Differential cardiac remodeling in preload versus afterload​
    Toischer, K. ; Rokita, A. G.; Unsoeld, B. W.; Zhu, W.; Kararigas, G.; Regitz-Zagrosek, V. & Backs, J. et al.​ (2010)
    European Heart Journal31 , Stockholm, SWEDEN.
    Oxford​: Oxford Univ Press.
    Details  WoS 
  • 2010 Journal Article | 
    ​ ​Impaired Ca2+-handling in HIF-1 alpha(+/-) mice as a consequence of pressure overload​
    Silter, M.; Koegler, H.; Zieseniss, A.; Wilting, J.; Schaefer, K. ; Toischer, K.   & Rokita, A. G. et al.​ (2010) 
    Pflügers Archiv - European Journal of Physiology459(4) pp. 569​-577​.​ DOI: https://doi.org/10.1007/s00424-009-0748-x 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article | Research Paper | 
    ​ ​Effects of mild hypothermia on hemodynamics in cardiac arrest survivors and isolated failing human myocardium​
    Jacobshagen, C. ; Pelster, T.; Pax, A.; Horn, W.; Schmidt-Schweda, S.; Unsoeld, B. W. & Seidler, T.  et al.​ (2010) 
    Clinical Research in Cardiology99(5) pp. 267​-276​.​ DOI: https://doi.org/10.1007/s00392-010-0113-2 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article | Research Paper | 
    ​ ​Altered Na+ Currents in Atrial Fibrillation Effects of Ranolazine on Arrhythmias and Contractility in Human Atrial Myocardium​
    Sossalla, S. ; Kallmeyer, B.; Wagner, S. ; Mazur, M.; Maurer, U.; Toischer, K.   & Schmitto, J. D. et al.​ (2010) 
    Journal of the American College of Cardiology55(21) pp. 2330​-2342​.​ DOI: https://doi.org/10.1016/j.jacc.2009.12.055 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article | Research Paper | 
    ​ ​Differential Cardiac Remodeling in Preload Versus Afterload​
    Toischer, K. ; Rokita, A. G.; Unsoeld, B. W.; Zhu, W.; Kararigas, G.; Sossalla, S.   & Reuter, S. P. et al.​ (2010) 
    Circulation122(10) pp. 993​-1003​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.110.943431 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article | Research Paper
    ​ ​CaMKII-Dependent Diastolic SR Ca2+ Leak and Elevated Diastolic Ca2+ Levels in Right Atrial Myocardium of Patients With Atrial Fibrillation​
    Neef, S.; Dybkova, N.; Sossalla, S. ; Ort, K. R.; Fluschnik, N.; Neumann, K. & Seipelt, R. et al.​ (2010) 
    Circulation Research106(6) pp. 1134​-1144​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.109.203836 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article | Research Paper | 
    ​ ​Inhibition of Elevated Ca2+/Calmodulin-Dependent Protein Kinase II Improves Contractility in Human Failing Myocardium​
    Sossalla, S. ; Fluschnik, N.; Schotola, H.; Ort, K. R.; Neef, S.; Schulte, T. & Wittkoepper, K. et al.​ (2010) 
    Circulation Research107(9) pp. 1150​-U215​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.110.220418 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article | Research Paper
    ​ ​A Common MLP (Muscle LIM Protein) Variant Is Associated With Cardiomyopathy​
    Knöll, R.; Kostin, S.; Klede, S.; Savvatis, K.; Klinge, L. ; Stehle, I. & Gunkel, S. et al.​ (2010) 
    Circulation Research106(4) pp. 695​-704​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.109.206243 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article | Research Paper | 
    ​ ​Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging​
    Wittoepper, K.; Fabritz, L.; Neef, S.; Ort, K. R.; Grefe, C.; Unsoeld, B. W. & Kirchhof, P. et al.​ (2010) 
    Journal of Clinical Investigation120(2) pp. 617​-626​.​ DOI: https://doi.org/10.1172/JCI40545 
    Details  DOI  PMID  PMC  WoS 
  • 2009 Journal Article | Research Paper
    ​ ​Effects of large volume, ice-cold intravenous fluid infusion on respiratory function in cardiac arrest survivors​
    Jacobshagen, C. ; Pax, A.; Unsoeld, B. W.; Seidler, T. ; Schmidt-Schweda, S.; Hasenfuß, G.   & Maier, L. S. ​ (2009) 
    Resuscitation80(11) pp. 1223​-1228​.​ DOI: https://doi.org/10.1016/j.resuscitation.2009.06.032 
    Details  DOI  PMID  PMC  WoS 
  • 2009 Journal Article | Research Paper | 
    ​ ​Abnormalities of calcium metabolism and myocardial contractility depression in the failing heart​
    Lehnart, S. E. ; Maier, L. S.   & Hasenfuß, G. ​ (2009) 
    Heart Failure Reviews14(4) pp. 213​-224​.​ DOI: https://doi.org/10.1007/s10741-009-9146-x 
    Details  DOI  PMID  PMC  WoS 
  • 2008 Journal Article | Research Paper
    ​ ​Inhibition of PI3K improves contractility in alpha(1)-adrenergically stimulated myocardium​
    Jacobshagen, C. ; Kortlepel, S.; Unsoeld, B. W.; Sowa, T.; Koegler, H.; Hasenfuß, G.   & Maier, L. S. ​ (2008) 
    Frontiers in Bioscience13 pp. 6841​-6849​.​ DOI: https://doi.org/10.2741/3192 
    Details  DOI  PMID  PMC  WoS 
  • 2008 Journal Article | Research Paper
    ​ ​Celecoxib modulates hypertrophic signalling and prevents load-induced cardiac dysfunction​
    Jacobshagen, C. ; Grueber, M.; Teucher, N. ; Schmidt, A. G.; Unsoeld, B. W.; Toischer, K.   & Van, P. N. et al.​ (2008) 
    European Journal of Heart Failure10(4) pp. 334​-342​.​ DOI: https://doi.org/10.1016/j.ejheart.2008.02.013 
    Details  DOI  PMID  PMC  WoS 
  • 2008 Journal Article | Research Paper
    ​ ​Frequency-dependence of the slow force response​
    Lewinski, D. von; Zhu, D.; Khafaga, M.; Kockskamper, J.; Maier, L. S. ; Hasenfuss, G.   & Pieske, B. ​ (2008) 
    Frontiers in Bioscience13 pp. 7202​-7209​.​ DOI: https://doi.org/10.2741/3222 
    Details  DOI  PMID  PMC  WoS 
  • 2008 Journal Article | Research Paper
    ​ ​Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts - Role of late sodium current and intracellular ion accumulation​
    Sossalla, S. ; Wagner, S. ; Rasenack, E. C. L.; Ruff, H.; Weber, S. L.; Schoendube, F. A.   & Tirilomis, T.  et al.​ (2008) 
    Journal of Molecular and Cellular Cardiology45(1) pp. 32​-43​.​ DOI: https://doi.org/10.1016/j.yjmcc.2008.03.006 
    Details  DOI  PMID  PMC  WoS 
  • 2008 Journal Article | Research Paper
    ​ ​Generation of functional murine cardiac myocytes from induced pluripotent stem cells​
    Mauritz, C.; Schwanke, K.; Reppel, M.; Neef, S.; Katsirntaki, K.; Maier, L. S.   & Nguemo, F. et al.​ (2008) 
    Circulation118(5) pp. 507​-517​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.108.778795 
    Details  DOI  PMID  PMC  WoS 
  • 2008 Journal Article | Research Paper | 
    ​ ​Mechanism of action of the new anti-ischemia drug ranolazine​
    Hasenfuß, G.   & Maier, L. S. ​ (2008) 
    Clinical Research in Cardiology97(4) pp. 222​-226​.​ DOI: https://doi.org/10.1007/s00392-007-0612-y 
    Details  DOI  PMID  PMC  WoS 
  • 2007 Journal Article | Research Paper
    ​ ​Generation of functional cardiomyocytes from adult mouse spermatogonial stem cells​
    Guan, K. ; Wagner, S. ; Unsoeld, B. W.; Maier, L. S. ; Kaiser, D.; Hemmerlein, B.   & Nayernia, K. et al.​ (2007) 
    Circulation Research100(11) pp. 1615​-1625​.​ DOI: https://doi.org/10.1161/01.RES.0000269182.22798.d9 
    Details  DOI  PMID  PMC  WoS 
  • 2007 Journal Article | Research Paper
    ​ ​Negative inotropy of the gastric proton pump inhibitor pantoprazole in myocardium from humans and rabbits - Evaluation of mechanisms​
    Schillinger, W. ; Teucher, N. ; Sossalla, S. ; Kettlewell, S.; Werner, C. ; Raddatz, D.   & Elgner, A. et al.​ (2007) 
    Circulation116(1) pp. 57​-66​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.106.666008 
    Details  DOI  PMID  PMC  WoS 
  • 2007 Review
    ​ ​Targeting altered calcium physiology in the heart: Translational approaches to excitation, contraction, and transcription​
    Seidler, T. ; Hasenfuß, G.  & Maier, L. S. ​ (2007)
    Physiology, 22​(5) pp. 328​-334​.​
    Amer Physiological Soc. DOI: https://doi.org/10.1152/physiol.00015.2007 
    Details  DOI  PMID  PMC  WoS 
  • 2006 Journal Article | Research Paper
    ​ ​Relevance of brain natriuretic peptide in preload-dependent regulation of cardiac sarcoplasmic reticulum Ca2+ ATPase expression​
    Koegler, H.; Schott, P. ; Toischer, K. ; Milting, H.; Van, P. N.; Kohlhaas, M. & Grebe, C. et al.​ (2006) 
    Circulation113(23) pp. 2724​-2732​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.105.608828 
    Details  DOI  PMID  PMC  WoS 
  • 2006 Journal Article | Research Paper
    ​ ​Pluripotency of spermatogonial stem cells from adult mouse testis​
    Guan, K. ; Nayernia, K.; Maier, L. S. ; Wagner, S. ; Dressel, R. ; Lee, J. H. & Nolte, J.  et al.​ (2006) 
    Nature440(7088) pp. 1199​-1203​.​ DOI: https://doi.org/10.1038/nature04697 
    Details  DOI  PMID  PMC  WoS 
  • 2006 Journal Article | Research Paper
    ​ ​Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels​
    Wagner, S. ; Dybkova, N.; Rasenack, E. C. L.; Jacobshagen, C. ; Fabritz, L.; Kirchhof, P. & Maier, S. K. G. et al.​ (2006) 
    Journal of Clinical Investigation116(12) pp. 3127​-3138​.​ DOI: https://doi.org/10.1172/JCI26620 
    Details  DOI  PMID  PMC  WoS 
  • 2006 Journal Article | Research Paper
    ​ ​High intracellular Na+ preserves myocardial function at low heart rates in isolated myocardium from failing hearts​
    Schillinger, W. ; Teucher, N. ; Christians, C.; Kohlhaas, M.; Sossalla, S. ; Van Nguyen, P. & Schmidt, A. G. et al.​ (2006) 
    European Journal of Heart Failure8(7) pp. 673​-680​.​ DOI: https://doi.org/10.1016/j.ejheart.2006.01.013 
    Details  DOI  PMID  PMC  WoS 
  • 2005 Conference Abstract
    ​ ​Adult mouse spermatogonial stem cells differentiate into cardiovascular lineages and generate functional cardiomyocytes​
    Guan, K. ; Nayernia, K.; Maier, L. S. ; Wagner, S.; Wolf, F.; Li, M. Y. & Engel, W. et al.​ (2005)
    Circulation Research97(11) ​Scientific Meeting of the American-Heart-Association​, Dallas, TX.
    Philadelphia​: Lippincott Williams & Wilkins.
    Details  WoS 
  • 2003 Journal Article | Research Paper
    ​ ​Na+-Ca2+ exchanger overexpression predisposes to reactive oxygen species-induced injury​
    Wagner, S. ; Seidler, T. ; Picht, E.; Maier, L. S. ; Kazanski, V.; Teucher, N.   & Schillinger, W.  et al.​ (2003) 
    Cardiovascular Research60(2) pp. 404​-412​.​ DOI: https://doi.org/10.1016/j.cardiores.2003.08.006 
    Details  DOI  PMID  PMC  WoS 
  • 2002 Journal Article | Research Paper
    ​ ​Influence of pyruvate on contractile performance and Ca2+ cycling in isolated failing human myocardium​
    Hasenfuß, G. ; Maier, L. S. ; Hermann, H.-P.; Luers, C.; Hünlich, M. ; Zeitz, O. & Janssen, P. M. L. et al.​ (2002) 
    Circulation105(2) pp. 194​-199​.​ DOI: https://doi.org/10.1161/hc0202.102238 
    Details  DOI  PMID  PMC  WoS 
  • 2001 Journal Article | Research Paper
    ​ ​Influence of mild hypothermia on myocardial contractility and circulatory function​
    Weisser, J.; Martin, J.; Bisping, E. ; Maier, L. S. ; Beyersdorf, F.; Hasenfuß, G.   & Pieske, B. ​ (2001) 
    Basic Research in Cardiology96(2) pp. 198​-205​.​ DOI: https://doi.org/10.1007/s003950170071 
    Details  DOI  PMID  PMC  WoS 
  • 2000 Journal Article | Research Paper
    ​ ​Influence of cyclosporine A on contractile function, calcium handling, and energetics in isolated human and rabbit myocardium​
    Janssen, P. M. L.; Zeitz, O.; Keweloh, B.; Siegel, U.; Maier, L. S. ; Barckhausen, P. & Pieske, B.  et al.​ (2000) 
    Cardiovascular Research47(1) pp. 99​-107​.​ DOI: https://doi.org/10.1016/S0008-6363(00)00052-3 
    Details  DOI  PMID  PMC  WoS 
  • 1998 Journal Article | Research Paper
    ​ ​Frequency-dependent changes in contribution of SR Ca2+ to Ca2+ transients in failing human myocardium assessed with ryanodine​
    Schlotthauer, K.; Schattmann, J.; Bers, D. M.; Maier, L. S. ; Schutt, U.; Minami, K. & Just, H.  et al.​ (1998) 
    Journal of Molecular and Cellular Cardiology30(7) pp. 1285​-1294​.​ DOI: https://doi.org/10.1006/jmcc.1998.0690 
    Details  DOI  PMID  PMC  WoS 

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